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\u30b3\u30ea\u30f3\uff08\u5375\u3001\u4e73\u88fd\u54c1\uff09\u3084L-\u30ab\u30eb\u30cb\u30c1\u30f3\uff08\u8d64\u8eab\u8089\uff09\u3092\u6442\u53d6\u3059\u308b\u3068\u3001\u5fae\u751f\u7269\u306e\u9175\u7d20\u2015\u2015\u5177\u4f53\u7684\u306b\u306f\u3001\u00a0 <em>\u30ab\u30c3\u30c8C\/D<\/em>\u00a0 \u305d\u3057\u3066\u00a0 <em>cntA\/B<\/em>\u00a0 \u907a\u4f1d\u5b50\u306f\u3001\u3053\u308c\u3089\u306e\u5316\u5408\u7269\u3092\u5207\u65ad\u3057\u3066\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3\uff08TMA\uff09\u3092\u751f\u6210\u3059\u308b\u3002.<\/li>\n<li><strong>\u305d\u306e<\/strong> <strong>$\\gamma<\/strong>$\u00a0 <strong>BB\u30cb\u30e5\u30a2\u30f3\u30b9\uff1a<\/strong>\u00a0 \u91cd\u8981\u306a\u3053\u3068\u306b\u3001\u30ab\u30eb\u30cb\u30c1\u30f3\u4ee3\u8b1d\u7d4c\u8def\u306b\u306f\u3001\u91cd\u8981\u306a\u4ee3\u8b1d\u4e2d\u9593\u4f53\u3067\u3042\u308b $\\gamma$ -\u30d6\u30c1\u30ed\u30d9\u30bf\u30a4\u30f3\uff08$\\gamma$ BB\uff09\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002 \u8fd1\u4f4d\u8178\u7ba1\u3067\u306f\u3001L-\u30ab\u30eb\u30cb\u30c1\u30f3\u306f\u3001\u76f4\u63a5\u7684\u306aTMA\u751f\u6210\u3088\u308a\u3082\u7d041,000\u500d\u9ad8\u3044\u901f\u5ea6\u3067$\\gamma$ BB\u306b\u5909\u63db\u3055\u308c\u3001\u7279\u6b8a\u306a\u5fae\u751f\u7269\u53e2\u306b\u3088\u308b\u305d\u306e\u5f8c\u306eTMA\u751f\u6210\u306e\u305f\u3081\u306e\u4e3b\u8981\u306a\u8caf\u8535\u5eab\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3066\u3044\u308b\u3002.<\/li>\n<li><strong>\u809d\u9178\u5316<\/strong> 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\u9b5a\u7531\u6765\u306eTMAO\u306f\u3001\u76f4\u63a5\u8840\u6d41\u306b\u5438\u53ce\u3055\u308c\u307e\u3059\u3002\u5bfe\u7167\u7684\u306b\u3001\u8089\u7531\u6765\u306e\u524d\u99c6\u4f53\u306f\u3001TMA\u3092\u751f\u6210\u3059\u308b\u305f\u3081\u306b\u5fae\u751f\u7269\u306b\u3088\u308b\u767a\u9175\u3092\u7d4c\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u5fae\u751f\u7269\u306b\u3088\u308b\u30d7\u30ed\u30bb\u30b9\u306f\u3001\u3057\u3070\u3057\u3070\u4ed6\u306e\u708e\u75c7\u6027\u526f\u7523\u7269\u3084\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u306e\u5909\u5316\uff08\u300c\u9023\u5ea7\u8cac\u4efb\u300d\uff09\u3068\u95a2\u9023\u4ed8\u3051\u3089\u308c\u307e\u3059\u304c\u3001\u9b5a\u7531\u6765\u306e\u65e2\u6210\u306eTMAO\u3092\u6442\u53d6\u3059\u308b\u5834\u5408\u306f\u3001\u3053\u3046\u3057\u305f\u73fe\u8c61\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3002.<\/li>\n<li><strong>\u6804\u990a\u306e\u76f8\u6bba<\/strong> \u9b5a\u4ecb\u985e\u306f\u30aa\u30e1\u30ac3\u591a\u4fa1\u4e0d\u98fd\u548c\u8102\u80aa\u9178\uff08EPA\u304a\u3088\u3073DHA\uff09\u3092\u9ad8\u6fc3\u5ea6\u3067\u4f9b\u7d66\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u6297\u708e\u75c7\u6027\u5316\u5408\u7269\u306f\u3001\u4e00\u6642\u7684\u306aTMAO\u6025\u4e0a\u6607\u306b\u3088\u308b\u6f5c\u5728\u7684\u306a\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u60aa\u5f71\u97ff\u52b9\u679c\u7684\u306b\u62ee\u6297\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002.<\/li>\n<li><strong>\u4e00\u904e\u6027\u306e\u66dd\u9732\u3068\u6162\u6027\u306e\u66dd\u9732\uff1a<\/strong> \u814e\u6a5f\u80fd\u304c\u6b63\u5e38\u306a\u4eba\u3067\u306f\u3001\u9b5a\u7531\u6765\u306eTMAO\u306f24\u6642\u9593\u4ee5\u5185\u306b\u7cf8\u7403\u4f53\u6ffe\u904e\u306b\u3088\u3063\u3066\u9664\u53bb\u3055\u308c\u307e\u3059\u3002\u4e00\u65b9\u3001\u8089\u4e2d\u5fc3\u306e\u98df\u4e8b\u306f\u3001\u6162\u6027\u7684\u306aTMA\u7523\u751f\u306b\u9069\u3057\u305f\u8178\u5185\u7d30\u83cc\u53e2\u3092\u5f62\u6210\u3057\u3001\u305d\u306e\u7d50\u679c\u3001\u98df\u4e8b\u306b\u3088\u308b\u6025\u6fc0\u306a\u5909\u52d5\u3088\u308a\u3082\u306f\u308b\u304b\u306b\u6709\u5bb3\u306a\u3001\u6301\u7d9a\u7684\u306a\u9ad8\u5024\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u30ec\u30d9\u30eb\u3092\u3082\u305f\u3089\u3057\u307e\u3059\u3002.<\/li>\n<\/ul>\n<h3>TMAO\u306f\u3001\u8840\u6db2\u306e\u51dd\u56fa\u30ea\u30b9\u30af\u3092\u8abf\u7bc0\u3059\u308b\u300c\u30ec\u30aa\u30b9\u30bf\u30c3\u30c8\u300d\u306e\u3088\u3046\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059<\/h3>\n<p>TMAO\u306f\u76f4\u63a5\u7684\u306b\u51dd\u56fa\u3092\u8a98\u767a\u3059\u308b\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u3080\u3057\u308d\u8840\u6813\u5f62\u6210\u4fc3\u9032\u6027\u611f\u4f5c\u7269\u8cea\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3002\u3053\u308c\u306f\u751f\u5316\u5b66\u7684\u306b\u00a0 <strong>\u30ec\u30aa\u30b9\u30bf\u30c3\u30c8<\/strong> , \u30c8\u30ed\u30f3\u30d3\u30f3\u3084\u30b3\u30e9\u30fc\u30b2\u30f3\u3068\u3044\u3063\u305f\u4e00\u6b21\u30a2\u30b4\u30cb\u30b9\u30c8\u306b\u5bfe\u3059\u308b\u8840\u5c0f\u677f\u306e\u53cd\u5fdc\u6027\u3092\u300c\u9ad8\u3081\u308b\u300d\u3002\u305d\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u306f\u3001\u7d30\u80de\u5185\u30ab\u30eb\u30b7\u30a6\u30e0\uff08 $Ca^{2+}$ \uff09\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u8abf\u7bc0\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002TMAO\u306f\u3001\u7d30\u80de\u5185\u306e\u8caf\u8535\u5eab\u2014\u2014\u5177\u4f53\u7684\u306b\u306f\u00a0 <strong>\u5bc6\u7ba1\u72b6\u7cfb<\/strong> \u2014\u8840\u5c0f\u677f\u5185\u90e8\u306b\u304a\u3044\u3066\u3002\u3053\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u6d41\u5165\u306e\u5897\u52a0\u306b\u3088\u308a\u3001\u8840\u5c0f\u677f\u306f\u300c\u904e\u654f\u300d\u306b\u306a\u308a\u3001\u9ad8\u305b\u3093\u65ad\u6761\u4ef6\u4e0b\u3067\u51dd\u96c6\u3057\u3084\u3059\u304f\u306a\u308a\u3001\u5fc3\u7b4b\u6897\u585e\u3084\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3002\u3053\u306e\u95a2\u9023\u6027\u306e\u56e0\u679c\u95a2\u4fc2\u306f\u3001\u5fae\u751f\u7269\u3092\u9664\u53bb\u3059\u308b\u3053\u3068\u3067\u5b9f\u8a3c\u3055\u308c\u305f\u3002\u00a0 <em>cutC<\/em>\u00a0 \u5b9f\u9a13\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\uff1b\u8178\u7ba1\u304cTMA\u306e\u524d\u99c6\u4f53\u3092\u7523\u751f\u3059\u308b\u80fd\u529b\u3092\u5b8c\u5168\u306b\u5931\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u3053\u306e\u8840\u6813\u5f62\u6210\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u306f\u5b8c\u5168\u306b\u89e3\u6d88\u3055\u308c\u305f\u3002.<\/p>\n<h3>\u5fc3\u81d3\u3092\u8d85\u3048\u3066\u2014\u8133\u3068\u814e\u81d3\u306e\u3064\u306a\u304c\u308a<\/h3>\n<p>TMAO\u306f\u5fc3\u8840\u7ba1\u7814\u7a76\u306b\u304a\u3044\u3066\u5b9a\u756a\u306e\u6307\u6a19\u3067\u3042\u308b\u4e00\u65b9\u3001\u5065\u5eb7\u306e\u5305\u62ec\u7684\u306a\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u307e\u3059\u307e\u3059\u6ce8\u76ee\u3055\u308c\u3066\u304a\u308a\u3001\u300c\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30bf\u30fb\u8178\u30fb\u8133\u8ef8\u300d\u3084\u814e\u81d3\u306e\u5bff\u547d\u306b\u591a\u5927\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002.<\/p>\n<ul>\n<li><strong>\u795e\u7d4c\u5909\u6027<\/strong> TMAO\u306f\u8840\u6db2\u8133\u95a2\u9580\u3092\u5bb9\u6613\u306b\u901a\u904e\u3059\u308b\u3002\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306b\u304a\u3044\u3066\u3001TMAO\u306f\u5316\u5b66\u30b7\u30e3\u30da\u30ed\u30f3\u3068\u3057\u3066\u4f5c\u7528\u3057\u3001\u30a2\u30df\u30ed\u30a4\u30c9\u03b2\u304a\u3088\u3073\u03b1-\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u306e\u51dd\u96c6\u3092\u4fc3\u9032\u3059\u308b\u3002\u3055\u3089\u306b\u3001TMAO\u306f\u00a0 <strong>\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u306e\u30d1\u30a4\u30ed\u30d7\u30c8\u30fc\u30b7\u30b9<\/strong>\u00a0 \u7d4c\u7531\u3067\u00a0 <strong>ROS-NLRP3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def<\/strong> , \u3001\u795e\u7d4c\u708e\u75c7\u3092\u4fc3\u9032\u3057\u3001\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u306b\u304a\u3044\u3066\u3057\u3070\u3057\u3070\u898b\u3089\u308c\u308b\u8131\u9ac4\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002.<\/li>\n<li><strong>\u814e\u81d3\u306e\u60aa\u5faa\u74b0\uff1a<\/strong> TMAO\u306f\u4e3b\u306b\u814e\u81d3\u306b\u3088\u3063\u3066\u6392\u6cc4\u3055\u308c\u307e\u3059\u304c\u3001\u300c\u5c3f\u6bd2\u75c7\u6bd2\u7d20\u300d\u3068\u3057\u3066\u306e\u50cd\u304d\u3082\u679c\u305f\u3057\u307e\u3059\u3002\u305d\u306e\u6fc3\u5ea6\u304c\u4e0a\u6607\u3059\u308b\u3068\u3001\u00a0 <strong>\u814e\u5c3f\u7d30\u7ba1\u9593\u8cea\u7dda\u7dad\u5316<\/strong>\u00a0 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TMAO\u7ba1\u7406\u306e\u5c06\u6765\u306f\u3001\u7d30\u83cc\u305d\u306e\u3082\u306e\u3067\u306f\u306a\u304f\u9175\u7d20\uff08TMA\u30ea\u30a2\u30fc\u30bc\uff09\u3092\u6a19\u7684\u3068\u3057\u3001\u6297\u751f\u7269\u8cea\u8010\u6027\u306e\u30ea\u30b9\u30af\u3092\u56de\u907f\u3059\u308b\u300c\u975e\u81f4\u6b7b\u6027\u300d\u306e\u4f4e\u5206\u5b50\u963b\u5bb3\u5264\u306b\u3042\u308b\u3002| \u963b\u5bb3\u5264\u306e\u7a2e\u985e | \u4e3b\u8981\u5316\u5408\u7269 | \u4f5c\u7528\u6a5f\u5e8f | \u52b9\u529b\u304a\u3088\u3073\u958b\u767a\u72b6\u6cc1 || \u2014\u2014 | \u2014\u2014 | \u2014\u2014 | \u2014\u2014 || <strong>\u7af6\u5408\u963b\u5bb3\u5264<\/strong> | DMB\uff08\u30aa\u30ea\u30fc\u30d6\u30aa\u30a4\u30eb\u306b\u542b\u307e\u308c\u308b\uff09 | \u30b3\u30ea\u30f3\u3068\u540c\u69d8\u306e\u4f5c\u7528\u3092\u793a\u3057\u3001CutC\/D\u3092\u7af6\u5408\u7684\u306b\u963b\u5bb3\u3059\u308b | \u524d\u81e8\u5e8a\u6bb5\u968e\uff1b\u5929\u7136\u7531\u6765 || <strong>\u81ea\u6bba\u57fa\u8cea<\/strong> | IMC \/ FMC | <strong>\u4e0d\u53ef\u9006\u7684\u306b<\/strong>\u00a0 CutC\/D\u9175\u7d20\u306b\u7d50\u5408\u3057\u3066\u4e0d\u6d3b\u6027\u5316\u3059\u308b <strong>\u30ca\u30ce\u30e2\u30eb\u6fc3\u5ea6\u306e\u6d3b\u6027<\/strong>\u00a0 ( $IC_{50}$ ); \u9ad8\u3044\u5b89\u5168\u6027 |<\/p>\n<p>\u30e8\u30fc\u30c9\u30e1\u30c1\u30eb\u30b3\u30ea\u30f3\uff08IMC\uff09\u306a\u3069\u306e\u5316\u5408\u7269\u306f\u3001\u51fa\u8840\u6642\u9593\u3092\u5ef6\u3070\u3059\u3053\u3068\u306a\u304f\u5168\u8eab\u6027\u306eTMAO\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u8840\u6813\u306e\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3059\u308b\u80fd\u529b\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u7cbe\u5bc6\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u85ac\u7406\u5b66\u306b\u304a\u3051\u308b\u30d1\u30e9\u30c0\u30a4\u30e0\u30b7\u30d5\u30c8\u3092\u4f53\u73fe\u3057\u3066\u3044\u307e\u3059\u3002.