\n| \u0647\u064a\u0643\u0631 \u0648\u0622\u062e\u0631\u0648\u0646\u060c \u0662\u0660\u0662\u0662\u00b9\u2076<\/td>\n | \u0642\u0631\u062f \u0627\u0644\u0643\u0627\u0628\u0648\u0643\n\n\n\n\n\u0642\u0631\u062f \u0627\u0644\u0645\u0643\u0627\u0643 \u0630\u0648 \u0627\u0644\u0630\u064a\u0644 \u0627\u0644\u0637\u0648\u064a\u0644<\/td>\n | \u062d\u0645\u064a\u0629 \u0627\u0644\u0627\u0646\u062d\u062f\u0627\u0631 + \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062e\u0627\u0641\u0636 \u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u062f\u0647\u0648\u0646 \u0645\u0646\u062e\u0641\u0636 \u0627\u0644\u0643\u062b\u0627\u0641\u0629<\/td>\n | \u0661\u0662 \u0634\u0647\u0631\u0627\u064b<\/td>\n | \u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u062a\u0623\u0643\u0633\u062f\u064a \u0648\u062a\u062d\u0633\u064a\u0646 \u0623\u0643\u0633\u064a\u062f \u0627\u0644\u0646\u064a\u062a\u0631\u064a\u0643 \u0627\u0644\u0628\u0637\u0627\u0646\u064a<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\u0627\u0644\u062a\u0631\u0627\u062c\u0639 \u0627\u0644\u062f\u0648\u0627\u0626\u064a: \u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a\u060c \u0648\u0645\u062b\u0628\u0637\u0627\u062a PCSK9\u060c \u0648\u0639\u0644\u0627\u062c \u0623\u0648\u0645\u064a\u063a\u0627 3<\/h3>\n\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a \u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0634\u062f\u0629<\/h4>\n\u0623\u0638\u0647\u0631\u062a \u062a\u062c\u0631\u0628\u0629 ASTEROID \u0623\u0646 \u062a\u0646\u0627\u0648\u0644 40 \u0645\u0644\u063a \u064a\u0648\u0645\u064a\u064b\u0627 \u0645\u0646 \u0627\u0644\u0631\u0648\u0632\u0648\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0623\u062f\u0649 \u0625\u0644\u0649 \u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0644\u062d\u062c\u0645 \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a (PAV) \u0628\u0645\u0642\u062f\u0627\u0631 0.98% \u0648\u062d\u062c\u0645 \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a (TAV) \u0628\u0645\u0642\u062f\u0627\u0631 6.8% \u0639\u0644\u0649 \u0645\u062f\u0627\u0631 24 \u0634\u0647\u0631\u064b\u0627.\u00b9 \u0648\u0623\u0643\u062f\u062a \u062a\u062c\u0631\u0628\u0629 SATURN \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0646\u0648\u0639\u064a\u0646 \u0645\u0646 \u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0641\u0639\u0627\u0644\u0629\u060c \u062d\u064a\u062b \u0623\u0638\u0647\u0631\u062a \u0623\u0646 \u0645\u062f\u0649 \u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u0643\u0648\u0644\u064a\u0633\u062a\u0631\u0648\u0644 \u0627\u0644\u0636\u0627\u0631 (LDL-C) \u064a\u0631\u062a\u0628\u0637 \u0627\u0631\u062a\u0628\u0627\u0637\u064b\u0627 \u0645\u0628\u0627\u0634\u0631\u064b\u0627 \u0628\u0645\u062f\u0649 \u062a\u0631\u0627\u062c\u0639 \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a.\u00b2 \u0648\u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u062e\u0641\u0636 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u062f\u0647\u0648\u0646\u060c \u062a\u064f\u0638\u0647\u0631 \u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u0627\u062a \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0645\u062a\u0639\u062f\u062f\u0629: \u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u064a C\u060c \u0648\u062a\u062d\u0633\u064a\u0646 \u0627\u0642\u062a\u0631\u0627\u0646 \u0625\u0646\u0632\u064a\u0645 eNOS\u060c \u0648\u062a\u0642\u0644\u064a\u0644 \u0627\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u062a\u0623\u0643\u0633\u062f\u064a.\u00b3 \u062a\u0633\u0627\u0639\u062f \u0647\u0630\u0647 \u0627\u0644\u0641\u0648\u0627\u0626\u062f \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a \u0641\u064a \u062a\u0641\u0633\u064a\u0631 \u0627\u0646\u062e\u0641\u0627\u0636 \u0645\u0639\u062f\u0644 \u062d\u062f\u0648\u062b \u0627\u0644\u0623\u062d\u062f\u0627\u062b \u062d\u062a\u0649 \u0639\u0646\u062f \u0645\u0633\u062a\u0648\u064a\u0627\u062a LDL \u0645\u062a\u0648\u0627\u0636\u0639\u0629.<\/p>\n \u0645\u0633\u0628\u0628\u0627\u062a \u0627\u0645\u062a\u0635\u0627\u0635 \u0627\u0644\u0643\u0648\u0644\u064a\u0633\u062a\u0631\u0648\u0644 PCSK9<\/h4>\n\u064a\u0639\u0632\u0632 \u0628\u0631\u0648\u062a\u064a\u0646 PCSK9 \u0627\u0644\u062a\u062d\u0644\u0644 \u0627\u0644\u0644\u064a\u0632\u0648\u0632\u0648\u0645\u064a \u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a LDL \u0627\u0644\u0643\u0628\u062f\u064a\u0629. \u0648\u064a\u0624\u062f\u064a \u062a\u062b\u0628\u064a\u0637 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0623\u062d\u0627\u062f\u064a\u0629 \u0627\u0644\u0646\u0633\u064a\u0644\u0629 (\u0625\u064a\u0641\u0648\u0644\u0648\u0643\u0648\u0645\u0627\u0628\u060c \u0623\u0644\u064a\u0631\u0648\u0643\u0648\u0645\u0627\u0628) \u0625\u0644\u0649 \u062a\u0639\u0632\u064a\u0632 \u0625\u0639\u0627\u062f\u0629 \u062a\u062f\u0648\u064a\u0631 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a\u060c \u0645\u0645\u0627 \u064a\u0646\u062a\u062c \u0639\u0646\u0647 \u0642\u064a\u0645 LDL-C \u0623\u0642\u0644 \u0645\u0646 30 \u0645\u062c\u0645\/\u062f\u064a\u0633\u064a\u0644\u062a\u0631. \u0648\u0641\u064a \u062f\u0631\u0627\u0633\u0629 GLAGOV\u060c \u0623\u062f\u0649 \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0625\u064a\u0641\u0648\u0644\u0648\u0643\u0648\u0645\u0627\u0628 \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646 \u0625\u0644\u0649 \u0627\u0646\u062e\u0641\u0627\u0636 \u0625\u0636\u0627\u0641\u064a \u0628\u0646\u0633\u0628\u0629 1% \u0641\u064a PAV \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646 \u0648\u062d\u062f\u0647.\u2074 \u0648\u0643\u0634\u0641\u062a \u062f\u0631\u0627\u0633\u062a\u0627 PACMAN-AMI \u0648HUYGENS \u0639\u0646 \u0648\u062c\u0648\u062f \u0623\u063a\u0637\u064a\u0629 \u0644\u064a\u0641\u064a\u0629 \u0623\u0643\u062b\u0631 \u0633\u0645\u0643\u064b\u0627 \u0648\u0646\u0648\u0649 \u062f\u0647\u0646\u064a\u0629 \u0623\u0635\u063a\u0631 \u062d\u062c\u0645\u064b\u0627 \u0645\u0639 \u062a\u062b\u0628\u064a\u0637 PCSK9.\u2075\u207b\u2076 \u0648\u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0641\u0648\u0627\u0626\u062f \u0627\u0644\u0646\u0633\u064a\u062c\u064a\u0629\u060c \u0644\u0645 \u064a\u062a\u063a\u064a\u0631 \u0645\u062a\u0648\u0633\u0637 \u0645\u0633\u0627\u062d\u0629 \u0627\u0644\u062a\u062c\u0648\u064a\u0641 \u0625\u0644\u0627 \u0642\u0644\u064a\u0644\u0627\u064b\u060c \u0648\u0647\u0648 \u0645\u0627 \u064a\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u062a\u0634\u0643\u064a\u0644 \u0627\u0644\u0639\u0643\u0633\u064a \u0628\u062f\u0644\u0627\u064b \u0645\u0646 \u0627\u0644\u0627\u0646\u0633\u062f\u0627\u062f \u0627\u0644\u0645\u0633\u062a\u0645\u0631.<\/p>\n \u0623\u062d\u0645\u0627\u0636 \u0623\u0648\u0645\u064a\u063a\u0627 3 \u0627\u0644\u062f\u0647\u0646\u064a\u0629 (\u0625\u064a\u0643\u0648\u0633\u0627\u0628\u0646\u062a \u0625\u064a\u062b\u064a\u0644)<\/h4>\n\u0641\u064a \u062f\u0631\u0627\u0633\u0629 \u00ab\u0625\u064a\u0641\u0627\u0628\u0648\u0631\u064a\u062a\u00bb (EVAPORATE)\u060c \u0623\u062f\u062a \u0627\u0644\u062c\u0631\u0639\u0627\u062a \u0627\u0644\u0639\u0627\u0644\u064a\u0629 \u0645\u0646 \u0625\u064a\u0643\u0648\u0633\u0627\u0628\u0646\u062a \u0625\u064a\u062b\u064a\u0644 \u0625\u0644\u0649 \u062a\u0642\u0644\u064a\u0644 \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a \u0630\u0627\u062a \u0627\u0644\u062a\u0648\u0647\u064a\u0646 \u0627\u0644\u0645\u0646\u062e\u0641\u0636 \u0628\u0646\u0633\u0628\u0629 17% \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0648\u0647\u0645\u064a\u060c \u0643\u0645\u0627 \u0623\u062f\u062a \u0625\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0646\u0633\u064a\u062c \u0627\u0644\u0644\u064a\u0641\u064a.\u2077 \u064a\u0646\u062f\u0645\u062c \u062d\u0645\u0636 \u0627\u0644\u0625\u064a\u0643\u0648\u0633\u0627\u0628\u0646\u062a \u0625\u064a\u062b\u064a\u0644 (EPA) \u0641\u064a \u0623\u063a\u0634\u064a\u0629 \u0627\u0644\u0641\u0648\u0633\u0641\u0648\u0644\u064a\u0628\u064a\u062f\u060c \u0648\u064a\u0642\u0644\u0644 \u0645\u0646 \u0627\u0644\u0625\u064a\u0643\u0648\u0633\u0627\u0646\u0648\u064a\u062f\u0627\u062a \u0627\u0644\u0645\u0634\u062a\u0642\u0629 \u0645\u0646 \u062d\u0645\u0636 \u0627\u0644\u0623\u0631\u0627\u0643\u064a\u062f\u0648\u0646\u064a\u0643\u060c \u0648\u064a\u0634\u0643\u0644 \u0645\u0631\u0643\u0628\u0627\u062a \u0627\u0644\u0631\u064a\u0632\u0648\u0644\u0641\u064a\u0646 \u0648\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0643\u062a\u064a\u0646 \u0627\u0644\u062a\u064a \u062a\u0639\u0645\u0644 \u0628\u0646\u0634\u0627\u0637 \u0639\u0644\u0649 \u062a\u0647\u062f\u0626\u0629 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628. \u0648\u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u0639\u062f\u064a\u0644 \u0627\u0644\u0648\u0633\u0637\u0627\u0621 \u0627\u0644\u062f\u0647\u0646\u064a\u064a\u0646 \u0648\u062a\u062d\u0633\u064a\u0646 \u0645\u0631\u0648\u0646\u0629 \u0627\u0644\u0628\u0637\u0627\u0646\u0629\u060c \u0642\u062f \u064a\u0643\u0645\u0644 \u062d\u0645\u0636 \u0627\u0644\u0625\u064a\u0643\u0648\u0633\u0627\u0628\u0646\u062a \u0625\u064a\u062b\u064a\u0644 (EPA) \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646 \u0644\u062a\u062d\u0642\u064a\u0642 \u0627\u0644\u0627\u0633\u062a\u0642\u0631\u0627\u0631 \u0648\u0627\u0644\u0641\u0648\u0627\u0626\u062f \u0627\u0644\u062d\u0631\u0643\u064a\u0629 \u0627\u0644\u0648\u0639\u0627\u0626\u064a\u0629 \u0639\u0644\u0649 \u062d\u062f \u0633\u0648\u0627\u0621.<\/p>\n \u0646\u0645\u0637 \u0627\u0644\u062d\u064a\u0627\u0629 \u0627\u0644\u0642\u0627\u0626\u0645 \u0639\u0644\u0649 \u0627\u0644\u0623\u0637\u0639\u0645\u0629 \u0627\u0644\u0646\u0628\u0627\u062a\u064a\u0629 \u0627\u0644\u0643\u0627\u0645\u0644\u0629 \u0648\u062a\u0631\u0627\u062c\u0639 \u0642\u0635\u0648\u0631 \u0627\u0644\u0634\u0631\u064a\u0627\u0646 \u0627\u0644\u062a\u0627\u062c\u064a<\/h3>\n\u0644\u0627 \u062a\u0632\u0627\u0644 \u062f\u0631\u0627\u0633\u0627\u062a \u062f\u064a\u0646 \u0623\u0648\u0631\u0646\u064a\u0634 \u0623\u0633\u0627\u0633\u064a\u0629. \u0641\u064a \u0644\u0627\u0646\u0633\u064a\u062a<\/em> (1990) \u0648 \u062c\u0627\u0645\u0627<\/em> (1998) \u0641\u064a \u0627\u0644\u062a\u062c\u0627\u0631\u0628\u060c \u0623\u0638\u0647\u0631 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0648\u0646 \u0627\u0644\u0630\u064a\u0646 \u0627\u062a\u0628\u0639\u0648\u0627 \u0646\u0638\u0627\u0645\u064b\u0627 \u063a\u0630\u0627\u0626\u064a\u064b\u0651\u0627 \u0645\u0646\u062e\u0641\u0636 \u0627\u0644\u062f\u0647\u0648\u0646 \u0648\u0642\u0627\u0626\u0645\u064b\u0627 \u0639\u0644\u0649 \u0627\u0644\u0646\u0628\u0627\u062a\u0627\u062a \u0628\u0627\u0644\u0643\u0627\u0645\u0644 (WFPB)\u060c \u0625\u0644\u0649 \u062c\u0627\u0646\u0628 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u0625\u062c\u0647\u0627\u062f \u0648\u0645\u0645\u0627\u0631\u0633\u0629 \u0627\u0644\u062a\u0645\u0627\u0631\u064a\u0646 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u0629 \u0648\u0627\u0644\u0625\u0642\u0644\u0627\u0639 \u0639\u0646 \u0627\u0644\u062a\u062f\u062e\u064a\u0646\u060c \u062a\u062d\u0633\u064f\u0651\u0646\u064b\u0627 \u0641\u064a \u0627\u0644\u062a\u0636\u064a\u0642 \u0627\u0644\u062a\u0627\u062c\u064a \u0648\u0641\u0642\u064b\u0627 \u0644\u0644\u062a\u0635\u0648\u064a\u0631 \u0627\u0644\u0648\u0639\u0627\u0626\u064a \u0628\u0646\u0633\u0628\u0629 7.9% \u0628\u0639\u062f \u062e\u0645\u0633 \u0633\u0646\u0648\u0627\u062a \u062f\u0648\u0646 \u0627\u0644\u0644\u062c\u0648\u0621 \u0625\u0644\u0649 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062f\u0648\u0627\u0626\u064a.\u2078\u207b\u2079 \u0648\u0623\u0634\u0627\u0631\u062a \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0625\u0644\u0649 \u0623\u0646 \u062a\u0635\u0644\u0628 \u0627\u0644\u0634\u0631\u0627\u064a\u064a\u0646 \u0627\u0644\u062a\u0627\u062c\u064a\u0629 \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u062a\u0631\u0627\u062c\u0639 \u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u063a\u064a\u064a\u0631 \u0627\u0644\u0633\u0644\u0648\u0643 \u0648\u062d\u062f\u0647.<\/p>\n\u0622\u0644\u064a\u0627\u062a \u0627\u0644\u062a\u0631\u0627\u062c\u0639 \u0627\u0644\u0645\u062f\u0641\u0648\u0639 \u0628\u0646\u0645\u0637 \u0627\u0644\u062d\u064a\u0627\u0629<\/strong><\/p>\n\n- \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u062f\u0647\u0648\u0646:<\/strong> \u0625\u0644\u063a\u0627\u0621 \u0627\u0644\u062f\u0647\u0648\u0646 \u0627\u0644\u062d\u064a\u0648\u0627\u0646\u064a\u0629 \u064a\u0642\u0644\u0644 \u0645\u0646 \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u0643\u0628\u062f \u0644\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u062f\u0647\u0646\u064a \u0645\u0646\u062e\u0641\u0636 \u0627\u0644\u0643\u062b\u0627\u0641\u0629\u061b \u0648\u0627\u0644\u0623\u0644\u064a\u0627\u0641 \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0630\u0648\u0628\u0627\u0646 \u062a\u0639\u0632\u0632 \u0625\u0641\u0631\u0627\u0632 \u0627\u0644\u0643\u0648\u0644\u064a\u0633\u062a\u0631\u0648\u0644.<\/li>\n
- \u0648\u0638\u064a\u0641\u0629 \u0628\u0637\u0627\u0646\u0629 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629:<\/strong> \u0646\u062a\u0631\u0627\u062a \u0627\u0644\u0646\u0628\u0627\u062a\u0627\u062a \u0645\u0646 \u0627\u0644\u062e\u0636\u0631\u0648\u0627\u062a \u0627\u0644\u0648\u0631\u0642\u064a\u0629 \u062a\u0632\u064a\u062f \u0645\u0646 \u062a\u0648\u0641\u0631 \u0623\u0643\u0633\u064a\u062f \u0627\u0644\u0646\u064a\u062a\u0631\u064a\u0643 (NO)\u061b \u0648\u0627\u0644\u0628\u0648\u0644\u064a \u0641\u0646\u0648\u0644 \u064a\u062d\u0633\u0646 \u0627\u0644\u0641\u0633\u0641\u0631\u0629 \u0644\u0625\u0646\u0632\u064a\u0645 \u0623\u0643\u0633\u064a\u062f \u0627\u0644\u0646\u064a\u062a\u0631\u064a\u0643 \u0627\u0644\u0628\u0637\u0627\u0646\u064a (eNOS).\u00b9\u2077\u060c\u00b2\u00b9<\/li>\n
