{"id":10699,"date":"2026-05-08T10:53:14","date_gmt":"2026-05-08T14:53:14","guid":{"rendered":"https:\/\/www.curingheartdisease.com\/?p=10699"},"modified":"2026-07-16T10:35:40","modified_gmt":"2026-07-16T14:35:40","slug":"%e3%83%86%e3%82%b9%e3%83%88%e3%82%b9%e3%83%86%e3%83%ad%e3%83%b3%e7%99%82%e6%b3%95%e3%81%a8%e5%bf%83%e8%87%93%ef%bc%9a%e3%81%aa%e3%81%9c%e7%b7%8f%e5%90%88%e3%82%b9%e3%82%b3%e3%82%a2%e3%81%8c%e8%aa%a4","status":"publish","type":"post","link":"https:\/\/www.curingheartdisease.com\/ja\/testosterone-therapy-and-your-heart-why-your-total-score-is-misleading\/","title":{"rendered":"\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u7642\u6cd5\u3068\u5fc3\u81d3\uff1a\u30c8\u30fc\u30bf\u30eb\u30b9\u30b3\u30a2\u304c\u8aa4\u89e3\u3092\u62db\u304f\u7406\u7531"},"content":{"rendered":"

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\u6284\u9332<\/h3>\n

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\"\"<\/p>\n

1. \u306f\u3058\u3081\u306b<\/h3>\n

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2. \u8840\u4e2d\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u30b3\u30f3\u30d1\u30fc\u30c8\u30e1\u30f3\u30c8\u5316<\/h3>\n

2.1 \u7d50\u5408\u7387\u3068\u305d\u306e\u751f\u7269\u5b66\u7684\u5f71\u97ff<\/h4>\n

\u5065\u5eb7\u306a\u6b63\u5e38\u30b4\u30ca\u30c9\u30c8\u30ed\u30d4\u30f3\u5024\u306e\u7537\u6027\u3067\u306f\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u7d0444\uff5e65\uff05\u304cSHBG\u306b\u7d50\u5408\u3057\u300130\uff5e50\uff05\u304c\u30a2\u30eb\u30d6\u30df\u30f3\u306b\u7de9\u3084\u304b\u306b\u7d50\u5408\u3057\u30011\uff5e4\uff05\u304c\u904a\u96e2\u30db\u30eb\u30e2\u30f3\u3068\u3057\u3066\u5faa\u74b0\u3057\u3066\u3044\u308b\u3002.1,2,3<\/sup> SHBG\u306f\u3001\u5206\u5b50\u91cf\u7d0495 kDa\u306e\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u30db\u30e2\u30c0\u30a4\u30de\u30fc\u3067\u3042\u308a\u3001\u4e3b\u306b\u809d\u81d3\u3067\u7523\u751f\u3055\u308c\u308b\u3002\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3068\u306e\u7d50\u5408\u5b9a\u6570\u306f1\u30e2\u30eb\u3042\u305f\u308a1 \u00d7 10\u2079\u306e\u30aa\u30fc\u30c0\u30fc\u3067\u3042\u308a\u3001\u3053\u306e\u5024\u306f\u3001\u6bdb\u7d30\u8840\u7ba1\u5e8a\u3092\u901a\u904e\u3059\u308b\u77ed\u6642\u9593\u306e\u9593\u306b\u3001SHBG\u306b\u7d50\u5408\u3057\u305f\u90e8\u5206\u304c\u5b9f\u8cea\u7684\u306b\u5229\u7528\u4e0d\u80fd\u3068\u306a\u308b\u306e\u306b\u5341\u5206\u306a\u5024\u3067\u3042\u308b\u3002.1<\/sup> \u5bfe\u7167\u7684\u306b\u3001\u30a2\u30eb\u30d6\u30df\u30f3\u306f\u8c4a\u5bcc\u306b\u5b58\u5728\u3057\u307e\u3059\u304c\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3068\u306e\u7d50\u5408\u89aa\u548c\u6027\u306f\u306f\u308b\u304b\u306b\u4f4e\u304f\u30011\u30e2\u30eb\u3042\u305f\u308a\u7d043 \u00d7 10\u2074\u3067\u3059\u3002.2,3<\/sup> \u30a2\u30eb\u30d6\u30df\u30f3\u7d50\u5408\u306f\u5341\u5206\u306b\u901f\u304f\u89e3\u96e2\u3059\u308b\u305f\u3081\u3001\u8f38\u9001\u4e2d\u306b\u30a2\u30eb\u30d6\u30df\u30f3\u7d50\u5408\u5206\u753b\u304c\u7d44\u7e54\u3078\u653e\u51fa\u3055\u308c\u308b\u3002\u305d\u306e\u305f\u3081\u3001\u904a\u96e2\u5206\u753b\u3068\u30a2\u30eb\u30d6\u30df\u30f3\u7d50\u5408\u5206\u753b\u306e\u5408\u8a08\u3092\u300c\u751f\u4f53\u5229\u7528\u53ef\u80fd\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u300d\u3068\u547c\u3076\u3002.2,4<\/sup><\/p>\n

\u300c\u904a\u96e2\u30db\u30eb\u30e2\u30f3\u4eee\u8aac\u300d\u306b\u3088\u308c\u3070\u3001\u7d50\u5408\u3057\u3066\u3044\u306a\u3044\u5206\u5b50\u306e\u307f\u304c\u7d30\u80de\u819c\u3092\u900f\u904e\u3057\u3066\u3001\u7d30\u80de\u5185\u306e\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\u306b\u4f5c\u7528\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u308b\u3002.4<\/sup> \u9ad8\u611f\u5ea6\u306a\u6e2c\u5b9a\u6cd5\u3092\u7528\u3044\u305f\u6700\u8fd1\u306e\u751f\u4f53\u5185\u30c7\u30fc\u30bf\u306b\u3088\u308a\u3001\u3053\u306e\u7406\u89e3\u304c\u3055\u3089\u306b\u7cbe\u7dfb\u5316\u3055\u308c\u3001\u7279\u306b\u6bdb\u7d30\u8840\u7ba1\u901a\u904e\u304c\u9045\u3044\u7d44\u7e54\u306b\u304a\u3044\u3066\u306f\u3001SHBG\u304a\u3088\u3073\u30a2\u30eb\u30d6\u30df\u30f3\u306e\u89e3\u96e2\u52d5\u614b\u306b\u3088\u3063\u3066\u3001\u53b3\u5bc6\u306a\u904a\u96e2\u30d7\u30fc\u30eb\u3092\u8d85\u3048\u308b\u4e00\u5b9a\u306e\u751f\u7269\u5b66\u7684\u5229\u7528\u80fd\u304c\u3082\u305f\u3089\u3055\u308c\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002.2<\/sup> \u5b9f\u7528\u4e0a\u306e\u7d50\u8ad6\u306f\u5909\u308f\u3063\u3066\u3044\u306a\u3044\u3002\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u5024\u3060\u3051\u3067\u306f\u8aa4\u89e3\u3092\u62db\u304f\u6050\u308c\u304c\u3042\u308a\u3001\u81e8\u5e8a\u7684\u306b\u610f\u7fa9\u306e\u3042\u308b\u66dd\u9732\u91cf\u306f\u3001\u751f\u4f53\u5229\u7528\u53ef\u80fd\u5206\u753b\u306b\u8fd1\u3044\u5024\u3067\u3042\u308b\u3002.<\/p>\n

\u88681. \u6210\u4eba\u7537\u6027\u306e\u8840\u6f3f\u4e2d\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u5206\u753b<\/em><\/strong><\/p>\n\n\n\n\n\n\n\n
\u5206\u6570<\/strong><\/td>\n\u7d50\u5408\u30d1\u30fc\u30c8\u30ca\u30fc<\/strong><\/td>\n\u89aa\u548c\u6027\uff08Ka\u3001M\u207b\u00b9\uff09<\/strong><\/td>\nT\u5168\u4f53\u306e\u5272\u5408<\/strong><\/td>\n\u81e8\u5e8a\u7684\u610f\u7fa9<\/strong><\/td>\n<\/tr>\n
\u7121\u6599<\/td>\n\u306a\u3057<\/td>\n\u8a72\u5f53\u306a\u3057<\/td>\n1\u20134%<\/td>\n\u7d30\u80de\u819c\u3092\u81ea\u7531\u306b\u900f\u904e\u3059\u308b\uff1b\u6d3b\u6027\u6210\u5206<\/td>\n<\/tr>\n
\u30a2\u30eb\u30d6\u30df\u30f3\u7d50\u5408<\/td>\n\u30a2\u30eb\u30d6\u30df\u30f3<\/td>\n\u7d043 \u00d7 10\u2074<\/td>\n30\u201350%<\/td>\n\u7de9\u3084\u304b\u306b\u7d50\u5408\u3057\u3066\u304a\u308a\u3001\u6bdb\u7d30\u8840\u7ba1\u5185\u3092\u79fb\u52d5\u3059\u308b\u904e\u7a0b\u3067\u653e\u51fa\u3055\u308c\u3001\u7d44\u7e54\u3078\u306e\u9001\u9054\u306b\u5bc4\u4e0e\u3059\u308b<\/td>\n<\/tr>\n
SHBG\u306b\u7d50\u5408\u3057\u305f<\/td>\nSHBG<\/td>\n\u7d041 \u00d7 10\u2079<\/td>\n44\u201365%<\/td>\n\u5f37\u56fa\u306b\u7d50\u5408\u3057\u3066\u3044\u308b\u3002\u901a\u5e38\u306e\u6761\u4ef6\u4e0b\u3067\u306f\u751f\u7269\u5b66\u7684\u306b\u4e0d\u6d3b\u6027\u3067\u3042\u308b\u3002<\/td>\n<\/tr>\n
\u751f\u4f53\u5229\u7528\u7387<\/td>\n\u904a\u96e2\u578b\uff0b\u30a2\u30eb\u30d6\u30df\u30f3\u7d50\u5408\u578b<\/td>\n\u6df7\u3056\u3063\u305f<\/td>\n~30\u201354%<\/td>\n\u7d44\u7e54\u30ec\u30d9\u30eb\u3067\u306e\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u66dd\u9732\u3092\u6700\u3082\u3088\u304f\u793a\u3059\u6307\u6a19<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

2.2 \u306a\u305c\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3060\u3051\u3067\u306f\u4e0d\u5341\u5206\u306a\u306e\u304b<\/h4>\n

SHBG\u7d50\u5408\u5206\u753b\u304a\u3088\u3073\u30a2\u30eb\u30d6\u30df\u30f3\u7d50\u5408\u5206\u753b\u306f\u8cea\u91cf\u4f5c\u7528\u306e\u5e73\u8861\u306b\u3088\u3063\u3066\u652f\u914d\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u305f\u3068\u3048\u7cbe\u5de3\u3067\u306e\u7523\u751f\u91cf\u304c\u5909\u5316\u3057\u306a\u304f\u3066\u3082\u3001SHBG\u6fc3\u5ea6\u306e\u5909\u5316\u306b\u3088\u3063\u3066\u7d50\u5408\u578b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3068\u904a\u96e2\u578b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u5206\u914d\u6bd4\u304c\u5909\u5316\u3059\u308b\u3002 \u82e5\u5e74\u6210\u4eba\u671f\u304b\u308970\u4ee3\u3078\u306e\u79fb\u884c\u671f\u306b\u306f\u73cd\u3057\u304f\u306a\u3044SHBG\u6fc3\u5ea6\u306e2\u500d\u5316\u306b\u3088\u308a\u3001\u751f\u7269\u5b66\u7684\u5229\u7528\u80fd\u306e\u3042\u308b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u304c\u5927\u5e45\u306b\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u306f\u6b63\u5e38\u7bc4\u56f2\u306b\u623b\u308b\u3053\u3068\u304c\u3042\u308b\u3002.2,9,13<\/sup> \u3053\u308c\u304c\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u304c\u6b63\u5e38\u7bc4\u56f2\u5185\u306b\u3042\u308b\u9ad8\u9f62\u306e\u7537\u6027\u3067\u3042\u3063\u3066\u3082\u3001\u81e8\u5e8a\u7684\u306b\u610f\u7fa9\u306e\u3042\u308b\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u6b20\u4e4f\u75c7\u72b6\u3092\u5448\u3059\u308b\u3053\u3068\u304c\u3042\u308b\u4e3b\u306a\u7406\u7531\u3067\u3042\u308b\u3002.<\/p>\n

3. \u306a\u305c\u52a0\u9f62\u3068\u3068\u3082\u306b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u304c\u6e1b\u5c11\u3059\u308b\u306e\u304b<\/h3>\n

\u7537\u6027\u306b\u304a\u3051\u308b\u52a0\u9f62\u306b\u4f34\u3046\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u30ec\u30d9\u30eb\u306e\u4f4e\u4e0b\u306f\u3001\u73fe\u5728\u3067\u306f\u5341\u5206\u306b\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u308b\u3002 \u300c\u30dc\u30eb\u30c1\u30e2\u30a2\u52a0\u9f62\u7e26\u65ad\u7814\u7a76\uff08Baltimore Longitudinal Study of Aging\uff09\u300d\u3067\u306f\u3001\u5065\u5eb7\u306a\u7537\u6027\u3092\u6570\u5341\u5e74\u306b\u308f\u305f\u308a\u8ffd\u8de1\u8abf\u67fb\u3057\u305f\u7d50\u679c\u300130\u4ee3\u4ee5\u964d\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u304c\u5e74\u9593\u7d041\uff5e2\uff05\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u305f\u3002\u307e\u305f\u3001SHBG\u304c\u4e26\u884c\u3057\u3066\u4e0a\u6607\u3059\u308b\u305f\u3081\u3001\u904a\u96e2\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u304a\u3088\u3073\u751f\u7269\u5b66\u7684\u5229\u7528\u80fd\u306e\u3042\u308b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306f\u3001\u5e74\u9593\u7d042\uff5e3\uff05\u3068\u3044\u3046\u3088\u308a\u6025\u6fc0\u306a\u6e1b\u5c11\u3092\u793a\u3057\u305f\u3002.9<\/sup> \u300c\u30de\u30b5\u30c1\u30e5\u30fc\u30bb\u30c3\u30c4\u7537\u6027\u52a0\u9f62\u7814\u7a76\u300d\u3067\u306f\u3001\u5730\u57df\u793e\u4f1a\u3092\u57fa\u76e4\u3068\u3057\u305f\u30b3\u30db\u30fc\u30c8\u306b\u304a\u3044\u3066\u3082\u540c\u69d8\u306e\u7d4c\u904e\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002.10<\/sup> \u307e\u305f\u3001\u6b27\u5dde\u7537\u6027\u52a0\u9f62\u7814\u7a76\uff08EMAS\uff09\u306b\u3088\u308c\u3070\u3001\u4e0b\u5782\u4f53\u6a5f\u80fd\u304c\u305d\u308c\u4ee5\u5916\u3067\u306f\u6b63\u5e38\u306a\u7537\u6027\u306b\u304a\u3044\u3066\u3082\u3001\u305d\u306e\u6a5f\u80fd\u4f4e\u4e0b\u306f\u7cbe\u5de3\u304a\u3088\u3073\u4e2d\u67a2\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u8907\u5408\u7684\u306b\u4f5c\u7528\u3057\u305f\u7d50\u679c\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002.11,15<\/sup><\/p>\n

3.1 \u8870\u9000\u306e\u30e1\u30ab\u30cb\u30ba\u30e0<\/h4>\n

\u8907\u6570\u306e\u7d4c\u8def\u304c\u540c\u6642\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u9045\u767a\u6027\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u306e\u75c7\u5019\u7fa4\u306f\u7570\u8cea\u6027\u304c\u9ad8\u3044\u3002.<\/p>\n