<\/p>\n<h3>\u7d50\u8ad6\uff1a\u500b\u5225\u5316\u4e88\u9632\u306b\u5411\u3051\u3066<\/h3>\n<p>TMAO\u306f\u3001\u79c1\u305f\u3061\u306e\u98df\u4e8b\u6442\u53d6\u3068\u4f53\u5185\u306e\u5fae\u751f\u7269\u751f\u614b\u7cfb\u3068\u306e\u76f8\u4e92\u95a2\u4fc2\u3092\u6620\u3057\u51fa\u3059\u3001\u9ad8\u7cbe\u5ea6\u306a\u93e1\u306e\u3088\u3046\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002\u3082\u306f\u3084\u5358\u306a\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3067\u306f\u306a\u304f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3001\u814e\u75be\u60a3\u3001\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u767a\u75c7\u904e\u7a0b\u306b\u304a\u3044\u3066\u3001\u751f\u7269\u5b66\u7684\u6d3b\u6027\u3092\u793a\u3059\u91cd\u8981\u306a\u56e0\u5b50\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u300c\u5c64\u5225\u5316\u6804\u990a\u5b66\u300d\u3078\u306e\u79fb\u884c\u304c\u9032\u3080\u4e2d\u3001\u500b\u4eba\u306e\u8178\u5185\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3001\u7279\u306b\u5fae\u751f\u7269\u306e\u00a0 <em>cutC<\/em>\u00a0 \u907a\u4f1d\u5b50\u3084\u809d\u81d3\u306eFMO3\u306e\u6d3b\u6027\u2015\u2015\u3053\u308c\u3089\u306b\u3088\u3063\u3066\u3001\u500b\u4eba\u306b\u5408\u308f\u305b\u305f\u98df\u4e8b\u7642\u6cd5\u306e\u65b9\u5411\u6027\u304c\u6c7a\u307e\u308b\u3067\u3057\u3087\u3046\u3002\u300cTMA\u9ad8\u7523\u751f\u8005\u300d\u3092\u65e9\u671f\u306b\u7279\u5b9a\u3059\u308b\u3053\u3068\u3067\u3001\u753b\u4e00\u7684\u306a\u30a2\u30c9\u30d0\u30a4\u30b9\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u30bf\u30fc\u30b2\u30c3\u30c8\u3092\u7d5e\u3063\u305f\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u7ba1\u7406\u3078\u3068\u9032\u3080\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u5fc3\u81d3\u306e\u72b6\u614b\u306f\u3001\u6587\u5b57\u901a\u308a\u3001\u8178\u5185\u3067\u8d77\u3053\u3063\u3066\u3044\u308b\u76ee\u306b\u898b\u3048\u306a\u3044\u4ee3\u8b1d\u306e\u30ea\u30ec\u30fc\u3092\u53cd\u6620\u3057\u305f\u3082\u306e\u3067\u3059\u3002\u3042\u306a\u305f\u306e\u4f53\u5185\u306e\u300c\u5de5\u5834\u300d\u306f\u3001\u4e00\u4f53\u4f55\u3092\u751f\u7523\u3057\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n<hr \/>\n<h2>TMAO\u7814\u7a76\u306e\u30c7\u30a3\u30fc\u30d7\u30c0\u30a4\u30d6<\/h2>\n<h3><strong>\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3 N-\u30aa\u30ad\u30b7\u30c9\u306e\u30e1\u30bf\u751f\u7269\u5b66\u7684\u30e1\u30bf\u8ef8\uff1a\u751f\u5316\u5b66\u7684\u7d4c\u8def\u3001\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u75c5\u614b\u5f62\u6210\u3001\u304a\u3088\u3073\u81e8\u5e8a\u7684\u610f\u7fa9\u306e\u5305\u62ec\u7684\u89e3\u6790<\/strong><\/h3>\n<p>\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3N-\u30aa\u30ad\u30b7\u30c9\uff08TMAO\uff09\u304c\u5fc3\u4ee3\u8b1d\u533b\u5b66\u306e\u4e2d\u5fc3\u7684\u306a\u5b58\u5728\u3068\u3057\u3066\u6d6e\u4e0a\u3057\u305f\u3053\u3068\u306f\u3001\u98df\u4e8b\u3001\u8178\u5185\u7d30\u83cc\u53e2\u3001\u305d\u3057\u3066\u4eba\u9593\u306e\u5065\u5eb7\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u5bfe\u3059\u308b\u7814\u7a76\u8005\u306e\u7406\u89e3\u306b\u304a\u3044\u3066\u3001\u5927\u304d\u306a\u8ee2\u63db\u70b9\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002TMAO\u306f\u3001\u5206\u5b50\u5f0f\u304c <strong>C5H11NO2<\/strong>, \u2026\u306f\u3001\u6c34\u6eb6\u6027\u30a2\u30df\u30f3N-\u30aa\u30ad\u30b7\u30c9\u306e\u4e00\u7a2e\u3067\u3042\u308a\u3001\u6d77\u6d0b\u751f\u7269\u5b66\u306b\u304a\u3044\u3066\u6bd4\u8f03\u7684\u77e5\u3089\u308c\u3066\u3044\u306a\u304b\u3063\u305f\u6d78\u900f\u5727\u8abf\u7bc0\u7269\u8cea\u304b\u3089\u3001\u73fe\u5728\u3067\u306f\u5e83\u304f\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u5019\u88dc\u304a\u3088\u3073\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6f5c\u5728\u7684\u306a\u5a92\u4ecb\u7269\u8cea\u3078\u3068\u305d\u306e\u4f4d\u7f6e\u3065\u3051\u304c\u5909\u5316\u3057\u305f\u3002 TMAO\u306e\u5408\u6210\u306f\u3001\u5916\u90e8\u74b0\u5883\uff08\u98df\u4e8b\uff09\u3001\u8178\u5185\u5fae\u751f\u7269\u751f\u614b\u7cfb\uff08\u8178\u5185\u7d30\u83cc\u53e2\uff09\u3001\u304a\u3088\u3073\u5bbf\u4e3b\u306e\u5185\u90e8\u751f\u7406\u6a5f\u80fd\uff08\u809d\u81d3\u3068\u814e\u81d3\uff09\u3092\u7d50\u3073\u3064\u3051\u308b\u591a\u6bb5\u968e\u306e\u30d7\u30ed\u30bb\u30b9\u3067\u3042\u308b\u3002 \u672c\u5831\u544a\u66f8\u3067\u306f\u3001TMAO\u8ef8\u306b\u3064\u3044\u3066\u5c02\u9580\u5bb6\u30ec\u30d9\u30eb\u306e\u5fb9\u5e95\u7684\u306a\u8a73\u7d30\u5206\u6790\u3092\u884c\u3044\u3001\u305d\u306e\u751f\u5316\u5b66\u7684\u69cb\u9020\u3001\u75be\u60a3\u3092\u4fc3\u9032\u3059\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3001\u4e88\u5f8c\u4fa1\u5024\u3092\u88cf\u4ed8\u3051\u308b\u81e8\u5e8a\u7684\u30a8\u30d3\u30c7\u30f3\u30b9\u3001\u304a\u3088\u3073\u5168\u8eab\u6027\u8178\u5185\u7d30\u83cc\u53e2\u306e\u4e71\u308c\u3084\u5fc3\u4ee3\u8b1d\u30ea\u30b9\u30af\u306e\u300c\u539f\u56e0\u56e0\u5b50\u300d\u304b\u300c\u4ee3\u66ff\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u300d\u304b\u3068\u3044\u3046\u73fe\u72b6\u3092\u3081\u3050\u308b\u8b70\u8ad6\u306b\u3064\u3044\u3066\u8003\u5bdf\u3059\u308b\u3002.<\/p>\n<h3>\u751f\u5316\u5b66\u7684\u30e9\u30f3\u30c9\u30b9\u30b1\u30fc\u30d7\uff1a\u8178\u30fb\u809d\u30fb\u814e\u9023\u95a2<\/h3>\n<p>TMAO\u306e\u7523\u751f\u306f\u3001\u30d2\u30c8\u306e\u7d30\u80de\u4ee3\u8b1d\u306b\u3088\u308b\u76f4\u63a5\u7684\u306a\u7d50\u679c\u3067\u306f\u306a\u304f\u3001\u3080\u3057\u308d\u8178\u5185\u5fae\u751f\u7269\u53e2\u304b\u3089\u306e\u4e0d\u53ef\u6b20\u306a\u5bc4\u4e0e\u3092\u5fc5\u8981\u3068\u3059\u308b\u30e1\u30bf\u751f\u7269\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u3067\u3042\u308b\u3002\u3053\u306e\u7d4c\u8def\u306f\u3001\u98df\u4e8b\u7531\u6765\u306e\u524d\u99c6\u4f53\u304c\u6442\u53d6\u3055\u308c\u3001\u305d\u306e\u5f8c\u3001\u5bbf\u4e3b\u304c\u4fee\u98fe\u3059\u308b\u63ee\u767a\u6027\u4e2d\u9593\u4f53\u306b\u5909\u63db\u3055\u308c\u308b\u3068\u304d\u306b\u958b\u59cb\u3055\u308c\u308b\u3002.<\/p>\n<h4>\u98df\u4e8b\u306e\u524d\u99c6\u7269\u8cea\u3068\u5fae\u751f\u7269\u306e\u30b2\u30fc\u30c8\u30a6\u30a7\u30a4<\/h4>\n<p>TMAO\u5408\u6210\u306e\u4e3b\u8981\u306a\u539f\u6599\u306f\u3001\u591a\u304f\u306e\u52d5\u7269\u6027\u98df\u54c1\u306b\u8c4a\u5bcc\u306b\u542b\u307e\u308c\u308b\u7b2c\u56db\u7d1a\u30a2\u30f3\u30e2\u30cb\u30a6\u30e0\u5316\u5408\u7269\u3067\u3059\u304c\u3001\u690d\u7269\u6027\u98df\u54c1\u306e\u4e00\u90e8\u3082\u30d9\u30bf\u30a4\u30f3\u3084\u30b3\u30ea\u30f3\u306e\u542b\u6709\u91cf\u3092\u4ecb\u3057\u3066\u5bc4\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u6700\u3082\u9855\u8457\u306a\u524d\u99c6\u4f53\u306b\u306f\u3001\u30b3\u30ea\u30f3\uff08\u591a\u304f\u306e\u5834\u5408\u30db\u30b9\u30d5\u30a1\u30c1\u30b8\u30eb\u30b3\u30ea\u30f3\u307e\u305f\u306f\u30ec\u30b7\u30c1\u30f3\u306e\u5f62\u3067\u5b58\u5728\u3059\u308b\uff09\u3001L-\u30ab\u30eb\u30cb\u30c1\u30f3\u3001\u30d9\u30bf\u30a4\u30f3\u304c\u542b\u307e\u308c\u307e\u3059\u3002, <strong>\u03b3-\u30d6\u30c1\u30ed\u30d9\u30bf\u30a4\u30f3<\/strong>, \u3001\u304a\u3088\u3073\u30af\u30ed\u30c8\u30ce\u30d9\u30bf\u30a4\u30f3\u3002.<\/p>\n<table>\n<thead>\n<tr>\n<td><strong>\u98df\u4e8b\u6027\u524d\u99c6\u4f53<\/strong><\/td>\n<td><strong>\u4e3b\u8981\u306a\u6804\u990a\u6e90<\/strong><\/td>\n<td><strong>\u4ee3\u8b1d\u4e2d\u9593\u4f53<\/strong><\/td>\n<td><strong>\u6700\u7d42\u5168\u8eab\u7528\u88fd\u54c1<\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u30b3\u30ea\u30f3 \/ \u30db\u30b9\u30d5\u30a1\u30c1\u30b8\u30eb\u30b3\u30ea\u30f3<\/td>\n<td>\u5375\u9ec4\u3001\u30ec\u30d0\u30fc\u3001\u4e73\u88fd\u54c1\u3001\u5927\u8c46<\/td>\n<td>\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3 (TMA)<\/td>\n<td>\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3 N-\u30aa\u30ad\u30b7\u30c9<\/td>\n<\/tr>\n<tr>\n<td>L-\u30ab\u30eb\u30cb\u30c1\u30f3<\/td>\n<td>\u8d64\u8eab\u8089\uff08\u725b\u8089\u3001\u30e9\u30e0\u8089\uff09\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8<\/td>\n<td>\u03b3-\u30d6\u30c1\u30ed\u30d9\u30bf\u30a4\u30f3\uff08\u03b3BB\uff09\uff0fTMA<\/td>\n<td>\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3 N-\u30aa\u30ad\u30b7\u30c9<\/td>\n<\/tr>\n<tr>\n<td>\u03b3-\u30d6\u30c1\u30ed\u30d9\u30bf\u30a4\u30f3<\/td>\n<td>\u4e00\u90e8\u306e\u8d64\u8eab\u8089\u306b\u4e8b\u524d\u306b\u5f62\u6210\u3055\u308c\u3066\u3044\u308b; \u5fae\u751f\u7269\u306e\u4e2d\u9593\u4f53<\/td>\n<td>\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3 (TMA)<\/td>\n<td>\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3 N-\u30aa\u30ad\u30b7\u30c9<\/td>\n<\/tr>\n<tr>\n<td>\u30d9\u30bf\u30a4\u30f3<\/td>\n<td>\u30d3\u30fc\u30c8\u3001\u307b\u3046\u308c\u3093\u8349\u3001\u5168\u7c92\u7a40\u7269<\/td>\n<td>\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3 (TMA)<\/td>\n<td>\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3 N-\u30aa\u30ad\u30b7\u30c9<\/td>\n<\/tr>\n<tr>\n<td>\u30af\u30ed\u30c8\u30ce\u30d9\u30bf\u30a4\u30f3<\/td>\n<td>\u30ab\u30eb\u30cb\u30c1\u30f3\u4ee3\u8b1d\u526f\u7523\u7269<\/td>\n<td>\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3 (TMA)<\/td>\n<td>\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3 