- \u0627\u0644\u0637\u0627\u0628\u0639 \u0627\u0644\u062a\u0623\u0643\u0633\u062f\u064a \u0648\u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u064a<\/strong> \u062d\u062f \u0627\u0633\u062a\u0647\u0644\u0627\u0643 \u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u0623\u0643\u0633\u062f\u0629 \u0645\u0646 \u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0623\u0643\u0633\u062c\u064a\u0646 \u0627\u0644\u062a\u0641\u0627\u0639\u0644\u064a\u0629 (ROS)\u061b \u0648\u0627\u0646\u062e\u0641\u0636 \u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u062a\u0641\u0627\u0639\u0644 C (CRP) \u062c\u0632\u064a\u0626\u0627\u062a \u0627\u0644\u0627\u0644\u062a\u0635\u0627\u0642.\u00b2\u2070\u060c\u00b2\u00b2<\/li>\n
- \u062a\u0639\u062f\u064a\u0644 \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u0628\u064a\u0648\u0645:<\/strong> \u0625\u0646 \u0627\u0646\u062e\u0641\u0627\u0636 \u0625\u0646\u062a\u0627\u062c \u0623\u0643\u0633\u064a\u062f \u062b\u0644\u0627\u062b\u064a \u0645\u064a\u062b\u064a\u0644 \u0627\u0644\u0623\u0645\u064a\u0646 (TMAO) \u0648\u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0623\u062d\u0645\u0627\u0636 \u0627\u0644\u062f\u0647\u0646\u064a\u0629 \u0642\u0635\u064a\u0631\u0629 \u0627\u0644\u0633\u0644\u0633\u0644\u0629 \u064a\u0642\u0644\u0644\u0627\u0646 \u0645\u0646 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u062c\u0647\u0627\u0632\u0649.<\/li>\n
- \u0627\u0644\u062a\u0643\u0627\u0645\u0644 \u0627\u0644\u0623\u064a\u0636\u064a:<\/strong> \u062a\u062d\u0633\u064a\u0646 \u062d\u0633\u0627\u0633\u064a\u0629 \u0627\u0644\u0623\u0646\u0633\u0648\u0644\u064a\u0646 \u0648\u062a\u0642\u0644\u064a\u0644 \u0627\u0644\u062f\u0647\u0648\u0646 \u0627\u0644\u062b\u0644\u0627\u062b\u064a\u0629 \u0628\u0639\u062f \u0627\u0644\u0623\u0643\u0644 \u064a\u0642\u0644\u0644\u0627\u0646 \u0645\u0646 \u0627\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u0628\u0637\u0627\u0646\u064a.<\/li>\n<\/ul>\n
\u062a\u0624\u0643\u062f \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0623\u0642\u0634\u0627\u0631 \u0627\u0644\u0643\u0628\u064a\u0631\u0629 (\u062f\u0631\u0627\u0633\u0629 \u0635\u062d\u0629 \u0627\u0644\u0633\u0628\u062a\u064a\u064a\u0646-2\u060c \u0648\u0625\u0628\u064a\u0643-\u0623\u0643\u0633\u0641\u0648\u0631\u062f) \u0627\u0646\u062e\u0641\u0627\u0636 \u0645\u0639\u062f\u0644 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0642\u0644\u0628 \u0627\u0644\u0625\u0650\u0642\u0652\u062d\u064e\u0627\u0645\u0650\u064a\u0651\u0629 (\u0627\u0644\u0625\u0650\u0642\u0652\u062d\u064e\u0627\u0645\u0650\u064a\u0651\u0629\/\u0627\u0644\u0625\u0650\u0634\u0652\u0643\u064a\u0645\u064a\u0651\u0629) \u0628\u064a\u0646 \u0627\u0644\u062a\u062c\u0645\u0639\u0627\u062a \u0627\u0644\u0633\u0643\u0627\u0646\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0639\u062a\u0645\u062f \u0628\u0634\u0643\u0644 \u0623\u0633\u0627\u0633\u064a \u0639\u0644\u0649 \u0627\u0644\u0646\u0628\u0627\u062a\u0627\u062a. \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a\u060c \u0641\u0625\u0646 \u062a\u0639\u062f\u064a\u0644 \u0646\u0645\u0637 \u0627\u0644\u062d\u064a\u0627\u0629 \u064a\u064f\u062d\u062f\u062b \u062a\u0646\u0627\u063a\u0645\u0627\u064b \u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0627\u064b \u062d\u064a\u0648\u064a\u0651\u0627\u064b\u060c \u0648\u0628\u0646\u064a\u0648\u064a\u0651\u0627\u064b\u060c \u0648\u0648\u0638\u064a\u0641\u064a\u0651\u0627\u064b.<\/p>\n \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0644\u0631\u064a\u0627\u0636\u064a\u064a\u0646 \u0627\u0644\u0630\u064a\u0646 \u064a\u0645\u0627\u0631\u0633\u0648\u0646 \u0631\u064a\u0627\u0636\u0627\u062a \u0627\u0644\u062a\u062d\u0645\u0644\u060c \u062a\u0648\u0641\u0631 \u0647\u0630\u0647 \u0627\u0644\u0622\u0644\u064a\u0627\u062a \u0645\u064a\u0632\u0629 \u0625\u0636\u0627\u0641\u064a\u0629\u060c \u0648\u0647\u064a \u0627\u0644\u0625\u0646\u062a\u0627\u062c \u0627\u0644\u0645\u0633\u062a\u0645\u0631 \u0644\u0623\u0643\u0633\u064a\u062f \u0627\u0644\u0646\u064a\u062a\u0631\u064a\u0643 \u0627\u0644\u0628\u0637\u0627\u0646\u064a \u0645\u0645\u0627 \u064a\u062a\u064a\u062d \u0642\u062f\u0631\u0629 \u0641\u0627\u0626\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u062a\u0643\u064a\u0641 \u0627\u0644\u0648\u0639\u0627\u0626\u064a \u0627\u0644\u062d\u0631\u0643\u064a. \u0648\u0639\u0644\u0649 \u0639\u0643\u0633 \u0627\u0644\u062a\u0631\u0627\u062c\u0639 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u060c \u0627\u0644\u0630\u064a \u0642\u062f \u064a\u0634\u062c\u0639 \u0639\u0644\u0649 \u0625\u0639\u0627\u062f\u0629 \u062a\u0634\u0643\u064a\u0644 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u0628\u0634\u0643\u0644 \u062a\u0636\u064a\u0642\u064a\u060c \u0641\u0625\u0646 \u0627\u0644\u062a\u0639\u0627\u0641\u064a \u0627\u0644\u0645\u062f\u0641\u0648\u0639 \u0628\u0646\u0645\u0637 \u0627\u0644\u062d\u064a\u0627\u0629 \u063a\u0627\u0644\u0628\u0627\u064b \u0645\u0627 \u064a\u062d\u0627\u0641\u0638 \u0639\u0644\u0649 \u0627\u0644\u0645\u0631\u0648\u0646\u0629 \u0627\u0644\u062e\u0627\u0631\u062c\u064a\u0629\u060c \u0645\u0645\u0627 \u064a\u0648\u0627\u0621\u0645 \u0628\u064a\u0646 \u0627\u0644\u0635\u062d\u0629 \u0648\u0627\u0644\u0623\u062f\u0627\u0621.<\/p>\n \u0627\u0644\u0623\u062f\u0644\u0629 \u0627\u0644\u062a\u0635\u0648\u064a\u0631\u064a\u0629 \u0648\u0637\u0628\u064a\u0639\u0629 \u062a\u0631\u0627\u062c\u0639 \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a<\/h3>\n\u0644\u0642\u062f \u0623\u062f\u062a \u062a\u0642\u0646\u064a\u0627\u062a \u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0627\u0644\u062d\u062f\u064a\u062b\u0629 \u0625\u0644\u0649 \u062a\u062d\u0648\u064a\u0644 \u0627\u0644\u0627\u0646\u0643\u0645\u0627\u0634 \u0645\u0646 \u0645\u062c\u0631\u062f \u062a\u062c\u0631\u064a\u062f \u0643\u064a\u0645\u064a\u0627\u0626\u064a \u062d\u064a\u0648\u064a \u0625\u0644\u0649 \u0638\u0627\u0647\u0631\u0629 \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0642\u064a\u0627\u0633 \u0627\u0644\u0643\u0645\u064a. \u0644\u0642\u062f \u0623\u062a\u0627\u062d \u0638\u0647\u0648\u0631 \u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u062f\u0627\u062e\u0644 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u0639\u0627\u0644\u064a \u0627\u0644\u062f\u0642\u0629 \u0648\u063a\u064a\u0631 \u0627\u0644\u063a\u0627\u0632\u064a \u0644\u0644\u0628\u0627\u062d\u062b\u064a\u0646 \u062a\u0648\u0635\u064a\u0641 \u062a\u0643\u0648\u064a\u0646 \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a\u060c \u0648\u0627\u0644\u062a\u0634\u0643\u064a\u0644 \u0627\u0644\u0623\u0628\u0646\u064a \u0627\u0644\u0648\u0639\u0627\u0626\u064a\u060c \u0648\u0645\u0647\u0646\u062f\u0633\u0629 \u0644\u0645\u0639\u0629 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0628\u0645\u0631\u0648\u0631 \u0627\u0644\u0648\u0642\u062a.<\/p>\n \u0627\u0644\u0645\u0648\u062c\u0627\u062a \u0641\u0648\u0642 \u0627\u0644\u0635\u0648\u062a\u064a\u0629 \u062f\u0627\u062e\u0644 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629<\/h4>\n\u0644\u0642\u062f \u0643\u0627\u0646 \u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0628\u0627\u0644\u0645\u0648\u062c\u0627\u062a \u0641\u0648\u0642 \u0627\u0644\u0635\u0648\u062a\u064a\u0629 \u062f\u0627\u062e\u0644 \u0627\u0644\u0634\u0631\u0627\u064a\u064a\u0646 (IVUS) \u062d\u062c\u0631 \u0627\u0644\u0623\u0633\u0627\u0633 \u0641\u064a \u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u062a\u0631\u0627\u062c\u0639 \u0645\u0646\u0630 \u062a\u0633\u0639\u064a\u0646\u064a\u0627\u062a \u0627\u0644\u0642\u0631\u0646 \u0627\u0644\u0639\u0634\u0631\u064a\u0646. \u0648\u0647\u0648 \u064a\u062a\u064a\u062d \u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u062d\u062c\u0645 \u062b\u0644\u0627\u062b\u064a \u0627\u0644\u0623\u0628\u0639\u0627\u062f \u0644\u0639\u0628\u0621 \u0627\u0644\u0639\u0635\u064a\u062f\u0629 \u0648\u0645\u0633\u0627\u062d\u0629 \u062c\u062f\u0627\u0631 \u0627\u0644\u0648\u0639\u0627\u0621 \u0627\u0644\u062f\u0645\u0648\u064a. \u0648\u0639\u0644\u0649 \u0639\u0643\u0633 \u062a\u0635\u0648\u064a\u0631 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629\u060c \u0627\u0644\u0630\u064a \u064a\u0639\u0643\u0633 \u0627\u0644\u0644\u0645\u0639\u0629 \u0641\u0642\u0637\u060c \u0641\u0625\u0646 \u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0628\u0627\u0644\u0645\u0648\u062c\u0627\u062a \u0641\u0648\u0642 \u0627\u0644\u0635\u0648\u062a\u064a\u0629 \u062f\u0627\u062e\u0644 \u0627\u0644\u0634\u0631\u0627\u064a\u064a\u0646 \u064a\u0635\u0648\u0631 \u062c\u062f\u0627\u0631 \u0627\u0644\u0634\u0631\u064a\u0627\u0646 \u0628\u0623\u0643\u0645\u0644\u0647\u060c \u0643\u0627\u0634\u0641\u0627\u064b \u0639\u0646 \u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u062a\u0634\u0643\u064a\u0644 \u0627\u0644\u062a\u0639\u0648\u064a\u0636\u064a\u0629\u060c \u0648\u062a\u062c\u0645\u0639\u0627\u062a \u0627\u0644\u062f\u0647\u0648\u0646\u060c \u0648\u0627\u0644\u062a\u0643\u0644\u0633. \u0648\u0641\u064a \u062d\u0627\u0644\u0627\u062a \u0627\u0644\u062a\u0631\u0627\u062c\u0639\u060c \u0639\u0627\u062f\u0629 \u0645\u0627 \u062a\u0633\u0628\u0642 \u0627\u0644\u0627\u0646\u062e\u0641\u0627\u0636\u0627\u062a \u0641\u064a \u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0644\u062d\u062c\u0645 \u0627\u0644\u0639\u0635\u064a\u062f\u0629 (PAV) \u0648\u0625\u062c\u0645\u0627\u0644\u064a \u062d\u062c\u0645 \u0627\u0644\u0639\u0635\u064a\u062f\u0629 (TAV) \u0627\u0644\u062a\u063a\u064a\u0631\u0627\u062a \u0641\u064a \u0627\u0644\u0644\u0645\u0639\u0629\u060c \u0623\u0648 \u062a\u062d\u062f\u062b \u0628\u0634\u0643\u0644 \u0645\u0633\u062a\u0642\u0644 \u0639\u0646\u0647\u0627. \u0643\u0645\u0627 \u064a\u0645\u064a\u0632 \u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0627\u0644\u0646\u0633\u062c\u064a \u0627\u0644\u0627\u0641\u062a\u0631\u0627\u0636\u064a (VH-IVUS) \u0628\u0634\u0643\u0644 \u0623\u0643\u0628\u0631 \u0628\u064a\u0646 \u0645\u0643\u0648\u0646\u0627\u062a \u0627\u0644\u0644\u0648\u064a\u062d\u0629\u060c \u0645\u0645\u0627 \u064a\u0648\u0636\u062d \u0623\u0646 \u062e\u0641\u0636 \u0627\u0644\u062f\u0647\u0648\u0646 \u0627\u0644\u0645\u0643\u062b\u0641 \u064a\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u062d\u062a\u0648\u0649 \u0627\u0644\u0644\u064a\u0641\u064a \u0648\u064a\u0642\u0644\u0644 \u0645\u0646 \u062d\u062c\u0645 \u0627\u0644\u0646\u0648\u0627\u0629 \u0627\u0644\u0646\u062e\u0631\u064a\u0629.<\/p>\n \u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0627\u0644\u0645\u0642\u0637\u0639\u064a \u0628\u0627\u0644\u062a\u0648\u0627\u0641\u0642 \u0627\u0644\u0628\u0635\u0631\u064a (OCT) \u0648\u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0637\u064a\u0641\u064a \u0644\u0644\u0623\u0634\u0639\u0629 \u062a\u062d\u062a \u0627\u0644\u062d\u0645\u0631\u0627\u0621 \u0627\u0644\u0642\u0631\u064a\u0628\u0629 (NIRS)<\/h4>\n\u064a\u0648\u0641\u0631 \u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0627\u0644\u0645\u0642\u0637\u0639\u064a \u0627\u0644\u062a\u0648\u0627\u0641\u0642\u064a \u0627\u0644\u0628\u0635\u0631\u064a (OCT) \u062f\u0642\u0629 \u062a\u0642\u0627\u0631\u0628 \u0627\u0644\u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0646\u0633\u064a\u062c\u064a \u0644\u0633\u0645\u0643 \u0627\u0644\u063a\u0637\u0627\u0621 \u0627\u0644\u0644\u064a\u0641\u064a\u060c \u0648\u0647\u0648 \u0645\u0624\u0634\u0631 \u0623\u0633\u0627\u0633\u064a \u0644\u062a\u0646\u0628\u0624 \u062e\u0637\u0631 \u0627\u0644\u062a\u0645\u0632\u0642. \u0648\u0639\u0642\u0628 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0643\u062b\u0641\u060c \u064a\u0643\u0634\u0641 \u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0627\u0644\u0645\u0642\u0637\u0639\u064a \u0627\u0644\u062a\u0648\u0627\u0641\u0642\u064a \u0627\u0644\u0628\u0635\u0631\u064a \u0639\u0646 \u063a\u0637\u0627\u0621 \u0623\u0643\u062b\u0631 \u0633\u0645\u0643\u0627\u064b \u0648\u062a\u062c\u0627\u0646\u0633\u0627\u064b \u0645\u0639 \u0642\u0646\u0648\u0627\u062a \u062f\u0642\u064a\u0642\u0629 \u0623\u0642\u0644. \u0648\u064a\u0645\u0643\u0646 \u0644\u0644\u0642\u0633\u0637\u0631\u0629 \u0627\u0644\u0647\u062c\u064a\u0646\u0629 (NIRS) \u0648(NIRS-IVUS) \u0642\u064a\u0627\u0633 \u0645\u0624\u0634\u0631 \u0639\u0628\u0621 \u0627\u0644\u0644\u0628 \u0627\u0644\u062f\u0647\u0646\u064a (LCBI)\u060c \u0645\u0645\u0627 \u064a\u064f\u0638\u0647\u0631 \u0627\u0646\u062e\u0641\u0627\u0636\u0627\u062a \u0645\u0644\u062d\u0648\u0638\u0629 \u062a\u062d\u062a \u062a\u0623\u062b\u064a\u0631 \u0639\u0644\u0627\u062c (PCSK9) \u0623\u0648 \u0623\u0648\u0645\u064a\u063a\u0627-3. \u0648\u0645\u0639\u0627\u064b\u060c \u062a\u062b\u0628\u062a \u0647\u0630\u0647 \u0627\u0644\u062a\u0642\u0646\u064a\u0627\u062a \u0627\u0644\u0627\u0633\u062a\u0642\u0631\u0627\u0631 \u0627\u0644\u0647\u0643\u0644\u064a \u062d\u062a\u0649 \u0639\u0646\u062f\u0645\u0627 \u062a\u0628\u062f\u0648 \u0647\u0646\u062f\u0633\u0629 \u0627\u0644\u062a\u062c\u0648\u064a\u0641 \u062b\u0627\u0628\u062a\u0629.