\u7cbe\u5de3\u306e\u8001\u5316\u3002. <\/strong>\u30e9\u30a4\u30c7\u30a3\u30c3\u30d2\u7d30\u80de\u306e\u6570\u306f\u6e1b\u5c11\u3057\u3001\u6b8b\u5b58\u3059\u308b\u30e9\u30a4\u30c7\u30a3\u30c3\u30d2\u7d30\u80de\u3067\u306f\u30b9\u30c6\u30ed\u30a4\u30c9\u751f\u6210\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u969c\u5bb3\u3001\u30ea\u30dd\u30d5\u30b9\u30c1\u30f3\u306e\u84c4\u7a4d\u3001\u304a\u3088\u3073StAR\u3092\u4ecb\u3057\u305f\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8f38\u9001\u306e\u969c\u5bb3\u304c\u3001\u3044\u305a\u308c\u30821\u7d30\u80de\u3042\u305f\u308a\u306e\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u7523\u751f\u91cf\u306e\u4f4e\u4e0b\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u3002.13<\/sup><\/p>\n

\u8996\u5e8a\u4e0b\u90e8\u30fb\u4e0b\u5782\u4f53\u306e\u30d1\u30eb\u30b9\u6027\u306e\u55aa\u5931\u3002. <\/strong>GnRH\u306e\u30d1\u30eb\u30b9\u983b\u5ea6\u306f\u4f4e\u4e0b\u3057\u3001\u632f\u5e45\u3082\u5c0f\u3055\u304f\u306a\u308a\u3001LH\u306e\u30d1\u30eb\u30b9\u3082\u540c\u69d8\u306b\u5909\u5316\u3057\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u5206\u6ccc\u3092\u4fc3\u3059\u306e\u306b\u5fc5\u8981\u306aLH\u306e\u632f\u5e45\u304c\u3001\u4ee5\u524d\u307b\u3069\u78ba\u5b9f\u306b\u9054\u6210\u3055\u308c\u306a\u304f\u306a\u308b\u3002Veldhuis\u3089\u306f\u3001\u3053\u306e\u898f\u5247\u7684\u306a\u30d1\u30eb\u30b9\u6027\u306e\u55aa\u5931\u81ea\u4f53\u304c\u3001\u7537\u6027\u306e\u751f\u6b96\u6a5f\u80fd\u306e\u52a0\u9f62\u306b\u304a\u3051\u308b\u72ec\u7acb\u3057\u305f\u8981\u56e0\u3067\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002.14<\/sup><\/p>\n

\u4f53\u7d44\u6210\u306e\u5909\u5316\u3002. <\/strong>\u5185\u81d3\u8102\u80aa\u306f\u3001\u4f53\u91cd\u3092\u5b89\u5b9a\u306b\u7dad\u6301\u3057\u3066\u3044\u308b\u7537\u6027\u3067\u3042\u3063\u3066\u3082\u3001\u4e2d\u5e74\u671f\u306b\u304b\u3051\u3066\u5897\u52a0\u3059\u308b\u3002\u8102\u80aa\u7d44\u7e54\u306f\u3001GnRH\u304a\u3088\u3073\u4e0b\u5782\u4f53\u6027\u6027\u817a\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\u306e\u5206\u6ccc\u3092\u6291\u5236\u3059\u308b\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u5206\u6ccc\u3059\u308b\u307b\u304b\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3092\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb\u306b\u5909\u63db\u3059\u308b\u30a2\u30ed\u30de\u30bf\u30fc\u30bc\u3092\u542b\u3093\u3067\u3044\u308b\u3002\u305d\u306e\u7d50\u679c\u3001\u539f\u767a\u6027\u7cbe\u5de3\u8001\u5316\u306b\u52a0\u3048\u3066\u3001\u6a5f\u80fd\u6027\u4e8c\u6b21\u6027\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u304c\u751f\u3058\u308b\u3002.20,21,22<\/sup><\/p>\n

SHBG\u306e\u4e0a\u6607\u3002. <\/strong>\u307b\u3068\u3093\u3069\u306e\u7537\u6027\u306b\u304a\u3044\u3066\u300130\u4ee3\u3092\u904e\u304e\u308b\u3068\u3001\u809d\u81d3\u3067\u306eSHBG\u306e\u5408\u6210\u91cf\u306f\u5e74\u9593\u304a\u3088\u305d1\uff05\u305a\u3064\u5897\u52a0\u3059\u308b\u3002.2,9<\/sup> SHBG\u306f\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3092\u7d50\u5408\u3055\u305b\u308b\u305f\u3081\u3001\u540c\u3058\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u91cf\u3067\u3042\u3063\u3066\u3082\u3001\u9ad8\u9f62\u7537\u6027\u3067\u306f\u751f\u7269\u5b66\u7684\u5229\u7528\u80fd\u306e\u5272\u5408\u304c\u4f4e\u304f\u306a\u308a\u307e\u3059\u3002\u30c8\u30e9\u30f4\u30a3\u30bd\u30f3\u8abf\u548c\u7814\u7a76\u3067\u306f\u3001\u3053\u306e\u751f\u7406\u5b66\u7684\u7279\u5fb4\u3092\u8003\u616e\u3057\u305f\u5e74\u9f62\u5c64\u5225\u306e\u57fa\u6e96\u7bc4\u56f2\u304c\u78ba\u7acb\u3055\u308c\u307e\u3057\u305f\u3002.12<\/sup><\/p>\n

\u9577\u671f\u7684\u306a\u50be\u5411\u3002. <\/strong>\u30c8\u30e9\u30f4\u30a3\u30bd\u30f3\u3089\u306f\u3001\u3053\u3053\u6570\u5341\u5e74\u306e\u9593\u306b\u3001\u5e74\u9f62\u3068\u306f\u7121\u95a2\u4fc2\u306b\u3001\u7c73\u56fd\u306e\u7537\u6027\u306b\u304a\u3044\u3066\u51fa\u751f\u30b3\u30db\u30fc\u30c8\u3092\u554f\u308f\u305a\u96c6\u56e3\u30ec\u30d9\u30eb\u306e\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u6fc3\u5ea6\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u5185\u5728\u7684\u306a\u52a0\u9f62\u30d7\u30ed\u30bb\u30b9\u306b\u52a0\u3048\u3001\u74b0\u5883\u8981\u56e0\uff08\u304a\u305d\u3089\u304f\u80a5\u6e80\u306e\u6709\u75c5\u7387\u3001\u5185\u5206\u6ccc\u304b\u304f\u4e71\u7269\u8cea\u3001\u8eab\u4f53\u6d3b\u52d5\u306e\u5909\u5316\u306a\u3069\u304c\u542b\u307e\u308c\u308b\uff09\u304c\u5f71\u97ff\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002.16<\/sup><\/p>\n

3.2 \u52a0\u9f62\u304c\u75c7\u72b6\u306b\u53ca\u307c\u3059\u5f71\u97ff<\/h4>\n

EMAS\u306f\u3001\u9ad8\u9f62\u7537\u6027\u306b\u304a\u3044\u3066\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u72b6\u614b\u3092\u78ba\u5b9f\u306b\u53cd\u6620\u3059\u308b\u75c7\u72b6\u306f\u3054\u304f\u9650\u3089\u308c\u305f\u3082\u306e\u306e\u307f\u3067\u3042\u308b\u3068\u660e\u3089\u304b\u306b\u3057\u305f\u30023\u3064\u306e\u6027\u6a5f\u80fd\u95a2\u9023\u75c7\u72b6\uff08\u671d\u7acb\u3061\u306e\u4f4e\u4e0b\u3001 \u6027\u6b32\u6e1b\u9000\u3001\u304a\u3088\u3073\u52c3\u8d77\u969c\u5bb3\uff09\u306b\u52a0\u3048\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u304c\u7d0411 nmol\/L\uff08320 ng\/dL\uff09\u672a\u6e80\u3001\u904a\u96e2\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u304c220 pmol\/L\uff0864 pg\/mL\uff09\u672a\u6e80\u3067\u3042\u308b\u3053\u3068\u304c\u3001\u9045\u767a\u6027\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u306e\u6700\u3082\u7279\u7570\u7684\u306a\u8868\u73fe\u578b\u3092\u5b9a\u7fa9\u3059\u308b\u3002.11<\/sup> \u75b2\u52b4\u3001\u6c17\u5206\u306e\u843d\u3061\u8fbc\u307f\u3001\u7b4b\u529b\u4f4e\u4e0b\u306a\u3069\u3001\u4e00\u822c\u7684\u306b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u306e\u4f4e\u4e0b\u306b\u8d77\u56e0\u3059\u308b\u3068\u3055\u308c\u308b\u305d\u306e\u4ed6\u306e\u75c7\u72b6\u306f\u3001\u9ad8\u9f62\u306e\u7537\u6027\u306b\u3088\u304f\u898b\u3089\u308c\u308b\u3082\u306e\u306e\u3001\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u72b6\u614b\u3092\u53cd\u6620\u3059\u308b\u6307\u6a19\u3068\u3057\u3066\u306f\u4fe1\u983c\u6027\u304c\u4f4e\u3044\u3002.<\/p>\n

4. SHBG\uff1a\u305d\u306e\u8abf\u7bc0\u6a5f\u69cb\u3068\u91cd\u8981\u6027<\/h3>\n

SHBG\u306f\u3001\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u304a\u3088\u3073\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u751f\u7269\u5b66\u7684\u5229\u7528\u80fd\u3092\u5236\u5fa1\u3059\u308b\u4e3b\u8981\u306a\u30b2\u30fc\u30c8\u30ad\u30fc\u30d1\u30fc\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3002\u305d\u306e\u809d\u81d3\u3067\u306e\u5408\u6210\u306fHNF-4\u03b1\u306b\u3088\u3063\u3066\u8abf\u7bc0\u3055\u308c\u3066\u304a\u308a\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u3001\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u3001\u6027\u30b9\u30c6\u30ed\u30a4\u30c9\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3001\u304a\u3088\u3073\u6804\u990a\u7d20\u30bb\u30f3\u30b5\u30fc\u304b\u3089\u306e\u4fc3\u9032\u7684\u307e\u305f\u306f\u6291\u5236\u7684\u306a\u30b7\u30b0\u30ca\u30eb\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002.1,5,6,17<\/sup> \u91cd\u8981\u306a\u70b9\u3068\u3057\u3066\u3001SHBG\u306e\u4f4e\u5024\u306f\u73fe\u5728\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304a\u3088\u30732\u578b\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u3092\u793a\u3059\u72ec\u7acb\u3057\u305f\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u8a8d\u8b58\u3055\u308c\u3066\u3044\u308b\u4e00\u65b9\u3001SHBG\u306e\u9ad8\u5024\u306f\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u306e\u89e3\u91c8\u3092\u5909\u3048\u308b\u3088\u3046\u306a\u809d\u6a5f\u80fd\u3084\u4ee3\u8b1d\u72b6\u614b\u306e\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u3002.18,19<\/sup><\/p>\n

4.1 SHBG\u3092\u4e0a\u6607\u3055\u305b\u308b\u8981\u56e0<\/h4>\n

\u52a0\u9f62\u306fSHBG\u4e0a\u6607\u306e\u6700\u3082\u4e00\u822c\u7684\u306a\u539f\u56e0\u3067\u3042\u308a\u3001\u524d\u8ff0\u306e\u3088\u3046\u306b\u305d\u306e\u5024\u306f\u5f90\u3005\u306b\u4e0a\u6607\u3057\u3066\u3044\u304f\u50be\u5411\u306b\u3042\u308b\u3002\u7532\u72b6\u817a\u6a5f\u80fd\u4ea2\u9032\u75c7\u306f\u3001HNF-4\u03b1\u304a\u3088\u3073HNF-1\u03b1\u3092\u523a\u6fc0\u3059\u308b\u3053\u3068\u3067SHBG\u3092\u4e0a\u6607\u3055\u305b\u308b\u3002.17<\/sup> \u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3078\u306e\u66dd\u9732\uff08\u5185\u56e0\u6027\u3001\u7d4c\u53e3\u907f\u598a\u85ac\u7531\u6765\u3001\u307e\u305f\u306f\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u88dc\u5145\u7642\u6cd5\u7531\u6765\uff09\u306f\u3001\u809d\u81d3\u306b\u304a\u3051\u308bSHBG\u306e\u5408\u6210\u3092\u8457\u3057\u304f\u8a98\u5c0e\u3059\u308b\u3002\u3053\u308c\u306f\u3001\u7d4c\u53e3\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\uff08\u7d4c\u76ae\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306f\u9664\u304f\uff09\u304c\u5973\u6027\u306e\u904a\u96e2\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u3064\u3067\u3042\u308b\u3002.6<\/sup> \u809d\u786c\u5909\u3067\u306f\u3001\u809d\u7d30\u80de\u306e\u4ee3\u8b1d\u7570\u5e38\u3084\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u306e\u4f4e\u4e0b\u306b\u3088\u308a\u3001SHBG\u304c\u4e0a\u6607\u3059\u308b\u3053\u3068\u304c\u591a\u3044\uff08\u809d\u5408\u6210\u6a5f\u80fd\u304c\u640d\u306a\u308f\u308c\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u9006\u8aac\u7684\u306b\u4e0a\u6607\u3059\u308b\u3053\u3068\u3082\u3042\u308b\uff09\u3002.24<\/sup> \u795e\u7d4c\u6027\u98df\u6b32\u4e0d\u632f\u75c7\u3001\u6975\u7aef\u306a\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u3001\u304a\u3088\u3073\u6162\u6027\u7684\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u6b20\u4e4f\u306f\u3001SHBG\u3092\u4e0a\u6607\u3055\u305b\u308b\u3002\u3044\u304f\u3064\u304b\u306e\u6297\u3051\u3044\u308c\u3093\u85ac\uff08\u30d5\u30a7\u30cb\u30c8\u30a4\u30f3\u3001\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\uff09\u3084\u4e00\u90e8\u306eHIV\u6cbb\u7642\u85ac\u306f\u3001\u809d\u9175\u7d20\u3078\u306e\u5f71\u97ff\u3092\u4ecb\u3057\u3066SHBG\u3092\u8a98\u5c0e\u3059\u308b\u3002.6<\/sup><\/p>\n