N-\u30aa\u30ad\u30b7\u30c9<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u3053\u308c\u3089\u306e\u6804\u990a\u7d20\u306e\u4ee3\u8b1d\u306f\u3001\u8178\u7ba1\u8154\u5185\u3067\u59cb\u307e\u308a\u307e\u3059\u3002\u98df\u4e8b\u7531\u6765\u306e\u30b3\u30ea\u30f3\u3068\u30ab\u30eb\u30cb\u30c1\u30f3\u306f\u3001\u7279\u5b9a\u306e\u5fae\u751f\u7269\u9175\u7d20\u306b\u3088\u3063\u3066\u4ee3\u8b1d\u3055\u308c\u307e\u3059\u3002\u30b3\u30ea\u30f3\u4e2d\u306e\u70ad\u7d20-\u7a92\u7d20\u7d50\u5408\u306e\u5207\u65ad\u306f\u3001\u30b0\u30ea\u30b7\u30eb\u30e9\u30b8\u30ab\u30eb\u9175\u7d20\u3067\u3042\u308b\u30b3\u30ea\u30f3\u30fb\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3\u30ea\u30a2\u30fc\u30bc\u306b\u3088\u3063\u3066\u89e6\u5a92\u3055\u308c\u3001\u3053\u306e\u9175\u7d20\u306f <strong>cutC<\/strong> \u907a\u4f1d\u5b50\u3001\u304a\u3088\u3073\u305d\u306e\u6d3b\u6027\u5316\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u4ee5\u4e0b\u306b\u30b3\u30fc\u30c9\u3055\u308c\u308b\uff09 <strong>\u30ab\u30c3\u30c8D<\/strong>. \u3002\u3053\u306e\u53cd\u5fdc\u306b\u3088\u308a\u3001\u63ee\u767a\u6027\u306e\u526f\u7523\u7269\u3068\u3057\u3066\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3\uff08TMA\uff09\u304c\u653e\u51fa\u3055\u308c\u307e\u3059\u3002\u540c\u69d8\u306b\u3001L-\u30ab\u30eb\u30cb\u30c1\u30f3\u306f\u3001\u30ab\u30eb\u30cb\u30c1\u30f3\u30e2\u30ce\u30aa\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc\u7cfb\uff08\u907a\u4f1d\u5b50\u30b3\u30fc\u30c9\u3055\u308c\u3066\u3044\u308b\uff09\u3092\u542b\u3080\u5225\u500b\u306e\u7d4c\u8def\u3092\u4ecb\u3057\u3066\u4ee3\u8b1d\u3055\u308c\u307e\u3059\u3002 <strong>cntA<\/strong> \u305d\u3057\u3066 <strong>cntB<\/strong>)\u3001\u305d\u308c\u306fTMA\u306e\u7523\u751f\u306b\u3082\u3064\u306a\u304c\u308b\u3002.<\/p>\n<p>\u8fd1\u5e74\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u30ab\u30eb\u30cb\u30c1\u30f3\u56de\u8def\u306b\u95a2\u3059\u308b\u91cd\u8981\u306a\u65b0\u305f\u306a\u5074\u9762\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002 <strong>\u03b3-\u30d6\u30c1\u30ed\u30d9\u30bf\u30a4\u30f3\uff08\u03b3BB\uff09<\/strong> \u4e3b\u8981\u306a\u4e2d\u9593\u4ee3\u8b1d\u7269\u3068\u3057\u3066\u3002L-\u30ab\u30eb\u30cb\u30c1\u30f3\u306e\u6442\u53d6\u5f8c\u3001\u8fd1\u4f4d\u8178\u7ba1\u306b\u304a\u3051\u308bTMA\u306e\u76f4\u63a5\u751f\u6210\u306b\u6bd4\u3079\u3066\u3001\u03b3BB\u306e\u751f\u6210\u901f\u5ea6\u306f\u7d041,000\u500d\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u03b3BB\u306f\u3001\u305d\u306e\u5f8c\u3001\u4e8c\u6b21\u7684\u306a\u6bb5\u968e\u306b\u304a\u3044\u3066\u3001\u7279\u5b9a\u306e\u5fae\u751f\u7269\u7fa4\u306b\u3088\u3063\u3066TMA\u306b\u5909\u63db\u3055\u308c\u307e\u3059\u3002 \u3053\u308c\u3089\u306e\u4e2d\u9593\u4f53\u306e\u5b58\u5728\u306f\u3001TMAO\u524d\u99c6\u4f53\u306b\u5bfe\u3059\u308b\u8178\u7ba1\u306e\u4ee3\u8b1d\u80fd\u529b\u304c\u5358\u4e00\u306e\u53cd\u5fdc\u3067\u306f\u306a\u304f\u3001\u7570\u306a\u308b\u5fae\u751f\u7269\u7fa4\u96c6\u9593\u306e\u8907\u96d1\u306a\u30ea\u30ec\u30fc\u53cd\u5fdc\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002.<\/p>\n<h4>\u809d\u81d3\u306e\u5909\u63db\u3068FMO3\u306e\u5f79\u5272<\/h4>\n<p>TMA\u304c\u8178\u5185\u3067\u751f\u6210\u3055\u308c\u308b\u3068\u3001\u8178\u4e0a\u76ae\u3092\u4ecb\u3057\u3066\u5438\u53ce\u3055\u308c\u3001\u9580\u8108\u3092\u7d4c\u7531\u3057\u3066\u809d\u81d3\u3078\u3068\u8f38\u9001\u3055\u308c\u308b\u3002TMA\u306f\u63ee\u767a\u6027\u304c\u9ad8\u304f\u3001\u60aa\u81ed\u3092\u653e\u3064\u5316\u5408\u7269\u3067\u3042\u308a\u3001\u30d2\u30c8\u306b\u304a\u3044\u3066\u306f\u3001\u7121\u81ed\u306eTMAO\u3078\u306e\u8fc5\u901f\u306a\u5909\u63db\u304c\u91cd\u8981\u306a\u89e3\u6bd2\u30b9\u30c6\u30c3\u30d7\u3068\u306a\u308b\u3002\u3053\u306e\u9178\u5316\u306f\u3001\u30d5\u30e9\u30d3\u30f3\u542b\u6709\u30e2\u30ce\u30aa\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc\uff08FMO\uff09\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u9175\u7d20\u3001\u5177\u4f53\u7684\u306b\u306f <strong>FMO3<\/strong> \u809d\u81d3\u306b\u304a\u3051\u308bTMA\u304b\u3089TMAO\u3078\u306e\u5909\u63db\u306e\u5927\u534a\u3092\u5360\u3081\u308b\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0.<\/p>\n<p>FMO3\u306e\u6d3b\u6027\u306f\u3001\u8840\u4e2dTMAO\u30ec\u30d9\u30eb\u306e\u4e3b\u8981\u306a\u6c7a\u5b9a\u8981\u56e0\u3067\u3042\u308b\u3002\u907a\u4f1d\u7684\u591a\u578b\u306f <strong>FMO3<\/strong> \u3053\u306e\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u306f\u9175\u7d20\u6d3b\u6027\u306e\u4f4e\u4e0b\u3092\u62db\u304d\u3001\u305d\u306e\u7d50\u679c\u3001TMA\u304c\u84c4\u7a4d\u3057\u3066\u300c\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3\u5c3f\u75c7\uff08\u9b5a\u81ed\u75c7\u5019\u7fa4\uff09\u300d\u3068\u547c\u3070\u308c\u308b\u72b6\u614b\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002\u3053\u306e\u72b6\u614b\u3067\u306f\u3001TMA\u304c\u6c57\u3001\u547c\u6c17\u3001\u5c3f\u4e2d\u306b\u6392\u6cc4\u3055\u308c\u308b\u3002 \u9006\u306b\u3001\u80c6\u6c41\u9178\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3084FXR\u95a2\u9023\u7d4c\u8def\u306a\u3069\u306e\u5bbf\u4e3b\u56e0\u5b50\u306b\u3088\u3063\u3066\u5f71\u97ff\u3092\u53d7\u3051\u308bFMO3\u6d3b\u6027\u306e\u4ea2\u9032\u306f\u3001\u524d\u99c6\u4f53\u306e\u6975\u7aef\u306a\u6442\u53d6\u304c\u306a\u3044\u5834\u5408\u3067\u3082\u3001\u5168\u8eab\u306eTMAO\u6fc3\u5ea6\u3092\u4e0a\u6607\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u809d\u81d3\u3067\u751f\u6210\u3055\u308c\u305fTMAO\u306f\u5168\u8eab\u5faa\u74b0\u306b\u5165\u308a\u3001\u4e3b\u306b\u814e\u81d3\u3067\u306e\u7cf8\u7403\u4f53\u6ffe\u904e\u306b\u3088\u3063\u3066\u6392\u6cc4\u3055\u308c\u307e\u3059\u3002.<\/p>\n<h3>TMAO\u306e\u5206\u5b50\u4f5c\u7528\u6a5f\u5e8f\uff1aTMAO\u304c\u75be\u60a3\u3092\u5f15\u304d\u8d77\u3053\u3059\u4ed5\u7d44\u307f<\/h3>\n<p>TMAO\u306e\u75c5\u539f\u6027\u306f\u3001\u7d30\u80de\u30b9\u30c8\u30ec\u30b9\u3001\u708e\u75c7\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3001\u8840\u6813\u75c7\u3001\u304a\u3088\u3073\u8102\u8cea\u6052\u5e38\u6027\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u591a\u69d8\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002 \u5b9f\u9a13\u30e2\u30c7\u30eb\u306f\u3001\u5358\u306a\u308b\u76f8\u95a2\u95a2\u4fc2\u306e\u89e3\u660e\u306b\u3068\u3069\u307e\u3089\u305a\u3001TMAO\u304c\u751f\u7406\u7684\u307e\u305f\u306f\u75c5\u614b\u751f\u7406\u5b66\u7684\u6fc3\u5ea6\u306b\u304a\u3044\u3066\u8abf\u7bc0\u3057\u3046\u308b\u7d30\u80de\u5185\u6a19\u7684\u306e\u7279\u5b9a\u3078\u3068\u9032\u5c55\u3057\u3066\u3044\u308b\u3002\u3068\u306f\u3044\u3048\u3001\u3053\u308c\u3089\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u591a\u304f\u306f\u3001\u6c7a\u5b9a\u7684\u306a\u30d2\u30c8\u4ecb\u5165\u7814\u7a76\u3068\u3044\u3046\u3088\u308a\u306f\u3001\u4f9d\u7136\u3068\u3057\u3066\u524d\u81e8\u5e8a\u7cfb\u306b\u304a\u3044\u3066\u6700\u3082\u78ba\u7acb\u3055\u308c\u3066\u3044\u308b\u3002.<\/p>\n<h4>\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4ee3\u8b1d\u3068\u9006\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8ee2\u9001<\/h4>\n<p>TMAO\u306b\u8d77\u56e0\u3059\u308b\u3068\u3055\u308c\u308b\u4ee3\u8868\u7684\u306a\u52d5\u8108\u786c\u5316\u4fc3\u9032\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u3064\u306f\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u6052\u5e38\u6027\u306e\u4e71\u308c\u3067\u3042\u308b\u3002 \u6b63\u5e38\u306a\u72b6\u614b\u3067\u306f\u3001\u4f53\u306f\u9006\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8f38\u9001\uff08RCT\uff09\u3092\u901a\u3058\u3066\u30d0\u30e9\u30f3\u30b9\u3092\u7dad\u6301\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u904e\u7a0b\u3067\u306f\u672b\u68a2\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u304b\u3089\u4f59\u5206\u306a\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u809d\u81d3\u3078\u3068\u904b\u3070\u308c\u3001\u80c6\u6c41\u3068\u3057\u3066\u6392\u6cc4\u3055\u308c\u308b\u3002\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001TMAO\u304c\u3053\u306e\u904e\u7a0b\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002.<\/p>\n<p>\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001TMAO\u3092\u98df\u4e8b\u304b\u3089\u88dc\u7d66\u3059\u308b\u3068\u3001RCT\u80fd\u529b\u304c\u304a\u3088\u305d35%\u4f4e\u4e0b\u3059\u308b\u3002\u3053\u306e\u6a5f\u80fd\u969c\u5bb3\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u4e26\u884c\u3059\u308b\u7d4c\u8def\u3092\u901a\u3058\u3066\u751f\u3058\u3066\u3044\u308b\u3088\u3046\u3067\u3042\u308b\uff1a<\/p>\n<ul>\n<li><strong>\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u6ce1\u6cab\u7d30\u80de\u3078\u306e\u5206\u5316\uff1a<\/strong> TMAO\u306f\u30b9\u30ab\u30d9\u30f3\u30b8\u30e3\u30fc\u53d7\u5bb9\u4f53\u306e\u767a\u73fe\u3092\u4e0a\u65b9\u5236\u5fa1\u3059\u308b\u3001\u5177\u4f53\u7684\u306b\u306f <strong>CD36<\/strong> \u305d\u3057\u3066 <strong>\u30b9\u30ab\u30d9\u30f3\u30b8\u30e3\u30fc\u53d7\u5bb9\u4f53A\uff08SR-A\uff09<\/strong>, \u3001\u3053\u308c\u306b\u3088\u308a\u3001\u4fee\u98feLDL\u304c\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u53d6\u308a\u8fbc\u307e\u308c\u3084\u3059\u304f\u306a\u308b\u3002\u305d\u306e\u7d50\u679c\u3001\u52d5\u8108\u58c1\u5185\u3067\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u304c\u708e\u75c7\u8a98\u767a\u6027\u6ce1\u6cab\u7d30\u80de\u3078\u3068\u5909\u5316\u3059\u308b\u901f\u5ea6\u304c\u9ad8\u307e\u308b\u3002.<\/li>\n<li><strong>\u80c6\u6c41\u9178\u963b\u5bb3<\/strong> TMAO\u306f\u3001\u80c6\u6c41\u9178\u5408\u6210\u306b\u95a2\u4e0e\u3059\u308b\u4e3b\u8981\u306a\u809d\u81d3\u9175\u7d20\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u3002\u4e2d\u3067\u3082\u7279\u7b46\u3059\u3079\u304d\u306f <strong>CYP7A1<\/strong> \u305d\u3057\u3066 <strong>CYP27A1<\/strong>. TMAO\u306f\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304b\u3089\u80c6\u6c41\u9178\u3078\u306e\u5909\u63db\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6392\u6cc4\u306e\u4e3b\u8981\u306a\u7d4c\u8def\u3092\u5236\u9650\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002.