<\/p>\n \u062a\u0635\u0648\u064a\u0631 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u0645\u0642\u0637\u0639\u064a \u0627\u0644\u0645\u062d\u0648\u0633\u0628 \u0644\u0644\u0634\u0631\u0627\u064a\u064a\u0646 \u0627\u0644\u062a\u0627\u062c\u064a\u0629<\/h4>\n\u064a\u0648\u0641\u0631 \u062a\u0635\u0648\u064a\u0631 \u0627\u0644\u0634\u0631\u0627\u064a\u064a\u0646 \u0627\u0644\u062a\u0627\u062c\u064a\u0629 \u0627\u0644\u0645\u0642\u0637\u0639\u064a \u0627\u0644\u0645\u062d\u0648\u0633\u0628 (CCTA) \u062a\u0635\u0648\u064a\u0631\u0627\u064b \u063a\u064a\u0631 \u062c\u0631\u0627\u062d\u064a \u0644\u0643\u0627\u0645\u0644 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0648\u062a\u0648\u0635\u064a\u0641\u0627\u064b \u0644\u0644\u0648\u064a\u062d\u0627\u062a. \u0641\u064a \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0645\u062b\u0644 EVAPORATE\u060c \u0623\u0638\u0647\u0631 \u062a\u0635\u0648\u064a\u0631 (CCTA) \u062a\u0631\u0627\u062c\u0639\u0627\u064b \u0645\u0644\u062d\u0648\u0638\u0627\u064b \u0641\u064a \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a \u0645\u0646\u062e\u0641\u0636\u0629 \u0627\u0644\u062a\u0648\u0647\u062c \u0648\u0627\u0644\u063a\u0646\u064a\u0629 \u0628\u0627\u0644\u062f\u0647\u0648\u0646 \u0628\u0639\u062f \u062a\u0646\u0627\u0648\u0644 \u062c\u0631\u0639\u0627\u062a \u0639\u0627\u0644\u064a\u0629 \u0645\u0646 \u0627\u0644\u0625\u064a\u0643\u0648\u0633\u0627\u0628\u0646\u062a\u064a\u0646 (EPA). \u0648\u0627\u0644\u0623\u0647\u0645 \u0645\u0646 \u0630\u0644\u0643\u060c \u0623\u0646 \u0647\u0630\u0647 \u0627\u0644\u062a\u063a\u064a\u0631\u0627\u062a \u0643\u0627\u0646\u062a \u0645\u0633\u062a\u0642\u0644\u0629 \u0639\u0646 \u0639\u0628\u0621 \u0627\u0644\u0643\u0627\u0644\u0633\u064a\u0648\u0645 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a\u060c \u0645\u0645\u0627 \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0623\u0646 \u0627\u0644\u062a\u062d\u0648\u0644 \u0641\u064a \u0627\u0644\u062a\u0631\u0643\u064a\u0628 - \u0648\u0644\u064a\u0633 \u0627\u0644\u062a\u0645\u062f\u062f \u0627\u0644\u062a\u0643\u0644\u0633\u064a - \u0647\u0648 \u0645\u0627 \u064a\u0641\u0633\u0631 \u062a\u062d\u0633\u0646 \u0627\u0644\u0627\u0633\u062a\u0642\u0631\u0627\u0631. \u062a\u0648\u0641\u0631 \u062f\u0631\u0627\u0633\u0627\u062a \u062a\u0635\u0648\u064a\u0631 (CCTA) \u0627\u0644\u0645\u062a\u0633\u0644\u0633\u0644\u0629 \u0627\u0644\u0622\u0646 \u0623\u062f\u0627\u0629 \u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0645\u062a\u0627\u0628\u0639\u0629 \u0627\u0644\u062a\u0631\u0627\u062c\u0639 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0644\u0627 \u062a\u0638\u0647\u0631 \u0639\u0644\u064a\u0647\u0645 \u0623\u0639\u0631\u0627\u0636 \u0623\u0648 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u064a\u0646 \u0627\u0644\u0630\u064a\u0646 \u064a\u062d\u062a\u0627\u062c\u0648\u0646 \u0625\u0644\u0649 \u0645\u0631\u0627\u0642\u0628\u0629 \u0637\u0648\u0644\u064a\u0629 \u062f\u0648\u0646 \u0627\u0644\u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0627\u0644\u0642\u0633\u0637\u0631\u064a.<\/p>\n \u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0628\u0627\u0644\u0631\u0646\u064a\u0646 \u0627\u0644\u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a<\/h4>\n\u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0628\u0627\u0644\u0631\u0646\u064a\u0646 \u0627\u0644\u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a \u0639\u0627\u0644\u064a \u0627\u0644\u0645\u062c\u0627\u0644 \u064a\u062d\u062f\u062f \u0643\u0645\u064a\u0629 \u0645\u0643\u0648\u0646\u0627\u062a \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a \u0627\u0644\u0633\u0628\u0627\u062a\u064a\u0629 \u0648\u0627\u0644\u0634\u062a\u0627\u062c\u064a\u0629\u060c \u0648\u064a\u0645\u064a\u0632 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628 \u0639\u0628\u0631 \u0627\u0644\u062a\u0639\u0632\u064a\u0632 \u0628\u0627\u0644\u0640 gadolinium\u060c \u0648\u064a\u0645\u0643\u0646\u0647 \u0642\u064a\u0627\u0633 \u0627\u0644\u062a\u0631\u0648\u064a\u0629 \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0644\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629. \u0623\u0638\u0647\u0631\u062a \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0628\u0627\u0644\u0631\u0646\u064a\u0646 \u0627\u0644\u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a \u0627\u0644\u0645\u062a\u0633\u0644\u0633\u0644\u0629 \u0627\u0646\u062e\u0641\u0627\u0636 \u062c\u0632\u0621 \u0627\u0644\u062f\u0647\u0648\u0646 \u0641\u064a \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a \u0648\u062a\u062d\u0633\u0646 \u062a\u0645\u062f\u062f \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u0627\u0644\u0630\u064a \u064a\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u0627\u0644\u0628\u0637\u0627\u0646\u0629 \u0625\u062b\u0631 \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646 \u0623\u0648 \u062a\u063a\u064a\u064a\u0631 \u0646\u0645\u0637 \u0627\u0644\u062d\u064a\u0627\u0629.\u00b9\u00b2<\/p>\n \u0623\u0643\u062f \u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0645\u062a\u0639\u062f\u062f \u0627\u0644\u0648\u0633\u0627\u0626\u0637 \u0645\u062c\u062a\u0645\u0639\u0627\u064b \u0623\u0646 \u062a\u0631\u0627\u062c\u0639 \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a \u0647\u0648 \u0639\u0645\u0644\u064a\u0629 \u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0645\u062a\u0643\u0627\u0645\u0644\u0629 - \u062a\u062a\u0645\u062b\u0644 \u0641\u064a \u062a\u063a\u064a\u064a\u0631 \u0627\u0644\u062a\u0631\u0643\u064a\u0628\u060c \u0648\u0627\u0644\u062d\u062f \u0645\u0646 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u060c \u0648\u0627\u0633\u062a\u0639\u0627\u062f\u0629 \u0633\u0644\u0627\u0645\u0629 \u062c\u062f\u0627\u0631 \u0627\u0644\u0634\u0631\u064a\u0627\u0646 - \u0648\u0644\u064a\u0633 \u0645\u062c\u0631\u062f \u062a\u0648\u0633\u064a\u0639 \u0644\u062a\u062c\u0648\u064a\u0641\u0647.<\/p>\n \u0627\u0644\u062c\u062f\u0648\u0644 2. \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0643\u0628\u0631\u0649 \u0644\u0644\u062a\u0631\u0627\u062c\u0639 \u0627\u0644\u0628\u0634\u0631\u064a<\/p>\n \u0645\u0644\u062e\u0635 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0645\u062d\u0648\u0631\u064a\u0629 \u0627\u0644\u0628\u0634\u0631\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0648\u0636\u062d \u0627\u0646\u0643\u0645\u0627\u0634 \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a \u0627\u0644\u0639\u0635\u064a\u062f\u064a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u062a\u062f\u062e\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0648\u0646\u0645\u0637 \u0627\u0644\u062d\u064a\u0627\u0629\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u0645 \u0642\u064a\u0627\u0633\u0647\u0627 \u0639\u0628\u0631 \u0648\u0633\u0627\u0626\u0644 \u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0627\u0644\u0645\u062a\u0642\u062f\u0645\u0629.<\/p>\n \n\n\n\u062f\u0631\u0627\u0633\u0629<\/strong><\/td>\n\u062a\u062f\u062e\u0644<\/strong><\/td>\n\u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0627\u0644\u0637\u0628\u064a<\/strong><\/td>\n\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0644\u0648\u064a\u062d\u0629<\/strong><\/td>\n\u062a\u0623\u062b\u064a\u0631 \u0644\u0648\u0645\u064a\u0646<\/strong><\/td>\n<\/tr>\n<\/thead>\n\n\n| \u0643\u0648\u064a\u0643\u0628<\/td>\n | \u0631\u0648\u0632\u0648\u0641\u0631\u0627\u062a\u0627\u0633\u062a\u064a\u0646 40 \u0645\u063a<\/td>\n | \u0627\u0644\u0645\u0648\u062c\u0627\u062a \u0641\u0648\u0642 \u0627\u0644\u0635\u0648\u062a\u064a\u0629 \u062f\u0627\u062e\u0644 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629<\/td>\n | \u2193PAV 0.98%\u060c \u2193TAV 6.8%<\/td>\n | \u0645\u062d\u0627\u064a\u062f<\/td>\n<\/tr>\n | \n| \u0633\u0627\u062a\u0648\u0631\u0646 \u00b2<\/td>\n | \u0631\u0648\u0632\u0648\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646 \u0645\u0642\u0627\u0628\u0644 \u0623\u062a\u0648\u0631\u0641\u0627\u0633\u062a\u0627\u062a\u064a\u0646<\/td>\n | \u0627\u0644\u0645\u0648\u062c\u0627\u062a \u0641\u0648\u0642 \u0627\u0644\u0635\u0648\u062a\u064a\u0629 \u062f\u0627\u062e\u0644 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629<\/td>\n | \u0627\u0644\u062a\u0642\u0647\u0642\u0631 \u0641\u064a \u0643\u0644\u0627 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u062a\u064a\u0646<\/td>\n | \u0645\u062a\u063a\u064a\u0631<\/td>\n<\/tr>\n | \n| \u062c\u0644\u0627\u063a\u0648\u0641\u2074<\/td>\n | \u0625\u064a\u0641\u0648\u0644\u0648\u0643\u0648\u0645\u0627\u0628 + \u0633\u062a\u0627\u062a\u064a\u0646<\/td>\n | \u0627\u0644\u0645\u0648\u062c\u0627\u062a \u0641\u0648\u0642 \u0627\u0644\u0635\u0648\u062a\u064a\u0629 \u062f\u0627\u062e\u0644 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629<\/td>\n | \u0627\u0644\u0627\u0646\u062d\u062f\u0627\u0631 \u0627\u0644\u0623\u0643\u0628\u0631<\/td>\n | \u0645\u062d\u0627\u064a\u062f<\/td>\n<\/tr>\n | \n| \u064a\u062a\u0628\u062e\u0631 \u2077<\/td>\n | \u0625\u064a\u0643\u0648\u0633\u0627\u0628\u0646\u062a \u0625\u064a\u062b\u064a\u0644 + \u0633\u062a\u0627\u062a\u064a\u0646<\/td>\n | \u062a\u0635\u0648\u064a\u0631 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u0627\u0644\u062a\u0627\u062c\u064a\u0629 \u0627\u0644\u0645\u0642\u0637\u0639\u064a \u0627\u0644\u0645\u062d\u0648\u0633\u0628<\/td>\n | \u0644\u0648\u064a\u062d\u0629 \u063a\u0646\u064a\u0629 \u0628\u0627\u0644\u062f\u0647\u0648\u0646<\/td>\n | \u0645\u062d\u0627\u064a\u062f<\/td>\n<\/tr>\n | \n| \u0623\u0648\u0631\u0646\u064a\u0634 \u0668-\u0669<\/td>\n | \u0646\u0645\u0637 \u062d\u064a\u0627\u0629 \u064a\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u0627\u0644\u0623\u063a\u0630\u064a\u0629 \u0627\u0644\u0643\u0627\u0645\u0644\u0629 \u0648\u0627\u0644\u0646\u0628\u0627\u062a\u064a\u0629<\/td>\n | \u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0645\u0643\u0648\u0646\u0627\u062a \u0627\u0644\u0646\u0648\u0639\u064a\u0629<\/td>\n | \u062a\u062d\u0633\u0646 \u0637\u0641\u064a\u0641 \u0641\u064a \u062a\u0635\u0648\u064a\u0631 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629<\/td>\n | \u0645\u0643\u0633\u0628 \u0648\u0638\u064a\u0641\u064a<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\u0645\u0641\u0627\u0631\u0642\u0629 \u0627\u0644\u0644\u0645\u0639\u0629 \u0648\u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u062a\u0634\u0643\u064a\u0644 \u0627\u0644\u0639\u0643\u0633\u064a<\/h3>\n\u0625\u062d\u062f\u0649 \u0623\u0643\u062b\u0631 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0645\u0646\u0627\u0642\u0636\u0629 \u0644\u0644\u062d\u062f\u0633 \u0641\u064a \u0637\u0628 \u0627\u0644\u0642\u0644\u0628 \u0648\u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u0647\u064a \u0623\u0646 \u0627\u0644\u062a\u0631\u0627\u062c\u0639 \u0627\u0644\u0642\u0627\u0628\u0644 \u0644\u0644\u0642\u064a\u0627\u0633 \u0641\u064a \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a \u0646\u0627\u062f\u0631\u0627\u064b \u0645\u0627 \u064a\u0646\u062a\u062c \u0639\u0646\u0647 \u0632\u064a\u0627\u062f\u0627\u062a \u0645\u062a\u0646\u0627\u0633\u0628\u0629 \u0641\u064a \u0645\u0633\u0627\u062d\u0629 \u0627\u0644\u062a\u062c\u0648\u064a\u0641. \u0647\u0630\u0647 \u0645\u0641\u0627\u0631\u0642\u0629 \u0644\u0648\u0645\u0646<\/strong> \u0646\u0634\u0623 \u0645\u0646 \u0627\u0644\u0633\u0644\u0648\u0643 \u0627\u0644\u0645\u064a\u0643\u0627\u0646\u064a\u0643\u064a \u0644\u0644\u0634\u0631\u0627\u064a\u064a\u0646 \u062a\u062d\u062a \u0627\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u0645\u0632\u0645\u0646.<\/p>\n\u0641\u064a \u062f\u0631\u0627\u0633\u0629 \u063a\u0644\u0627\u063a\u0648\u0641 \u0627\u0644\u062a\u064a \u0623\u064f\u062c\u0631\u064a\u062a \u0639\u0627\u0645 1987\u060c \u0623\u0638\u0647\u0631\u062a \u0639\u0645\u0644\u064a\u0627\u062a \u062a\u0634\u0631\u064a\u062d \u0627\u0644\u062c\u062b\u062b \u0627\u0644\u0628\u0634\u0631\u064a\u0629 \u062d\u062f\u0648\u062b \u062a\u0648\u0633\u0639 \u062a\u0639\u0648\u064a\u0636\u064a \u0641\u064a \u0627\u0644\u063a\u0634\u0627\u0621 \u0627\u0644\u0645\u0631\u0646 \u0627\u0644\u062e\u0627\u0631\u062c\u064a (EEM) \u0623\u062b\u0646\u0627\u0621 \u0646\u0645\u0648 \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a \u2014 \u0648\u0647\u064a \u0622\u0644\u064a\u0629 \u062a\u062d\u0627\u0641\u0638 \u0639\u0644\u0649 \u062d\u062c\u0645 \u0627\u0644\u062a\u062c\u0648\u064a\u0641 \u062d\u062a\u0649 \u062a\u0634\u063a\u0644 \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a \u0645\u0627 \u064a\u0642\u0627\u0631\u0628 40% \u0645\u0646 \u0645\u0633\u0627\u062d\u0629 \u0627\u0644\u0645\u0642\u0637\u0639 \u0627\u0644\u0639\u0631\u0636\u064a.\u00b9\u2070 \u0648\u0639\u0646\u062f \u062a\u062c\u0627\u0648\u0632 \u0647\u0630\u0627 \u0627\u0644\u062d\u062f\u060c \u064a\u0641\u0634\u0644 \u0627\u0644\u062a\u0648\u0633\u0639 \u0627\u0644\u062a\u0639\u0648\u064a\u0636\u064a\u060c \u0648\u064a\u0635\u0628\u062d \u0627\u0644\u062a\u0636\u064a\u0642 \u0648\u0627\u0636\u062d\u064b\u0627.<\/p>\n \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0639\u0646\u062f\u0645\u0627 \u062a\u062a\u0631\u0627\u062c\u0639 \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a\u060c \u064a\u0647\u062f\u0623 \u0627\u0644\u062a\u0647\u0627\u0628 \u0648\u062a\u062a\u0637\u0628\u064a\u0639 \u0625\u062c\u0647\u0627\u062f \u0627\u0644\u062c\u062f\u0627\u0631. \u0642\u062f \u062a\u0646\u0642\u0628\u0636 \u0627\u0644\u063a\u0644\u0627\u0644\u0629 \u0627\u0644\u0628\u0631\u0627\u0646\u064a\u0629\u060c \u0645\u0645\u0627 \u064a\u0639\u0643\u0633 \u0627\u0644\u062a\u0648\u0633\u0639 \u0627\u0644\u0633\u0627\u0628\u0642. \u0647\u0630\u0627 \u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u062a\u0634\u0643\u064a\u0644 \u0627\u0644\u0639\u0643\u0633\u064a<\/strong> \u0646\u062a\u0627\u0626\u062c \u062a\u062a\u0631\u062c\u0645 \u0625\u0644\u0649 \u0645\u0633\u0627\u062d\u0627\u062a \u0644\u0645\u0639\u0629 \u0623\u0635\u063a\u0631 \u0623\u0648 \u062f\u0648\u0646 \u062a\u063a\u064a\u064a\u0631 \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0627\u0646\u062e\u0641\u0627\u0636 \u0639\u0628\u0621 \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a \u0648\u062a\u062d\u0633\u064a\u0646 \u062a\u0643\u0648\u064a\u0646 \u062c\u062f\u0627\u0631 \u0627\u0644\u0634\u0631\u064a\u0627\u0646.