4.2 SHBG\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u8981\u56e0<\/h4>\n

\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u8840\u75c7\u306f\u3001\u73fe\u4ee3\u306e\u4eba\u53e3\u96c6\u56e3\u306b\u304a\u3044\u3066\u3001SHBG\u306e\u4f4e\u5024\u3092\u5f15\u304d\u8d77\u3053\u3059\u6700\u3082\u81e8\u5e8a\u7684\u306b\u91cd\u8981\u306a\u5358\u4e00\u306e\u539f\u56e0\u3067\u3042\u308b\u3002Selva\u3089\u306f\u3001\u5358\u7cd6\u985e\uff08\u5177\u4f53\u7684\u306b\u306f\u30d5\u30eb\u30af\u30c8\u30fc\u30b9\u304a\u3088\u3073\u30b0\u30eb\u30b3\u30fc\u30b9\uff09\u304c\u3001HNF-4\u03b1\u306e\u767a\u73fe\u4f4e\u4e0b\u3092\u4ecb\u3057\u3066\u809d\u81d3\u306b\u304a\u3051\u308bSHBG\u306e\u8ee2\u5199\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3057\u305f\u3002\u305d\u306e\u76f4\u63a5\u7684\u306a\u5a92\u4ecb\u56e0\u5b50\u3068\u3057\u3066\u3001\u809d\u81d3\u3067\u306e\u8102\u8cea\u751f\u5408\u6210\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002.5<\/sup> \u3053\u308c\u304c\u3001SHBG\u306e\u4f4e\u5024\u304c\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u3001\u80a5\u6e80\u30012\u578b\u7cd6\u5c3f\u75c5\u306b\u3053\u308c\u307b\u3069\u78ba\u5b9f\u306b\u4f34\u3046\u7406\u7531\u3067\u3042\u308a\u3001\u307e\u305f\u3001SHBG\u304c\u73fe\u5728\u3001\u4ee3\u8b1d\u306b\u95a2\u3059\u308b\u7814\u7a76\u306b\u304a\u3044\u3066\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u7406\u7531\u3092\u8aac\u660e\u3057\u3066\u3044\u308b\u3002.18,19,40<\/sup> \u305d\u306e\u4ed6\u306e\u6291\u5236\u56e0\u5b50\u3068\u3057\u3066\u306f\u3001\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u3001\u5916\u56e0\u6027\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\uff08\u751f\u7406\u7684\u6fc3\u5ea6\u3092\u8d85\u3048\u308b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3001\u30a2\u30ca\u30dc\u30ea\u30c3\u30af\u30b9\u30c6\u30ed\u30a4\u30c9\u3001\u30c0\u30ca\u30be\u30fc\u30eb\u306a\u3069\uff09\u3001\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u306e\u904e\u5270\u3001\u6210\u9577\u30db\u30eb\u30e2\u30f3\u307e\u305f\u306fIGF-1\u306e\u904e\u5270\u3001\u304a\u3088\u3073\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u4f5c\u7528\u3092\u6709\u3059\u308b\u30d7\u30ed\u30b2\u30b9\u30c1\u30f3\u306a\u3069\u304c\u6319\u3052\u3089\u308c\u308b\u3002.6<\/sup><\/p>\n

\u88682. \u809d\u81d3\u306b\u304a\u3051\u308bSHBG\u5408\u6210\u306e\u4e3b\u306a\u4fee\u98fe\u56e0\u5b50<\/em><\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
SHBG\u3092\u4e0a\u6607\u3055\u305b\u308b<\/strong><\/td>\nSHBG\u3092\u4f4e\u4e0b\u3055\u305b\u308b<\/strong><\/td>\n<\/tr>\n
\u52a0\u9f62\uff0830\u4ee3\u304b\u3089\u7740\u5b9f\u306b\u5897\u52a0\uff09<\/td>\n\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u8840\u75c7\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027<\/td>\n<\/tr>\n
\u7532\u72b6\u817a\u6a5f\u80fd\u4ea2\u9032\u75c7<\/td>\n\u80a5\u6e80\u3001\u7279\u306b\u5185\u81d3\u8102\u80aa<\/td>\n<\/tr>\n
\u7d4c\u53e3\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u66dd\u9732\uff08\u7d4c\u53e3\u907f\u598a\u85ac\u3001\u598a\u5a20\uff09<\/td>\n2\u578b\u7cd6\u5c3f\u75c5<\/td>\n<\/tr>\n
\u809d\u786c\u5909<\/td>\n\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7<\/td>\n<\/tr>\n
\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u3068\u795e\u7d4c\u6027\u98df\u6b32\u4e0d\u632f\u75c7<\/td>\n\u5916\u56e0\u6027\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u304a\u3088\u3073\u30a2\u30ca\u30dc\u30ea\u30c3\u30af\u30b9\u30c6\u30ed\u30a4\u30c9<\/td>\n<\/tr>\n
HIV\u611f\u67d3\uff08\u591a\u56e0\u5b50\u6027\uff09<\/td>\n\u30b0\u30eb\u30b3\u30b3\u30eb\u30c1\u30b3\u30a4\u30c9\u904e\u5270\uff08\u30af\u30c3\u30b7\u30f3\u30b0\u75c7\u5019\u7fa4\uff09<\/td>\n<\/tr>\n
\u6297\u3051\u3044\u308c\u3093\u85ac\uff08\u30d5\u30a7\u30cb\u30c8\u30a4\u30f3\u3001\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\uff09<\/td>\n\u5148\u7aef\u5de8\u5927\u75c7\uff08GH\/IGF-1\u904e\u5270\uff09<\/td>\n<\/tr>\n
\u6162\u6027\u708e\u75c7\uff08\u52b9\u679c\u306b\u3070\u3089\u3064\u304d\u3042\u308a\uff09<\/td>\n\u30cd\u30d5\u30ed\u30fc\u30bc\u75c7\u5019\u7fa4\uff08\u5c3f\u4e2d\u30bf\u30f3\u30d1\u30af\u55aa\u5931\uff09<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

4.3 \u975e\u85ac\u7269\u7642\u6cd5\u306b\u3088\u308b\u81e8\u5e8a\u7684\u306b\u9ad8\u5024\u306eSHBG\u306e\u4f4e\u4e0b<\/h4>\n

\u81e8\u5e8a\u7684\u306b\u610f\u7fa9\u306e\u3042\u308b\u72b6\u6cc1\uff08\u4e00\u822c\u7684\u306b\u3001\u6bd4\u8f03\u7684\u75e9\u305b\u305f\u4f53\u683c\u306e\u9ad8\u9f62\u7537\u6027\u3001\u7121\u75c7\u5019\u6027\u7532\u72b6\u817a\u6a5f\u80fd\u4ea2\u9032\u75c7\u3001\u3042\u308b\u3044\u306f\u4f55\u3089\u304b\u306e\u7406\u7531\u3067\u7d4c\u53e3\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u7537\u6027\u306a\u3069\uff09\u3067SHBG\u5024\u304c\u9ad8\u3044\u5834\u5408\u3001\u307e\u305a\u306f\u305d\u306e\u6839\u672c\u7684\u306a\u539f\u56e0\u306b\u5bfe\u51e6\u3059\u308b\u3053\u3068\u304c\u512a\u5148\u3055\u308c\u307e\u3059\u3002 \u4ee5\u4e0b\u306e\u6226\u7565\u306f\u3001\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89b3\u70b9\u304b\u3089\u6700\u3082\u5f37\u3044\u88cf\u4ed8\u3051\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u305d\u306e\u591a\u304f\u306f\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\u3067\u306f\u306a\u304f\u89b3\u5bdf\u7814\u7a76\u306b\u57fa\u3065\u304f\u30a8\u30d3\u30c7\u30f3\u30b9\u3067\u3059\u3002.<\/p>\n

\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3068\u5341\u5206\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u6442\u53d6\u3002. <\/strong>\u904b\u52d5\u3001\u7279\u306b\u30ec\u30b8\u30b9\u30bf\u30f3\u30b9\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306b\u3088\u308b\u9664\u8102\u80aa\u4f53\u91cd\u306e\u5897\u52a0\u306f\u3001\u304a\u305d\u3089\u304f\u7b4b\u8089\u30ec\u30d9\u30eb\u3067\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u306e\u6539\u5584\u3092\u901a\u3058\u3066\u3001SHBG\u306e\u308f\u305a\u304b\u306a\u6e1b\u5c11\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3002 \u9069\u5207\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u6442\u53d6\u91cf\uff08\u6d3b\u52d5\u7684\u306a\u9ad8\u9f62\u7537\u6027\u306e\u5834\u5408\u3001\u4f53\u91cd1kg\u3042\u305f\u308a1.2\uff5e1.6g\uff09\u306f\u3001\u7b4b\u8089\u91cf\u306e\u5897\u52a0\u3092\u652f\u3048\u3001\u305d\u308c\u81ea\u4f53\u304cSHBG\u3092\u4e0a\u6607\u3055\u305b\u308b\u7570\u5316\u72b6\u614b\u3092\u6291\u5236\u3059\u308b\u3002.20,21<\/sup><\/p>\n

\u70ad\u6c34\u5316\u7269\u306e\u8cea\u3068\u30b0\u30ea\u30bb\u30df\u30c3\u30af\u8ca0\u8377\u3002. <\/strong>\u98df\u4e8b\u7642\u6cd5\u304cSHBG\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306f\u3001\u3069\u306e\u8981\u56e0\u304c\u4e3b\u56e0\u3067\u3042\u308b\u304b\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u3001\u60a3\u8005\u306e\u30d5\u30a7\u30ce\u30bf\u30a4\u30d7\u3054\u3068\u306b\u500b\u5225\u306b\u8003\u616e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002SHBG\u5024\u304c\u4f4e\u3044\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u7537\u6027\u306e\u5834\u5408\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u6539\u5584\u3059\u308b\u3053\u3068\uff08\u7cbe\u88fd\u7cd6\u3001\u679c\u7cd6\u542b\u6709\u98f2\u6599\u3001\u9ad8\u30b0\u30ea\u30bb\u30df\u30c3\u30af\u8ca0\u8377\u98df\u54c1\u306e\u6442\u53d6\u3092\u63a7\u3048\u308b\u3053\u3068\uff09\u306b\u3088\u308a\u3001SHBG\u5024\u306f\u6b63\u5e38\u5024\u306b\u5411\u304b\u3063\u3066\u4e0a\u6607\u3059\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002 \u30ab\u30ed\u30ea\u30fc\u5236\u9650\u306b\u3088\u308aSHBG\u5024\u304c\u9ad8\u304f\u306a\u3063\u3066\u3044\u308b\u6804\u990a\u4e0d\u826f\u307e\u305f\u306f\u30a8\u30cd\u30eb\u30ae\u30fc\u4e0d\u8db3\u306e\u7537\u6027\u306b\u304a\u3044\u3066\u306f\u3001\u9069\u5207\u306a\u30ab\u30ed\u30ea\u30fc\u88dc\u7d66\u3092\u884c\u3046\u3053\u3068\u3067SHBG\u5024\u304c\u4f4e\u4e0b\u3059\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u7532\u72b6\u817a\u75be\u60a3\u3001\u7d4c\u53e3\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3001\u6297\u3051\u3044\u308c\u3093\u85ac\u3001\u307e\u305f\u306f\u809d\u75be\u60a3\u306b\u8d77\u56e0\u3059\u308bSHBG\u5024\u304c\u9ad8\u3044\u7537\u6027\u306e\u5834\u5408\u3001\u98df\u4e8b\u7642\u6cd5\u306e\u307f\u3067\u306f\u4e0d\u5341\u5206\u3067\u3042\u308a\u3001\u6839\u672c\u7684\u306a\u8981\u56e0\u3092\u6a19\u7684\u3068\u3057\u305f\u9069\u5207\u306a\u4ecb\u5165\u304c\u5fc5\u8981\u3067\u3059\u3002.5,18<\/sup><\/p>\n

\u7121\u75c7\u5019\u6027\u7532\u72b6\u817a\u6a5f\u80fd\u4ea2\u9032\u75c7\u306e\u6cbb\u7642\u3002. <\/strong>TSH\u304c\u6291\u5236\u3055\u308c\u3001SHBG\u304c\u9ad8\u3044\u5834\u5408\u3001\u7532\u72b6\u817a\u306e\u7570\u5e38\u306b\u5bfe\u51e6\u3059\u308b\u3053\u3068\u3067\u3001\u591a\u304f\u306e\u5834\u5408\u3001\u6570\u30f6\u6708\u4ee5\u5185\u306bSHBG\u5024\u304c\u6b63\u5e38\u5316\u3057\u307e\u3059\u3002.17<\/sup><\/p>\n

\u7d4c\u53e3\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u6e1b\u91cf\u307e\u305f\u306f\u4ee3\u66ff\u7642\u6cd5\u3002. <\/strong>\u4f55\u3089\u304b\u306e\u7406\u7531\u3067\u7d4c\u53e3\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3092\u6295\u4e0e\u3055\u308c\u3066\u3044\u308b\u60a3\u8005\u306f\u3001\u7d4c\u76ae\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3078\u306e\u5207\u308a\u66ff\u3048\u304c\u53ef\u80fd\u3067\u3059\u3002\u7d4c\u76ae\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306f\u3001\u521d\u56de\u901a\u904e\u52b9\u679c\u3092\u56de\u907f\u3057\u3001SHBG\u3078\u306e\u5f71\u97ff\u3082\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093\u3002.6<\/sup><\/p>\n

\u670d\u7528\u4e2d\u306e\u85ac\u306e\u898b\u76f4\u3057\u3002. <\/strong>\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u304c\u78ba\u8a8d\u3055\u308c\u3001\u305d\u306e\u4e3b\u306a\u539f\u56e0\u304cSHBG\u306b\u3042\u308b\u5834\u5408\u306f\u3001\u6297\u3051\u3044\u308c\u3093\u85ac\u3084\u7279\u5b9a\u306e\u6297\u30ec\u30c8\u30ed\u30a6\u30a4\u30eb\u30b9\u85ac\u306e\u4ee3\u66ff\u304c\u5fc5\u8981\u3068\u306a\u308b\u5834\u5408\u304c\u3042\u308b\u3002.6<\/sup><\/p>\n

\u809d\u75be\u60a3\u3078\u306e\u5bfe\u5fdc\u3002. <\/strong>\u6162\u6027\u809d\u75be\u60a3\u3092\u6709\u3059\u308b\u7537\u6027\u3067\u3001SHBG\u304c\u9006\u8aac\u7684\u306b\u4e0a\u6607\u3057\u3066\u3044\u308b\u5834\u5408\u3001\u809d\u75be\u60a3\u305d\u306e\u3082\u306e\u306b\u5bfe\u3059\u308b\u6cbb\u7642\uff08\u7981\u9152\u3001C\u578b\u809d\u708e\u306b\u5bfe\u3059\u308b\u6297\u30a6\u30a4\u30eb\u30b9\u7642\u6cd5\u3001\u3042\u308b\u3044\u306f\u8102\u80aa\u809d\u306b\u5bfe\u3059\u308b\u6e1b\u91cf\uff09\u304c\u9069\u5207\u306a\u4ecb\u5165\u3068\u306a\u308b\u3002.24<\/sup><\/p>\n

\u5341\u5206\u306a\u30ab\u30ed\u30ea\u30fc\u6442\u53d6\u3002. <\/strong>\u6804\u990a\u4e0d\u8db3\u306e\u72b6\u614b\u3067\u306f\u3001SHBG\u304c\u6025\u6fc0\u306b\u4e0a\u6607\u3059\u308b\u3002\u30a8\u30cd\u30eb\u30ae\u30fc\u53ce\u652f\u304c\u30de\u30a4\u30ca\u30b9\u3068\u306a\u3063\u3066\u3044\u308b\u30a2\u30b9\u30ea\u30fc\u30c8\u3084\u9ad8\u9f62\u7537\u6027\u3067\u306f\u3001SHBG\u5024\u304c\u9ad8\u304f\u306a\u308b\u5834\u5408\u304c\u3042\u308b\u304c\u3001\u3053\u308c\u306f\u30ab\u30ed\u30ea\u30fc\u88dc\u7d66\u3092\u884c\u3046\u3053\u3068\u3067\u6539\u5584\u3059\u308b\u3002.6,15<\/sup><\/p>\n

SHBG\u306e\u8abf\u7bc0\u3092\u76ee\u7684\u3068\u3057\u3066\u3001\u30db\u30a6\u7d20\u3001\u4e9c\u925b\u3001\u30de\u30b0\u30cd\u30b7\u30a6\u30e0\u306e\u88dc\u7d66\u304c\u63a8\u5968\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u81e8\u5e8a\u7684\u6839\u62e0\u306f\u9650\u5b9a\u7684\u3067\u4e00\u8cab\u6027\u3082\u306a\u304f\u3001\u3053\u308c\u3089\u306f\u3044\u305a\u308c\u3082\u3001\u524d\u8ff0\u306e\u4e0a\u6d41\u8981\u56e0\u306b\u5bfe\u51e6\u3059\u308b\u4ee3\u308f\u308a\u3068\u306a\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002.<\/p>\n