<\/li>\n<li><strong>\u80c6\u6c41\u9178\u8f38\u9001<\/strong> \u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u7814\u7a76\u306b\u3088\u308a\u3001TMAO\u304c\u80c6\u6c41\u9178\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u306e\u767a\u73fe\u91cf\u3092\u6e1b\u5c11\u3055\u305b\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4ee3\u8b1d\u7269\u306e\u6d41\u52d5\u3092\u3055\u3089\u306b\u963b\u5bb3\u3057\u3001\u84c4\u7a4d\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002.<\/li>\n<\/ul>\n<h4>\u5185\u76ae\u6a5f\u80fd\u969c\u5bb3\u3068NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0<\/h4>\n<p>TMAO\u306f\u3001\u52d5\u8108\u786c\u5316\u306e\u91cd\u8981\u306a\u521d\u671f\u6bb5\u968e\u3067\u3042\u308b\u8840\u7ba1\u708e\u75c7\u304a\u3088\u3073\u5185\u76ae\u6a5f\u80fd\u969c\u5bb3\u306e\u8a98\u767a\u56e0\u5b50\u3068\u3057\u3066\u4f5c\u7528\u3059\u308b\u3002\u3053\u306e\u6587\u8108\u3067\u983b\u7e41\u306b\u8b70\u8ad6\u3055\u308c\u308b\u7d4c\u8def\u306e\u4e00\u3064\u306f\u3001 <strong>NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0<\/strong>.<\/p>\n<p>\u63d0\u6848\u3055\u308c\u3066\u3044\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u969c\u5bb3\u304a\u3088\u3073\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u7531\u6765\u6d3b\u6027\u9178\u7d20\u7a2e\uff08mtROS\uff09\u306e\u84c4\u7a4d\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002TMAO\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u8131\u30a2\u30bb\u30c1\u30eb\u5316\u9175\u7d20\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002 <strong>\u30b5\u30fc\u30c1\u30e5\u30a4\u30f33<\/strong>, \u3001\u305d\u306e\u7d50\u679c\u3001\u904e\u30a2\u30bb\u30c1\u30eb\u5316\u304c\u751f\u3058\u3001\u305d\u306e\u6d3b\u6027\u304c\u4f4e\u4e0b\u3057\u3001 <strong>\u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\u30b8\u30b9\u30e0\u30bf\u30fc\u30bc2 (SOD2)<\/strong>. \u3053\u306e\u6297\u9178\u5316\u7de9\u885d\u80fd\u306e\u55aa\u5931\u306f\u3001\u9178\u5316\u30d0\u30fc\u30b9\u30c8\u3092\u4fc3\u9032\u3057\u3001\u305d\u308c\u306b\u3088\u3063\u3066 <strong>\u30c1\u30aa\u30ec\u30c9\u30ad\u30b7\u30f3\u76f8\u4e92\u4f5c\u7528\u30bf\u30f3\u30d1\u30af\u8cea (TXNIP)<\/strong>, \u3001\u3053\u308c\u304c\u3055\u3089\u306bNLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u5f62\u6210\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002\u305d\u306e\u5f8c\u3001\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u6d3b\u6027\u5316\u306b\u3088\u308a\u3001\u30d7\u30ed\u30ab\u30b9\u30d1\u30bc-1\u306e\u5207\u65ad\u304a\u3088\u3073\u708e\u75c7\u8a98\u767a\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u653e\u51fa\u304c\u4fc3\u9032\u3055\u308c\u308b <strong>IL-1\u03b2<\/strong> \u305d\u3057\u3066 <strong>IL-18<\/strong>.<\/p>\n<table>\n<thead>\n<tr>\n<td><strong>\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def<\/strong><\/td>\n<td><strong>TMAO\u306e\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u306e\u4f5c\u7528<\/strong><\/td>\n<td><strong>\u75c5\u7406\u8a3a\u65ad\u7d50\u679c<\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>NLRP3 \/ TXNIP<\/td>\n<td>\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u306e\u6d3b\u6027\u5316\u3068\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08IL-1\u03b2\u3001IL-18\uff09\u306e\u653e\u51fa<\/td>\n<td>\u5185\u76ae\u306e\u708e\u75c7\u3001\u8840\u7ba1\u640d\u50b7<\/td>\n<\/tr>\n<tr>\n<td>NF-\u03baB<\/td>\n<td>VCAM-1\u304a\u3088\u3073ICAM-1\u306e\u767a\u73fe\u5897\u52a0<\/td>\n<td>\u767d\u8840\u7403\u306e\u63a5\u7740\u304a\u3088\u3073\u904a\u8d70\u306e\u5897\u5f37<\/td>\n<\/tr>\n<tr>\n<td>MAPK \/ ERK<\/td>\n<td>I\u03baB\u95a2\u9023\u708e\u75c7\u6027\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u30ce\u30fc\u30c9\u306e\u30ea\u30f3\u9178\u5316<\/td>\n<td>\u708e\u75c7\u8a98\u767a\u6027\u907a\u4f1d\u5b50\u306e\u8ee2\u5199<\/td>\n<\/tr>\n<tr>\n<td>PERK\uff08UPR\uff09<\/td>\n<td>\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u306e\u6d3b\u6027\u5316<\/td>\n<td>FoxO1\u8a98\u5c0e\u3068\u4ee3\u8b1d\u7570\u5e38<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u708e\u75c7\u4ee5\u5916\u306b\u3082\u3001TMAO\u306f\u5185\u76ae\u7d30\u80de\u306e\u81ea\u5df1\u4fee\u5fa9\u3092\u963b\u5bb3\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u7d30\u80de\u30ec\u30d9\u30eb\u306e\u7814\u7a76\u3067\u306f\u3001TMAO\u306f\u30d2\u30c8\u81cd\u5e2f\u9759\u8108\u5185\u76ae\u7d30\u80de\uff08HUVEC\uff09\u306e\u5897\u6b96\u304a\u3088\u3073\u904a\u8d70\u3092\u963b\u5bb3\u3057\u3001\u30d7\u30ed\u30c6\u30a4\u30f3\u30ad\u30ca\u30fc\u30bcC\uff08PKC\uff09\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u708e\u75c7\u8a98\u767a\u6027\u306e\u5185\u76ae\u7d30\u80de\u8868\u73fe\u578b\u3092\u3055\u3089\u306b\u5b89\u5b9a\u5316\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002.<\/p>\n<h4>\u8840\u5c0f\u677f\u904e\u5270\u53cd\u5fdc\u6027\u3068\u8840\u6813\u5f62\u6210\u80fd<\/h4>\n<p>TMAO\u306f\u8840\u6813\u4fc3\u9032\u6027\u306e\u5171\u4ee3\u8b1d\u7269\u3068\u3057\u3066\u5e83\u304f\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u30c8\u30ed\u30f3\u30d3\u30f3\u3084\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u3088\u3046\u306a\u4e00\u6b21\u30a2\u30b4\u30cb\u30b9\u30c8\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u3080\u3057\u308d\u8840\u5c0f\u677f\u3092\u3053\u308c\u3089\u306e\u523a\u6fc0\u306b\u5bfe\u3057\u3066\u611f\u4f5c\u3055\u305b\u308b\u3088\u3046\u306b\u50cd\u304f\u3002\u3053\u306e\u4f5c\u7528\u306e\u5206\u5b50\u57fa\u76e4\u306f\u3001\u7d30\u80de\u5185\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u8abf\u7bc0\u306b\u3042\u308b\uff08<strong>Ca2+<\/strong>) \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3002TMAO\u306f\u3001\u653e\u51fa\u3092\u4fc3\u9032\u3059\u308b <strong>Ca2+<\/strong> \u5185\u56e0\u6027\u306e\u8840\u5c0f\u677f\u30d7\u30fc\u30eb\u304b\u3089\u653e\u51fa\u3055\u308c\u3001\u9ad8\u305b\u3093\u65ad\u6761\u4ef6\u4e0b\u3067\u306e\u51dd\u96c6\u4ea2\u9032\u3068\u8840\u6813\u5f62\u6210\u306e\u8fc5\u901f\u5316\u306b\u3064\u306a\u304c\u308b\u3002\u91cd\u8981\u306a\u3053\u3068\u306b\u3001\u5b9f\u9a13\u7cfb\u306b\u304a\u3051\u308b\u5fae\u751f\u7269\u7531\u6765\u306eTMA\u7523\u751f\u80fd\u306e\u9664\u53bb\u306b\u3088\u308a\u3001\u3053\u306e\u8840\u6813\u5f62\u6210\u80fd\u306e\u4ea2\u9032\u304c\u6d88\u5931\u3059\u308b\u3053\u3068\u304b\u3089\u3001\u8178\u5185\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u304c\u5168\u8eab\u6027\u306e\u8840\u6db2\u51dd\u56fa\u30ea\u30b9\u30af\u306e\u8abf\u7bc0\u8a08\uff08\u30ec\u30aa\u30b9\u30bf\u30c3\u30c8\uff09\u3068\u3057\u3066\u6a5f\u80fd\u3057\u5f97\u308b\u3068\u3044\u3046\u6982\u5ff5\u304c\u652f\u6301\u3055\u308c\u308b\u3002.<\/p>\n<h3><strong>\u81e8\u5e8a\u7684\u8a3c\u62e0\uff1a\u5168\u822c\u7684\u306a\u4e88\u5f8c\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306eTMAO<\/strong><\/h3>\n<p>2011\u5e74\u306bTMAO\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u3068\u306e\u95a2\u9023\u6027\u3092\u6307\u6458\u3057\u305f\u6700\u521d\u306e\u5831\u544a\u4ee5\u6765\u3001\u8907\u6570\u306e\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3084\u30e1\u30bf\u89e3\u6790\u306b\u304a\u3044\u3066\u3001TMAO\u304c\u4e3b\u8981\u306a\u5fc3\u8840\u7ba1\u30fb\u8133\u8840\u7ba1\u6709\u5bb3\u4e8b\u8c61\uff08MACCE\u307e\u305f\u306fMACE\uff09\u306e\u72ec\u7acb\u3057\u305f\u4e88\u6e2c\u56e0\u5b50\u3067\u3042\u308b\u304b\u3069\u3046\u304b\u304c\u8a55\u4fa1\u3055\u308c\u3066\u304d\u305f\u3002.<\/p>\n<h4>\u5fc3\u8840\u7ba1\u75be\u60a3\u304a\u3088\u3073\u5168\u6b7b\u4ea1\u7387<\/h4>\n<p>\u6570\u4e07\u4eba\u306e\u53c2\u52a0\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u5927\u898f\u6a21\u306a\u30e1\u30bf\u5206\u6790\u306b\u3088\u308a\u3001\u8840\u6f3fTMAO\u5024\u306e\u4e0a\u6607\u3068\u6709\u5bb3\u306a\u8ee2\u5e30\u3068\u306e\u95a2\u9023\u3092\u793a\u3059\u5b9a\u91cf\u7684\u8a3c\u62e0\u304c\u5f97\u3089\u308c\u3066\u3044\u308b\u3002\u3088\u304f\u5f15\u7528\u3055\u308c\u308b14\u4ef6\u306e\u7814\u7a76\uff08\u53c2\u52a0\u800515,662\u4eba\uff09\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3042\u308b\u30e1\u30bf\u5206\u6790\u3067\u306f\u3001\u8840\u6f3fTMAO\u5024\u304c\u9ad8\u3044\u5834\u5408\u3001\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08HR\uff09\u304c <strong>1.91<\/strong> \u5168\u6b7b\u56e0\u6b7b\u4ea1\u7387\u306b\u3064\u3044\u3066\u306f\u3001\u3088\u308a\u4f4e\u3044\u30ec\u30d9\u30eb\u3068\u6bd4\u8f03\u3057\u3066\u3002.<\/p>\n<table>\n<thead>\n<tr>\n<td><strong>\u81e8\u5e8a\u8ee2\u5e30<\/strong><\/td>\n<td><strong>\u88ab\u9a13\u8005 \/ \u30b3\u30db\u30fc\u30c8<\/strong><\/td>\n<td><strong>\u7d71\u8a08\u7684\u63a8\u5b9a\u91cf (HR\/RR)<\/strong><\/td>\n<td><strong>\u4fe1\u983c\u533a\u9593 (95%)<\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u5168\u56e0\u6b7b\u4ea1\u7387<\/td>\n<td>15,662\u4eba\u306e\u88ab\u9a13\u8005<\/td>\n<td>\u5fc3\u62cd\u6570: 1.91<\/td>\n<td>1.40-2.61<\/td>\n<\/tr>\n<tr>\n<td>MACCE \/ MACE<\/td>\n<td>13,944\u4eba\u306e\u88ab\u9a13\u8005<\/td>\n<td>HR\uff1a1.67<\/td>\n<td>1.33-2.11<\/td>\n<\/tr>\n<tr>\n<td>\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8<\/td>\n<td>10,245\u540d\u7fa9\u306e\u88ab\u9a13\u8005<\/td>\n<td>\u4eba\u4e8b\uff1a1.23<\/td>\n<td>1.07-1.42<\/td>\n<\/tr>\n<tr>\n<td>\u9577\u671f\u6b7b\u4ea1\u7387<\/td>\n<td>218\u4eba\u306e\u88ab\u9a13\u8005\uff08\u4f4e\u6804\u990a\uff09<\/td>\n<td>HR: 2.01<\/td>\n<td>1.23-3.31<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u7528\u91cf\u53cd\u5fdc\u5206\u6790\u306b\u3088\u308b\u3068\u3001TMAO\u6fc3\u5ea6\u304c\u9ad8\u304f\u306a\u308b\u306b\u3064\u308c\u3066\u30ea\u30b9\u30af\u304c\u6bb5\u968e\u7684\u306b\u4e0a\u6607\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002\u3042\u308b\u30e1\u30bf\u5206\u6790\u3067\u306f\u30011 <strong>10 \u00b5mol\/L<\/strong> \u8840\u6f3fTMAO\u306e\u5897\u52a0\u306f\u3001\u7d04 <strong>7.6%<\/strong> \u5168\u6b7b\u56e0\u6b7b\u4ea1\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u3002\u3053\u308c\u3089\u306e\u95a2\u9023\u6027\u306f\u3001\u5e74\u9f62\u3001\u6027\u5225\u3001BMI\u3001\u8840\u5727\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u55ab\u7159\u72b6\u6cc1\u3067\u8abf\u6574\u3057\u305f\u5f8c\u3082\u3001\u591a\u304f\u306e\u5834\u5408\u3001\u7d71\u8a08\u7684\u306b\u6709\u610f\u306a\u307e\u307e\u3067\u3042\u308a\u3001TMAO\u306b\u306f\u3001\u5f93\u6765\u306e\u5371\u967a\u56e0\u5b50\u3060\u3051\u3067\u306f\u5341\u5206\u306b\u53cd\u6620\u3055\u308c\u3066\u3044\u306a\u3044\u4e88\u5f8c\u60c5\u5831\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u308b\u3002.