\u00b9\u00b9 \u0648\u0628\u0639\u064a\u062f\u0627\u064b \u0639\u0646 \u0643\u0648\u0646 \u0647\u0630\u0627 \u0627\u0644\u062a\u0643\u064a\u0641 \u0627\u0644\u0627\u0646\u0642\u0628\u0627\u0636\u064a \u0645\u0631\u0636\u064a\u0627\u064b\u060c \u0641\u0647\u0648 \u064a\u0639\u064a\u062f \u0627\u0644\u062a\u0648\u062a\u0631 \u0627\u0644\u0641\u0633\u064a\u0648\u0644\u0648\u062c\u064a \u0639\u0628\u0631 \u0627\u0644\u0637\u0628\u0642\u0629 \u0627\u0644\u0648\u0633\u0637\u0649 \u0648\u0627\u0644\u0637\u0628\u0642\u0629 \u0627\u0644\u062e\u0627\u0631\u062c\u064a\u0629.<\/p>\n\u064a\u064f\u0631\u062c\u062d \u0623\u0646 \u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u062a\u0634\u0643\u064a\u0644 \u0627\u0644\u0639\u0643\u0633\u064a \u062a\u0645\u062b\u0644 \u0645\u062d\u0627\u0648\u0644\u0629 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0648\u0639\u0627\u0626\u064a \u0644\u0625\u0639\u0627\u062f\u0629 \u0625\u0646\u0634\u0627\u0621 \u062a\u0648\u0632\u064a\u0639 \u0641\u0639\u0627\u0644 \u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u062c\u062f\u0627\u0631. \u062a\u0624\u0643\u062f \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062a\u0635\u0648\u064a\u0631\u064a\u0629 \u0648\u0627\u0644\u0646\u0633\u064a\u062c\u064a\u0629 \u0623\u0646\u0647 \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u062b\u0628\u0627\u062a \u0623\u0628\u0639\u0627\u062f \u0627\u0644\u062a\u062c\u0645\u064a\u0639\u060c \u0625\u0644\u0627 \u0623\u0646 \u0627\u0644\u0645\u062d\u062a\u0648\u0649 \u0627\u0644\u0644\u064a\u0641\u064a \u064a\u0632\u062f\u0627\u062f\u060c \u0648\u0627\u0644\u0646\u0648\u0627\u0629 \u0627\u0644\u0646\u062e\u0631\u064a\u0629 \u062a\u062a\u0646\u0627\u0642\u0635\u060c \u0648\u0627\u0644\u0627\u0633\u062a\u0642\u0631\u0627\u0631 \u0627\u0644\u0645\u064a\u0643\u0627\u0646\u064a\u0643\u064a \u064a\u062a\u062d\u0633\u0646.\u0661\u0662<\/p>\n \u0622\u062b\u0627\u0631 \u0630\u0644\u0643 \u0639\u0644\u0649 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u064a\u0646 \u0627\u0644\u062a\u062d\u0645\u0644\u064a\u064a\u0646<\/h4>\n\u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0631\u064a\u0627\u0636\u064a\u064a \u0627\u0644\u062a\u062d\u0645\u0644\u060c \u062a\u062b\u064a\u0631 \u0627\u0644\u0645\u0641\u0627\u0631\u0642\u0629 \u0623\u0633\u0626\u0644\u0629 \u0639\u0645\u0644\u064a\u0629. \u064a\u062c\u0628 \u0623\u0646 \u062a\u062a\u0643\u064a\u0641 \u0627\u062d\u062a\u064a\u0627\u0637\u064a\u0627\u062a \u062a\u062f\u0641\u0642 \u0627\u0644\u062f\u0645 \u0627\u0644\u062a\u0627\u062c\u064a \u0644\u062f\u064a\u0647\u0645 \u0644\u062a\u062f\u0639\u0645 \u0632\u064a\u0627\u062f\u0629 \u062a\u062a\u0631\u0627\u0648\u062d \u0628\u064a\u0646 5 \u0625\u0644\u0649 6 \u0623\u0636\u0639\u0627\u0641 \u0641\u064a \u0627\u0644\u0646\u062a\u0627\u062c \u0627\u0644\u0642\u0644\u0628\u064a \u0623\u062b\u0646\u0627\u0621 \u0623\u0642\u0635\u0649 \u062f\u0631\u062c\u0627\u062a \u0627\u0644\u0625\u062c\u0647\u0627\u062f. \u0646\u0638\u0631\u064a\u0627\u064b\u060c \u062d\u062a\u0649 \u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u0647\u064a\u0643\u0644\u0629 \u0627\u0644\u062a\u0636\u064a\u064a\u0642\u064a\u0629 \u0627\u0644\u0637\u0641\u064a\u0641\u0629 \u0642\u062f \u062a\u0642\u0644\u0644 \u0645\u0646 \u0633\u0639\u0629 \u0627\u0644\u062a\u0631\u0648\u064a\u0629 \u0627\u0644\u0642\u0635\u0648\u0649. \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0642\u062f \u064a\u062a\u0645 \u062a\u062e\u0641\u064a\u0641 \u0647\u0630\u0627 \u0627\u0644\u062e\u0637\u0631 \u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u062d\u0633\u0646 \u0648\u0638\u064a\u0641\u0629 \u0627\u0644\u0628\u0637\u0627\u0646\u0629 \u0648\u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u0648\u062a\u0648\u0633\u062f \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0628\u0648\u0633\u0627\u0637\u0629 \u0623\u0643\u0633\u064a\u062f \u0627\u0644\u0646\u064a\u062a\u0631\u064a\u0643 \u0644\u062f\u0649 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u064a\u0646\u060c \u0645\u0645\u0627 \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0648\u0633\u0639 \u0646\u0635\u0641 \u0642\u0637\u0631 \u0627\u0644\u062a\u062c\u0648\u064a\u0641 \u062f\u064a\u0646\u0627\u0645\u064a\u0643\u064a\u0627\u064b \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u062a\u0645\u0631\u064a\u0646. \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a\u060c \u064a\u0635\u0628\u062d \u0627\u062d\u062a\u064a\u0627\u0637\u064a \u0627\u0644\u062a\u062f\u0641\u0642 \u0627\u0644\u0648\u0638\u064a\u0641\u064a\u060c \u0628\u062f\u0644\u0627\u064b \u0645\u0646 \u062d\u062c\u0645 \u0627\u0644\u062a\u062c\u0648\u064a\u0641 \u0627\u0644\u062b\u0627\u0628\u062a\u060c \u0647\u0648 \u0627\u0644\u0645\u062d\u062f\u062f \u0627\u0644\u062d\u0627\u0633\u0645 \u0644\u0644\u0623\u062f\u0627\u0621 \u0648\u0627\u0644\u0633\u0644\u0627\u0645\u0629.<\/p>\n \u0645\u0631\u0636 \u0627\u0644\u0634\u0631\u064a\u0627\u0646 \u0627\u0644\u062a\u0627\u062c\u064a \u062a\u062d\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a \u0648\u0627\u0644\u062a\u0643\u0644\u0633 \u0644\u062f\u0649 \u0631\u064a\u0627\u0636\u064a \u0627\u0644\u062a\u062d\u0645\u0644 \u0627\u0644\u0645\u062a\u0645\u064a\u0632\u064a\u0646<\/h3>\n\u0639\u0644\u0649 \u0645\u062f\u0627\u0631 \u0627\u0644\u0639\u0642\u062f \u0627\u0644\u0645\u0627\u0636\u064a, \u0643\u0634\u0641\u062a \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u062f\u0647\u0634\u0629 \u0645\u0646 \u0627\u0644\u0623\u0628\u062d\u0627\u062b \u0623\u0646 \u062a\u0645\u0627\u0631\u064a\u0646 \u0627\u0644\u062a\u062d\u0645\u0644 \u0637\u0648\u0627\u0644 \u0627\u0644\u0639\u0645\u0631 \u0644\u0627 \u062a\u062c\u0639\u0644 \u0634\u062c\u0631\u0629 \u0627\u0644\u0634\u0631\u064a\u0627\u0646 \u0627\u0644\u062a\u0627\u062c\u064a \u0645\u0646\u064a\u0639\u0629 \u0636\u062f \u062a\u0635\u0644\u0628 \u0627\u0644\u0634\u0631\u0627\u064a\u064a\u0646. \u0641\u064a \u0627\u0644\u0648\u0627\u0642\u0639, \u062a\u0634\u064a\u0631 \u0628\u0639\u0636 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0625\u0644\u0649 \u0627\u0631\u062a\u0641\u0627\u0639 \u0627\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a \u0627\u0644\u062a\u0627\u062c\u064a\u0629 \u0648\u0627\u0644\u062a\u0643\u0644\u0633 \u0644\u062f\u0649 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u064a\u0646 \u0627\u0644\u0646\u062e\u0628\u0629 \u0623\u0648 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u064a\u0646 \u0627\u0644\u0645\u062e\u0636\u0631\u0645\u064a\u0646 \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0623\u0634\u062e\u0627\u0635 \u0627\u0644\u062e\u0627\u0645\u0644\u064a\u0646 \u0645\u0645\u0646 \u0647\u0645 \u0641\u064a \u0646\u0641\u0633 \u0627\u0644\u0641\u0626\u0629 \u0627\u0644\u0639\u0645\u0631\u064a\u0629.<\/p>\n \u062f\u0631\u0627\u0633\u0629 \u0645\u0631\u063a\u0646\u064a \u0648\u0622\u062e\u0631\u0648\u0646 (2017\u060c \u0633\u064a\u0631\u0643\u0648\u0644\u064a\u0634\u0646)<\/p>\n \u0642\u0627\u0645 \u0645\u064a\u0631\u063a\u0627\u0646\u064a \u0648\u0632\u0645\u0644\u0627\u0624\u0647 \u0628\u0641\u062d\u0635 152 \u0631\u064a\u0627\u0636\u064a\u064b\u0627 \u0648\u0631\u064a\u0627\u0636\u064a\u0629 \u0645\u0646 \u0641\u0626\u0629 \u0643\u0628\u0627\u0631 \u0627\u0644\u0633\u0646 \u0641\u064a \u0631\u064a\u0627\u0636\u0627\u062a \u0627\u0644\u062a\u062d\u0645\u0644 (\u0645\u062a\u0648\u0633\u0637 \u0623\u0639\u0645\u0627\u0631\u0647\u0645 54 \u0639\u0627\u0645\u064b\u0627) \u0648\u0642\u0627\u0631\u0646\u0648\u0647\u0645 \u0628\u0640 92 \u0634\u062e\u0635\u064b\u0627 \u0645\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0636\u0627\u0628\u0637\u0629 \u0627\u0644\u0623\u0635\u062d\u0627\u0621 \u0627\u0644\u0645\u062a\u0637\u0627\u0628\u0642\u064a\u0646 \u0645\u0639\u0647\u0645 \u0641\u064a \u0627\u0644\u0639\u0645\u0631 \u0648\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u062e\u0637\u0631.\u00b9\u2077 \u0648\u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0627\u0644\u0645\u0642\u0637\u0639\u064a \u0627\u0644\u0645\u062d\u0648\u0633\u0628 \u0644\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062a\u0627\u062c\u064a\u0629 (CCTA)\u060c \u0648\u062c\u062f\u0648\u0627 \u0623\u0646 44% \u0645\u0646 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u064a\u0646 \u0627\u0644\u0630\u0643\u0648\u0631 \u0623\u0638\u0647\u0631\u0648\u0627 \u0648\u062c\u0648\u062f \u0644\u0648\u064a\u062d\u0627\u062a \u062a\u0627\u062c\u064a\u0629 \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0640 22% \u0645\u0646 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0636\u0627\u0628\u0637\u0629. \u0648\u0643\u0627\u0646 \u0644\u062f\u0649 11 \u0641\u064a \u0627\u0644\u0645\u0627\u0626\u0629 \u0645\u0646 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u064a\u0646 \u062f\u0631\u062c\u0627\u062a \u0643\u0627\u0644\u0633\u064a\u0648\u0645 \u062a\u0632\u064a\u062f \u0639\u0646 300 \u0648\u062d\u062f\u0629 \u0623\u063a\u0627\u062a\u0633\u062a\u0648\u0646\u060c \u0648\u0643\u0627\u0646 \u0644\u062f\u0649 7.5% \u0645\u0646\u0647\u0645 \u062a\u0636\u064a\u0642\u0627\u062a \u0641\u064a \u062a\u062c\u0648\u064a\u0641 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u062a\u062a\u062c\u0627\u0648\u0632 50%. \u0648\u0645\u0646 \u0627\u0644\u0645\u062b\u064a\u0631 \u0644\u0644\u0627\u0647\u062a\u0645\u0627\u0645 \u0623\u0646 \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a \u0644\u062f\u0649 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u064a\u0646 \u0643\u0627\u0646\u062a \u0645\u062a\u0643\u0644\u0633\u0629 \u0641\u064a \u0627\u0644\u063a\u0627\u0644\u0628 (72.7%) \u0628\u062f\u0644\u0627\u064b \u0645\u0646 \u0623\u0646 \u062a\u0643\u0648\u0646 \u0645\u062e\u062a\u0644\u0637\u0629 \u0623\u0648 \u063a\u0646\u064a\u0629 \u0628\u0627\u0644\u062f\u0647\u0648\u0646\u060c \u0645\u0645\u0627 \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0627\u0633\u062a\u0642\u0631\u0627\u0631 \u0623\u0643\u0628\u0631 \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0627\u0631\u062a\u0641\u0627\u0639 \u0627\u0644\u062d\u0645\u0644 \u0627\u0644\u0625\u062c\u0645\u0627\u0644\u064a. \u0639\u0644\u0627\u0648\u0629 \u0639\u0644\u0649 \u0630\u0644\u0643\u060c \u0623\u0638\u0647\u0631 14% \u0645\u0646 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u064a\u0646 \u0627\u0644\u0630\u0643\u0648\u0631 \u062a\u0644\u064a\u0641\u064b\u0627 \u0639\u0636\u0644\u064a\u064b\u0651\u0627 \u0635\u0627\u0645\u062a\u064b\u0627 \u0641\u064a \u0627\u0644\u0642\u0644\u0628 \u0639\u0646\u062f \u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0628\u0627\u0644\u0631\u0646\u064a\u0646 \u0627\u0644\u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a \u0644\u0644\u0642\u0644\u0628 \u2014 \u0648\u0647\u0648 \u062f\u0644\u064a\u0644 \u0639\u0644\u0649 \u0625\u0635\u0627\u0628\u0629 \u0625\u0642\u0641\u0627\u0631\u064a\u0629 \u0633\u0627\u0628\u0642\u0629 \u062f\u0648\u0646 \u0623\u0639\u0631\u0627\u0636 \u0633\u0631\u064a\u0631\u064a\u0629.<\/p>\n \u062f\u0631\u0627\u0633\u0627\u062a \u0645\u0624\u0643\u062f\u0629 \u0648\u0645\u0646\u0627\u0642\u0636\u0629<\/p>\n \u062a\u0645 \u062a\u0648\u0633\u064a\u0639 \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0645\u0646 \u0642\u0628\u0644 \u0623\u064a\u0646\u062c\u064a\u0641\u0627\u0631\u064a\u0646 \u0648\u0622\u062e\u0631\u0648\u0646 (\u0627\u0644\u0645\u062c\u0644\u0629 \u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a\u0629 \u0644\u0644\u0642\u0644\u0628\u060c 2017)\u060c \u0627\u0644\u0630\u064a\u0646 \u0623\u0628\u0644\u063a\u0648\u0627 \u0639\u0646 \u0639\u0644\u0627\u0642\u0629 \u0639\u0644\u0649 \u0634\u0643\u0644 \u062d\u0631\u0641 U \u0628\u064a\u0646 \u062d\u062c\u0645 \u0627\u0644\u062a\u0645\u0627\u0631\u064a\u0646 \u0645\u062f\u0649 \u0627\u0644\u062d\u064a\u0627\u0629 \u0639\u0628\u0621 \u062f\u0631\u062c\u0627\u062a \u0627\u0644\u0643\u0627\u0644\u0633\u064a\u0648\u0645 \u0627\u0644\u062a\u0627\u062c\u064a (CAC).\u00b9\u2078 \u0643\u0627\u0646 \u0644\u062f\u0649 \u0627\u0644\u0645\u0645\u0627\u0631\u0633\u064a\u0646 \u0644\u0644\u062a\u0645\u0627\u0631\u064a\u0646 \u0628\u0627\u0639\u062a\u062f\u0627\u0644 \u0623\u062f\u0646\u0649 \u0627\u0644\u062f\u0631\u062c\u0627\u062a\u060c \u0628\u064a\u0646\u0645\u0627 \u0643\u0627\u0646 \u0644\u062f\u0649 \u0623\u0648\u0644\u0626\u0643 \u0627\u0644\u0630\u064a\u0646 \u0623\u062c\u0631\u0648\u0627 \u062a\u0645\u0631\u064a\u0646\u0627\u064b \u0628\u062f\u0646\u064a\u0627\u064b \u0642\u0627\u0633\u064a\u0627\u064b \u0648\u0645\u0633\u062a\u0645\u0631\u0627\u064b \u0645\u062f\u0649 \u0627\u0644\u062d\u064a\u0627\u0629 \u0645\u0639\u062f\u0644 \u0623\u0639\u0644\u0649 \u0644\u0627\u0646\u062a\u0634\u0627\u0631 \u062a\u0631\u0633\u0628\u0627\u062a \u0627\u0644\u0643\u0627\u0644\u0633\u064a\u0648\u0645 \u0648\u0627\u0644\u0644\u0648\u062d\u0627\u062a\u060c \u0648\u0644\u0643\u0646 \u0628\u0646\u0645\u0637 \u0638\u0627\u0647\u0631\u064a \u0623\u0643\u062b\u0631 \u062a\u0643\u0644\u0633\u0627\u064b \u0648\u0627\u0633\u062a\u0642\u0631\u0627\u0631\u0627\u064b. \u0641\u0633\u0631 \u0628\u0627\u063a\u064a\u0634 \u0648\u0644\u0641\u064a\u0646 (2017) \u0647\u0630\u0647 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0639\u0644\u0649 \u0623\u0646\u0647\u0627 \u062a\u0643\u064a\u0641 - \u0641\u0642\u062f \u062a\u0633\u0631\u064a\u0639 \u0627\u0644\u062a\u0645\u0627\u0631\u064a\u0646 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u0629 \u062a\u0643\u0644\u0633 \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a \u0627\u0644\u0631\u062e\u0648\u0629 \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629\u060c \u0645\u0645\u0627 \u064a\u062d\u0648\u0644\u0647\u0627 \u0625\u0644\u0649 \u0647\u064a\u0627\u0643\u0644 \u0645\u0633\u062a\u0642\u0631\u0629 \u0648\u062e\u0627\u0645\u0644\u0629 \u0623\u0642\u0644 \u0639\u0631\u0636\u0629 \u0644\u0644\u062a\u0645\u0632\u0642.