5. \u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3068\u751f\u7269\u5b66\u7684\u5229\u7528\u80fd\u306e\u3042\u308b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u76f8\u95a2\u3092\u963b\u5bb3\u3059\u308b\u8981\u56e0<\/h3>\n

5.1 \u80a5\u6e80\u3068\u6a5f\u80fd\u6027\u7d9a\u767a\u6027\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7<\/h4>\n

\u80a5\u6e80\u3001\u3068\u308a\u308f\u3051\u5185\u81d3\u80a5\u6e80\u306f\u3001\u300c\u7537\u6027\u80a5\u6e80\u95a2\u9023\u4e8c\u6b21\u6027\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\uff08MOSH\uff09\u300d\u3068\u547c\u3070\u308c\u308b\u75c5\u614b\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002.22<\/sup> \u3053\u306e\u30d1\u30bf\u30fc\u30f3\u306f\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u304c\u4f4e\u304f\u3001LH\u304a\u3088\u3073FSH\u5024\u304c\u4e0d\u9069\u5207\u306b\u6b63\u5e38\u307e\u305f\u306f\u4f4e\u3044\u3068\u3044\u3046\u7279\u5fb4\u304c\u3042\u308a\u3001\u4e2d\u67a2\u6027\u306e\u8981\u56e0\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u30023\u3064\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u540c\u6642\u306b\u4f5c\u7528\u3057\u3066\u3044\u308b\u3002\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u8840\u75c7\u306f\u809d\u81d3\u3067\u306eSHBG\u3092\u6291\u5236\u3057\u3001\u904a\u96e2\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u3092\u5fc5\u305a\u3057\u3082\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u306a\u304f\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3002 \u5185\u81d3\u8102\u80aa\u7d44\u7e54\u306f\u3001\u8996\u5e8a\u4e0b\u90e8\u306eGnRH\u3092\u6291\u5236\u3059\u308b\u3088\u3046\u306a\u30d1\u30bf\u30fc\u30f3\u3067IL-6\u3001TNF-\u03b1\u3001\u304a\u3088\u3073\u30ec\u30d7\u30c1\u30f3\u3092\u5206\u6ccc\u3057\uff1b\u3055\u3089\u306b\u3001\u8102\u80aa\u7d44\u7e54\u306e\u30a2\u30ed\u30de\u30bf\u30fc\u30bc\u304c\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3092\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb\u306b\u5909\u63db\u3059\u308b\u3053\u3068\u3067\u3001\u8996\u5e8a\u4e0b\u90e8\u306b\u5bfe\u3057\u3066\u3055\u3089\u306a\u308b\u8ca0\u306e\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u3092\u3082\u305f\u3089\u3059\u3002.20,22,23<\/sup> \u6a2a\u65ad\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u30c0\u30a4\u30a2\u30d9\u30b7\u30c6\u30a3\u306e\u3042\u308b\u7537\u6027\u306e30\uff05\u4ee5\u4e0a\u304c\u3001\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u306e\u751f\u5316\u5b66\u7684\u57fa\u6e96\u3092\u6e80\u305f\u3057\u3066\u3044\u308b\u3002.23<\/sup><\/p>\n

\u91cd\u8981\u306a\u3053\u3068\u306b\u3001\u4f53\u91cd\u6e1b\u5c11\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u306e\u6539\u5584\u306b\u3088\u308a\u3001\u3053\u3046\u3057\u305f\u72b6\u614b\u306f\u3057\u3070\u3057\u3070\u90e8\u5206\u7684\u3042\u308b\u3044\u306f\u5b8c\u5168\u306b\u6539\u5584\u3055\u308c\u308b\u3002\u80a5\u6e80\u306b\u4f34\u3046\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u306e\u7537\u6027\u306b\u304a\u3044\u3066\u3001\u6e1b\u91cf\u624b\u8853\u3092\u884c\u3046\u3053\u3068\u3067\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u304c\u6b63\u5e38\u5316\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u30015\uff5e10\uff05\u3068\u3044\u3046\u308f\u305a\u304b\u306a\u4f53\u91cd\u6e1b\u5c11\u3067\u3082\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u304a\u3088\u3073\u904a\u96e2\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u4e21\u65b9\u304c\u6539\u5584\u3055\u308c\u308b\u3002.20,21,22<\/sup><\/p>\n

5.2 \u4ee3\u8b1d\u6a5f\u80fd\u969c\u5bb3\u306b\u4f34\u3046\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08MASLD\uff09<\/h4>\n

\u8102\u80aa\u809d\u306f\u3001\u809d\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u8868\u73fe\u578b\u3067\u3042\u308a\u3001SHBG\u306e\u4f4e\u4e0b\u304a\u3088\u3073\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u4f4e\u4e0b\u3068\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3002.19,40<\/sup> \u3053\u3046\u3057\u305f\u60a3\u8005\u306b\u304a\u3044\u3066\u306f\u3001\u904a\u96e2\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u307e\u305f\u306f\u751f\u7269\u5b66\u7684\u5229\u7528\u80fd\u306e\u3042\u308b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u6e2c\u5b9a\u5024\u306e\u65b9\u304c\u3088\u308a\u6709\u610f\u7fa9\u3067\u3042\u308b\u3002\u8102\u80aa\u6027\u809d\u708e\u3092\u4f75\u767a\u3057\u3066\u3044\u308b\u5834\u5408\u3001\u7dda\u7dad\u5316\u3084\u809d\u786c\u5909\u3078\u306e\u9032\u884c\u306b\u4f34\u3044\u3001\u9006\u8aac\u7684\u306bSHBG\u304c\u4e0a\u6607\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u72b6\u6cc1\u306f\u3055\u3089\u306b\u8907\u96d1\u306b\u306a\u308b\u3002.24<\/sup><\/p>\n

5.3 \u809d\u786c\u5909<\/h4>\n

\u9032\u884c\u6027\u809d\u786c\u5909\u306f\u3001\u8907\u96d1\u306a\u5185\u5206\u6ccc\u7570\u5e38\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002\u4ed6\u306e\u591a\u304f\u306e\u9818\u57df\u306b\u304a\u3044\u3066\u809d\u5408\u6210\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001SHBG\u306f\u4e0a\u6607\u3057\u3001\u30a2\u30eb\u30d6\u30df\u30f3\u306f\u4f4e\u4e0b\u3057\u3001\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb\u306e\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u306f\u4f4e\u4e0b\u3059\u308b\u3002\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u306f\u4e00\u898b\u6b63\u5e38\u306b\u4fdd\u305f\u308c\u3066\u3044\u308b\u3088\u3046\u306b\u898b\u3048\u308b\u304c\u3001\u904a\u96e2\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u306f\u8457\u3057\u304f\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3002.24<\/sup> \u3053\u306e\u60a3\u8005\u7fa4\u3067\u306f\u3001\u751f\u7269\u5b66\u7684\u5229\u7528\u80fd\u306e\u6e2c\u5b9a\u304c\u5fc5\u9808\u3067\u3042\u308a\u3001\u305d\u3046\u3057\u306a\u3051\u308c\u3070\u8a3a\u65ad\u3092\u898b\u9003\u3059\u3053\u3068\u306b\u306a\u308b\u3002.<\/p>\n

5.4 \u30cd\u30d5\u30ed\u30fc\u30bc\u75c7\u5019\u7fa4<\/h4>\n

\u5927\u91cf\u306e\u30bf\u30f3\u30d1\u30af\u5c3f\u306b\u3088\u308a\u3001SHBG\u304a\u3088\u3073\u30a2\u30eb\u30d6\u30df\u30f3\u304c\u5c3f\u4e2d\u306b\u5931\u308f\u308c\u3001\u305d\u306e\u6fc3\u5ea6\u304c\u3068\u3082\u306b\u4f4e\u4e0b\u3059\u308b\u3002\u7d50\u5408\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u305f\u3081\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u306f\u4f4e\u4e0b\u3059\u308b\u3002\u904a\u96e2\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306f\u3001\u5f53\u521d\u306fHPG\u8ef8\u306b\u3088\u308b\u4ee3\u511f\u4f5c\u7528\u306b\u3088\u3063\u3066\u7dad\u6301\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u304c\u3001\u6162\u6027\u7684\u306a\u7570\u5316\u30b9\u30c8\u30ec\u30b9\u3084\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c\u30e9\u30a4\u30c7\u30a3\u30c3\u30d2\u7d30\u80de\u306b\u53ca\u307c\u3059\u76f4\u63a5\u7684\u306a\u5f71\u97ff\u306b\u3088\u308a\u3001\u6700\u7d42\u7684\u306b\u306f\u7523\u751f\u6a5f\u80fd\u304c\u640d\u306a\u308f\u308c\u308b\u3002.25<\/sup><\/p>\n

5.5 \u7532\u72b6\u817a\u6a5f\u80fd\u4ea2\u9032\u75c7\u3068\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7<\/h4>\n

\u7532\u72b6\u817a\u6a5f\u80fd\u4ea2\u9032\u75c7\u306f\u3001HNF-1\u03b1\u304a\u3088\u3073HNF-4\u03b1\u306e\u767a\u73fe\u8a98\u5c0e\u3092\u901a\u3058\u3066SHBG\u3092\u4e0a\u6607\u3055\u305b\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u3092\u4e0a\u6607\u3055\u305b\u308b\u304c\u3001\u751f\u7269\u5b66\u7684\u5229\u7528\u80fd\u306e\u3042\u308b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3078\u306e\u5f71\u97ff\u306f\u5c0f\u3055\u3044\u3002.17<\/sup> \u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u3067\u306f\u3001\u3053\u308c\u3068\u306f\u9006\u306e\u30d1\u30bf\u30fc\u30f3\u304c\u898b\u3089\u308c\u307e\u3059\u3002\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u5024\u3092\u81e8\u5e8a\u7684\u306b\u8a55\u4fa1\u3059\u308b\u60a3\u8005\u306b\u3064\u3044\u3066\u306f\u3001\u7532\u72b6\u817a\u306e\u72b6\u614b\u3092\u628a\u63e1\u3057\u3066\u304a\u304f\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002.<\/p>\n

6. \u751f\u4f53\u5229\u7528\u53ef\u80fd\u306a\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u5fc3\u8840\u7ba1\u7cfb\u3078\u306e\u5f71\u97ff<\/h3>\n

\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u72b6\u614b\u3068\u5fc3\u8840\u7ba1\u7cfb\u3068\u306e\u95a2\u9023\u6027\u306f\u3001\u3053\u306e\u5206\u91ce\u306b\u304a\u3044\u3066\u904e\u53bb20\u5e74\u9593\u3067\u6700\u3082\u5927\u304d\u304f\u5909\u5316\u3057\u305f\u90e8\u5206\u3067\u3042\u308b\u3002\u5f93\u6765\u306e\u6587\u732e\u3067\u306f\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306f\u5fc3\u8840\u7ba1\u7cfb\u306b\u5bfe\u3057\u3066\u4e2d\u7acb\u7684\u3042\u308b\u3044\u306f\u6709\u5bb3\u3067\u3042\u308b\u3068\u6271\u308f\u308c\u3066\u3044\u305f\u304c\u3001\u73fe\u5728\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u3001\u3088\u308a\u5fae\u5999\u306a\u898b\u89e3\u3092\u88cf\u4ed8\u3051\u3066\u3044\u308b\u3002\u3059\u306a\u308f\u3061\u3001\u751f\u7406\u5b66\u7684\u30ec\u30d9\u30eb\u306e\u751f\u7269\u5b66\u7684\u5229\u7528\u80fd\u306e\u3042\u308b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306f\u5fc3\u8840\u7ba1\u7cfb\u306e\u826f\u597d\u306a\u8868\u73fe\u578b\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u4e00\u65b9\u3067\u3001\u975e\u5e38\u306b\u4f4e\u3044\u30ec\u30d9\u30eb\u304a\u3088\u3073\u751f\u7406\u5b66\u7684\u30ec\u30d9\u30eb\u3092\u8d85\u3048\u308b\u30ec\u30d9\u30eb\u306f\u3044\u305a\u308c\u3082\u30ea\u30b9\u30af\u3092\u4f34\u3046\u3068\u3044\u3046\u3082\u306e\u3067\u3042\u308b\u3002.<\/p>\n

6.1 \u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u8840\u7ba1\u751f\u7269\u5b66<\/h4>\n

\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306b\u306f\u3001\u8840\u7ba1\u306b\u5bfe\u3059\u308b\u76f4\u63a5\u7684\u306a\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306f\u3001\u5185\u76ae\u4f9d\u5b58\u6027\u8840\u7ba1\u62e1\u5f35\u3092\u652f\u3048\u308b\u5185\u76ae\u578b\u4e00\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d20\u306e\u6d3b\u6027\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u8840\u7ba1\u5e73\u6ed1\u7b4b\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u306e\u6d3b\u6027\u3092\u8abf\u7bc0\u3057\u3001\u51a0\u52d5\u8108\u304a\u3088\u3073\u672b\u68a2\u8840\u7ba1\u306e\u62e1\u5f35\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u8840\u7ba1\u58c1\u306e\u708e\u75c7\u53cd\u5fdc\u306b\u3082\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3001\u591a\u304f\u306e\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u304c\u4f4e\u3044\u3068CRP\u304a\u3088\u3073IL-6\u306e\u4e0a\u6607\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002.34,50,56<\/sup> \u5fc3\u7b4b\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u306f\u3001\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\u304c\u767a\u73fe\u3057\u3066\u304a\u308a\u3001\u751f\u7406\u7684\u306a\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u306e\u4f9b\u7d66\u304c\u3001\u6b63\u5e38\u306a\u5fc3\u7b4b\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3092\u8a31\u5bb9\u3059\u308b\u8981\u56e0\u3068\u306a\u3063\u3066\u3044\u308b\u3088\u3046\u3067\u3042\u308b\u3002.<\/p>\n

\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306f\u3001ASCVD\u30ea\u30b9\u30af\u306e\u89b3\u70b9\u304b\u3089\u81e8\u5e8a\u7684\u306b\u91cd\u8981\u306a\u5f62\u3067\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u7cfb\u3068\u3082\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3002\u751f\u7406\u7684\u7bc4\u56f2\u3092\u8d85\u3048\u308b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\uff08\u307b\u3068\u3093\u3069\u306e\u30a2\u30ca\u30dc\u30ea\u30c3\u30af\u30b9\u30c6\u30ed\u30a4\u30c9\u4e71\u7528\u30d1\u30bf\u30fc\u30f3\u3092\u542b\u3080\uff09\u306f\u3001HDL\u3092\u4f4e\u4e0b\u3055\u305b\u3001ApoB\u542b\u6709\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4e0a\u6607\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002 \u5bfe\u7167\u7684\u306b\u3001\u751f\u7406\u7684\u7bc4\u56f2\u5185\u306e\u88dc\u5145\u7642\u6cd5\u3067\u306f\u3001\u901a\u5e38\u3001\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304a\u3088\u3073ApoB\u304c\u308f\u305a\u304b\u306b\u6e1b\u5c11\u3057\u3001HDL\u304c\u9069\u5ea6\u306b\u6e1b\u5c11\u3059\u308b\u4e00\u65b9\u3067\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3084\u5185\u81d3\u8102\u80aa\u306b\u5bfe\u3057\u3066\u306f\u4e2d\u7acb\u7684\u307e\u305f\u306f\u597d\u307e\u3057\u3044\u5f71\u97ff\u3092\u3082\u305f\u3089\u3059\u3002.49,50,56<\/sup> \u751f\u7406\u7684\u9650\u754c\u3092\u8d85\u3048\u308b\u66dd\u9732\u3068\u306f\u5bfe\u7167\u7684\u306b\u3001\u6b63\u5e38\u306a\u751f\u7406\u6a5f\u80fd\u306e\u56de\u5fa9\u304c\u6b6f\u57a2\u306e\u751f\u7269\u5b66\u7684\u7279\u6027\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3053\u305d\u304c\u3001\u4e88\u9632\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u8981\u7d20\u3067\u3042\u308b\u3002.<\/p>\n