<\/p>\n<h3>\u5fc3\u4e0d\u5168\u3068\u5fc3\u7b4b\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0<\/h3>\n<p>\u5fc3\u4e0d\u5168\uff08HF\uff09\u60a3\u8005\u306b\u304a\u3044\u3066\u3001TMAO\u6fc3\u5ea6\u306f\u75be\u60a3\u306e\u91cd\u75c7\u5ea6\u306e\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u3068\u540c\u6642\u306b\u3001\u75c5\u72b6\u306e\u9032\u884c\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3082\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u5fc3\u4e0d\u5168\u60a3\u8005\u306f\u3001\u5065\u5e38\u306a\u5bfe\u7167\u7fa4\u306b\u6bd4\u3079\u3066TMAO\u6fc3\u5ea6\u304c\u9ad8\u3044\u3053\u3068\u304c\u591a\u304f\u3001\u305d\u306e\u6fc3\u5ea6\u306fBNP\u3084NYHA\u6a5f\u80fd\u5206\u985e\u3068\u76f8\u95a2\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\u306f\u3001TMAO\u306f\u3044\u304f\u3064\u304b\u306e\u7d4c\u8def\u3092\u901a\u3058\u3066\u6709\u5bb3\u306a\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\uff1a<\/p>\n<ul>\n<li><strong>\u7dda\u7dad\u75c7<\/strong> TMAO\u306f\u30d2\u30b9\u30c8\u30f3\u306e\u30e1\u30c1\u30eb\u5316\u3092\u5897\u5f37\u3057\u3001\u5185\u76ae\u9593\u8449\u79fb\u884c\uff08EndMT\uff09\u3092\u4fc3\u9032\u3057\u3066\u3001\u5fc3\u81d3\u306b\u304a\u3051\u308b\u30b3\u30e9\u30fc\u30b2\u30f3\u6c88\u7740\u3092\u5897\u52a0\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002.<\/li>\n<li><strong>\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d<\/strong> TMAO\u306f\u3001\u9178\u5316\u7684\u30ea\u30f3\u9178\u5316\u3084ATP\uff0f\u30af\u30ec\u30a2\u30c1\u30f3\u30ea\u30f3\u9178\u6bd4\u3078\u306e\u5f71\u97ff\u3092\u542b\u3081\u3001\u5fc3\u7b4b\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u969c\u5bb3\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002.<\/li>\n<li><strong>\u76f4\u63a5\u7684\u306a\u6709\u5bb3\u6027\uff1a<\/strong> \u4e00\u90e8\u306e\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001\u9ad8\u7528\u91cf\u306eTMAO\u88dc\u5145\u306f\u904b\u52d5\u306b\u3088\u308b\u5fc3\u81d3\u4fdd\u8b77\u52b9\u679c\u3092\u6e1b\u5f31\u3055\u305b\u3001\u5fc3\u7b4b\u306e\u708e\u75c7\u3092\u60aa\u5316\u3055\u305b\u308b\u3002.<\/li>\n<\/ul>\n<p>\u5fc3\u4e0d\u5168\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u306f\u3001\u6b21\u306e\u3088\u3046\u306a\u591a\u69d8\u306a\u5730\u57df\u4f4f\u6c11\u30d9\u30fc\u30b9\u306e\u30b3\u30db\u30fc\u30c8\u306b\u304a\u3044\u3066\u3082\u691c\u8a0e\u3055\u308c\u3066\u3044\u308b\u3002 <strong>\u5fc3\u8840\u7ba1\u5065\u5eb7\u7814\u7a76<\/strong> \u305d\u3057\u3066\u3001\u305d\u306e <strong>\u591a\u6c11\u65cf\u52d5\u8108\u786c\u5316\u7814\u7a76\uff08MESA\uff09<\/strong>. \u3053\u308c\u3089\u306e\u30b3\u30db\u30fc\u30c8\u3067\u306f\u3001TMAO\uff08\u30cf\u30b6\u30fc\u30c9\u6bd41.15\uff09\u304a\u3088\u3073\u305d\u306e\u524d\u99c6\u4f53\u3067\u3042\u308b\u30b3\u30ea\u30f3\uff08\u30cf\u30b6\u30fc\u30c9\u6bd41.44\uff09\u306e\u9ad8\u6fc3\u5ea6\u304c\u3001\u5fc3\u4e0d\u5168\u306e\u767a\u75c7\u3068\u72ec\u7acb\u3057\u3066\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u4e00\u90e8\u306e\u5206\u6790\u3067\u306f\u3001\u9ed2\u4eba\u304a\u3088\u3073\u30d2\u30b9\u30d1\u30cb\u30c3\u30af\/\u30e9\u30c6\u30a3\u30fc\u30ce\u96c6\u56e3\u306b\u304a\u3044\u3066\u3088\u308a\u5f37\u3044\u95a2\u9023\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002.<\/p>\n<h4><strong>\u6162\u6027\u814e\u81d3\u75c5\u3068\u814e\u81d3\u306e\u96e3\u554f<\/strong><\/h4>\n<p>TMAO\u3068\u6162\u6027\u814e\u81d3\u75c5\uff08CKD\uff09\u3068\u306e\u95a2\u4fc2\u306f\u8907\u96d1\u3067\u3001\u53cc\u65b9\u5411\u7684\u306a\u3082\u306e\u3067\u3059\u3002TMAO\u306f\u814e\u81d3\u306b\u3088\u3063\u3066\u6392\u6cc4\u3055\u308c\u308b\u305f\u3081\u3001\u814e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u306b\u3064\u308c\u3066\u305d\u306e\u6fc3\u5ea6\u306f\u4e0a\u6607\u3057\u307e\u3059\u3002\u672b\u671f\u814e\u4e0d\u5168\uff08ESRD\uff09\u306e\u60a3\u8005\u3067\u306f\u3001TMAO\u6fc3\u5ea6\u304c <strong>90 \u00b5mol\/L<\/strong>, \u3001\u304a\u3088\u305d\u3068\u6bd4\u8f03\u3057\u3066 <strong>3 \u00b5mol\/L<\/strong> \u5065\u5e38\u5bfe\u7167\u7fa4\u306b\u304a\u3044\u3066.<\/p>\n<p>\u3057\u304b\u3057\u3001TMAO\u306f\u5358\u306a\u308b\u814e\u969c\u5bb3\u306e\u53d7\u52d5\u7684\u306a\u30de\u30fc\u30ab\u30fc\u306b\u3068\u3069\u307e\u3089\u306a\u3044\u3002\u5b9f\u9a13\u7684\u7814\u7a76\u306b\u3088\u308a\u3001TMAO\u306f\u814e\u5c3f\u7d30\u7ba1\u9593\u8cea\u7dda\u7dad\u5316\u3084\u7cf8\u7403\u4f53\u786c\u5316\u3092\u4fc3\u9032\u3059\u308b\u5c3f\u6bd2\u7d20\u3068\u3057\u3066\u4f5c\u7528\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u814e\u969c\u5bb3\u304cTMAO\u306e\u4e0a\u6607\u3092\u62db\u304d\u3001\u4e0a\u6607\u3057\u305fTMAO\u304c\u814e\u969c\u5bb3\u3092\u3055\u3089\u306b\u60aa\u5316\u3055\u305b\u308b\u3068\u3044\u3046\u60aa\u5faa\u74b0\u304c\u751f\u307e\u308c\u308b\u3002\u814e\u79fb\u690d\u306e\u6210\u529f\u306b\u3088\u308a\u8840\u6f3fTMAO\u306f\u8457\u3057\u304f\u4f4e\u4e0b\u3057\u3001\u3053\u306e\u96c6\u56e3\u306b\u304a\u3044\u3066\u306f\u814e\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u304c\u5168\u8eab\u30ec\u30d9\u30eb\u306e\u4e3b\u8981\u306a\u6c7a\u5b9a\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u3092\u88cf\u4ed8\u3051\u3066\u3044\u308b\u3002.<\/p>\n<h3>\u8ad6\u4e89\u3068\u6279\u5224\u7684\u8a55\u4fa1\uff1a\u56e0\u679c\u95a2\u4fc2\u5bfe\u76f8\u95a2\u95a2\u4fc2<\/h3>\n<p>\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u56e0\u5b50\u3068\u3057\u3066\u306eTMAO\u306e\u6025\u901f\u306a\u6d6e\u4e0a\u306f\u3001\u305d\u308c\u304c\u75be\u60a3\u306e\u56e0\u679c\u7684\u8981\u56e0\u3067\u3042\u308b\u306e\u304b\u3001\u3042\u308b\u3044\u306f\u52d5\u8108\u786c\u5316\u60f9\u8d77\u6027\u98df\u4e8b\u3001\u814e\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u306e\u969c\u5bb3\u3001\u307e\u305f\u306f\u3088\u308a\u5e83\u7bc4\u306a\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u306e\u4e0d\u5747\u8861\u306e\u30de\u30fc\u30ab\u30fc\u306b\u904e\u304e\u306a\u3044\u306e\u304b\u3092\u3081\u3050\u3063\u3066\u3001\u7279\u306b\u591a\u304f\u306e\u79d1\u5b66\u7684\u691c\u8a3c\u306b\u3055\u3089\u3055\u308c\u3066\u304d\u305f\u3002.<\/p>\n<h4>\u9b5a\u306e\u30d1\u30e9\u30c9\u30c3\u30af\u30b9<\/h4>\n<p>\u6700\u3082\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u308b\u8ad6\u4e89\u306f\u3001\u300c\u9b5a\u306e\u30d1\u30e9\u30c9\u30c3\u30af\u30b9\u300d\u3067\u3042\u308b\u3002\u9b5a\u3084\u9b5a\u4ecb\u985e\u306b\u306f\u3001\u6d78\u900f\u5727\u4fdd\u8b77\u7269\u8cea\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u65e2\u6210\u306eTMAO\u304c\u5929\u7136\u306b\u8c4a\u5bcc\u306b\u542b\u307e\u308c\u3066\u3044\u308b\u3002 \u9b5a\u3092\u6442\u53d6\u3059\u308b\u3068\u3001\u8840\u6f3f\u4e2d\u306eTMAO\u6fc3\u5ea6\u304c\u5373\u5ea7\u306b\u5927\u5e45\u306b\u4e0a\u6607\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u3001\u305d\u306e\u4e0a\u6607\u5e45\u306f\u8d64\u8eab\u8089\u3092\u6442\u53d6\u3057\u305f\u5f8c\u306b\u898b\u3089\u308c\u308b\u3082\u306e\u3088\u308a\u3082\u5927\u304d\u3044\u5834\u5408\u304c\u591a\u3044\u3002\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u9b5a\u306e\u6442\u53d6\u306f\u4e00\u8cab\u3057\u3066\u5fc3\u81d3\u3092\u4fdd\u8b77\u3059\u308b\u98df\u4e8b\u30d1\u30bf\u30fc\u30f3\u3068\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u591a\u304f\u306e\u75ab\u5b66\u30c7\u30fc\u30bf\u30bb\u30c3\u30c8\u306b\u304a\u3044\u3066\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3002.<\/p>\n<p>\u3044\u304f\u3064\u304b\u306e\u8aac\u660e\u304c\u63d0\u6848\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n<ul>\n<li><strong>\u4ee3\u8b1d\u7d4c\u8def<\/strong> \u9b5a\u7531\u6765\u306eTMAO\u306f\u305d\u306e\u307e\u307eTMAO\u3068\u3057\u3066\u5438\u53ce\u3055\u308c\u308b\u306e\u306b\u5bfe\u3057\u3001\u8d64\u8eab\u8089\u7531\u6765\u306e\u524d\u99c6\u4f53\u306f\u591a\u304f\u306e\u5834\u5408\u3001\u307e\u305a\u8178\u5185\u7d30\u83cc\u306b\u3088\u3063\u3066TMA\u306b\u5909\u63db\u3055\u308c\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u3053\u306e\u7d30\u83cc\u306b\u3088\u308b\u7523\u751f\u30d7\u30ed\u30bb\u30b9\u306f\u3001TMAO\u81ea\u4f53\u3068\u306f\u7121\u95a2\u4fc2\u306b\u91cd\u8981\u3068\u306a\u308b\u3001\u3088\u308a\u5e83\u7bc4\u306a\u98df\u4e8b\u304a\u3088\u3073\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u306e\u7279\u6027\u3092\u4f34\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002.<\/li>\n<li><strong>\u6804\u990a\u306e\u76f8\u6bba<\/strong> \u9b5a\u306f\u30aa\u30e1\u30ac3\u591a\u4fa1\u4e0d\u98fd\u548c\u8102\u80aa\u9178\uff08EPA\u304a\u3088\u3073DHA\uff09\u3092\u4f9b\u7d66\u3059\u308b\u305f\u3081\u3001\u4e00\u6642\u7684\u306aTMAO\u306e\u4e0a\u6607\u306b\u3088\u308b\u6f5c\u5728\u7684\u306a\u60aa\u5f71\u97ff\u3092\u76f8\u6bba\u3059\u308b\u304b\u3001\u305d\u308c\u3092\u4e0a\u56de\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002.<\/li>\n<li><strong>\u4e00\u6642\u7684\u66dd\u9732<\/strong> \u814e\u6a5f\u80fd\u304c\u6b63\u5e38\u306a\u4eba\u3067\u306f\u3001\u9b5a\u306b\u3088\u308bTMAO\u306e\u4e0a\u6607\u306f\u901a\u5e38\u3001\u7d0424\u6642\u9593\u4ee5\u5185\u306b\u57fa\u6e96\u5024\u4ed8\u8fd1\u307e\u3067\u623b\u308a\u307e\u3059\u3002\u8089\u3092\u591a\u304f\u542b\u3080\u98df\u4e8b\u306b\u3088\u308b\u6162\u6027\u7684\u306a\u5fae\u751f\u7269\u7531\u6765\u306eTMAO\u7523\u751f\u306f\u3001\u98df\u5f8c\u306e\u6025\u6027\u306a\u4e0a\u6607\u3088\u308a\u3082\u3001\u3088\u308a\u6301\u7d9a\u7684\u306a\u66dd\u9732\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002.