\u00b9\u2079<\/p>\n \u0641\u0631\u0636\u064a\u0627\u062a \u0645\u064a\u0643\u0627\u0646\u064a\u0643\u064a\u0629<\/p>\n \u062a\u0634\u0645\u0644 \u0627\u0644\u0622\u0644\u064a\u0627\u062a \u0627\u0644\u0643\u0627\u0645\u0646\u0629 \u0648\u0631\u0627\u0621 \u0647\u0630\u0627 \u0627\u0644\u062a\u0643\u0644\u0633 \u0627\u0644\u0645\u062a\u0646\u0627\u0642\u0636 \u0627\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u0642\u0635\u064a \u0627\u0644\u0645\u062a\u0643\u0631\u0631\u060c \u0648\u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0627\u0644\u062a\u0623\u0643\u0633\u062f\u064a\u0629 \u0627\u0644\u0639\u0627\u0628\u0631\u0629\u060c \u0648\u062a\u0635\u064a\u0628 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u062a\u062f\u0631\u064a\u0628 \u0639\u0627\u0644\u064a \u0627\u0644\u0643\u062b\u0627\u0641\u0629 \u0644\u0641\u062a\u0631\u0627\u062a \u0637\u0648\u064a\u0644\u0629. \u064a\u0645\u0643\u0646 \u0644\u0647\u0630\u0647 \u0627\u0644\u0645\u062d\u0641\u0632\u0627\u062a \u0623\u0646 \u062a\u062d\u0641\u0632 \u0627\u0644\u062a\u062d\u0648\u0644 \u0627\u0644\u0639\u0638\u0645\u064a \u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u0645\u0644\u0633\u0627\u0621 \u0627\u0644\u0648\u0639\u0627\u0626\u064a\u0629\u060c \u0645\u0645\u0627 \u064a\u0639\u0632\u0632 \u0627\u0644\u062a\u0643\u0644\u0633 \u0627\u0644\u062f\u0642\u064a\u0642 \u0627\u0644\u0630\u064a \u064a\u062a\u0635\u0644\u0628 \u0644\u0627\u062d\u0642\u0627\u064b \u0644\u064a\u0635\u0628\u062d \u0635\u0641\u0627\u0626\u062d \u0643\u0627\u0644\u0633\u064a\u0648\u0645 \u0643\u062b\u064a\u0641\u0629.<\/p>\n \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0647\u064a\u0643\u0644\u064a\u0629, \u062a\u0638\u0644 \u0645\u0639\u062f\u0644\u0627\u062a \u0627\u0644\u0623\u062d\u062f\u0627\u062b \u0644\u062f\u0649 \u0631\u064a\u0627\u0636\u064a\u064a\u0646 \u0627\u0644\u062a\u062d\u0645\u0644 \u0645\u0646\u062e\u0641\u0636\u0629 \u0628\u0634\u0643\u0644 \u0645\u0644\u062d\u0648\u0638, \u0645\u0645\u0627 \u064a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0623\u0646 \u0627\u0633\u062a\u0642\u0631\u0627\u0631 \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a \u064a\u0641\u0648\u0642 \u0639\u0628\u0626\u0647\u0627. \u0642\u062f \u064a\u0645\u062b\u0644 \u0627\u0644\u062a\u0643\u0644\u0633, \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0633\u064a\u0627\u0642, \u062a\u0644\u064a\u0641\u0627\u064b \u062a\u0643\u064a\u0641\u064a\u0627\u064b \u0628\u062f\u0644\u0627\u064b \u0645\u0646 \u062a\u0637\u0648\u0631 \u0627\u0644\u0645\u0631\u0636.<\/p>\n \u0627\u0644\u0622\u062b\u0627\u0631 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0644\u0641\u062d\u0635<\/p>\n \u062a\u0639\u064a\u062f \u0647\u0630\u0647 \u0627\u0644\u0631\u0624\u0649 \u062a\u0634\u0643\u064a\u0644 \u0637\u0628 \u0627\u0644\u0642\u0644\u0628 \u0627\u0644\u0648\u0642\u0627\u0626\u064a \u0644\u062f\u0649 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u064a\u0646. \u062a\u0642\u0644\u0644 \u062f\u0631\u062c\u0627\u062a \u0627\u0644\u0645\u062e\u0627\u0637\u0631 \u0627\u0644\u062a\u0642\u0644\u064a\u062f\u064a\u0629 \u0645\u0646 \u062a\u0642\u062f\u064a\u0631 \u0627\u0646\u062a\u0634\u0627\u0631 \u0645\u0631\u0636 \u0627\u0644\u0634\u0631\u064a\u0627\u0646 \u0627\u0644\u062a\u0627\u062c\u064a \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629\u060c \u0628\u064a\u0646\u0645\u0627 \u0642\u062f \u064a\u062a\u0645 \u0627\u062e\u0641\u0627\u0621 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0628\u0633\u0628\u0628 \u0627\u0644\u0644\u064a\u0627\u0642\u0629 \u0627\u0644\u0628\u062f\u0646\u064a\u0629 \u0627\u0644\u0641\u0627\u0626\u0642\u0629. \u064a\u0639\u062f \u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0627\u0644\u0627\u0646\u062a\u0642\u0627\u0626\u064a -\u0644\u0627 \u0633\u064a\u0645\u0627 \u062a\u0633\u062c\u064a\u0644 \u0627\u0644\u0643\u0627\u0644\u0633\u064a\u0648\u0645 \u0627\u0644\u062a\u0627\u062c\u064a \u0623\u0648 \u062a\u0635\u0648\u064a\u0631 \u0627\u0644\u0634\u0631\u0627\u064a\u064a\u0646 \u0627\u0644\u062a\u0627\u062c\u064a\u0629 \u0627\u0644\u0645\u0642\u0637\u0639\u064a \u0627\u0644\u0645\u062d\u0648\u0633\u0628- \u0645\u0646\u0627\u0633\u0628\u0627\u064b \u0644\u0644\u0631\u064a\u0627\u0636\u064a\u064a\u0646 \u0627\u0644\u0630\u064a\u0646 \u062a\u0632\u064a\u062f \u0623\u0639\u0645\u0627\u0631\u0647\u0645 \u0639\u0646 45 \u0639\u0627\u0645\u0627\u064b \u0648\u0644\u062f\u064a\u0647\u0645 \u062a\u0627\u0631\u064a\u062e \u0639\u0627\u0626\u0644\u064a\u060c \u0623\u0648 \u0627\u0636\u0637\u0631\u0627\u0628 \u0634\u062d\u0645\u064a\u0627\u062a \u0627\u0644\u062f\u0645\u060c \u0623\u0648 \u0627\u0646\u062e\u0641\u0627\u0636 \u063a\u064a\u0631 \u0645\u0628\u0631\u0631 \u0641\u064a \u0627\u0644\u0623\u062f\u0627\u0621. \u0625\u0646 \u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0622\u0641\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u0642\u0631\u0629 \u0648\u0627\u0644\u0645\u062a\u0643\u0644\u0633\u0629 \u064a\u0648\u062c\u0647 \u0627\u0644\u0625\u0631\u0634\u0627\u062f \u062f\u0648\u0646 \u062a\u062b\u0628\u064a\u0637 \u0627\u0644\u062a\u062f\u0631\u064a\u0628.<\/p>\n \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0644\u0623\u0637\u0628\u0627\u0621\u060c \u064a\u064f\u0639\u062f \u0641\u0647\u0645 \u0627\u0644\u0641\u0631\u0642 \u0628\u064a\u0646 \u0639\u0628\u0621 \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a \u0648\u0636\u0639\u0641 \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a \u0623\u0645\u0631\u0627\u064b \u0628\u0627\u0644\u063a \u0627\u0644\u0623\u0647\u0645\u064a\u0629. \u0641\u0627\u0644\u0622\u0641\u0629 \u0634\u062f\u064a\u062f\u0629 \u0627\u0644\u062a\u0643\u0644\u0633 \u0642\u062f \u062a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0634\u0631\u064a\u0627\u0646 \u0645\u0644\u062a\u0626\u0645 \u0623\u0648 \u0645\u0633\u062a\u0642\u0631\u060c \u0641\u064a \u062d\u064a\u0646 \u0623\u0646 \u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a \u063a\u064a\u0631 \u0627\u0644\u0645\u062a\u0643\u0644\u0633\u0629 \u0648\u0627\u0644\u063a\u0646\u064a\u0629 \u0628\u0627\u0644\u062f\u0647\u0648\u0646 \u062a\u0638\u0644 \u0627\u0644\u062a\u0647\u062f\u064a\u062f \u0627\u0644\u062d\u0642\u064a\u0642\u064a - \u062d\u062a\u0649 \u0641\u064a \u0627\u0644\u0642\u0644\u0648\u0628 \u0627\u0644\u062a\u064a \u062a\u0628\u062f\u0648 \u201c\u0627\u0644\u0623\u0643\u062b\u0631 \u0644\u064a\u0627\u0642\u0629\u201d.<\/p>\n \u0627\u0644\u0625\u0646\u062a\u0634\u0627\u0631 \u0627\u0644\u0635\u0627\u0645\u062a \u0648\u0645\u0639\u0627\u0644\u062c\u0629 \u0627\u0644\u0623\u0644\u0645 \u0644\u062f\u0649 \u0631\u064a\u0627\u0636\u064a\u064a \u0627\u0644\u062a\u062d\u0645\u0644<\/h3>\n\u0644\u0637\u0627\u0644\u0645\u0627 \u062d\u064a\u0631 \u063a\u064a\u0627\u0628 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0644\u062f\u0649 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u064a\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0645\u0631\u0636 \u062a\u0627\u062c\u064a \u062e\u0637\u064a\u0631 \u0627\u0644\u0623\u0637\u0628\u0627\u0621. \u0648\u064a\u064f\u0646\u0638\u0631 \u0625\u0644\u0649 \u0638\u0627\u0647\u0631\u0629 \u201c\u0627\u0644\u0625\u0650\u0634\u0652\u0643\u064a\u0645 (\u0646\u0642\u0635 \u0627\u0644\u062a\u0631\u0648\u064a\u0629) \u0627\u0644\u0635\u0627\u0645\u062a\u201d \u0647\u0630\u0647 \u0627\u0644\u0622\u0646 \u0639\u0644\u0649 \u0623\u0646\u0647\u0627 \u0646\u062a\u064a\u062c\u0629 \u0644\u0644\u062a\u0643\u064a\u0641 \u0627\u0644\u0639\u0635\u0628\u064a \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a \u0645\u0639 \u0627\u0644\u0645\u062c\u0647\u0648\u062f \u0627\u0644\u0645\u0632\u0645\u0646 \u0648\u0627\u0644\u062a\u0646\u0634\u064a\u0637 \u0627\u0644\u0648\u062f\u064a \u0627\u0644\u0645\u062a\u0643\u0631\u0631.<\/p>\n \u0627\u0644\u0623\u0633\u0627\u0633 \u0627\u0644\u0641\u0633\u064a\u0648\u0644\u0648\u062c\u064a \u0627\u0644\u0639\u0635\u0628\u064a<\/h4>\n\u064a\u0624\u062f\u064a \u062a\u062f\u0631\u064a\u0628 \u0627\u0644\u062a\u062d\u0645\u0644 \u0627\u0644\u0645\u0637\u0648\u0644 \u0625\u0644\u0649 \u0631\u0641\u0639 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0628\u0628\u062a\u064a\u062f\u0627\u062a \u0627\u0644\u0623\u0641\u064a\u0648\u0646\u064a\u0629 \u0627\u0644\u062f\u0627\u062e\u0644\u064a\u0629 (\u0628\u064a\u062a\u0627-\u0625\u0646\u062f\u0648\u0631\u0641\u064a\u0646 \u0648\u0627\u0644\u0625\u0646\u0643\u064a\u0641\u0627\u0644\u064a\u0646)\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u062b\u0628\u0637 \u0625\u0634\u0627\u0631\u0627\u062a \u0627\u0644\u0623\u0644\u0645 (\u0627\u0644\u0646\u0633\u0647) \u0639\u0628\u0631 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0623\u0641\u064a\u0648\u0646 \u0645\u064a\u0648 \u0641\u064a \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0639\u0635\u0628\u064a \u0627\u0644\u0645\u0631\u0643\u0632\u064a \u0648\u0627\u0644\u0645\u062d\u064a\u0637\u064a.\u00b2\u0664 \u0648\u062a\u064f\u0638\u0647\u0631 \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0628\u0627\u0644\u0631\u0646\u064a\u0646 \u0627\u0644\u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a \u0627\u0644\u0648\u0638\u064a\u0641\u064a \u0627\u0646\u062e\u0641\u0627\u0636 \u062a\u0646\u0634\u064a\u0637 \u0642\u0634\u0631\u0629 \u0627\u0644\u062c\u0632\u064a\u0631\u0629 \u0648\u0627\u0644\u0642\u0634\u0631\u0629 \u0627\u0644\u062d\u0632\u0627\u0645\u064a\u0629 \u0627\u0644\u0623\u0645\u0627\u0645\u064a\u0629 -\u0648\u0647\u064a \u0645\u0646\u0627\u0637\u0642 \u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0625\u062f\u0631\u0627\u0643 \u0627\u0644\u0623\u0644\u0645- \u0644\u062f\u0649 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u064a\u0646 \u0627\u0644\u0645\u062f\u0631\u0628\u064a\u0646 \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u062a\u0639\u0631\u0636 \u0644\u0644\u0645\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0645\u0624\u0644\u0645\u0629. \u0647\u0630\u0627 \u0627\u0644\u062a\u0643\u064a\u0641 \u0627\u0644\u0645\u0631\u0643\u0632\u064a \u064a\u0631\u0641\u0639 \u0628\u0641\u0639\u0627\u0644\u064a\u0629 \u0639\u062a\u0628\u0629 \u0627\u0644\u0634\u0639\u0648\u0631 \u0628\u0627\u0644\u0627\u0646\u0632\u0639\u0627\u062c \u0648\u064a\u0639\u064a\u062f \u062a\u0635\u0646\u064a\u0641 \u0623\u062d\u0627\u0633\u064a\u0633 \u0646\u0642\u0635 \u0627\u0644\u0625\u0631\u0648\u0627\u0626\u064a\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0639\u0644\u0649 \u0623\u0646\u0647\u0627 \u0645\u062c\u0647\u0648\u062f \u0637\u0628\u064a\u0639\u064a.<\/p>\n \u0627\u0644\u0623\u062f\u0644\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629<\/h4>\n\u0623\u0638\u0647\u0631\u062a \u0639\u062f\u0629 \u0623\u0641\u0648\u0627\u062c \u0645\u0646 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u064a\u0646 \u0627\u0644\u0645\u062e\u0636\u0631\u0645\u064a\u0646 \u0623\u062f\u0644\u0629 \u062a\u062e\u0637\u064a\u0637\u064a\u0629 \u0643\u0647\u0631\u0628\u0627\u0626\u064a\u0629 \u0623\u0648 \u062a\u0631\u0648\u0648\u064a\u0629 \u0639\u0644\u0649 \u0646\u0642\u0635 \u062a\u0633\u0643\u064a\u0631 \u0639\u0636\u0644\u0629 \u0627\u0644\u0642\u0644\u0628 \u0641\u064a \u063a\u064a\u0627\u0628 \u0623\u0644\u0645 \u0627\u0644\u0635\u062f\u0631. \u062d\u062f\u062f\u062a \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0628\u0627\u0644\u062b\u0627\u0644\u064a\u0648\u0645 \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u062a\u0645\u0631\u064a\u0646 \u0645\u0646 \u062a\u0633\u0639\u064a\u0646\u064a\u0627\u062a \u0627\u0644\u0642\u0631\u0646 \u0627\u0644\u0645\u0627\u0636\u064a \u0647\u0630\u0627 \u0627\u0644\u0646\u0645\u0637 \u0644\u0623\u0648\u0644 \u0645\u0631\u0629\u061b \u0648\u062a\u0624\u0643\u062f \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0627\u0644\u0645\u0642\u0637\u0639\u064a \u0628\u0627\u0644\u0625\u0635\u062f\u0627\u0631 \u0627\u0644\u0628\u0648\u0632\u064a\u062a\u0631\u0648\u0646\u064a \u0648\u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0628\u0627\u0644\u0631\u0646\u064a\u0646 \u0627\u0644\u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a \u0627\u0644\u062d\u062f\u064a\u062b\u0629 \u0648\u062c\u0648\u062f \u0646\u0642\u0635 \u062a\u0633\u0643\u064a\u0631 \u0628\u062f\u0648\u0646 \u0630\u0628\u062d \u0635\u062f\u0631\u064a\u0629 \u0623\u062b\u0646\u0627\u0621 \u0623\u0642\u0635\u0649 \u062f\u0631\u062c\u0627\u062a \u0639\u0628\u0621 \u0627\u0644\u0639\u0645\u0644. \u0648\u0627\u0644\u0623\u0647\u0645 \u0645\u0646 \u0630\u0644\u0643\u060c \u0623\u0646 \u0628\u0639\u0636 \u0647\u0624\u0644\u0627\u0621 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u064a\u0646 \u064a\u0638\u0647\u0631\u0648\u0646 \u062a\u0639\u0632\u064a\u0632\u0627\u064b \u0645\u062a\u0623\u062e\u0631\u0627\u064b \u0628\u0627\u0644\u0640\u062c\u0627\u062f\u0647\u0648\u0644\u064a\u0646\u064a\u0648\u0645 \u0645\u062a\u0648\u0627\u0641\u0642\u0627\u064b \u0645\u0639 \u0627\u0644\u062a\u0644\u064a\u0641 \u0627\u0644\u0642\u0644\u0628\u064a \u0627\u0644\u0635\u0627\u0645\u062a - \u0623\u064a \u0627\u062d\u062a\u0634\u0627\u0621\u0627\u062a \u201c\u0645\u0644\u062a\u0626\u0645\u0629\u201d \u0644\u0645 \u064a\u062a\u0645 \u0627\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u064a\u0647\u0627 \u062e\u0644\u0627\u0644 \u062d\u064a\u0627\u062a\u0647\u0645.