6.2 \u5185\u56e0\u6027\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3068\u5fc3\u8840\u7ba1\u7cfb\u30a2\u30a6\u30c8\u30ab\u30e0<\/h4>\n

\u5927\u898f\u6a21\u306a\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3067\u306f\u3001\u4e00\u822c\u7684\u306b\u3001\u5185\u56e0\u6027\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u4f4e\u5024\u304c\u3001\u7537\u6027\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u6b7b\u304a\u3088\u3073\u5168\u6b7b\u56e0\u6b7b\u4ea1\u7387\u306e\u4e0a\u6607\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002 Yeap\u3089\u306b\u3088\u308b\u300111\u306e\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u306824,000\u4eba\u4ee5\u4e0a\u306e\u7537\u6027\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7d71\u5408\u89e3\u6790\u3067\u306f\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u304c\u6700\u4e0b\u4f4d\u4e94\u5206\u4f4d\u7fa4\u306b\u5c5e\u3059\u308b\u7537\u6027\u306f\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u3001\u904a\u96e2\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u304c\u6975\u3081\u3066\u4f4e\u3044\uff08\u7d04184 pmol\/L\u672a\u6e80\u3001 \u307e\u305f\u306f53 pg\/mL\uff09\u304c\u6700\u3082\u9ad8\u3044\u30ea\u30b9\u30af\u3092\u4f34\u3046\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002.34<\/sup> Corona\u3089\u306b\u3088\u308b\u30e1\u30bf\u89e3\u6790\u3067\u306f\u3001\u5185\u56e0\u6027\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3068\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3068\u306e\u9593\u306b\u540c\u69d8\u306e\u9006\u76f8\u95a2\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002.35<\/sup> \u30e1\u30f3\u30c7\u30eb\u30e9\u30f3\u30c0\u30e0\u5316\u89e3\u6790\u306e\u7d50\u679c\u306f\u307e\u3061\u307e\u3061\u3067\u3042\u308b\u304c\u3001\u6982\u3057\u3066\u3001\u751f\u7406\u7684\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u304c\u5fc3\u8840\u7ba1\u7cfb\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u6709\u5bb3\u306a\u56e0\u679c\u95a2\u4fc2\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u4e00\u90e8\u306e\u89e3\u6790\u3067\u306f\u3001\u5206\u5e03\u306e\u6700\u4e0b\u4f4d\u5c64\u306b\u304a\u3044\u3066\u4fdd\u8b77\u7684\u306a\u95a2\u9023\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002.55<\/sup><\/p>\n

SHBG\u81ea\u4f53\u306f\u3001\u72ec\u7acb\u3057\u305f\u5fc3\u8840\u7ba1\u304a\u3088\u3073\u4ee3\u8b1d\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002SHBG\u5024\u304c\u4f4e\u3044\u3053\u3068\u306f\u30012\u578b\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u3092\u4e88\u6e2c\u3057\u3001,18<\/sup> \u307e\u305f\u3001\u9ad8\u9f62\u7537\u6027\u306b\u304a\u3051\u308bSHBG\u5024\u306e\u8457\u3057\u3044\u4e0a\u6607\u306f\u3001\u4e00\u90e8\u306e\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u306b\u304a\u3044\u3066\u6b7b\u4ea1\u7387\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u9006\u56e0\u679c\u95a2\u4fc2\uff08\u865a\u5f31\u3084\u6804\u990a\u4e0d\u826f\u304cSHBG\u5024\u3092\u4e0a\u6607\u3055\u305b\u308b\uff09\u306e\u5b58\u5728\u306b\u3088\u308a\u3001\u305d\u306e\u89e3\u91c8\u306f\u8907\u96d1\u306b\u306a\u3063\u3066\u3044\u308b\u3002.19,58<\/sup><\/p>\n

6.3 \u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u88dc\u5145\u7642\u6cd5\u3068\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\uff1aTRAVERSE\u7814\u7a76\u5f8c\u306e\u6700\u65b0\u306e\u30a8\u30d3\u30c7\u30f3\u30b9<\/h4>\n

2013\u5e74\u30682014\u5e74\u306b\u3001\u5e83\u304f\u5831\u3058\u3089\u308c\u305f2\u3064\u306e\u7814\u7a76\uff08VA\u30b7\u30b9\u30c6\u30e0\u306b\u304a\u3051\u308bVigen\u3089\u306b\u3088\u308b\u7814\u7a76\u304a\u3088\u3073\u8acb\u6c42\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u7528\u3044\u305fFinkle\u3089\u306b\u3088\u308b\u7814\u7a76\uff09\u304c\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u88dc\u5145\u7642\u6cd5\uff08TRT\uff09\u3068\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3068\u306e\u95a2\u9023\u6027\u3092\u5831\u544a\u3057\u305f\u3002 \u3044\u305a\u308c\u306e\u7814\u7a76\u3082\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u306e\u628a\u63e1\u304c\u4e0d\u5b8c\u5168\u3067\u3042\u308b\u3053\u3068\u3001\u8ffd\u8de1\u671f\u9593\u304c\u77ed\u3044\u3053\u3068\u3001\u9078\u629c\u30d0\u30a4\u30a2\u30b9\u306a\u3069\u306e\u554f\u984c\u306a\u3069\u3001\u6df1\u523b\u306a\u65b9\u6cd5\u8ad6\u4e0a\u306e\u9650\u754c\u3092\u62b1\u3048\u3066\u3044\u305f\u3002\u305d\u306e\u5f8c\u306e\u5206\u6790\u306b\u3088\u308a\u3001\u4e21\u7814\u7a76\u306b\u3064\u3044\u3066\u65b9\u6cd5\u8ad6\u4e0a\u306e\u61f8\u5ff5\u304c\u6307\u6458\u3055\u308c\u305f\u3002.54,54b<\/sup> \u305d\u308c\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001FDA\u306f2015\u5e74\u306b\u5fc3\u8840\u7ba1\u7cfb\u306e\u30ea\u30b9\u30af\u304c\u751f\u3058\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3059\u8b66\u544a\u30e9\u30d9\u30eb\u3092\u8ffd\u52a0\u3057\u305f\u305f\u3081\u3001\u51e6\u65b9\u91cf\u304c\u6e1b\u5c11\u3057\u305f\u3002.<\/p>\n

\u305d\u308c\u4ee5\u6765\u3001\u3088\u308a\u660e\u78ba\u306b\u5b9a\u7fa9\u3055\u308c\u305f\u96c6\u56e3\u3092\u5bfe\u8c61\u3068\u3057\u305f\u8907\u6570\u306e\u89b3\u5bdf\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u4e2d\u7acb\u7684\u3042\u308b\u3044\u306f\u6709\u76ca\u306a\u95a2\u9023\u6027\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002Sharma\u3089\u306f\u300183,000\u4eba\u4ee5\u4e0a\u306e\u7537\u6027\u304b\u3089\u306a\u308bVA\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u306b\u304a\u3044\u3066\u3001TRT\u306b\u3088\u308b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u306e\u6b63\u5e38\u5316\u306f\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u304c\u4f4e\u3044\u307e\u307e\u3067\u3042\u3063\u305f\u308a\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u306a\u304b\u3063\u305f\u7537\u6027\u3068\u6bd4\u8f03\u3057\u3066\u3001\u5fc3\u7b4b\u6897\u585e\u3001\u8133\u5352\u4e2d\u3001\u304a\u3088\u3073\u5168\u6b7b\u56e0\u6b7b\u4ea1\u7387\u306e\u767a\u751f\u7387\u306e\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002.37<\/sup> \u30c1\u30fc\u30bf\u30e0\u3089\u306f\u3001\u30ab\u30a4\u30b6\u30fc\u30fb\u30d1\u30fc\u30de\u30cd\u30f3\u30c6\u306e\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u304d\u3001TRT\u6cbb\u7642\u3092\u53d7\u3051\u305f\u7537\u6027\u306b\u304a\u3044\u3066\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u304c33\uff05\u4f4e\u3044\u3053\u3068\u3092\u5831\u544a\u3057\u305f\u3002.38<\/sup> \u30a4\u30f3\u30bf\u30fc\u30de\u30a6\u30f3\u30c6\u30f3\u30fb\u30d8\u30eb\u30b9\u30b1\u30a2\u30fb\u30b7\u30b9\u30c6\u30e0\u306b\u6240\u5c5e\u3059\u308b\u30a2\u30f3\u30c0\u30fc\u30bd\u30f3\u3089\u306f\u3001\u540c\u69d8\u306b\u3001\u5fc3\u8840\u7ba1\u7cfb\u306e\u8ee2\u5e30\u304c\u4e2d\u7acb\u7684\u307e\u305f\u306f\u826f\u597d\u3067\u3042\u3063\u305f\u3068\u5831\u544a\u3057\u3066\u3044\u308b\u3002.39<\/sup><\/p>\n

\u3053\u308c\u307e\u3067\u3067\u6700\u5927\u898f\u6a21\u306e\u5fc3\u8840\u7ba1\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\u306f\u3001TRAVERSE\u8a66\u9a13\uff08Lincoff et al., New England Journal of Medicine, 2023\uff09\u3067\u3042\u308a\u3001\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u3092\u6709\u3057\u3001\u304b\u3064\u65e2\u5b58\u306e\u5fc3\u8840\u7ba1\u75be\u60a3\u307e\u305f\u306f\u9ad8\u3044\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u3044\u305a\u308c\u304b\u3092\u4f75\u305b\u6301\u306445\u6b73\u304b\u308980\u6b73\u306e\u7537\u6027\u7d045,200\u540d\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3001\u7121\u4f5c\u70ba\u5316\u3001\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u3001\u975e\u52a3\u6027\u8a66\u9a13\u3067\u3042\u3063\u305f\u3002 \u5e73\u574722\u304b\u6708\u306e\u8ffd\u8de1\u671f\u9593\u306b\u304a\u3044\u3066\u3001\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u6027\u5fc3\u7b4b\u6897\u585e\u3001 \u304a\u3088\u3073\u975e\u81f4\u6b7b\u6027\u8133\u5352\u4e2d\u304b\u3089\u306a\u308b\u4e3b\u8981\u8907\u5408\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u7fa4\u30677.0\uff05\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u30677.3\uff05\u306b\u8a8d\u3081\u3089\u308c\u3001\u4e8b\u524d\u306b\u8a2d\u5b9a\u3055\u308c\u305f\u975e\u52a3\u6027\u57fa\u6e96\u3092\u6e80\u305f\u3057\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd40.96\uff1b95\uff05\u4fe1\u983c\u533a\u95930.78\uff5e1.17\uff09\u3002.36<\/sup> \u5fc3\u623f\u7d30\u52d5\u3001\u6025\u6027\u814e\u969c\u5bb3\u3001\u304a\u3088\u3073\u80ba\u585e\u6813\u75c7\u306f\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u7fa4\u3067\u308f\u305a\u304b\u306b\u591a\u304f\u8a8d\u3081\u3089\u308c\u305f\u304c\u3001\u3053\u308c\u306f\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306b\u3088\u308b\u8d64\u8840\u7403\u5897\u52a0\u306e\u65e2\u77e5\u306e\u751f\u7269\u5b66\u7684\u6a5f\u5e8f\u3068\u4e00\u81f4\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306f\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u304c\u5fc5\u8981\u306a\u4e3b\u8981\u306a\u6b8b\u5b58\u5b89\u5168\u6027\u30b7\u30b0\u30ca\u30eb\u3067\u3042\u308b\u3002 TRAVERSE\u8a66\u9a13\u306f\u3001\u8ffd\u8de1\u671f\u9593\u304c\u4e2d\u7a0b\u5ea6\u306e\u975e\u52a3\u6027\u8a66\u9a13\u3067\u3042\u308a\u3001\u9577\u671f\u7684\u306a\u5fc3\u8840\u7ba1\u7cfb\u306e\u6709\u76ca\u6027\u3092\u7acb\u8a3c\u3059\u308b\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u30d7\u30e9\u30fc\u30af\u306e\u751f\u7269\u5b66\u7684\u7279\u6027\u3001\u8840\u5727\u3001\u3042\u308b\u3044\u306f\u3088\u308a\u5e83\u7bc4\u306a\u9069\u5fdc\u5916\u4f7f\u7528\u306b\u3064\u3044\u3066\u5b8c\u5168\u306b\u89e3\u660e\u3057\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3002.<\/p>\n

2025\u5e74\u3001FDA\u306f\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u88fd\u5264\u306b\u3064\u3044\u3066\u3001\u5168\u88fd\u54c1\u3092\u5bfe\u8c61\u3068\u3057\u305f\u6dfb\u4ed8\u6587\u66f8\u306e\u5909\u66f4\u3092\u767a\u8868\u3057\u307e\u3057\u305f\u3002\u6539\u8a02\u3055\u308c\u305f\u6dfb\u4ed8\u6587\u66f8\u306b\u306f\u3001TRAVERSE\u8a66\u9a13\u306e\u7d50\u679c\u304c\u53cd\u6620\u3055\u308c\u3001\u91cd\u5927\u306a\u5fc3\u8840\u7ba1\u7cfb\u6709\u5bb3\u4e8b\u8c61\u306e\u30ea\u30b9\u30af\u5897\u52a0\u306b\u95a2\u3059\u308b\u30dc\u30c3\u30af\u30b9\u8b66\u544a\u306e\u6587\u8a00\u304c\u524a\u9664\u3055\u308c\u307e\u3057\u305f\u3002 \u6539\u8a02\u3055\u308c\u305f\u6dfb\u4ed8\u6587\u66f8\u3067\u306f\u3001\u8840\u5727\u4e0a\u6607\u306b\u95a2\u3059\u308b\u8b66\u544a\u304c\u8ffd\u52a0\u307e\u305f\u306f\u5f37\u5316\u3055\u308c\u3001\u751f\u5316\u5b66\u7684\u6b20\u4e4f\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u306a\u3044\u5e74\u9f62\u95a2\u9023\u6027\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u306b\u5bfe\u3059\u308b\u65e2\u5b58\u306e\u4f7f\u7528\u5236\u9650\u306f\u7dad\u6301\u3055\u308c\u305f\u3002\u81e8\u5e8a\u533b\u306f\u3001\u4f7f\u7528\u3057\u3066\u3044\u308b\u5177\u4f53\u7684\u306a\u88fd\u5264\u306b\u3064\u3044\u3066\u3001\u6700\u65b0\u306e\u51e6\u65b9\u60c5\u5831\u3092\u53c2\u7167\u3059\u3079\u304d\u3067\u3042\u308b\u3002.<\/p>\n

6.4 \u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3068\u51a0\u52d5\u8108\u30d7\u30e9\u30fc\u30af<\/h4>\n