<\/li>\n<\/ul>\n<h4>\u30e1\u30f3\u30c7\u30eb\u30e9\u30f3\u30c0\u30e0\u5316\u3068\u907a\u4f1d\u5b66\u7684\u77e5\u898b<\/h4>\n<p>\u56e0\u679c\u95a2\u4fc2\u3092\u89e3\u660e\u3059\u308b\u305f\u3081\u3001\u7814\u7a76\u8005\u3089\u306f\u30e1\u30f3\u30c7\u30eb\u30e9\u30f3\u30c0\u30e0\u5316\uff08MR\uff09\u624b\u6cd5\u3092\u7528\u3044\u3066\u304d\u305f\u3002\u3053\u306e\u624b\u6cd5\u3067\u306f\u3001\u907a\u4f1d\u7684\u5909\u7570\u3092 Instrumental Variable\uff08IV\uff09\u3068\u3057\u3066\u6d3b\u7528\u3057\u3001TMAO \u306a\u3069\u306e\u66dd\u9732\u304c\u51a0\u52d5\u8108\u75be\u60a3\u3084\u8133\u5352\u4e2d\u3068\u3044\u3063\u305f\u8ee2\u5e30\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u63a8\u5b9a\u3057\u3066\u3044\u308b\u3002.<\/p>\n<p>MR\u306b\u95a2\u3059\u308b\u6587\u732e\u3067\u306f\u3001\u7d50\u679c\u306b\u3070\u3089\u3064\u304d\u304c\u898b\u3089\u308c\u308b\u3002\u4e00\u90e8\u306e\u7814\u7a76\u3067\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u3063\u3066\u4e88\u6e2c\u3055\u308c\u308bTMAO\u5024\u306e\u4e0a\u6607\u3068\u51a0\u52d5\u8108\u75be\u60a3\u3084\u8133\u5352\u4e2d\u3068\u306e\u9593\u306b\u76f4\u63a5\u7684\u306a\u56e0\u679c\u95a2\u4fc2\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u3053\u306e\u3053\u3068\u306f\u3001\u7279\u306b\u6162\u6027\u814e\u81d3\u75c5\uff08CKD\uff09\u3001\u7cd6\u5c3f\u75c5\u3001\u305d\u306e\u4ed6\u306e\u6162\u6027\u75be\u60a3\u306b\u3088\u3063\u3066\u4e8c\u6b21\u7684\u306bTMAO\u5024\u304c\u4e0a\u6607\u3059\u308b\u5834\u5408\u3001TMAO\u5024\u306e\u4e0a\u6607\u304c\u6642\u306b\u9006\u56e0\u679c\u95a2\u4fc2\u3092\u53cd\u6620\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3044\u3046\u4e3b\u5f35\u3092\u88cf\u4ed8\u3051\u308b\u3082\u306e\u3068\u306a\u3063\u3066\u3044\u308b\u3002 \u3057\u304b\u3057\u3001\u4ed6\u306eMR\u89e3\u6790\u3067\u306f\u3001\u53ce\u7e2e\u671f\u8840\u5727\u30842\u578b\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u3068\u306e\u9593\u306b\u56e0\u679c\u95a2\u4fc2\u306e\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002\u3053\u3046\u3057\u305f\u76f8\u53cd\u3059\u308b\u7d50\u679c\u306f\u3001\u4eee\u306bTMAO\u306b\u56e0\u679c\u95a2\u4fc2\u304c\u3042\u308b\u3068\u3057\u3066\u3082\u3001\u305d\u306e\u5f71\u97ff\u306f\u7d4c\u8def\u3084\u96c6\u56e3\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u307e\u305f\u814e\u6a5f\u80fd\u3001\u98df\u4e8b\u3001\u5bbf\u4e3b\u306e\u907a\u4f1d\u7684\u8981\u56e0\u306b\u3088\u3063\u3066\u4fee\u98fe\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002.<\/p>\n<h4>\u814e\u6a5f\u80fd\u3068\u98df\u4e8b\u306b\u3088\u308b\u4ea4\u7d61<\/h4>\n<p>TMAO\u306b\u95a2\u3059\u308b\u7814\u7a76\u306b\u304a\u3051\u308b\u5927\u304d\u306a\u9650\u754c\u306f\u3001\u814e\u6a5f\u80fd\u306b\u3088\u308b\u4ea4\u7d61\u3067\u3042\u308b\u3002TMAO\u306f\u7cf8\u7403\u4f53\u6ffe\u904e\u7387\u306b\u5927\u304d\u304f\u4f9d\u5b58\u3059\u308b\u305f\u3081\u3001\u63a8\u7b97\u7cf8\u7403\u4f53\u6ffe\u904e\u7387\uff08eGFR\uff09\u306f\u3001TMAO\u3068\u5fc3\u8840\u7ba1\u7cfb\u30a2\u30a6\u30c8\u30ab\u30e0\u3068\u306e\u9593\u306b\u89b3\u5bdf\u3055\u308c\u308b\u3042\u3089\u3086\u308b\u95a2\u9023\u6027\u306b\u5b9f\u8cea\u7684\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002 \u3044\u304f\u3064\u304b\u306e\u7814\u7a76\u3067\u306f\u3001\u814e\u6a5f\u80fd\u30de\u30fc\u30ab\u30fc\u3092\u8abf\u6574\u3057\u305f\u5f8c\u3001TMAO\u306e\u4e88\u6e2c\u529b\u304c\u5f31\u307e\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u98df\u4e8b\u306e\u8cea\u3082\u3082\u3046\u4e00\u3064\u306e\u4e3b\u8981\u306a\u4ea4\u7d61\u56e0\u5b50\u3067\u3042\u308a\u3001TMAO\u5024\u304c\u9ad8\u3044\u3053\u3068\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3068\u72ec\u7acb\u3057\u3066\u95a2\u9023\u3057\u3066\u3044\u308b\u897f\u6d0b\u578b\u306e\u98df\u4e8b\u30d1\u30bf\u30fc\u30f3\u3068\u3057\u3070\u3057\u3070\u4f75\u5b58\u3059\u308b\u3002.<\/p>\n<h3>\u98df\u751f\u6d3b\u304a\u3088\u3073\u751f\u6d3b\u7fd2\u6163\u304cTMAO\u7d4c\u8def\u306b\u53ca\u307c\u3059\u5f71\u97ff<\/h3>\n<p>TMAO\u306e\u7523\u751f\u306f\u57fa\u672c\u7684\u306b\u98df\u4e8b\u3068\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u306e\u76f8\u4e92\u4f5c\u7528\u3067\u3042\u308b\u305f\u3081\u3001\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u5909\u66f4\u306f\u3001\u9ad8\u5024\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306e\u5b9f\u7528\u7684\u306a\u7b2c\u4e00\u9078\u629e\u306e\u6226\u7565\u3067\u3042\u308a\u7d9a\u3051\u3066\u3044\u307e\u3059\u3002.<\/p>\n<h4>\u6804\u990a\u5b66\u7684\u8abf\u7bc0<\/h4>\n<p>\u98df\u4e8b\u30d1\u30bf\u30fc\u30f3\u306f\u8178\u5185\u7d30\u83cc\u53e2\u306e\u4ee3\u8b1d\u80fd\u3092\u5f37\u304f\u898f\u5b9a\u3059\u308b\u3002.<\/p>\n<ul>\n<li><strong>\u690d\u7269\u6027\u98df\u3068\u5730\u4e2d\u6d77\u5f0f\u98df\u4e8b\u6cd5\uff1a<\/strong> \u3053\u3046\u3057\u305f\u50be\u5411\u306f\u3001\u4e00\u822c\u7684\u306bTMAO\u6fc3\u5ea6\u306e\u4f4e\u4e0b\u3084\u3001\u3088\u308a\u5e83\u7bc4\u306a\u5fc3\u4ee3\u8b1d\u9762\u3067\u306e\u6709\u76ca\u306a\u52b9\u679c\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3002\u98df\u7269\u7e4a\u7dad\u306e\u6442\u53d6\u91cf\u3092\u5897\u3084\u3059\u3068\u3001\u8178\u5185\u7d30\u83cc\u53e2\u306e\u591a\u69d8\u6027\u304c\u9ad8\u307e\u308a\u3001TMA\u3092\u7523\u751f\u3059\u308b\u83cc\u7fa4\u306e\u8c4a\u5bcc\u3055\u3084\u6d3b\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002.<\/li>\n<li><strong>\u8d64\u8eab\u8089\u3068\u5375\uff1a<\/strong> \u3053\u308c\u3089\u306f\u30ab\u30eb\u30cb\u30c1\u30f3\u3068\u30b3\u30ea\u30f3\u306e\u4e3b\u306a\u4f9b\u7d66\u6e90\u3067\u3042\u308b\u3002\u8d64\u8eab\u8089\u3092\u690d\u7269\u6027\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u3042\u308b\u3044\u306f\u72b6\u6cc1\u306b\u3088\u3063\u3066\u306f\u767d\u8089\u306b\u7f6e\u304d\u63db\u3048\u308b\u3053\u3068\u3067\u3001\u77ed\u671f\u9593\u3067TMAO\u5024\u3092\u5927\u5e45\u306b\u4e0b\u3052\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002.<\/li>\n<li><strong>\u30b1\u30c8\u30b8\u30a7\u30cb\u30c3\u30af\u30c0\u30a4\u30a8\u30c3\u30c8\uff1a<\/strong> \u30b1\u30c8\u30b8\u30a7\u30cb\u30c3\u30af\u30c0\u30a4\u30a8\u30c3\u30c8\u306f\u5375\u3001\u8089\u3001\u4e73\u88fd\u54c1\u306b\u5927\u304d\u304f\u4f9d\u5b58\u3059\u308b\u3053\u3068\u304c\u3042\u308b\u305f\u3081\u3001\u4e00\u90e8\u306e\u4eba\u306b\u304a\u3044\u3066TMAO\u3092\u5897\u52a0\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u3053\u306e\u70b9\u306f\u4ed6\u306e\u4ee3\u8b1d\u52b9\u679c\u3068\u7167\u3089\u3057\u5408\u308f\u305b\u3066\u614e\u91cd\u306b\u8003\u616e\u3055\u308c\u308b\u3079\u304d\u3067\u3042\u308b\u3002.<\/li>\n<\/ul>\n<h4>\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u6a19\u7684\u6226\u7565<\/h4>\n<p>\u98df\u751f\u6d3b\u3092\u8d85\u3048\u3066\u3001\u8178\u5185\u7d30\u83cc\u53e2\u306e\u76f4\u63a5\u7684\u306a\u8abf\u7bc0\u306f\u6d3b\u767a\u306a\u7814\u7a76\u5206\u91ce\u3067\u3042\u308b\u3002.<\/p>\n<ul>\n<li><strong>\u6297\u751f\u7269\u8cea\uff1a<\/strong> \u5e83\u57df\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u6297\u83cc\u85ac\u306f\u3001\u30d2\u30c8\u304a\u3088\u3073\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066TMAO\u306e\u7523\u751f\u3092\u8457\u3057\u304f\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u304c\u3001\u8010\u6027\u306e\u554f\u984c\u3001\u5e38\u5728\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u3078\u306e\u4e8c\u6b21\u7684\u969c\u5bb3\u3001\u304a\u3088\u3073\u30ea\u30d0\u30a6\u30f3\u30c9\u52b9\u679c\u306e\u305f\u3081\u3001\u3053\u308c\u306f\u9577\u671f\u7684\u306a\u5b9f\u7528\u6226\u7565\u3068\u306f\u306a\u3089\u306a\u3044\u3002.<\/li>\n<li><strong>\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u3068\u30d7\u30ec\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff1a<\/strong> \u4e00\u90e8\u306e\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u682a\u3001\u7279\u306b <strong>\u30d3\u30d5\u30a3\u30ba\u30b9\u83cc<\/strong> \u305d\u3057\u3066 <strong>\u4e73\u9178\u83cc<\/strong>, \u3055\u3089\u306b\u3001\u30a4\u30cc\u30ea\u30f3\u306a\u3069\u306e\u30d7\u30ec\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u7e4a\u7dad\u306f\u98df\u5f8c\u306eTMAO\u53cd\u5fdc\u3092\u548c\u3089\u3052\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u3044\u308b\u304c\u3001\u30d2\u30c8\u3067\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u4f9d\u7136\u3068\u3057\u3066\u9650\u5b9a\u7684\u304b\u3064\u591a\u69d8\u6027\u306b\u5bcc\u3093\u3067\u3044\u308b\u3002.<\/li>\n<\/ul>\n<h3>\u6cbb\u7642\u6226\u7565\uff1a\u85ac\u7406\u5b66\u7684\u963b\u5bb3<\/h3>\n<p>TMAO\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u305f\u3081\u306e\u6700\u3082\u7a4d\u6975\u7684\u306a\u85ac\u7406\u5b66\u7684\u6226\u7565\u306f\u3001\u7406\u60f3\u7684\u306b\u306f\u8178\u7ba1\u5c40\u6240\u4f5c\u7528\u578b\u306e\u975e\u81f4\u6b7b\u6027\u5316\u5408\u7269\u3092\u7528\u3044\u3066\u3001TMA\u3092\u7523\u751f\u3059\u308b\u5fae\u751f\u7269\u9175\u7d20\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306b\u7126\u70b9\u3092\u5f53\u3066\u3066\u304d\u305f\u3002.<\/p>\n<h4>TMA\u30ea\u30a2\u30fc\u30bc\u963b\u5bb3\u5264<\/h4>\n<p>\u6700\u3082\u6709\u671b\u306a\u6cbb\u7642\u6cd5\u306f\u3001\u5fae\u751f\u7269\u306eTMA\u30ea\u30a2\u30fc\u30bc\u306e\u963b\u5bb3\u3001\u7279\u306b <strong>CutC\/D<\/strong> \u6297\u751f\u7269\u8cea\u3068\u306f\u7570\u306a\u308a\u3001\u3053\u308c\u3089\u306e\u85ac\u5264\u306f\u7d30\u83cc\u3092\u6b7b\u6ec5\u3055\u305b\u308b\u3053\u3068\u306a\u304f\u9175\u7d20\u306e\u6d3b\u6027\u3092\u963b\u5bb3\u3059\u308b\u3088\u3046\u306b\u8a2d\u8a08\u3055\u308c\u3066\u304a\u308a\u3001\u85ac\u5264\u8010\u6027\u306b\u5bfe\u3059\u308b\u9078\u629e\u5727\u3092\u4f4e\u6e1b\u3057\u307e\u3059\u3002.