<\/p>\n Implications for Clinical Assessment<\/h4>\nBecause athletes may misinterpret or ignore prodromal symptoms, reliance on symptom-driven testing is inadequate. Cardiologists should consider baseline CAC or CCTA screening in athletes over 45 years old, particularly those with familial dyslipidemia or long training histories. Exercise stress testing with imaging\u2014rather than ECG alone\u2014can reveal perfusion defects that plain treadmill tests miss.\u00b2\u00b3 Recognition of silent ischemia is crucial to prevent sudden cardiac events during competition.<\/p>\n Hemodynamic Principles: Why Millimeters Matter<\/h3>\nTo appreciate how structural and functional changes translate to performance, one must understand the physics governing blood flow. Coronary blood flow follows Poiseuille\u2019s law<\/strong>, which states:<\/p>\n$$Q = \\frac{\\pi \\cdot \\Delta P \\cdot r^4}{8 \\cdot \\mu \\cdot L}$$<\/p>\n where $Q$ is flow, $\\Delta P$ is pressure difference, $r$ is vessel radius, $\\mu$ is blood viscosity, and $L$ is vessel length. Flow thus increases with the fourth power of radius<\/strong>.<\/p>\nPhysiologic Consequences<\/h4>\nA 10% increase in radius increases flow by approximately 46%; a 20% increase nearly doubles it. Conversely, small decreases in radius\u2014whether from plaque accumulation or constrictive remodeling\u2014produce disproportionate reductions in perfusion capacity. For endurance athletes whose cardiac output may reach 30 L\/min, these geometric nuances determine the ceiling of aerobic performance.<\/p>\n Dynamic Vasomotion<\/h4>\nDuring exercise, coronary vasodilation is mediated by shear-stress\u2013induced NO release. Healthy endothelium expands epicardial vessels and dilates arterioles to match myocardial oxygen demand. When endothelial dysfunction coexists with plaque, this dilation reserve is blunted. Lifestyle interventions that enhance NO availability\u2014such as WFPB diets rich in dietary nitrates and polyphenols\u2014restore this reserve, effectively expanding functional lumen radius even if anatomic dimensions are static.<\/p>\n Integration with Regression<\/h4>\nPharmacologic therapies reduce plaque and risk; lifestyle therapies maintain or enhance flow. The combination creates a \u201cdual benefit\u201d: structural regression within the wall and preserved hemodynamic reserve in the lumen. This synergy underpins the thesis that optimal care of the endurance athlete requires both medical and nutritional precision.<\/p>\n Clinical Implications and Author Perspective<\/h3>\nThe convergence of molecular biology, imaging science, and performance physiology underscores a transformative principle: vascular health and athletic performance are not separate domains but mutually reinforcing.<\/p>\n For clinicians, regression is no longer an aspirational concept but a measurable endpoint. Percent atheroma volume, plaque composition, and cap thickness have replaced crude angiographic narrowing as markers of success. Yet, for the athlete, the practical endpoint remains flow reserve\u2014the ability of the coronary circulation to respond instantaneously to metabolic demand.<\/p>\n Pharmacologic therapy secures biochemical normalization; lifestyle modification restores endothelial adaptability. The challenge is to personalize interventions such that structural regression does not come at the expense of vasomotor responsiveness.<\/p>\n It is within this framework that Dr. Peter Megdal\u2019s personal experience becomes instructive.<\/p>\n Author Reflection: The N + 1 Story \u2014 Healing, Adaptation, and Performance<\/h4>\nDr. Peter Megdal, a lifelong endurance athlete and scientist, exemplifies the dual pursuit of vascular healing and human performance. In his early fifties, despite holding several age-group world records in ultra-endurance events, he was unexpectedly found to have subclinical coronary atherosclerosis during imaging performed for research. The discovery was paradoxical: how could someone with exceptional aerobic capacity harbor measurable plaque?<\/p>\n Rather than view this as defeat, Dr. Megdal approached it as the ultimate experiment\u2014his \u201cN + 1\u201d study, the one subject who mattered most. Drawing on decades of biochemical expertise, he implemented a rigorous combination of intensive lipid lowering, whole-food plant-based nutrition, and structured endurance training designed around recovery and endothelial optimization.<\/p>\n Over months, lipid levels normalized, inflammatory markers declined, and repeat imaging showed regression of plaque burden. Endothelial function, assessed by flow-mediated dilation, improved dramatically. Subjectively, recovery times shortened, and performance metrics\u2014power output, VO\u2082 max, lactate threshold\u2014surpassed pre-diagnosis levels. Within two years, he returned to elite competition and established new age-group world records, a living demonstration that arterial healing and peak human function can coexist.<\/p>\n Dr. Megdal\u2019s journey illustrates the paper\u2019s central argument: that regression is not merely an imaging artifact but a biological transformation that, when aligned with lifestyle and disciplined training, restores both vascular integrity and athletic potential. His experience reframes the physician-scientist\u2019s role\u2014from treating disease to guiding adaptive performance grounded in physiology.<\/p>\n \u0627\u0644\u0627\u062a\u062c\u0627\u0647\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0629<\/h3>\n\n- Beyond LDL: Molecular and Functional Targets<\/li>\n<\/ol>\n
The traditional emphasis on LDL-cholesterol reduction, while transformative, represents only part of the regression equation. Future therapies will increasingly target residual inflammatory and oxidative pathways. Agents modulating interleukin-1\u03b2 (e.g., canakinumab) or lipoprotein(a) hold promise for individuals with low LDL yet persistent plaque activity. For athletes, whose oxidative flux is naturally elevated, therapies that temper reactive oxygen species without blunting mitochondrial adaptation may optimize both vascular and muscular recovery.<\/p>\n Simultaneously, attention is shifting toward functional outcomes\u2014arterial compliance, flow-mediated dilation, and endothelial repair capacity\u2014as more relevant markers of cardiovascular fitness than static lipid values. Integration of these physiologic metrics into athletic screening may redefine how cardiometabolic performance is measured.<\/p>\n \n- Advanced Imaging and Computational Hemodynamics<\/li>\n<\/ol>\n
Serial CCTA and IVUS will continue to refine our understanding of regression kinetics. Next-generation photon-counting CT and ultra-high-resolution MRI promise to detect microcalcification, cap thickness, and neovascularization with unprecedented clarity. When paired with computational fluid dynamics, these images can model shear stress distribution, predicting which plaques will regress or stabilize under various interventions.<\/p>\n For athletes, such modeling could reveal how training intensity, heart rate variability, and coronary flow patterns interact with plaque biology\u2014a fusion of engineering and medicine that may personalize training prescriptions to minimize vascular stress.<\/p>\n \n- Lifestyle\u2013Pharmacologic Synergy<\/li>\n<\/ol>\n
Emerging evidence supports a hybrid model: pharmacologic LDL-C suppression combined with whole-food, plant-based nutrition to sustain endothelial tone and systemic metabolic health. This integrated approach aligns with the concept of systems biology\u2014addressing multiple convergent pathways rather than a single biochemical target.<\/p>\n Randomized trials comparing pharmacologic therapy alone versus combination with WFPB interventions are urgently needed. Endpoints should extend beyond plaque regression to include arterial elasticity, flow reserve, and athletic performance metrics. Such studies could redefine cardiovascular prevention as a continuum between disease management and physiologic optimization.<\/p>\n \n- Exercise Physiology and Adaptive Remodeling<\/li>\n<\/ol>\n
An unresolved question concerns how chronic endurance training interacts with regression and remodeling. Is the increased calcification seen in lifelong athletes a benign stabilization process or an adaptive trade-off? Understanding the cellular signals that drive osteogenic transformation in vascular smooth muscle could reveal ways to preserve arterial flexibility without compromising stability.<\/p>\n Future research should distinguish between beneficial physiologic remodeling and maladaptive calcification, possibly through longitudinal cohorts combining high-resolution imaging with molecular biomarkers of bone\u2013vascular crosstalk (e.g., osteoprotegerin, BMP-2).<\/p>\n \n- Precision Prevention in Athletic Cardiology<\/li>\n<\/ol>\n
As data accumulate, prevention will become individualized\u2014integrating lipidomics, metabolomics, genetic risk scores, and imaging biomarkers to craft precise regimens. Machine-learning models may soon predict who among master athletes is most likely to develop subclinical CAD despite fitness, and who will benefit most from aggressive lipid lowering versus lifestyle modification alone.<\/p>\n This personalized approach will ensure that the mantra \u201cfit but not immune\u201d translates into actionable, evidence-based prevention.<\/p>\n \u062e\u0627\u062a\u0645\u0629<\/h3>\nAtherosclerosis regression represents one of the most hopeful narratives in modern cardiovascular medicine. It is not merely the reversal of a pathological process but the reawakening of the vessel\u2019s innate capacity for repair. From molecular efflux to endothelial restoration, regression exemplifies biology\u2019s plasticity\u2014a dynamic equilibrium between injury and healing.<\/p>\n The lumen paradox\u2014regression without enlargement\u2014reminds us that vascular health cannot be judged by geometry alone. Stability, composition, and functional responsiveness are equally vital. For endurance athletes, whose survival and success depend on maximizing coronary flow, small improvements in radius or endothelial tone yield exponential gains in performance, as defined by Poiseuille\u2019s law.<\/p>\n Pharmacologic therapy and WFPB nutrition are not competing paradigms but complementary instruments of the same symphony: one removes the pathological stimulus; the other restores physiologic harmony. Together they promote a vessel that is not only structurally sound but dynamically alive.<\/p>\n Dr. Peter Megdal\u2019s \u201cN + 1 Story\u201d embodies this synthesis. His journey from the discovery of subclinical atherosclerosis to documented regression and renewed world-record performance symbolizes the translation of scientific knowledge into human transformation. It illustrates that the frontier of cardiovascular medicine lies not merely in survival, but in the realization of optimal function\u2014arterial, cellular, and human.<\/p>\n Acknowledgment<\/h3>\nThe author reports no conflicts of interest.<\/p>\n \u0627\u0644\u0645\u0631\u0627\u062c\u0639<\/h3>\n\n- Nissen SE, Nicholls SJ, Sipahi I, et al. Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial.\u00a0\u062c\u0627\u0645\u0627<\/i>. 2006;295(13):1556-1565. doi:10.1001\/jama.295.13.jpc60002<\/li>\n
- Nicholls SJ, Ballantyne CM, Barter PJ, et al. Effect of two intensive statin regimens on progression of coronary disease.\u00a0\u0645\u062c\u0644\u0629 \u0646\u064a\u0648 \u0625\u0646\u063a\u0644\u0627\u0646\u062f \u0627\u0644\u0637\u0628\u064a\u0629<\/i>. 2011;365(22):2078-2087. doi:10.1056\/NEJMoa1110874<\/li>\n
- Rivera FB, Cha SW, Varona MC, et al. Atherosclerotic coronary plaque regression from lipid-lowering therapies: A meta-analysis and meta-regression.\u00a0Am J Prev Cardiol<\/i>. 2024;18:100645. Published 2024 Mar 11. doi:10.1016\/j.ajpc.2024.100645<\/li>\n
- Nicholls SJ, Puri R, Anderson T, et al. Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients: The GLAGOV Randomized Clinical Trial.\u00a0\u062c\u0627\u0645\u0627<\/i>. 2016;316(22):2373-2384. doi:10.1001\/jama.2016.16951<\/li>\n
- R\u00e4ber L, Ueki Y, Otsuka T, et al. Effect of Alirocumab Added to High-Intensity Statin Therapy on Coronary Atherosclerosis in Patients With Acute Myocardial Infarction: The PACMAN-AMI Randomized Clinical Trial.\u00a0\u062c\u0627\u0645\u0627<\/i>. 2022;327(18):1771-1781. doi:10.1001\/jama.2022.5218<\/li>\n
- Oyama K, Furtado RHM, Fagundes A Jr, et al. Effect of Evolocumab on Complex Coronary Disease Requiring Revascularization.\u00a0\u0645\u062c\u0644\u0629 \u0627\u0644\u0643\u0644\u064a\u0629 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 \u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0642\u0644\u0628<\/i>. 2021;77(3):259-267. doi:10.1016\/j.jacc.2020.11.011<\/li>\n
- Budoff MJ, Bhatt DL, Kinninger A, et al. Effect of icosapent ethyl on progression of coronary atherosclerosis in patients with elevated triglycerides on statin therapy: final results of the EVAPORATE trial.\u00a0\u0645\u062c\u0644\u0629 \u0627\u0644\u0642\u0644\u0628 \u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a\u0629<\/i>. 2020;41(40):3925-3932. doi:10.1093\/eurheartj\/ehaa652<\/li>\n
- Ornish D, Brown SE, Scherwitz LW, et al. Can lifestyle changes reverse coronary heart disease? The Lifestyle Heart Trial.\u00a0\u0644\u0627\u0646\u0633\u064a\u062a<\/i>. 1990;336(8708):129-133. doi:10.1016\/0140-6736(90)91656-u<\/li>\n