\u300c\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u8a66\u9a13\u300d\u306e\u5fc3\u8840\u7ba1\u30b5\u30d6\u30b9\u30bf\u30c7\u30a3\uff08Budoff\u3089\u3001JAMA\u30012017\u5e74\uff09\u3067\u306f\u30011\u5e74\u9593\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u30b2\u30eb\u3092\u6295\u4e0e\u3055\u308c\u305f\u7537\u6027\u306b\u304a\u3044\u3066\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001\u51a0\u52d5\u8108CT\u30a2\u30f3\u30ae\u30aa\u30b0\u30e9\u30d5\u30a3\u30fc\u306b\u3088\u308b\u975e\u77f3\u7070\u5316\u51a0\u52d5\u8108\u30d7\u30e9\u30fc\u30af\u306e\u4f53\u7a4d\u306e\u5897\u52a0\u304c\u3088\u308a\u5927\u304d\u304b\u3063\u305f\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u305f\u3002.48<\/sup> \u672c\u8a66\u9a13\u306f\u81e8\u5e8a\u4e8b\u8c61\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306e\u691c\u51fa\u529b\u3092\u6301\u305f\u305a\u3001\u975e\u77f3\u7070\u5316\u30d7\u30e9\u30fc\u30af\u306e\u5897\u52a0\u306f\u8efd\u5fae\u3067\u3042\u308a\u3001\u9577\u671f\u7684\u306a\u81e8\u5e8a\u7684\u610f\u7fa9\u306b\u3064\u3044\u3066\u306f\u4f9d\u7136\u3068\u3057\u3066\u4e0d\u900f\u660e\u3067\u3042\u308b\u3002 TRAVERSE\u8a66\u9a13\u3068\u4f75\u305b\u3066\u691c\u8a0e\u3059\u308b\u3068\u3001\u6700\u3082\u59a5\u5f53\u306a\u89e3\u91c8\u306f\u3001\u4e2d\u7a0b\u5ea6\u306e\u8ffd\u8de1\u671f\u9593\u306b\u304a\u3044\u3066\u306f\u3001\u751f\u7406\u5b66\u7684\u56de\u5fa9\u304c\u81e8\u5e8a\u7684\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u5897\u52a0\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u306f\u793a\u3055\u308c\u3066\u3044\u306a\u3044\u4e00\u65b9\u3067\u3001\u30d7\u30e9\u30fc\u30af\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306e\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u304b\u3089\u306f\u3001\u7d99\u7d9a\u7684\u306a\u7d4c\u904e\u89b3\u5bdf\u3092\u5fc5\u8981\u3068\u3059\u308b\u5146\u5019\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3042\u308b\u3002.<\/p>\n

6.5 \u8d64\u8840\u7403\u5897\u52a0\u75c7\u3068\u8840\u6813\u30ea\u30b9\u30af<\/h4>\n

TRT\u306b\u304a\u3044\u3066\u6700\u3082\u4e00\u8cab\u3057\u3066\u518d\u73fe\u6027\u306e\u3042\u308b\u5fc3\u8840\u7ba1\u7cfb\u306e\u6709\u5bb3\u4e8b\u8c61\u306f\u3001\u8d64\u8840\u7403\u5897\u52a0\u75c7\u3067\u3042\u308b\u3002\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306f\u3001\u9aa8\u9ac4\u3078\u306e\u76f4\u63a5\u7684\u306a\u4f5c\u7528\u3068\u30a8\u30ea\u30b9\u30ed\u30dd\u30a8\u30c1\u30f3\u7523\u751f\u306e\u5897\u52a0\u306e\u4e21\u65b9\u3092\u901a\u3058\u3066\u8d64\u8840\u7403\u751f\u6210\u3092\u523a\u6fc0\u3059\u308b\u304c\u3001\u305d\u306e\u4f5c\u7528\u306e\u7a0b\u5ea6\u306f\u88fd\u5264\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u3002\u6ce8\u5c04\u7528\u30a8\u30b9\u30c6\u30eb\u88fd\u5264\u306f\u8840\u4e2d\u6fc3\u5ea6\u304c\u30d4\u30fc\u30af\u306b\u9054\u3057\u305f\u6642\u70b9\u3067\u6700\u5927\u306e\u5897\u52a0\u3092\u3082\u305f\u3089\u3057\u3001\u7d4c\u76ae\u5438\u53ce\u88fd\u5264\u306f\u6700\u3082\u5c0f\u3055\u3044\u5897\u52a0\u3092\u3082\u305f\u3089\u3059\u3002 \u30d8\u30de\u30c8\u30af\u30ea\u30c3\u30c8\u5024\u304c54\uff05\u3092\u8d85\u3048\u308b\u5834\u5408\u306f\u3001\u4e00\u822c\u7684\u306b\u3001\u7528\u91cf\u306e\u6e1b\u91cf\u3001\u88fd\u5264\u306e\u5909\u66f4\u3001\u3042\u308b\u3044\u306f\u6cbb\u7642\u306e\u4e00\u6642\u4e2d\u65ad\u3092\u884c\u3046\u3079\u304d\u3068\u3055\u308c\u3001\u9589\u585e\u6027\u7761\u7720\u6642\u7121\u547c\u5438\u3084\u8131\u6c34\u75c7\u306a\u3069\u306e\u4ea4\u7d61\u56e0\u5b50\u306e\u6709\u7121\u3092\u78ba\u8a8d\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002.7,54<\/sup><\/p>\n

6.6 \u5fc3\u8840\u7ba1\u75be\u60a3\u5c02\u9580\u533b\u306e\u305f\u3081\u306e\u7dcf\u8aac<\/h4>\n

\u751f\u7406\u7684\u7bc4\u56f2\u306e\u4e0b\u9650\u306b\u3042\u308b\u5185\u56e0\u6027\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u306f\u307b\u307c\u9593\u9055\u3044\u306a\u304f\u3001\u771f\u306e\u751f\u7269\u5b66\u7684\u8106\u5f31\u6027\u3068\u3001\u6709\u5bb3\u306a\u4ee3\u8b1d\u30d5\u30a7\u30ce\u30bf\u30a4\u30d7\u306b\u3088\u308b\u4ea4\u7d61\u56e0\u5b50\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u75c7\u72b6\u3092\u5448\u3059\u308b\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u306e\u7537\u6027\u306b\u304a\u3044\u3066\u3001\u9069\u5207\u306a\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u306e\u4e0b\u3067\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3092\u751f\u7406\u7684\u7bc4\u56f2\u307e\u3067\u56de\u5fa9\u3055\u305b\u305f\u5834\u5408\u3001\u8abf\u67fb\u5bfe\u8c61\u3068\u306a\u3063\u305f\u8ffd\u8de1\u671f\u9593\u306b\u304a\u3044\u3066\u3001\u4e3b\u8981\u306a\u5fc3\u8840\u7ba1\u6709\u5bb3\u4e8b\u8c61\u306e\u5897\u52a0\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002 \u8d64\u8840\u7403\u5897\u52a0\u75c7\u306b\u3064\u3044\u3066\u306f\u3001\u7d4c\u904e\u89b3\u5bdf\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002\u5f93\u6765\u306e\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u56e0\u5b50\uff08ApoB\u306e\u4f4e\u4e0b\u3001\u8840\u5727\u7ba1\u7406\u3001\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3001\u7981\u7159\u3001\u8eab\u4f53\u6d3b\u52d5\uff09\u306b\u5bfe\u3059\u308b\u96c6\u4e2d\u7684\u306a\u7ba1\u7406\u304c\u3001\u4f9d\u7136\u3068\u3057\u3066\u4e3b\u8981\u306a\u5fc3\u8840\u7ba1\u4ecb\u5165\u3067\u3042\u308b\u3002\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u88dc\u5145\u7642\u6cd5\u306f\u3001\u305d\u308c\u81ea\u4f53\u304c\u72ec\u7acb\u3057\u305f\u5fc3\u8840\u7ba1\u6cbb\u7642\u6cd5\u3068\u3044\u3046\u3088\u308a\u306f\u3001\u7279\u5b9a\u306e\u6b20\u4e4f\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306e\u88dc\u52a9\u7642\u6cd5\u3067\u3042\u308b\u3002.<\/p>\n

7. \u6027\u6b32\uff1a\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u6b20\u4e4f\u75c7\u306b\u304a\u3044\u3066\u8a3a\u65ad\u4e0a\u6700\u3082\u6709\u7528\u306a\u75c7\u72b6<\/h3>\n

\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u4f4e\u5024\u306b\u8d77\u56e0\u3059\u308b\u3068\u3055\u308c\u308b\u3042\u3089\u3086\u308b\u75c7\u72b6\u306e\u4e2d\u3067\u3001\u6027\u6b32\u306e\u4f4e\u4e0b\u306f\u3001\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u306e\u72b6\u614b\u3068\u6700\u3082\u78ba\u5b9f\u304b\u3064\u7279\u7570\u7684\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3082\u306e\u3067\u3059\u3002\u3053\u308c\u306f\u4e9b\u7d30\u306a\u70b9\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u52a0\u9f62\u3084\u4ee3\u8b1d\u6027\u75be\u60a3\u306b\u3057\u3070\u3057\u3070\u4f34\u3046\u975e\u7279\u7570\u7684\u306a\u8a34\u3048\u3092\u7cbe\u67fb\u3059\u308b\u969b\u3001\u81e8\u5e8a\u533b\u306b\u3068\u3063\u3066\u6700\u3082\u6709\u7528\u306a\u8a3a\u65ad\u306e\u6307\u91dd\u3068\u306a\u308b\u304b\u3089\u3067\u3059\u3002 \u306a\u304a\u3001\u5185\u5206\u6ccc\u5b66\u4f1a\u306f\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u6b20\u4e4f\u3068\u4e00\u81f4\u3059\u308b\u75c7\u72b6\u304c\u3042\u308a\u3001\u304b\u3064\u5c11\u306a\u304f\u3068\u30822\u56de\u306e\u5225\u3005\u306e\u671d\u306e\u6e2c\u5b9a\u3067\u660e\u78ba\u304b\u3064\u4e00\u8cab\u3057\u3066\u4f4e\u3044\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u6fc3\u5ea6\u304c\u78ba\u8a8d\u3055\u308c\u305f\u7537\u6027\u306e\u307f\u306b\u3001\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u306e\u8a3a\u65ad\u3092\u4e0b\u3059\u3053\u3068\u3092\u63a8\u5968\u3057\u3066\u3044\u308b\u70b9\u306b\u7559\u610f\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3002\u75c7\u72b6\u306e\u6709\u7121\u3060\u3051\u3067\u306f\u4e0d\u5341\u5206\u3067\u3042\u308b\u3002.7<\/sup><\/p>\n

7.1 \u6027\u6b32\u6e1b\u9000\u304c\u8a3a\u65ad\u4e0a\u6700\u3082\u6709\u7528\u306a\u75c7\u72b6\u3067\u3042\u308b\u7406\u7531<\/h4>\n

\u30c8\u30e9\u30f4\u30a3\u30bd\u30f3\u3089\u306f\u3001\u300c\u30de\u30b5\u30c1\u30e5\u30fc\u30bb\u30c3\u30c4\u7537\u6027\u52a0\u9f62\u7814\u7a76\u300d\u306e\u30c7\u30fc\u30bf\u3092\u5206\u6790\u3057\u3001\u751f\u4f53\u5229\u7528\u80fd\u306e\u3042\u308b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3068\u6027\u6b32\u306e\u9593\u306b\u306f\u3001\u751f\u7406\u7684\u7bc4\u56f2\u5168\u4f53\u306b\u308f\u305f\u3063\u3066\u6bb5\u968e\u7684\u306a\u76f8\u95a2\u95a2\u4fc2\u304c\u8a8d\u3081\u3089\u308c\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3057\u305f\u3002\u4e00\u65b9\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3068\u52c3\u8d77\u6a5f\u80fd\u3068\u306e\u95a2\u4fc2\u306f\u3001\u305d\u308c\u307b\u3069\u4e00\u8cab\u6027\u304c\u306a\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002.29<\/sup> EMAS\u306f\u3001\u5e74\u9f62\u306e\u5f71\u97ff\u3092\u8003\u616e\u3057\u305f\u4e0a\u3067\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u306e\u4f4e\u4e0b\u3068\u76f8\u95a2\u3057\u3001\u304b\u3064\u59a5\u5f53\u306a\u7279\u7570\u5ea6\u3092\u793a\u3059\u552f\u4e00\u306e\u75c7\u72b6\u3068\u3057\u3066\u30013\u3064\u306e\u6027\u7684\u75c7\u72b6\uff08\u671d\u306e\u52c3\u8d77\u4e0d\u5168\u3001\u6027\u6b32\u6e1b\u9000\u3001\u52c3\u8d77\u969c\u5bb3\uff09\u3092\u72ec\u81ea\u306b\u7279\u5b9a\u3057\u305f\u3002.11<\/sup> \u3053\u306e3\u3064\u306e\u3046\u3061\u3001\u6027\u6b32\u306e\u4f4e\u4e0b\u306f\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u72b6\u614b\u3068\u6700\u3082\u7279\u7570\u7684\u306a\u95a2\u9023\u6027\u304c\u3042\u308b\u3002\u52c3\u8d77\u969c\u5bb3\u306f\u3001\u8840\u7ba1\u6027\u3001\u795e\u7d4c\u6027\u3001\u85ac\u7269\u6027\u306e\u8981\u56e0\u306b\u3088\u308b\u5f71\u97ff\u3092\u5f37\u304f\u53d7\u3051\u3066\u304a\u308a\u3001\u671d\u306e\u52c3\u8d77\u306f\u611f\u5ea6\u304c\u9ad8\u3044\u3082\u306e\u306e\u3001\u7279\u7570\u6027\u306f\u4f4e\u3044\u6307\u6a19\u3067\u3042\u308b\u3002.<\/p>\n

\u7121\u4f5c\u70ba\u5316\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u88dc\u5145\u7642\u6cd5\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u6700\u3082\u4e00\u8cab\u6027\u304c\u9ad8\u304f\u3001\u52b9\u679c\u30b5\u30a4\u30ba\u304c\u6700\u3082\u5927\u304d\u3044\u306e\u306f\u6027\u6b32\u306b\u5bfe\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u300c\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u8a66\u9a13\u6027\u6a5f\u80fd\u30b5\u30d6\u30b9\u30bf\u30c7\u30a3\u300d\uff08Cunningham et al., 2016\uff09\u3067\u306f\u30013\u3064\u306e\u4e3b\u8981\u306a\u6027\u6a5f\u80fd\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u3046\u3061\u3001\u6027\u6b32\u30b9\u30b3\u30a2\u306e\u5411\u4e0a\u306f\u3001\u7537\u6027\u5168\u4f53\u306b\u304a\u3044\u3066\u6700\u3082\u4e00\u8cab\u6027\u304c\u9ad8\u304f\u3001\u304b\u3064\u81e8\u5e8a\u7684\u306b\u3082\u6700\u3082\u610f\u7fa9\u6df1\u3044\u3082\u306e\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002.30<\/sup> TRT\u304c\u6027\u6a5f\u80fd\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306b\u95a2\u3059\u308b\u30e1\u30bf\u5206\u6790\u3067\u3082\u540c\u69d8\u306b\u3001\u6027\u6b32\u304c\u4e3b\u306a\u6307\u6a19\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u52c3\u8d77\u6a5f\u80fd\u3078\u306e\u5f71\u97ff\u306f\u6bd4\u8f03\u7684\u5c0f\u3055\u304f\u3001\u5909\u52d5\u3082\u5927\u304d\u3044\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u308b\u3002.32<\/sup><\/p>\n