<\/p>\n<ul>\n<li><strong>3,3-\u30b8\u30e1\u30c1\u30eb-1-\u30d6\u30bf\u30ce\u30fc\u30eb\uff08DMB\uff09<\/strong> \u4e00\u90e8\u306e\u98df\u54c1\u306b\u5fae\u91cf\u306b\u542b\u307e\u308c\u308b\u3001\u30b3\u30ea\u30f3\u306e\u69cb\u9020\u985e\u4f3c\u4f53\u3002DMB\u306f\u3001\u5fae\u751f\u7269\u7531\u6765\u306eTMA\u30ea\u30a2\u30fc\u30bc\u306e\u7af6\u5408\u7684\u963b\u5bb3\u5264\u3068\u3057\u3066\u4f5c\u7528\u3059\u308b\u3002\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001DMB\u306f\u8840\u6f3f\u4e2d\u306eTMAO\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u6ce1\u6cab\u7d30\u80de\u306e\u5f62\u6210\u3092\u6291\u5236\u3057\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u3092\u8efd\u6e1b\u3059\u308b\u3002.<\/li>\n<li><strong>\u30cf\u30ed\u30e1\u30c1\u30eb\u30b3\u30ea\u30f3\uff08IMC\u304a\u3088\u3073FMC\uff09\uff1a<\/strong> \u30e8\u30fc\u30c9\u30e1\u30c1\u30eb\u30b3\u30ea\u30f3\uff08IMC\uff09\u3068\u30d5\u30eb\u30aa\u30ed\u30e1\u30c1\u30eb\u30b3\u30ea\u30f3\uff08FMC\uff09\u306f\u3001\u524d\u81e8\u5e8a\u7814\u7a76\u306b\u304a\u3044\u3066DMB\u3088\u308a\u3082\u306f\u308b\u304b\u306b\u5f37\u529b\u306a\u3001\u7b2c2\u4e16\u4ee3\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u30d9\u30fc\u30b9\u963b\u5bb3\u5264\u3067\u3042\u308b\u3002\u7814\u7a76\u793a\u5506\u306b\u3088\u308c\u3070\u3001IMC\u306f\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001TMAO\u3092\u9577\u671f\u9593\u306b\u308f\u305f\u3063\u3066\u4f4e\u4e0b\u3055\u305b\u3001\u5bbf\u4e3b\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4ee3\u8b1d\u3092\u518d\u69cb\u7bc9\u3057\u3001\u51fa\u8840\u6642\u9593\u3092\u660e\u3089\u304b\u306b\u5ef6\u9577\u3055\u305b\u308b\u3053\u3068\u306a\u304f\u8840\u6813\u5f62\u6210\u80fd\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002.<\/li>\n<\/ul>\n<table>\n<thead>\n<tr>\n<td><strong>\u963b\u5bb3\u5264\u30af\u30e9\u30b9<\/strong><\/td>\n<td><strong>\u4e3b\u8981\u5316\u5408\u7269<\/strong><\/td>\n<td><strong>\u4f5c\u7528\u6a5f\u5e8f<\/strong><\/td>\n<td><strong>\u81e8\u5e8a\u30fb\u7814\u7a76\u30b9\u30c6\u30fc\u30bf\u30b9<\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u7af6\u5408\u963b\u5bb3\u5264<\/td>\n<td>DMB<\/td>\n<td>\u30b3\u30ea\u30f3\u985e\u4f3c\u4f53; CutC\/D\u3092\u963b\u5bb3\u3059\u308b<\/td>\n<td>\u975e\u81e8\u5e8a<\/td>\n<\/tr>\n<tr>\n<td>\u81ea\u6bba\u57fa\u8cea<\/td>\n<td>IMC \/ FMC<\/td>\n<td>CutC\/D\u3092\u4e0d\u53ef\u9006\u7684\u306b\u963b\u5bb3\u3059\u308b<\/td>\n<td>\u975e\u81e8\u5e8a<\/td>\n<\/tr>\n<tr>\n<td>\u809d\u81d3\u6291\u5236\u56e0\u5b50<\/td>\n<td>FMO3\u963b\u5bb3\u85ac<\/td>\n<td>TMA\u9178\u5316\u3092\u963b\u5bb3\u3059\u308b<\/td>\n<td>\u6bd2\u6027\uff0f\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3\u5c3f\u75c7\u306e\u30ea\u30b9\u30af\u306b\u3088\u308b\u5236\u9650<\/td>\n<\/tr>\n<tr>\n<td>\u9593\u63a5\u5909\u8abf\u5668<\/td>\n<td>\u30ab\u30ca\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3<\/td>\n<td>\u8178\u3068\u5bbf\u4e3b\u9593\u306e\u4ee3\u8b1d\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b<\/td>\n<td>\u81e8\u5e8a\u7684\u306b\u627f\u8a8d\u3055\u308c\u3066\u3044\u308b\u304c\u3001TMAO\u7279\u7570\u7684\u306a\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u3067\u306f\u306a\u3044<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h4>\u5bbf\u4e3b\u9175\u7d20\u963b\u5bb3<\/h4>\n<p>\u809d\u81d3\u306e\u963b\u5bb3 <strong>FMO3<\/strong> TMAO\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3082\u3046\u4e00\u3064\u306e\u7406\u8ad6\u7684\u306a\u65b9\u6cd5\u304c\u5b58\u5728\u3059\u308b\u304c\u3001\u305d\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u56f0\u96e3\u3067\u3042\u308b\u3002FMO3\u306f\u591a\u304f\u306e\u5916\u6765\u7269\u8cea\u306e\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u5f37\u529b\u306a\u963b\u5bb3\u306f\u30aa\u30d5\u30bf\u30fc\u30b2\u30c3\u30c8\u6bd2\u6027\u3084\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3\u5c3f\u75c7\u306e\u30ea\u30b9\u30af\u3092\u4f34\u3044\u3001\u901a\u5e38\u306e\u81e8\u5e8a\u73fe\u5834\u3067\u306f\u304a\u305d\u3089\u304f\u5fcd\u5bb9\u6027\u304c\u4f4e\u3044\u3068\u8003\u3048\u3089\u308c\u308b\u3002.<\/p>\n<h3>\u65b0\u305f\u306a\u30d5\u30ed\u30f3\u30c6\u30a3\u30a2\uff1a\u795e\u7d4c\u5909\u6027\u3068\u30de\u30eb\u30c1\u30aa\u30df\u30af\u30b9<\/h3>\n<p>TMAO\u7814\u7a76\u306e\u7bc4\u56f2\u306f\u3001\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u75be\u60a3\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u795e\u7d4c\u5909\u6027\u3084\u30d7\u30ec\u30b7\u30b8\u30e7\u30f3\u30fb\u30e1\u30c7\u30a3\u30b7\u30f3\u306b\u5411\u3051\u305f\u30b7\u30b9\u30c6\u30e0\u751f\u7269\u5b66\u30a2\u30d7\u30ed\u30fc\u30c1\u3078\u3068\u62e1\u5927\u3057\u3066\u3044\u308b\u3002.<\/p>\n<h4>TMAO\u3068\u5fae\u751f\u7269\u53e2-\u8178-\u8133\u76f8\u95a2<\/h4>\n<p>\u6700\u8fd1\u306e\u7814\u7a76\u306b\u3088\u308b\u3068\u3001TMAO\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002TMAO\u306f\u8133\u810a\u9ac4\u6db2\u4e2d\u304b\u3089\u691c\u51fa\u3055\u308c\u3066\u304a\u308a\u3001\u5b9f\u9a13\u7814\u7a76\u304b\u3089\u306f\u3001TMAO\u304c\u8840\u6db2\u8133\u95a2\u9580\u306e\u6a5f\u80fd\u3084\u795e\u7d4c\u708e\u75c7\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002.<\/p>\n<p>\u8133\u5185\u3067\u306f\u3001\u63d0\u6848\u3055\u308c\u3066\u3044\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<ul>\n<li><strong>\u30bf\u30f3\u30d1\u30af\u8cea\u51dd\u96c6<\/strong> TMAO\u306f\u5316\u5b66\u30b7\u30e3\u30da\u30ed\u30f3\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u75be\u60a3\u95a2\u9023\u306e\u6587\u8108\u306b\u304a\u3044\u3066\u3001TMAO\u306f\u4ee5\u4e0b\u306e\u51dd\u96c6\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\uff1a <strong>\u03b1-\u30b7\u30cc\u30af\u30ec\u30a4\u30f3<\/strong> \u305d\u3057\u3066 <strong>\u30a2\u30df\u30ed\u30a4\u30c9\u30d9\u30fc\u30bf<\/strong>.<\/li>\n<li><strong>\u795e\u7d4c\u708e\u75c7<\/strong> TMAO\u306f\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3084\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3092\u6d3b\u6027\u5316\u3055\u305b\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u708e\u75c7\u6027\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u306e\u653e\u51fa\u3092\u5897\u52a0\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002 <strong>TNF-\u03b1<\/strong> \u305d\u3057\u3066 <strong>IL-6<\/strong>.<\/li>\n<li><strong>\u8131\u9ac4<\/strong> \u9ad8\u8840\u5727\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001TMAO\u306fROS-NLRP3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u4ecb\u3057\u3066\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u306e\u30d4\u30ed\u30c8\u30fc\u30b7\u30b9\u306b\u95a2\u4e0e\u3057\u3001\u767d\u8cea\u969c\u5bb3\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002.<\/li>\n<\/ul>\n<h4>\u30de\u30eb\u30c1\u30aa\u30df\u30af\u30b9\u3068\u30d7\u30ec\u30b7\u30b8\u30e7\u30f3\u30fb\u30e1\u30c7\u30a3\u30b7\u30f3<\/h4>\n<p>\u30e1\u30bf\u30dc\u30ed\u30df\u30af\u30b9\u3001\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u3001\u30e1\u30bf\u30b2\u30ce\u30df\u30af\u30b9\u3001\u304a\u3088\u3073\u81e8\u5e8a\u7684\u8868\u73fe\u578b\u306e\u7d71\u5408\u306b\u3088\u308a\u3001TMAO\u8ef8\u306b\u95a2\u3059\u308b\u3088\u308a\u5305\u62ec\u7684\u306a\u77e5\u898b\u304c\u5f97\u3089\u308c\u3064\u3064\u3042\u308b\u3002\u6a5f\u68b0\u5b66\u7fd2\u3092\u7528\u3044\u305f\u5927\u898f\u6a21\u306a\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u89e3\u6790\u306b\u3088\u308b\u3068\u3001\u30de\u30eb\u30c1\u30aa\u30df\u30af\u30b9\u7279\u5fb4\u91cf\u3092\u8ffd\u52a0\u3059\u308b\u3053\u3068\u3067\u3001\u5f93\u6765\u306e\u81e8\u5e8a\u30de\u30fc\u30ab\u30fc\u306e\u307f\u306e\u5834\u5408\u3088\u308a\u3082\u75be\u60a3\u4e88\u6e2c\u7cbe\u5ea6\u304c\u5411\u4e0a\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002 \u7cbe\u5bc6\u6804\u990a\u5b66\u306f\u3001\u5c06\u6765\u7684\u306b\u7279\u306b\u91cd\u8981\u306a\u5fdc\u7528\u5206\u91ce\u3068\u306a\u308b\u3067\u3057\u3087\u3046\u3002\u4f8b\u3048\u3070\u3001\u500b\u4eba\u306e\u8178\u5185\u7d30\u83cc\u306b\u3088\u308bTMA\u7523\u751f\u80fd\u529b\u3092\u7279\u5fb4\u3065\u3051\u308b\u3053\u3068\u3067\u2015\u2015, <strong>cutC<\/strong> \u8c4a\u5bcc\u3055\u2015\u2015\u305d\u308c\u306b\u52a0\u3048\u3066\u3001\u30db\u30b9\u30c8\u306e\u907a\u4f1d\u7684\u7279\u5fb4\u306a\u3069 <strong>FMO3<\/strong> 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TMA-\u30ea\u30a2\u30fc\u30bc\u963b\u5bb3\u306f\u52d5\u7269\u5b9f\u9a13\u306b\u304a\u3044\u3066\u5f37\u3044\u6709\u671b\u6027\u3092\u793a\u3057\u3066\u3044\u308b\u304c\u3001\u30e9\u30f3\u30c0\u30e0\u5316\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u30d2\u30c8\u8a66\u9a13\u306f\u3044\u307e\u3060\u4e0d\u8db3\u3057\u3066\u3044\u308b\u3002.<\/li>\n<li><strong>\u591a\u69d8\u306a\u96c6\u56e3\u306b\u304a\u3051\u308b\u56e0\u679c\u95a2\u4fc2\uff1a<\/strong> 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\u73fe\u5728\u306e\u6cbb\u7642\u6cd5\u306f\u98df\u4e8b\u30d1\u30bf\u30fc\u30f3\u3001\u7279\u306b\u5730\u4e2d\u6d77\u5f0f\u3084\u690d\u7269\u6027\u98df\u54c1\u3092\u591a\u304f\u53d6\u308a\u5165\u308c\u305f\u98df\u4e8b\u306b\u91cd\u70b9\u304c\u7f6e\u304b\u308c\u3066\u304a\u308a\u3001\u5fae\u751f\u7269\u7531\u6765\u306e\u9175\u7d20\u963b\u5bb3\u5264\u306b\u3064\u3044\u3066\u306f\u4f9d\u7136\u3068\u3057\u3066\u5b9f\u9a13\u6bb5\u968e\u306b\u3068\u3069\u307e\u3063\u3066\u3044\u308b\u3002.<\/li>\n<li><strong>\u6ce2\u53ca\u52b9\u679c\uff1a<\/strong> TMAO\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u95a2\u3059\u308b\u6587\u732e\u307b\u3069\u6210\u719f\u3057\u3066\u3044\u306a\u3044\u3082\u306e\u306e\u3001\u795e\u7d4c\u708e\u75c7\u3001\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u3001\u304a\u3088\u3073\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u304a\u3044\u3066\u3082\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002.<\/li>\n<\/ul>\n<h3>\u67fb\u8aad\u6e08\u307f\u5f15\u7528\u306e\u518d\u30de\u30c3\u30d4\u30f3\u30b0<\/h3>\n<ol>\n<li>Tang WH\u3001Hazen SL. \u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u304a\u3051\u308b\u8178\u5185\u7d30\u83cc\u53e2\u306e\u95a2\u4e0e\u3002. <em>J Clin Invest<\/em>. 