- Ornish D, Scherwitz LW, Billings JH, et al. Intensive lifestyle changes for reversal of coronary heart disease.\u00a0\u062c\u0627\u0645\u0627<\/i>. 1998;280(23):2001-2007. doi:10.1001\/jama.280.23.2001<\/li>\n
- Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ. Compensatory enlargement of human atherosclerotic coronary arteries.\u00a0\u0645\u062c\u0644\u0629 \u0646\u064a\u0648 \u0625\u0646\u063a\u0644\u0627\u0646\u062f \u0627\u0644\u0637\u0628\u064a\u0629<\/i>. 1987;316(22):1371-1375. doi:10.1056\/NEJM198705283162204<\/li>\n
- Tsujita K, Sugiyama S, Sumida H, et al. Plaque REgression with Cholesterol absorption Inhibitor or Synthesis inhibitor Evaluated by IntraVascular UltraSound (PRECISE-IVUS Trial): Study protocol for a randomized controlled trial.\u00a0J Cardiol<\/i>. 2015;66(4):353-358. doi:10.1016\/j.jjcc.2014.12.011<\/li>\n
- Yuan C, Kerwin WS, Yarnykh VL, et al. MRI of atherosclerosis in clinical trials.\u00a0NMR Biomed<\/i>. 2006;19(6):636-654. doi:10.1002\/nbm.1065<\/li>\n
- Armstrong ML, Warner ED, Connor WE. Regression of coronary atheromatosis in rhesus monkeys.\u00a0Circ Res<\/i>. 1970;27(1):59-67. doi:10.1161\/01.res.27.1.59<\/li>\n
- Weingand KW. Atherosclerosis research in cynomolgus monkeys (Macaca fascicularis).\u00a0Exp Mol Pathol<\/i>. 1989;50(1):1-15. doi:10.1016\/0014-4800(89)90052-x<\/li>\n
- Yamada T, Yoshikuni Y, Taira M, et al. Diet-induced atherosclerosis in cynomolgus monkey aorta and regression by the sixth-month observation.\u00a0Angiology<\/i>. 1992;43(12):1008-1019. doi:10.1177\/000331979204301207<\/li>\n
- Hecker M, Moser M, Schmoldt H, et al. Regression of atherosclerosis with LDL lowering and oxidative stress reduction in primates.\u00a0Sci Rep<\/i>. 2022;12(1):4589.<\/li>\n
- Merghani A, Maestrini V, Rosmini S, et al. Prevalence of Subclinical Coronary Artery Disease in Masters Endurance Athletes With a Low Atherosclerotic Risk Profile.\u00a0\u0627\u0644\u062a\u062f\u0627\u0648\u0644<\/i>. 2017;136(2):126-137. doi:10.1161\/CIRCULATIONAHA.116.026964<\/li>\n
- Aengevaeren VL, Mosterd A, Braber TL, et al. Relationship Between Lifelong Exercise Volume and Coronary Atherosclerosis in Athletes.\u00a0\u0627\u0644\u062a\u062f\u0627\u0648\u0644<\/i>. 2017;136(2):138-148. doi:10.1161\/CIRCULATIONAHA.117.027834<\/li>\n
- Baggish AL, Levine BD. Coronary Artery Calcification Among Endurance Athletes: “Hearts of Stone”.\u00a0\u0627\u0644\u062a\u062f\u0627\u0648\u0644<\/i>. 2017;136(2):149-151. doi:10.1161\/CIRCULATIONAHA.117.028750<\/li>\n
- Esposito K, Marfella R, Ciotola M, et al. Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial.\u00a0\u062c\u0627\u0645\u0627<\/i>. 2004;292(12):1440-1446. doi:10.1001\/jama.292.12.1440<\/li>\n
- Mathur R, Ahmid Z, Ashor AW, Shannon O, Stephan BCM, Siervo M. Effects of dietary-based weight loss interventions on biomarkers of endothelial function: a systematic review and meta-analysis.\u00a0Eur J Clin Nutr<\/i>. 2023;77(10):927-940. doi:10.1038\/s41430-023-01307-6<\/li>\n
- Dod HS, Bhardwaj R, Sajja V, et al. Effect of intensive lifestyle changes on endothelial function and on inflammatory markers of atherosclerosis.\u00a0Am J Cardiol<\/i>. 2010;105(3):362-367. doi:10.1016\/j.amjcard.2009.09.038<\/li>\n
- Sharma S, Merghani A, Mont L. Exercise and the heart: the good, the bad, and the ugly.\u00a0\u0645\u062c\u0644\u0629 \u0627\u0644\u0642\u0644\u0628 \u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a\u0629<\/i>. 2015;36(23):1445-1453. doi:10.1093\/eurheartj\/ehv090<\/li>\n
- Thornton C, Baird A, Sheffield D. Athletes and Experimental Pain: A Systematic Review and Meta-Analysis.\u00a0J Pain<\/i>. 2024;25(6):104450. doi:10.1016\/j.jpain.2023.12.007<\/li>\n<\/ol>","protected":false},"excerpt":{"rendered":"
\u062a\u062e\u064a\u0644 \u0639\u062f\u0627\u0621\u064b \u0645\u0646 \u0627\u0644\u0637\u0631\u0627\u0632 \u0627\u0644\u0639\u0627\u0644\u0645\u064a. \u064a\u062a\u0633\u0627\u0628\u0642 \u0647\u0630\u0627 \u0627\u0644\u0634\u062e\u0635 \u0641\u064a \u0627\u0644\u0645\u0627\u0631\u0627\u062b\u0648\u0646\u0627\u062a\u060c \u0648\u064a\u062a\u0646\u0627\u0648\u0644 \u0645\u0627 \u064a\u0639\u062a\u0642\u062f \u0623\u0646\u0647 \u0646\u0638\u0627\u0645 \u063a\u0630\u0627\u0626\u064a \u201c\u0645\u062b\u0627\u0644\u064a\u201d\u060c \u0648\u064a\u0634\u0639\u0631 \u0648\u0643\u0623\u0646\u0647 \u0641\u064a \u0623\u0641\u0636\u0644 \u062d\u0627\u0644\u0627\u062a \u0644\u064a\u0627\u0642\u062a\u0647 \u0627\u0644\u0628\u062f\u0646\u064a\u0629. \u062b\u0645\u060c \u062f\u0648\u0646 \u0633\u0627\u0628\u0642 \u0625\u0646\u0630\u0627\u0631\u060c \u064a\u0635\u0627\u0628 \u0628\u0646\u0648\u0628\u0629 \u0642\u0644\u0628\u064a\u0629. \u0647\u0630\u0647 \u0647\u064a \u0645\u0641\u0627\u0631\u0642\u0629 \u201c\u0644\u0627\u0626\u0642 \u0648\u0644\u0643\u0646 \u0644\u064a\u0633 \u0645\u062d\u0635\u0646\u0627\u064b\u201d. \u0625\u0646\u0647 \u062e\u0648\u0641 \u062e\u0641\u064a \u0644\u0643\u062b\u064a\u0631 \u0645\u0646 \u0627\u0644\u0646\u0627\u0633 \u0627\u0644\u0646\u0634\u0637\u064a\u0646.<\/p>","protected":false},"author":16,"featured_media":8297,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[216,222,223,224],"tags":[],"class_list":["post-8254","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-diet-and-nutrition","category-plant-based-diets","category-plaque-arteries-and-disease","category-regression-and-reversal"],"acf":[],"yoast_head":"\n Coronary Plaque Regression, the Lumen Paradox, and Vascular Remodeling in Athletes: Integrating Pharmacologic and Whole-Food, Plant-Based Strategies - The Premiere Heart Health Education Platform<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.curingheartdisease.com\/ar\/\u062a\u0631\u0627\u062c\u0639-\u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a-\u0627\u0644\u062a\u0627\u062c\u064a\u0629\u060c-\u0645\u0641\u0627\u0631\u0642\u0629-\u0644\u0645\u0639\u0629-\u0627\/\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Coronary Plaque Regression, the Lumen Paradox, and Vascular Remodeling in Athletes: Integrating Pharmacologic and Whole-Food, Plant-Based Strategies - The Premiere Heart Health Education Platform\" \/>\n<meta property=\"og:description\" content=\"Imagine a world-class runner. This person races through marathons, eats what they believe is a "perfect" diet, and feels like they are in the best shape of their life. Then, without warning, they suffer a heart attack. This is the "fit but not immune" paradox. It is a secret fear for many active people.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.curingheartdisease.com\/ar\/\u062a\u0631\u0627\u062c\u0639-\u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a-\u0627\u0644\u062a\u0627\u062c\u064a\u0629\u060c-\u0645\u0641\u0627\u0631\u0642\u0629-\u0644\u0645\u0639\u0629-\u0627\/\" \/>\n<meta property=\"og:site_name\" content=\"The Premiere Heart Health Education Platform\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/curingheartdisease\" \/>\n<meta property=\"article:published_time\" content=\"2025-03-01T14:38:24+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-08-02T16:38:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.curingheartdisease.com\/wp-content\/uploads\/2025\/11\/post-image-03b.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"630\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Peter Megdal PhD\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@RMHDInc\" \/>\n<meta name=\"twitter:site\" content=\"@RMHDInc\" \/>\n<meta name=\"twitter:label1\" content=\"\u0643\u064f\u062a\u0628 \u0628\u0648\u0627\u0633\u0637\u0629\" \/>\n\t<meta name=\"twitter:data1\" content=\"Peter Megdal PhD\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u0648\u0642\u062a \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0627\u0644\u0645\u064f\u0642\u062f\u0651\u0631\" \/>\n\t<meta name=\"twitter:data2\" content=\"20 \u062f\u0642\u064a\u0642\u0629\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\\\/\"},\"author\":{\"name\":\"Peter Megdal PhD\",\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/#\\\/schema\\\/person\\\/1468f3f6d05d6929d0583938c1236e53\"},\"headline\":\"Coronary Plaque Regression, the Lumen Paradox, and Vascular Remodeling in Athletes: Integrating Pharmacologic and Whole-Food, Plant-Based Strategies\",\"datePublished\":\"2025-03-01T14:38:24+00:00\",\"dateModified\":\"2026-08-02T16:38:26+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\\\/\"},\"wordCount\":4457,\"publisher\":{\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.curingheartdisease.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/post-image-03b.jpg\",\"articleSection\":[\"Diet and Nutrition\",\"Plant-Based Diets\",\"Plaque, Arteries and Disease\",\"Regression and Reversal\"],\"inLanguage\":\"ar\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\\\/\",\"url\":\"https:\\\/\\\/www.curingheartdisease.com\\\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\\\/\",\"name\":\"Coronary Plaque Regression, the Lumen Paradox, and Vascular Remodeling in Athletes: Integrating Pharmacologic and Whole-Food, Plant-Based Strategies - The Premiere Heart Health Education Platform\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.curingheartdisease.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/post-image-03b.jpg\",\"datePublished\":\"2025-03-01T14:38:24+00:00\",\"dateModified\":\"2026-08-02T16:38:26+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\\\/#breadcrumb\"},\"inLanguage\":\"ar\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.curingheartdisease.com\\\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"ar\",\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.curingheartdisease.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/post-image-03b.jpg\",\"contentUrl\":\"https:\\\/\\\/www.curingheartdisease.com\\\/wp-content\\\/uploads\\\/2025\\\/11\\\/post-image-03b.jpg\",\"width\":1200,\"height\":630},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.curingheartdisease.com\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Coronary Plaque Regression, the Lumen Paradox, and Vascular Remodeling in Athletes: Integrating Pharmacologic and Whole-Food, Plant-Based Strategies\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/#website\",\"url\":\"https:\\\/\\\/www.curingheartdisease.com\\\/\",\"name\":\"The Premiere Heart Health Education Platform\",\"description\":\"To make available to the public the state of the art information on how to reverse heart disease. This is an evidence-based organization utilizing the best available science, including diet, exercise drugs, and other resources to best fight this disease.\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.curingheartdisease.com\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ar\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/#organization\",\"name\":\"Curing Heart Disease, LLC\",\"url\":\"https:\\\/\\\/www.curingheartdisease.com\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ar\",\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.curingheartdisease.com\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/cropped-Curing-Heart-icon-red.png\",\"contentUrl\":\"https:\\\/\\\/www.curingheartdisease.com\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/cropped-Curing-Heart-icon-red.png\",\"width\":512,\"height\":512,\"caption\":\"Curing Heart Disease, LLC\"},\"image\":{\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/curingheartdisease\",\"https:\\\/\\\/x.com\\\/RMHDInc\",\"https:\\\/\\\/www.instagram.com\\\/rmhdinc\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCm8dh9c_D5RfJL7Z1f-yY4w\"],\"description\":\"Curing Heart Disease, LLC is an independent cardiovascular health education organization that publishes evidence-based articles, videos, podcasts, and educational tools about cardiovascular disease prevention, lipid science, nutrition, exercise, and related health topics.\",\"founder\":{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/#\\\/schema\\\/person\\\/1468f3f6d05d6929d0583938c1236e53\",\"name\":\"Peter Megdal, PhD\"},\"foundingPerson\":{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/#\\\/schema\\\/person\\\/1468f3f6d05d6929d0583938c1236e53\",\"name\":\"Peter Megdal, PhD\"},\"knowsAbout\":[\"Cardiovascular health\",\"Cardiovascular disease prevention\",\"Heart disease education\",\"Nutrition\",\"Exercise\",\"Lipid science\",\"Atherosclerosis\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/#\\\/schema\\\/person\\\/1468f3f6d05d6929d0583938c1236e53\",\"name\":\"Peter Megdal, PhD\",\"url\":\"https:\\\/\\\/www.curingheartdisease.com\\\/peters-story\\\/\",\"givenName\":\"Peter\",\"familyName\":\"Megdal\",\"honorificSuffix\":\"PhD\",\"jobTitle\":\"Nutrition Researcher and Cardiovascular Health Educator\",\"description\":\"Peter Megdal, PhD, is a nutrition researcher, cardiovascular health educator, published researcher, and longtime competitive cyclist. He earned a PhD in nutrition from the University of Massachusetts and publishes evidence-based cardiovascular health education through Curing Heart Disease.