7.2 \u60a3\u8005\u306e\u8a34\u3048\u3068\u78ba\u8a8d\u3059\u3079\u304d\u4e8b\u9805<\/h4>\n

\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u6b20\u4e4f\u306b\u3088\u308b\u6027\u6b32\u6e1b\u9000\u3092\u5448\u3059\u308b\u7537\u6027\u306f\u3001\u4ee5\u524d\u306f\u6027\u7684\u601d\u8003\u3084\u884c\u52d5\u306e\u304d\u3063\u304b\u3051\u3068\u306a\u3063\u3066\u3044\u305f\u81ea\u767a\u7684\u306a\u95a2\u5fc3\u304c\u6839\u672c\u7684\u306b\u4f4e\u4e0b\u3057\u305f\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002\u5f7c\u3089\u306f\u3001\u81ea\u767a\u7684\u306b\u30bb\u30c3\u30af\u30b9\u306e\u3053\u3068\u3092\u8003\u3048\u306a\u304f\u306a\u3063\u305f\u3053\u3068\u3001\u901a\u5e38\u306e\u523a\u6fc0\u3092\u6027\u7684\u306b\u523a\u6fc0\u7684\u3060\u3068\u611f\u3058\u306a\u304f\u306a\u3063\u305f\u3053\u3068\u306b\u6c17\u3065\u3044\u3066\u304a\u308a\u3001\u3053\u306e\u5909\u5316\u3092\u300c\u80fd\u529b\u306e\u55aa\u5931\u300d\u3067\u306f\u306a\u304f\u300c\u5185\u767a\u7684\u306a\u885d\u52d5\u306e\u55aa\u5931\u300d\u3068\u3057\u3066\u8868\u73fe\u3059\u308b\u3053\u3068\u304c\u3088\u304f\u3042\u308a\u307e\u3059\u3002 \u7537\u6027\u306f\u901a\u5e38\u3001\u81ea\u8eab\u306e\u904e\u53bb\u306e\u57fa\u6e96\u5024\u3068\u6bd4\u8f03\u3057\u3066\u6027\u6b32\u306b\u5909\u5316\u304c\u3042\u3063\u305f\u304b\u3069\u3046\u304b\u3092\u5831\u544a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u3053\u308c\u306f\u4e00\u822c\u4eba\u53e3\u3092\u57fa\u6e96\u3068\u3057\u305f\u95be\u5024\u3088\u308a\u3082\u8a3a\u65ad\u4e0a\u3001\u6709\u76ca\u306a\u60c5\u5831\u3068\u306a\u308b\u3002.<\/p>\n

\u591c\u9593\u304a\u3088\u3073\u65e9\u671d\u306e\u52c3\u8d77\u306e\u6d88\u5931\u306f\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u3057\u3070\u3057\u3070\u4f75\u305b\u3066\u5831\u544a\u3055\u308c\u308b\u3002\u81e8\u5e8a\u9762\u63a5\u3067\u306f\u3001\u6027\u6b32\u3068\u671d\u306e\u52c3\u8d77\u306e\u4e21\u65b9\u306b\u3064\u3044\u3066\u660e\u78ba\u306b\u5c0b\u306d\u308b\u3079\u304d\u3067\u3042\u308b\u3002\u52c3\u8d77\u6a5f\u80fd\u306b\u3064\u3044\u3066\u306e\u307f\u5c0b\u306d\u308b\u3068\u3001\u8840\u7ba1\u6027\u3001\u795e\u7d4c\u6027\u3001\u85ac\u7406\u5b66\u7684\u3001\u304a\u3088\u3073\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u306b\u3088\u308b\u8981\u56e0\u304c\u6df7\u540c\u3055\u308c\u305f\u56de\u7b54\u304c\u5f97\u3089\u308c\u308b\u304c\u3001\u6027\u6b32\u3068\u671d\u306e\u52c3\u8d77\u306b\u3064\u3044\u3066\u5177\u4f53\u7684\u306b\u5c0b\u306d\u308b\u3053\u3068\u3067\u3001\u3053\u308c\u3089\u3092\u533a\u5225\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002.<\/p>\n

7.3 \u3069\u306e\u3088\u3046\u306a\u6027\u7684\u75c7\u72b6\u304c\u4e88\u6e2c\u56e0\u5b50\u3068\u306a\u3089\u306a\u3044\u304b<\/h4>\n

\u6027\u6b32\u306e\u4f4e\u4e0b\u3092\u4f34\u308f\u306a\u3044\u52c3\u8d77\u4e0d\u5168\u306f\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u88dc\u5145\u7642\u6cd5\u306e\u307f\u3067\u306f\u6539\u5584\u3055\u308c\u308b\u3053\u3068\u306f\u3081\u3063\u305f\u306b\u3042\u308a\u307e\u305b\u3093\u3002\u5b64\u7acb\u6027\u52c3\u8d77\u4e0d\u5168\u3092\u5448\u3057\u3001\u751f\u4f53\u5229\u7528\u53ef\u80fd\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u304c\u660e\u3089\u304b\u306b\u6b63\u5e38\u3067\u3042\u308b\u7537\u6027\u306b\u304a\u3044\u3066\u3001\u9451\u5225\u8a3a\u65ad\u306e\u4e3b\u306a\u5bfe\u8c61\u3068\u306a\u308b\u306e\u306f\u3001\u8840\u7ba1\u75be\u60a3\uff08\u591a\u304f\u306e\u5834\u5408\u3001\u5168\u8eab\u6027\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306e\u6700\u521d\u306e\u75c7\u72b6\uff09\u3001\u795e\u7d4c\u6027\u8981\u56e0\u3001\u964d\u5727\u85ac\u3001\u6297\u3046\u3064\u85ac\u3001\u304a\u3088\u3073\u5fc3\u7406\u7684\u8981\u56e0\u3067\u3059\u3002 \u3053\u3046\u3057\u305f\u60a3\u8005\u306b\u5bfe\u3057\u3066\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u7642\u6cd5\u3092\u884c\u3063\u3066\u3082\u3001\u52b9\u679c\u304c\u5f97\u3089\u308c\u308b\u3053\u3068\u306f\u307b\u3068\u3093\u3069\u306a\u304f\u3001\u76f8\u5fdc\u306e\u5229\u76ca\u304c\u306a\u3044\u307e\u307e\u88dc\u5145\u7642\u6cd5\u306e\u526f\u4f5c\u7528\u306b\u3055\u3089\u3055\u308c\u308b\u3053\u3068\u306b\u306a\u308b\u3002.32,33<\/sup><\/p>\n

8. \u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u6b20\u4e4f\u75c7\u306e\u305d\u306e\u4ed6\u306e\u75c7\u72b6<\/h3>\n

\u6027\u6a5f\u80fd\u306e\u75c7\u72b6\u4ee5\u5916\u306b\u3082\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u6b20\u4e4f\u75c7\u5019\u7fa4\u306b\u306f\u3001\u8eab\u4f53\u7684\u3001\u4ee3\u8b1d\u7684\u3001\u5fc3\u7406\u7684\u306a\u7279\u5fb4\u304c\u898b\u3089\u308c\u307e\u3059\u3002\u6027\u6b32\u6e1b\u9000\u307b\u3069\u7279\u7570\u7684\u306a\u75c7\u72b6\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u9069\u5207\u306a\u81e8\u5e8a\u7684\u72b6\u6cc1\u4e0b\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u75c7\u72b6\u304c\u8a3a\u65ad\u3092\u88cf\u4ed8\u3051\u308b\u3082\u306e\u3068\u306a\u308a\u307e\u3059\u3002.<\/p>\n

8.1 \u4f53\u7d44\u6210\u3068\u4ee3\u8b1d<\/h4>\n

\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u306e\u7537\u6027\u3067\u306f\u3001\u5185\u81d3\u8102\u80aa\u304c\u84c4\u7a4d\u3057\u3001\u9664\u8102\u80aa\u7b4b\u8089\u91cf\u304c\u6e1b\u5c11\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u305d\u308c\u306b\u4f34\u3063\u3066\u7b4b\u529b\u3082\u4f4e\u4e0b\u3059\u308b\u3002.20,21,49,60<\/sup> \u3053\u308c\u306f\u3001\u4e00\u90e8\u306b\u306f\u7b4b\u8089\u3084\u8102\u80aa\u7d44\u7e54\u306b\u304a\u3051\u308b\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u55aa\u5931\u304c\u76f4\u63a5\u7684\u306a\u539f\u56e0\u3067\u3042\u308a\u3001\u307e\u305f\u4e00\u90e8\u306b\u306f\u3001\u80a5\u6e80\u306b\u8d77\u56e0\u3059\u308b\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u304c\u767a\u75c7\u3059\u308b\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u306e\u72b6\u614b\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308b\u3002.59<\/sup> \u80a5\u6e80\u304b\u3064\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u306e\u7537\u6027\u3092\u5bfe\u8c61\u3068\u3057\u305f\u9577\u671f\u306e\u7f6e\u63db\u7642\u6cd5\u7814\u7a76\u3067\u306f\u3001\u30a6\u30a8\u30b9\u30c8\u5468\u56f2\u5f84\u3001\u4f53\u91cd\u3001\u304a\u3088\u3073HbA1c\u306e\u6709\u610f\u306a\u6e1b\u5c11\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u3053\u308c\u3089\u306e\u52b9\u679c\u306f\u3001\u96c6\u4e2d\u7684\u306a\u751f\u6d3b\u7fd2\u6163\u4ecb\u5165\u306b\u3088\u3063\u3066\u5f97\u3089\u308c\u308b\u52b9\u679c\u306b\u6bd4\u3079\u3066\u63a7\u3048\u3081\u306a\u5834\u5408\u304c\u591a\u3044\u304c\u3001\u305d\u308c\u3089\u3068\u76f8\u4e57\u7684\u306b\u4f5c\u7528\u3059\u308b\u3088\u3046\u3060\u3002.49<\/sup><\/p>\n

8.2 \u9aa8<\/h4>\n

\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306f\u3001\u4e00\u90e8\u304c\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb\u3078\u306e\u82b3\u9999\u5316\u3092\u901a\u3058\u3066\u3001\u7537\u6027\u306e\u9aa8\u5bc6\u5ea6\u3092\u7dad\u6301\u30fb\u5411\u4e0a\u3055\u305b\u308b\u50cd\u304d\u304c\u3042\u308a\u307e\u3059\u3002\u300c\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u30fb\u30c8\u30e9\u30a4\u30a2\u30eb\u300d\u306e\u9aa8\u306b\u95a2\u3059\u308b\u30b5\u30d6\u30b9\u30bf\u30c7\u30a3\u3067\u306f\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u304c\u4f4e\u3044\u9ad8\u9f62\u7537\u6027\u3092\u5bfe\u8c61\u306b\u30011\u5e74\u9593\u306e\u88dc\u5145\u7642\u6cd5\u3092\u884c\u3063\u305f\u7d50\u679c\u3001\u4f53\u7a4d\u9aa8\u5bc6\u5ea6\u304a\u3088\u3073\u63a8\u5b9a\u9aa8\u5f37\u5ea6\u306b\u6709\u610f\u306a\u5411\u4e0a\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002.46<\/sup><\/p>\n

8.3 \u8ca7\u8840<\/h4>\n

\u672a\u6cbb\u7642\u306e\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u3067\u306f\u3001\u8efd\u5ea6\u306e\u8ca7\u8840\u304c\u3088\u304f\u898b\u3089\u308c\u308b\u3002\u300c\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u8a66\u9a13\u300d\u306e\u8ca7\u8840\u306b\u95a2\u3059\u308b\u30b5\u30d6\u30b9\u30bf\u30c7\u30a3\u3067\u306f\u3001\u6cbb\u7642\u3092\u53d7\u3051\u305f\u7537\u6027\u306e\u304b\u306a\u308a\u306e\u5272\u5408\u3067\u8ca7\u8840\u304c\u6539\u5584\u3057\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u4e2d\u306b\u306f\u4ed6\u306e\u660e\u78ba\u306a\u539f\u56e0\u304c\u7279\u5b9a\u3067\u304d\u306a\u3044\u75c7\u4f8b\u3082\u542b\u307e\u308c\u3066\u3044\u305f\u3002.47<\/sup><\/p>\n

8.4 \u6c17\u5206\u3001\u52d5\u6a5f\u4ed8\u3051\u3001\u304a\u3088\u3073\u8a8d\u77e5<\/h4>\n

\u591a\u304f\u306e\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u306e\u7537\u6027\u304b\u3089\u3001\u6c17\u5206\u306e\u843d\u3061\u8fbc\u307f\u3001\u30a4\u30e9\u30a4\u30e9\u3001\u6d3b\u529b\u306e\u4f4e\u4e0b\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u30db\u30eb\u30e2\u30f3\u88dc\u5145\u7642\u6cd5\u306b\u3088\u308a\u3053\u308c\u3089\u306e\u75c7\u72b6\u306f\u591a\u5c11\u6539\u5584\u3059\u308b\u50be\u5411\u306b\u3042\u308b\u3002\u305f\u3060\u3057\u3001\u3053\u308c\u3089\u306e\u75c7\u72b6\u306b\u306f\u4ed6\u306b\u3082\u591a\u304f\u306e\u539f\u56e0\u304c\u3042\u308a\u3001\u305d\u308c\u3060\u3051\u3067\u306f\u8a3a\u65ad\u306e\u6839\u62e0\u3068\u3059\u3079\u304d\u3067\u306f\u306a\u3044\u3002.7,33<\/sup> \u8efd\u5ea6\u306e\u8a18\u61b6\u969c\u5bb3\u3092\u8a34\u3048\u308b\u9ad8\u9f62\u7537\u6027\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u88dc\u5145\u7642\u6cd5\u306e\u8a8d\u77e5\u6a5f\u80fd\u3078\u306e\u5f71\u97ff\u306f\u5c0f\u3055\u304f\u3001\u7d50\u679c\u3082\u4e00\u8cab\u3057\u3066\u3044\u306a\u304b\u3063\u305f\u3002.57<\/sup><\/p>\n

9. \u6e2c\u5b9a\uff1a\u6709\u52b9\u306a\u624b\u6cd5\u3068\u8aa4\u89e3\u3092\u62db\u304f\u624b\u6cd5<\/h3>\n

9.1 \u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3<\/h4>\n

\u5185\u5206\u6ccc\u5b66\u4f1a\u304a\u3088\u3073CDC\u30db\u30eb\u30e2\u30f3\u6a19\u6e96\u5316\u30d7\u30ed\u30b0\u30e9\u30e0\u306f\u300110\u5e74\u4ee5\u4e0a\u306b\u308f\u305f\u308a\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u6e2c\u5b9a\u3001\u7279\u306b\u8a3a\u65ad\u4e0a\u91cd\u8981\u306a\u4f4e\u6fc3\u5ea6\u57df\u306b\u304a\u3044\u3066\u3001LC-MS\/MS\u3092\u6a19\u6e96\u6cd5\u3068\u3057\u3066\u63a8\u5968\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u5f93\u6765\u306e\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3092\u7528\u3044\u305f\u514d\u75ab\u6e2c\u5b9a\u6cd5\u306f\u3001\u6210\u4eba\u7537\u6027\u306e\u4e2d\uff5e\u9ad8\u6fc3\u5ea6\u57df\u3067\u306f\u4fe1\u983c\u6027\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u4f4e\u6fc3\u5ea6\u57df\u3067\u306f\u304b\u306a\u308a\u306e\u8aa4\u5dee\u304c\u751f\u3058\u308b\u305f\u3081\u3001\u5973\u6027\u3078\u306e\u9069\u7528\u306f\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002.26,27<\/sup><\/p>\n