2014;124(10):4204-4211. doi:10.1172\/JCI72331<\/li>\n<li>Wang Z\u3001Klipfell E\u3001Bennett BJ\u3001\u4ed6\u3002\u8178\u5185\u7d30\u83cc\u53e2\u306b\u3088\u308b\u30db\u30b9\u30d5\u30a1\u30c1\u30b8\u30eb\u30b3\u30ea\u30f3\u306e\u4ee3\u8b1d\u304c\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u4fc3\u9032\u3059\u308b\u3002. <em>\u81ea\u7136<\/em>. 2011;472(7341):57-63. doi:10.1038\/nature09922<\/li>\n<li>Chen ML\u3001Zhu XH\u3001Ran L\u3001Lang HD\u3001Yi L\u3001Mi MT. \u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3-N-\u30aa\u30ad\u30b7\u30c9\u306f\u3001SIRT3-SOD2-mtROS\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u4ecb\u3057\u3066NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u8840\u7ba1\u708e\u75c7\u3092\u8a98\u767a\u3059\u308b\u3002. <em>J Am Heart Assoc<\/em>. 2017;6(9):e006347. 2017\u5e749\u67084\u65e5\u767a\u884c. doi:10.1161\/JAHA.117.006347<\/li>\n<li>Tang WHW\u3001Lemaitre RN\u3001Jensen PN \u307b\u304b\u3002\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3 <em>N<\/em>-\u9178\u5316\u7269\u304a\u3088\u3073\u95a2\u9023\u3059\u308b\u8178\u5185\u7d30\u83cc\u7531\u6765\u306e\u4ee3\u8b1d\u7523\u7269\u3068\u3001\u4e00\u822c\u96c6\u56e3\u306b\u304a\u3051\u308b\u5fc3\u4e0d\u5168\u306e\u767a\u75c7\u3068\u306e\u95a2\u9023\u3002. <em>\u5fc3\u4e0d\u5168<\/em>. 2024;17(8):e011569. doi:10.1161\/CIRCHEARTFAILURE.124.011569<\/li>\n<li>Roberts AB\u3001Gu X\u3001Buffa JA\u3001\u4ed6\u3002\u8840\u6813\u5f62\u6210\u306e\u53ef\u80fd\u6027\u3092\u6291\u5236\u3059\u308b\u305f\u3081\u306e\u3001\u8178\u5185\u5fae\u751f\u7269\u3092\u6a19\u7684\u3068\u3057\u305f\u975e\u81f4\u6b7b\u6027\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3002. <em>Nat Med<\/em>. 2018;24(9):1407-1417. doi:10.1038\/s41591-018-0128-1<\/li>\n<li>Koeth RA\u3001Levison BS\u3001Culley MK \u307b\u304b\u3002\u03b3-\u30d6\u30c1\u30ed\u30d9\u30bf\u30a4\u30f3\u306f\u3001L-\u30ab\u30eb\u30cb\u30c1\u30f3\u304cTMAO\u3078\u3068\u4ee3\u8b1d\u3055\u308c\u308b\u8178\u5185\u7d30\u83cc\u53e2\u306e\u4ee3\u8b1d\u904e\u7a0b\u306b\u304a\u3051\u308b\u3001\u52d5\u8108\u786c\u5316\u4fc3\u9032\u6027\u306e\u4e2d\u9593\u4ee3\u8b1d\u7523\u7269\u3067\u3042\u308b\u3002. <em>Cell Metab<\/em>. 2014;20(5):799-812. doi:10.1016\/j.cmet.2014.10.006<\/li>\n<li>Cho CE\u3001Caudill MA. \u300c\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3-N-\u30aa\u30ad\u30b7\u30c9\uff1a\u5473\u65b9\u304b\u3001\u6575\u304b\u3001\u305d\u308c\u3068\u3082\u5358\u306b\u5dfb\u304d\u8fbc\u307e\u308c\u305f\u3060\u3051\u304b\uff1f\u300d. <em>Trends Endocrinol Metab<\/em>. 2017;28(2):121-130. doi:10.1016\/j.tem.2016.10.005<\/li>\n<li>Wang Z\u3001Tang WHW\u3001O\u2019Connell T\u3001\u4ed6\u3002\u9b5a\u3084\u9b5a\u4ecb\u985e\u306e\u6442\u53d6\u5f8c\u306e\u8840\u4e2d\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3N-\u30aa\u30ad\u30b7\u30c9\u6fc3\u5ea6\u3002. <em>Eur J Nutr<\/em>. 2022;61(5):2357-2364. doi:10.1007\/s00394-022-02803-4<\/li>\n<li>Schiattarella GG\u3001Sannino A\u3001Toscano E\u3001\u4ed6\u3002\u8178\u5185\u7d30\u83cc\u7531\u6765\u306e\u4ee3\u8b1d\u7523\u7269\u3067\u3042\u308b\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3-N-\u30aa\u30ad\u30b7\u30c9\u3092\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\uff1a\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u304a\u3088\u3073\u7528\u91cf\u53cd\u5fdc\u30e1\u30bf\u89e3\u6790\u3002. <em>\u6b27\u5dde\u5fc3\u81d3\u75c5\u5b66\u4f1a\u8a8c<\/em>. 2017;38(39):2948-2956. doi:10.1093\/eurheartj\/ehx342<\/li>\n<li>Li X\u3001Geng J\u3001Zhao J\u3001\u4ed6\u3002\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3N-\u30aa\u30ad\u30b7\u30c9\u306f\u3001NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067\u5fc3\u7dda\u7dad\u5316\u3092\u60aa\u5316\u3055\u305b\u308b\u3002. <em>Front Physiol<\/em>. 2019;10:866. 2019\u5e747\u67089\u65e5\u516c\u958b. doi:10.3389\/fphys.2019.00866<\/li>\n<li>Hu X\u3001Ren H\u3001Cao Y. \u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3N-\u30aa\u30ad\u30b7\u30c9\u6fc3\u5ea6\u3068\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u767a\u75c7\u3068\u306e\u95a2\u9023\uff1a\u30e1\u30bf\u89e3\u6790\u304a\u3088\u3073\u30e1\u30f3\u30c7\u30eb\u30e9\u30f3\u30c0\u30e0\u5316\u7814\u7a76\u3002. <em>BMC Neurol<\/em>. 2023;23(1):413. 2023\u5e7411\u670821\u65e5\u516c\u958b. doi:10.1186\/s12883-023-03458-2<\/li>\n<li>Koeth RA\u3001Levison BS\u3001Culley MK \u307b\u304b\u3002\u03b3-\u30d6\u30c1\u30ed\u30d9\u30bf\u30a4\u30f3\u306f\u3001L-\u30ab\u30eb\u30cb\u30c1\u30f3\u304cTMAO\u3078\u3068\u4ee3\u8b1d\u3055\u308c\u308b\u8178\u5185\u7d30\u83cc\u53e2\u306e\u4ee3\u8b1d\u904e\u7a0b\u306b\u304a\u3051\u308b\u3001\u52d5\u8108\u786c\u5316\u4fc3\u9032\u6027\u306e\u4e2d\u9593\u4ee3\u8b1d\u7523\u7269\u3067\u3042\u308b\u3002. <em>Cell Metab<\/em>. 2014;20(5):799-812. doi:10.1016\/j.cmet.2014.10.006<\/li>\n<li>Pathak P\u3001Helsley RN\u3001Brown 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<em>\u6b27\u5dde\u5fc3\u81d3\u75c5\u5b66\u4f1a\u8a8c<\/em>. 2017;38(11):814-824. doi:10.1093\/eurheartj\/ehw582<\/li>\n<li>Stubbs JR\u3001House JA\u3001Ocque AJ \u307b\u304b\u3002\u6162\u6027\u814e\u81d3\u75c5\uff08CKD\uff09\u60a3\u8005\u3067\u306f\u8840\u6e05\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3-N-\u30aa\u30ad\u30b7\u30c9\u6fc3\u5ea6\u304c\u4e0a\u6607\u3057\u3066\u304a\u308a\u3001\u51a0\u52d5\u8108\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u306e\u75c5\u5909\u91cf\u3068\u76f8\u95a2\u3057\u3066\u3044\u308b\u3002. <em>J Am Soc Nephrol<\/em>. 2016;27(1):305-313. doi:10.1681\/ASN.2014111063<\/li>\n<li>Tang WH\u3001Hazen SL. \u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30e0\u3001\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3N-\u30aa\u30ad\u30b7\u30c9\u3001\u304a\u3088\u3073\u5fc3\u4ee3\u8b1d\u75be\u60a3\u3002. <em>Transl Res<\/em>. 2017;179:108-115. doi:10.1016\/j.trsl.2016.07.007<\/li>\n<li>Heianza Y\u3001Ma W\u3001DiDonato JA\u3001\u4ed6\u3002\u8178\u5185\u5fae\u751f\u7269\u7531\u6765\u306e\u4ee3\u8b1d\u7523\u7269\u3067\u3042\u308b\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3-N-\u30aa\u30ad\u30b7\u30c9\u306e\u9577\u671f\u7684\u306a\u5909\u5316\u3068\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3002. <em>\u7c73\u56fd\u5fc3\u81d3\u75c5\u5b66\u4f1a\u8a8c<\/em>. 2020;75(7):763-772. doi:10.1016\/j.jacc.2019.11.060<\/li>\n<li>Wang Z\u3001Roberts AB\u3001Buffa JA\u3001\u4ed6\u3002\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306e\u6cbb\u7642\u3092\u76ee\u7684\u3068\u3057\u305f\u3001\u8178\u5185\u7d30\u83cc\u306b\u3088\u308b\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3\u7523\u751f\u306e\u975e\u81f4\u6b7b\u7684\u306a\u963b\u5bb3\u3002. <em>\u30bb\u30eb<\/em>. 2015;163(7):1585-1595. doi:10.1016\/j.cell.2015.11.055<\/li>\n<li>Vogt NM\u3001Romano KA\u3001Darst BF \u307b\u304b\u3002\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3067\u306f\u3001\u8178\u5185\u7d30\u83cc\u53e2\u7531\u6765\u306e\u4ee3\u8b1d\u7523\u7269\u3067\u3042\u308b\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3N-\u30aa\u30ad\u30b7\u30c9\u306e\u6fc3\u5ea6\u304c\u4e0a\u6607\u3057\u3066\u3044\u308b\u3002. <em>Alzheimers Res Ther<\/em>. 2018;10(1):124. 2018\u5e7412\u670822\u65e5\u516c\u958b. doi:10.1186\/s13195-018-0451-2<\/li>\n<li>Ji X\u3001Tian L\u3001Niu S\u3001Yao S\u3001Qu C. \u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3N-\u30aa\u30ad\u30b7\u30c9\u306f\u3001\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u306e\u30d4\u30ed\u30d7\u30c8\u30b7\u30b9\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u81ea\u7136\u767a\u75c7\u6027\u9ad8\u8840\u5727\u30e9\u30c3\u30c8\u306b\u304a\u3051\u308b\u8131\u9ac4\u3092\u4fc3\u9032\u3059\u308b\u3002. <em>Front Aging Neurosci<\/em>. 2022;14:963876. 2022\u5e748\u670822\u65e5\u516c\u958b. doi:10.3389\/fnagi.2022.963876<\/li>\n<li>Obeid R\u3001Mohr L\u3001White BA \u307b\u304b\u3002\u8840\u4e2d\u30c8\u30ea\u30e1\u30c1\u30eb\u30a2\u30df\u30f3N-\u30aa\u30ad\u30b7\u30c9\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u3001\u8133\u75be\u60a3\u3001\u814e\u75be\u60a3\u304a\u3088\u3073\u6b7b\u4ea1\u7387\u3068\u306e\u95a2\u9023\uff1a\u516c\u8868\u6e08\u307f\u306e\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30fb\u30ec\u30d3\u30e5\u30fc\u304a\u3088\u3073\u30e1\u30bf\u89e3\u6790\u306e\u30a2\u30f3\u30d6\u30ec\u30e9\u30fb\u30ec\u30d3\u30e5\u30fc\u3002. <em>Nutr Metab Cardiovasc Dis<\/em>. 2025;35(8):103908. doi:10.1016\/j.numecd.2025.103908<\/li>\n<li>Zeevi D\u3001Korem T\u3001Zmora N\u3001\u4ed6. \u8840\u7cd6\u53cd\u5fdc\u306e\u4e88\u6e2c\u306b\u57fa\u3065\u304f\u500b\u5225\u5316\u6804\u990a\u3002. <em>\u30bb\u30eb<\/em>. 2015;163(5):1079-1094. doi:10.1016\/j.cell.2015.11.001<\/li>\n<\/ol>\n<p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>\u8178\u3068\u5fc3\u81d3\u3092\u7d50\u3076\u5206\u5b50\uff1aTMAO\u306b\u95a2\u3059\u308b5\u3064\u306e\u610f\u5916\u306a\u771f\u5b9f\u3002\u898b\u3048\u306a\u3044\u4ee3\u8b1d\u306e\u4e2d\u7d99\uff1a\u30e1\u30bf\u30aa\u30fc\u30ac\u30cb\u30ba\u30e0\u8ef8\u3002\u304b\u3064\u3066\u30d2\u30c8\u306e\u5065\u5eb7\u306f\u7d14\u7c8b\u306b\u30b2\u30ce\u30e0\u306e\u30ec\u30f3\u30ba\u3092\u901a\u3057\u3066\u898b\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u8178\u3068\u81d3\u5668\u306e\u8ef8\u306b\u95a2\u3059\u308b\u65b0\u305f\u306a\u7814\u7a76\u306b\u3088\u308a\u3001\u79c1\u305f\u3061\u306e\u751f\u7406\u6a5f\u80fd\u306f\u300c\u30e1\u30bf\u30aa\u30fc\u30ac\u30cb\u30ba\u30e0\uff08\u8d85\u500b\u4f53\uff09\u300d\u306e\u4e2d\u7d99\u306b\u3088\u3063\u3066\u7ba1\u7406\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002.<\/p>","protected":false},"author":16,"featured_media":10325,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[216,259,231,223],"tags":[],"class_list":["post-10321","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-diet-and-nutrition","category-gut-and-molecular","category-inflammation","category-plaque-arteries-and-disease"],"acf":[],"yoast_head":"<!-- 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