\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/peters-story\\\/\"},\"worksFor\":{\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/#organization\"},\"affiliation\":{\"@id\":\"https:\\\/\\\/www.curingheartdisease.com\\\/#organization\"},\"alumniOf\":{\"@type\":\"CollegeOrUniversity\",\"name\":\"University of Massachusetts\"},\"knowsAbout\":[\"Nutrition\",\"Cardiovascular health education\",\"Cardiovascular disease prevention\",\"Lipid science\",\"Exercise physiology\",\"Scientific research\"],\"sameAs\":[\"https:\\\/\\\/www.curingheartdisease.com\\\/author\\\/peter-megdal\\\/\",\"https:\\\/\\\/www.linkedin.com\\\/in\\\/peter-megdal-56075a2\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Coronary Plaque Regression, the Lumen Paradox, and Vascular Remodeling in Athletes: Integrating Pharmacologic and Whole-Food, Plant-Based Strategies - The Premiere Heart Health Education Platform","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.curingheartdisease.com\/ar\/\u062a\u0631\u0627\u062c\u0639-\u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a-\u0627\u0644\u062a\u0627\u062c\u064a\u0629\u060c-\u0645\u0641\u0627\u0631\u0642\u0629-\u0644\u0645\u0639\u0629-\u0627\/","og_locale":"ar_AR","og_type":"article","og_title":"Coronary Plaque Regression, the Lumen Paradox, and Vascular Remodeling in Athletes: Integrating Pharmacologic and Whole-Food, Plant-Based Strategies - The Premiere Heart Health Education Platform","og_description":"Imagine a world-class runner. This person races through marathons, eats what they believe is a \"perfect\" diet, and feels like they are in the best shape of their life. Then, without warning, they suffer a heart attack. This is the \"fit but not immune\" paradox. It is a secret fear for many active people.","og_url":"https:\/\/www.curingheartdisease.com\/ar\/\u062a\u0631\u0627\u062c\u0639-\u0627\u0644\u0644\u0648\u064a\u062d\u0627\u062a-\u0627\u0644\u062a\u0627\u062c\u064a\u0629\u060c-\u0645\u0641\u0627\u0631\u0642\u0629-\u0644\u0645\u0639\u0629-\u0627\/","og_site_name":"The Premiere Heart Health Education Platform","article_publisher":"https:\/\/www.facebook.com\/curingheartdisease","article_published_time":"2025-03-01T14:38:24+00:00","article_modified_time":"2026-08-02T16:38:26+00:00","og_image":[{"width":1200,"height":630,"url":"https:\/\/www.curingheartdisease.com\/wp-content\/uploads\/2025\/11\/post-image-03b.jpg","type":"image\/jpeg"}],"author":"Peter Megdal PhD","twitter_card":"summary_large_image","twitter_creator":"@RMHDInc","twitter_site":"@RMHDInc","twitter_misc":{"\u0643\u064f\u062a\u0628 \u0628\u0648\u0627\u0633\u0637\u0629":"Peter Megdal PhD","\u0648\u0642\u062a \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0627\u0644\u0645\u064f\u0642\u062f\u0651\u0631":"20 \u062f\u0642\u064a\u0642\u0629"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.curingheartdisease.com\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\/#article","isPartOf":{"@id":"https:\/\/www.curingheartdisease.com\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\/"},"author":{"name":"Peter Megdal PhD","@id":"https:\/\/www.curingheartdisease.com\/#\/schema\/person\/1468f3f6d05d6929d0583938c1236e53"},"headline":"Coronary Plaque Regression, the Lumen Paradox, and Vascular Remodeling in Athletes: Integrating Pharmacologic and Whole-Food, Plant-Based Strategies","datePublished":"2025-03-01T14:38:24+00:00","dateModified":"2026-08-02T16:38:26+00:00","mainEntityOfPage":{"@id":"https:\/\/www.curingheartdisease.com\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\/"},"wordCount":4457,"publisher":{"@id":"https:\/\/www.curingheartdisease.com\/#organization"},"image":{"@id":"https:\/\/www.curingheartdisease.com\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\/#primaryimage"},"thumbnailUrl":"https:\/\/www.curingheartdisease.com\/wp-content\/uploads\/2025\/11\/post-image-03b.jpg","articleSection":["Diet and Nutrition","Plant-Based Diets","Plaque, Arteries and Disease","Regression and Reversal"],"inLanguage":"ar"},{"@type":"WebPage","@id":"https:\/\/www.curingheartdisease.com\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\/","url":"https:\/\/www.curingheartdisease.com\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\/","name":"Coronary Plaque Regression, the Lumen Paradox, and Vascular Remodeling in Athletes: Integrating Pharmacologic and Whole-Food, Plant-Based Strategies - The Premiere Heart Health Education Platform","isPartOf":{"@id":"https:\/\/www.curingheartdisease.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.curingheartdisease.com\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\/#primaryimage"},"image":{"@id":"https:\/\/www.curingheartdisease.com\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\/#primaryimage"},"thumbnailUrl":"https:\/\/www.curingheartdisease.com\/wp-content\/uploads\/2025\/11\/post-image-03b.jpg","datePublished":"2025-03-01T14:38:24+00:00","dateModified":"2026-08-02T16:38:26+00:00","breadcrumb":{"@id":"https:\/\/www.curingheartdisease.com\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\/#breadcrumb"},"inLanguage":"ar","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.curingheartdisease.com\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\/"]}]},{"@type":"ImageObject","inLanguage":"ar","@id":"https:\/\/www.curingheartdisease.com\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\/#primaryimage","url":"https:\/\/www.curingheartdisease.com\/wp-content\/uploads\/2025\/11\/post-image-03b.jpg","contentUrl":"https:\/\/www.curingheartdisease.com\/wp-content\/uploads\/2025\/11\/post-image-03b.jpg","width":1200,"height":630},{"@type":"BreadcrumbList","@id":"https:\/\/www.curingheartdisease.com\/coronary-plaque-regression-the-lumen-paradox-and-vascular-remodeling-in-athletes-integrating-pharmacologic-and-whole-food-plant-based-strategies\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.curingheartdisease.com\/"},{"@type":"ListItem","position":2,"name":"Coronary Plaque Regression, the Lumen Paradox, and Vascular Remodeling in Athletes: Integrating Pharmacologic and Whole-Food, Plant-Based Strategies"}]},{"@type":"WebSite","@id":"https:\/\/www.curingheartdisease.com\/#website","url":"https:\/\/www.curingheartdisease.com\/","name":"\u0645\u0646\u0635\u0629 \u0627\u0644\u062a\u062b\u0642\u064a\u0641 \u0627\u0644\u0635\u062d\u064a \u0644\u0644\u0642\u0644\u0628 \u0627\u0644\u0631\u0627\u0626\u062f\u0629","description":"\u0625\u062a\u0627\u062d\u0629 \u0623\u062d\u062f\u062b \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0644\u0644\u062c\u0645\u0647\u0648\u0631 \u062d\u0648\u0644 \u0643\u064a\u0641\u064a\u0629 \u0639\u0643\u0633 \u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0642\u0644\u0628. \u0647\u0630\u0647 \u0645\u0646\u0638\u0645\u0629 \u0642\u0627\u0626\u0645\u0629 \u0639\u0644\u0649 \u0627\u0644\u0623\u062f\u0644\u0629 \u0648\u062a\u0633\u062a\u062e\u062f\u0645 \u0623\u0641\u0636\u0644 \u0627\u0644\u0639\u0644\u0648\u0645 \u0627\u0644\u0645\u062a\u0627\u062d\u0629\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0627\u0644\u0646\u0638\u0627\u0645 \u0627\u0644\u063a\u0630\u0627\u0626\u064a\u060c \u0648\u0627\u0644\u062a\u0645\u0627\u0631\u064a\u0646 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u0629\u060c \u0648\u0627\u0644\u0623\u062f\u0648\u064a\u0629\u060c \u0648\u063a\u064a\u0631\u0647\u0627 \u0645\u0646 \u0627\u0644\u0645\u0648\u0627\u0631\u062f \u0644\u0645\u062d\u0627\u0631\u0628\u0629 \u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636 \u0628\u0623\u0641\u0636\u0644 \u0634\u0643\u0644 \u0645\u0645\u0643\u0646.","publisher":{"@id":"https:\/\/www.curingheartdisease.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.curingheartdisease.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ar"},{"@type":"Organization","@id":"https:\/\/www.curingheartdisease.com\/#organization","name":"\u0634\u0631\u0643\u0629 \u0639\u0644\u0627\u062c \u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0642\u0644\u0628 \u0627\u0644\u0645\u062d\u062f\u0648\u062f\u0629","url":"https:\/\/www.curingheartdisease.com\/","logo":{"@type":"ImageObject","inLanguage":"ar","@id":"https:\/\/www.curingheartdisease.com\/#\/schema\/logo\/image\/","url":"https:\/\/www.curingheartdisease.com\/wp-content\/uploads\/2026\/06\/cropped-Curing-Heart-icon-red.png","contentUrl":"https:\/\/www.curingheartdisease.com\/wp-content\/uploads\/2026\/06\/cropped-Curing-Heart-icon-red.png","width":512,"height":512,"caption":"Curing Heart Disease, LLC"},"image":{"@id":"https:\/\/www.curingheartdisease.com\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/curingheartdisease","https:\/\/x.com\/RMHDInc","https:\/\/www.instagram.com\/rmhdinc\/","https:\/\/www.youtube.com\/channel\/UCm8dh9c_D5RfJL7Z1f-yY4w"],"description":"\u0634\u0631\u0643\u0629 \u0639\u0644\u0627\u062c \u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0642\u0644\u0628 \u0627\u0644\u0645\u062d\u062f\u0648\u062f\u0629 (Curing Heart Disease, LLC) \u0647\u064a \u0645\u0646\u0638\u0645\u0629 \u0645\u0633\u062a\u0642\u0644\u0629 \u0644\u0644\u062a\u062b\u0642\u064a\u0641 \u0627\u0644\u0635\u062d\u064a \u0644\u0644\u0642\u0644\u0628 \u0648\u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u062a\u0646\u0634\u0631 \u0645\u0642\u0627\u0644\u0627\u062a \u0648\u0645\u0642\u0627\u0637\u0639 \u0641\u064a\u062f\u064a\u0648 \u0648\u0628\u0648\u062f\u06a9\u0627\u062a \u0648\u0623\u062f\u0648\u0627\u062a \u062a\u0639\u0644\u064a\u0645\u064a\u0629 \u0645\u062f\u0639\u0648\u0645\u0629 \u0628\u0627\u0644\u0623\u062f\u0644\u0629 \u062d\u0648\u0644 \u0627\u0644\u0648\u0642\u0627\u064a\u0629 \u0645\u0646 \u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0642\u0644\u0628 \u0648\u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629\u060c \u0648\u0639\u0644\u0645 \u0627\u0644\u062f\u0647\u0648\u0646\u060c \u0648\u0627\u0644\u062a\u063a\u0630\u064a\u0629\u060c \u0648\u0627\u0644\u062a\u0645\u0627\u0631\u064a\u0646 \u0627\u0644\u0631\u064a\u0627\u0636\u064a\u0629\u060c \u0648\u0627\u0644\u0645\u0648\u0627\u0636\u064a\u0639 \u0627\u0644\u0635\u062d\u064a\u0629 \u0630\u0627\u062a \u0627\u0644\u0635\u0644\u0629.","founder":{"@type":"Person","@id":"https:\/\/www.curingheartdisease.com\/#\/schema\/person\/1468f3f6d05d6929d0583938c1236e53","name":"Peter Megdal, PhD"},"foundingPerson":{"@type":"Person","@id":"https:\/\/www.curingheartdisease.com\/#\/schema\/person\/1468f3f6d05d6929d0583938c1236e53","name":"Peter Megdal, PhD"},"knowsAbout":["Cardiovascular health","Cardiovascular disease prevention","Heart disease education","Nutrition","Exercise","Lipid science","Atherosclerosis"]},{"@type":"Person","@id":"https:\/\/www.curingheartdisease.com\/#\/schema\/person\/1468f3f6d05d6929d0583938c1236e53","name":"Peter Megdal, PhD","url":"https:\/\/www.curingheartdisease.com\/peters-story\/","givenName":"Peter","familyName":"Megdal","honorificSuffix":"PhD","jobTitle":"Nutrition Researcher and Cardiovascular Health Educator","description":"Peter Megdal, PhD\u060c \u0647\u0648 \u0628\u0627\u062d\u062b \u0641\u064a \u0645\u062c\u0627\u0644 \u0627\u0644\u062a\u063a\u0630\u064a\u0629\u060c \u0648\u0645\u062b\u0642\u0641 \u0641\u064a \u0645\u062c\u0627\u0644 \u0635\u062d\u0629 \u0627\u0644\u0642\u0644\u0628 \u0648\u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629\u060c \u0648\u0628\u0627\u062d\u062b \u0644\u0647 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0646\u0634\u0648\u0631\u0627\u062a \u0627\u0644\u0639\u0644\u0645\u064a\u0629\u060c \u0648\u062f\u0631\u0627\u062c \u062a\u0646\u0627\u0641\u0633\u064a \u0645\u0646\u0630 \u0641\u062a\u0631\u0629 \u0637\u0648\u064a\u0644\u0629. \u062d\u0635\u0644 \u0639\u0644\u0649 \u062f\u0631\u062c\u0629 \u0627\u0644\u062f\u0643\u062a\u0648\u0631\u0627\u0647 \u0641\u064a \u0627\u0644\u062a\u063a\u0630\u064a\u0629 \u0645\u0646 \u062c\u0627\u0645\u0639\u0629 \u0645\u0627\u0633\u0627\u062a\u0634\u0648\u0633\u062a\u0633\u060c \u0648\u064a\u0642\u0648\u0645 \u0628\u0646\u0634\u0631 \u0645\u0648\u0627\u062f \u062a\u062b\u0642\u064a\u0641\u064a\u0629 \u062d\u0648\u0644 \u0635\u062d\u0629 \u0627\u0644\u0642\u0644\u0628 \u0648\u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 \u062a\u0633\u062a\u0646\u062f \u0625\u0644\u0649 \u0627\u0644\u0623\u062f\u0644\u0629 \u0627\u0644\u0639\u0644\u0645\u064a\u0629 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0645\u0648\u0642\u0639 \u00abCuring Heart Disease\u00bb.","mainEntityOfPage":{"@id":"https:\/\/www.curingheartdisease.com\/peters-story\/"},"worksFor":{"@id":"https:\/\/www.curingheartdisease.com\/#organization"},"affiliation":{"@id":"https:\/\/www.curingheartdisease.com\/#organization"},"alumniOf":{"@type":"CollegeOrUniversity","name":"University of Massachusetts"},"knowsAbout":["Nutrition","Cardiovascular health education","Cardiovascular disease prevention","Lipid science","Exercise physiology","Scientific research"],"sameAs":["https:\/\/www.curingheartdisease.com\/author\/peter-megdal\/","https:\/\/www.linkedin.com\/in\/peter-megdal-56075a2\/"]}]}},"_links":{"self":[{"href":"https:\/\/www.curingheartdisease.com\/ar\/wp-json\/wp\/v2\/posts\/8254","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.curingheartdisease.com\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.curingheartdisease.com\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.curingheartdisease.com\/ar\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/www.curingheartdisease.com\/ar\/wp-json\/wp\/v2\/comments?post=8254"}],"version-history":[{"count":22,"href":"https:\/\/www.curingheartdisease.com\/ar\/wp-json\/wp\/v2\/posts\/8254\/revisions"}],"predecessor-version":[{"id":12297,"href":"https:\/\/www.curingheartdisease.com\/ar\/wp-json\/wp\/v2\/posts\/8254\/revisions\/12297"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.curingheartdisease.com\/ar\/wp-json\/wp\/v2\/media\/8297"}],"wp:attachment":[{"href":"https:\/\/www.curingheartdisease.com\/ar\/wp-json\/wp\/v2\/media?parent=8254"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.curingheartdisease.com\/ar\/wp-json\/wp\/v2\/categories?post=8254"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.curingheartdisease.com\/ar\/wp-json\/wp\/v2\/tags?post=8254"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}} | | | | | | |
![\"\"](\"https:\/\/www.curingheartdisease.com\/wp-content\/uploads\/2025\/03\/Coronary-Plaque-Regression-1024x572.png\")
<\/h3>\n