\u691c\u4f53\u524d\u8981\u56e0\u306f\u91cd\u8981\u3067\u3059\u3002\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u306f\u3001\u671d\u306b\u9855\u8457\u306a\u30d4\u30fc\u30af\u3092\u793a\u3057\u3001\u5348\u5f8c\u306b\u306f\u8c37\u5024\u304c\u4f4e\u304f\u306a\u308a\u307e\u3059\u304c\u3001\u9ad8\u9f62\u7537\u6027\u3067\u306f\u3053\u306e\u65e5\u5468\u5909\u52d5\u306e\u632f\u5e45\u304c\u5f31\u307e\u308a\u307e\u3059\u3002\u4f4e\u30b4\u30ca\u30c9\u30c8\u30ed\u30d4\u30f3\u75c7\u306e\u8a3a\u65ad\u3092\u78ba\u5b9a\u3059\u308b\u524d\u306b\u3001\u5c11\u306a\u304f\u3068\u30822\u56de\u3001\u5348\u524d7\u6642\u304b\u308910\u6642\u306e\u9593\u306b\u7a7a\u8179\u72b6\u614b\u3067\u63a1\u8840\u3092\u884c\u3046\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002 \u6025\u6027\u75be\u60a3\u3001\u76f4\u8fd1\u306e\u6fc0\u3057\u3044\u904b\u52d5\u3001\u304a\u3088\u3073\u76f4\u8fd1\u306e\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u306f\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u3092\u4e00\u6642\u7684\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u5358\u72ec\u3067\u4f4e\u3044\u6570\u5024\u304c\u8a8d\u3081\u3089\u308c\u305f\u5834\u5408\u306f\u3001\u3053\u308c\u3089\u306e\u8981\u56e0\u3092\u8003\u616e\u3057\u305f\u4e0a\u3067\u7d50\u679c\u3092\u89e3\u91c8\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002.<\/p>\n

9.2 \u904a\u96e2\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\uff1a\u6e2c\u5b9a\u6cd5\u3001\u9806\u4f4d\u4ed8\u3051<\/h4>\n

\u904a\u96e2\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u76f4\u63a5\u30a2\u30ca\u30ed\u30b0\u514d\u75ab\u6e2c\u5b9a\u6cd5\u306f\u4fe1\u983c\u6027\u304c\u4f4e\u304f\u3001\u4e3b\u8981\u306a\u5185\u5206\u6ccc\u5b66\u4f1a\u304a\u3088\u3073\u7537\u6027\u5b66\u5b66\u4f1a\u304b\u3089\u306f\u660e\u78ba\u306b\u63a8\u5968\u3055\u308c\u3066\u3044\u306a\u3044\u3002.26,27<\/sup> \u3053\u308c\u3089\u306e\u6e2c\u5b9a\u6cd5\u3067\u306f\u3001\u771f\u306e\u904a\u96e2\u5206\u753b\u5024\u304b\u3089\u6570\u500d\u3082\u306e\u3070\u3089\u3064\u304d\u304c\u751f\u3058\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u6e2c\u5b9a\u7d50\u679c\u304c\u6700\u3082\u91cd\u8981\u3068\u306a\u308b\u96c6\u56e3\uff08SHBG\u306b\u7570\u5e38\u304c\u898b\u3089\u308c\u308b\u7537\u6027\uff09\u306b\u304a\u3044\u3066\u3001\u8aa4\u5dee\u304c\u6700\u5927\u3068\u306a\u308b\u3002.<\/p>\n

\u5e73\u8861\u900f\u6790\u3068\u305d\u308c\u306b\u7d9a\u304fLC-MS\/MS\u304c\u6a19\u6e96\u6cd5\u3067\u3042\u308b\u3002\u8840\u6e05\u30b5\u30f3\u30d7\u30eb\u3092\u534a\u900f\u819c\u3092\u4ecb\u3057\u3066\u7de9\u885d\u6db2\u3068\u900f\u6790\u3057\u3001\u904a\u96e2\u30db\u30eb\u30e2\u30f3\u3060\u3051\u304c\u819c\u3092\u901a\u904e\u3059\u308b\u3002\u305d\u306e\u5f8c\u3001\u900f\u6790\u6db2\u4e2d\u306e\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3092\u8cea\u91cf\u5206\u6790\u6cd5\u3067\u6e2c\u5b9a\u3059\u308b\u3002\u3053\u308c\u306f\u30b4\u30fc\u30eb\u30c9\u30b9\u30bf\u30f3\u30c0\u30fc\u30c9\u3067\u3042\u308b\u304c\u3001\u624b\u9593\u304c\u304b\u304b\u308a\u3001\u5e83\u304f\u5229\u7528\u3055\u308c\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3002.3,28<\/sup><\/p>\n

\u30f4\u30a7\u30eb\u30df\u30e5\u30fc\u30ec\u30f3\u306e\u5f0f\u3092\u7528\u3044\u3066\u7b97\u51fa\u3057\u305f\u904a\u96e2\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306f\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u304a\u3088\u3073SHBG\u304c\u6b63\u78ba\u306a\u6e2c\u5b9a\u6cd5\u306b\u3088\u3063\u3066\u6e2c\u5b9a\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u524d\u63d0\u3068\u3057\u3066\u3001\u5e73\u8861\u900f\u6790\u6cd5\u3068\u6975\u3081\u3066\u826f\u597d\u306a\u4e00\u81f4\u3092\u793a\u3057\u3066\u3044\u308b\uff08\u9069\u5207\u306b\u5b9f\u65bd\u3055\u308c\u305f\u6bd4\u8f03\u7814\u7a76\u306b\u304a\u3051\u308b\u76f8\u95a2\u4fc2\u6570 r \u2248 0.99\uff09\u3002.3,28<\/sup> \u3053\u306e\u8a08\u7b97\u6cd5\u306f\u3001\u307b\u3068\u3093\u3069\u306e\u81e8\u5e8a\u533b\u304c\u63a1\u7528\u3059\u3079\u304d\u5b9f\u7528\u7684\u306a\u624b\u6cd5\u3067\u3042\u308b\u3002\u3088\u308a\u65b0\u3057\u3044\u30b4\u30fc\u30eb\u30c9\u30de\u30f3\u3089\u306b\u3088\u308b\u591a\u6bb5\u968e\u30a2\u30ed\u30b9\u30c6\u30ea\u30c3\u30af\u30e2\u30c7\u30eb\u306f\u3001SHBG\u6fc3\u5ea6\u304c\u6975\u7aef\u306a\u5834\u5408\u306b\u304a\u3051\u308b\u7cbe\u5ea6\u3092\u5411\u4e0a\u3055\u305b\u308b\u304c\u3001\u73fe\u6642\u70b9\u3067\u306f\u307e\u3060\u65e5\u5e38\u7684\u306b\u5229\u7528\u53ef\u80fd\u3067\u306f\u306a\u3044\u3002.2<\/sup><\/p>\n

\u88683. \u904a\u96e2\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u6e2c\u5b9a\u307e\u305f\u306f\u63a8\u5b9a\u65b9\u6cd5<\/em><\/strong><\/p>\n\n\n\n\n\n\n\n
\u65b9\u6cd5<\/strong><\/td>\n\u7cbe\u5ea6<\/strong><\/td>\n\u5b9f\u7528\u4f8b<\/strong><\/td>\n\u5236\u9650<\/strong><\/td>\n<\/tr>\n
\u76f4\u63a5\u30a2\u30ca\u30ed\u30b0\u514d\u75ab\u6e2c\u5b9a\u6cd5<\/td>\n\u8ca7\u3057\u3044<\/td>\n\u304a\u52e7\u3081\u3057\u307e\u305b\u3093<\/td>\nSHBG\u5024\u304c\u4f4e\u3044\u5834\u5408\u304a\u3088\u3073\u9ad8\u3044\u5834\u5408\u306b\u304a\u3044\u3066\u3001\u7cbe\u5ea6\u304c\u8457\u3057\u304f\u4f4e\u4e0b\u3059\u308b\u3002\u6e2c\u5b9a\u7d50\u679c\u304c\u6700\u3082\u91cd\u8981\u3068\u306a\u308b\u96c6\u56e3\u306b\u304a\u3044\u3066\u3001\u8aa4\u5dee\u304c\u6700\u5927\u3068\u306a\u308b\u3002<\/td>\n<\/tr>\n
\u5e73\u8861\u900f\u6790\uff0bLC-MS\/MS<\/td>\n\u53c2\u7167\u6a19\u6e96<\/td>\n\u7814\u7a76\u304a\u3088\u3073\u8a3a\u65ad\u304c\u56f0\u96e3\u306a\u75c7\u4f8b<\/td>\n\u624b\u9593\u304c\u304b\u304b\u308a\u3001\u6642\u9593\u304c\u304b\u304b\u308a\u3001\u8cbb\u7528\u3082\u9ad8\u304f\u3001\u901a\u5e38\u306e\u81e8\u5e8a\u691c\u67fb\u5ba4\u3067\u306f\u5e83\u304f\u5229\u7528\u3055\u308c\u3066\u3044\u306a\u3044<\/td>\n<\/tr>\n
\u30f4\u30a7\u30eb\u30e0\u30fc\u30ec\u30f3\u306f\u81ea\u7531T\u3092\u8a08\u7b97\u3057\u305f<\/td>\n\u9ad8\u3044\uff08r \u2248 0.99\u3001\u5e73\u8861\u900f\u6790\u6cd5\u3068\u306e\u6bd4\u8f03\uff09<\/td>\n\u65e5\u5e38\u7684\u306a\u81e8\u5e8a\u3067\u306e\u4f7f\u7528<\/td>\n\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u304a\u3088\u3073SHBG\u306e\u6fc3\u5ea6\u306b\u4f9d\u5b58\u3059\u308b\u3002SHBG\u306e\u6fc3\u5ea6\u304c\u6975\u7aef\u306a\u5834\u5408\u3001\u7cbe\u5ea6\u306f\u4f4e\u4e0b\u3059\u308b\u3002<\/td>\n<\/tr>\n
\u30b4\u30fc\u30eb\u30c9\u30de\u30f3\u306e\u591a\u6bb5\u968e\u30a2\u30ed\u30b9\u30c6\u30ea\u30c3\u30af\u30e2\u30c7\u30eb<\/td>\nSHBG\u306e\u6975\u5024\u306b\u304a\u3051\u308b\u6700\u9ad8\u5024<\/td>\n\u9078\u5b9a\u3055\u308c\u305f\u96e3\u75c7\u4f8b<\/td>\n\u65e5\u5e38\u7684\u306a\u81e8\u5e8a\u691c\u67fb\u30b7\u30b9\u30c6\u30e0\u3067\u306f\u3001\u307e\u3060\u5e83\u304f\u5c0e\u5165\u3055\u308c\u3066\u3044\u306a\u3044<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

10. \u751f\u4f53\u5229\u7528\u53ef\u80fd\u306a\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u56de\u5fa9\uff1a\u85ac\u7406\u5b66<\/h3>\n

10.1 \u6cbb\u7642\u6a19\u7684<\/h4>\n

\u88dc\u5145\u7642\u6cd5\u306e\u76ee\u7684\u306f\u3001\u5065\u5eb7\u306a\u82e5\u5e74\u7537\u6027\u306e\u751f\u5316\u5b66\u7684\u6307\u6a19\u3092\u751f\u7406\u7684\u7bc4\u56f2\u5185\u306b\u7dad\u6301\u3057\u3064\u3064\u3001\u75c7\u72b6\uff08\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3068\u3057\u3066\u6027\u6b32\uff09\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u3067\u3042\u308b\u3002 \u5185\u5206\u6ccc\u5b66\u4f1a\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u5024\u3092\u6b63\u5e38\u5024\u306e\u4e2d\u9593\u7bc4\u56f2\u3001\u901a\u5e38400\uff5e700 ng\/dL\uff0814\uff5e24 nmol\/L\uff09\u3068\u3057\u3001\u3053\u308c\u306b\u5bfe\u5fdc\u3059\u308b\u904a\u96e2\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3082\u6b63\u5e38\u5024\u306e\u4e2d\u9593\u7bc4\u56f2\u5185\u3068\u3059\u308b\u3053\u3068\u3092\u76ee\u6a19\u3068\u3057\u3066\u3044\u308b\u3002.7<\/sup> SHBG\u5024\u304c\u4e0a\u6607\u3057\u3066\u3044\u308b\u7537\u6027\u306e\u5834\u5408\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u76ee\u6a19\u5024\u306f\u614e\u91cd\u306b\u89e3\u91c8\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3067\u306f\u306a\u304f\u3001\u751f\u7269\u5b66\u7684\u5229\u7528\u80fd\u306e\u3042\u308b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3092\u57fa\u6e96\u3068\u3057\u3066\u6295\u4e0e\u91cf\u306e\u8abf\u6574\u3092\u884c\u3046\u3079\u304d\u3067\u3059\u3002.<\/p>\n

10.2 \u88fd\u5264<\/h4>\n

\u5916\u7528\u30b8\u30a7\u30eb\u3084\u6eb6\u6db2\u306f\u3001\u751f\u7406\u7684\u306a\u6982\u65e5\u30ea\u30ba\u30e0\u306b\u8fd1\u3044\u5b89\u5b9a\u3057\u305f\u8840\u4e2d\u6fc3\u5ea6\u3092\u7dad\u6301\u3057\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u591a\u304f\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u304a\u3044\u3066\u7b2c\u4e00\u9078\u629e\u85ac\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u4e00\u65b9\u3067\u3001\u6bce\u65e5\u306e\u5857\u5e03\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u3001\u8efd\u5ea6\u306e\u76ae\u819a\u53cd\u5fdc\u304c\u751f\u3058\u308b\u3053\u3068\u3001\u305d\u3057\u3066\u4ed6\u8005\u3078\u306e\u611f\u67d3\u30ea\u30b9\u30af\u306f\u5c0f\u3055\u3044\u3082\u306e\u306e\u78ba\u304b\u306b\u5b58\u5728\u3059\u308b\u3053\u3068\u3068\u3044\u3063\u305f\u30c8\u30ec\u30fc\u30c9\u30aa\u30d5\u304c\u3042\u308a\u307e\u3059\u3002.7<\/sup><\/p>\n

\u7b4b\u8089\u5185\u6295\u4e0e\u7528\u306e\u30a8\u30b9\u30c6\u30eb\u88fd\u5264\uff08\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u30fb\u30b5\u30a4\u30d4\u30aa\u30cd\u30fc\u30c8\u307e\u305f\u306f\u30a8\u30ca\u30f3\u30c8\u9178\u30a8\u30b9\u30c6\u30eb\uff09\u306f\u3001\u5b89\u4fa1\u3067\u52b9\u679c\u7684\u3067\u3059\u3002 1\uff5e2\u9031\u9593\u3054\u3068\u306b100\uff5e200 mg\u3092\u6295\u4e0e\u3059\u308b\u5f93\u6765\u306e\u6295\u4e0e\u6cd5\u3067\u306f\u3001\u8840\u4e2d\u6fc3\u5ea6\u306e\u5927\u304d\u306a\u30d4\u30fc\u30af\u3068\u8c37\u304c\u751f\u3058\u307e\u3059\u3002\u73fe\u5728\u3067\u306f\u3001\u591a\u304f\u306e\u81e8\u5e8a\u533b\u304c\u3001\u85ac\u7269\u52d5\u614b\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u5e73\u5766\u5316\u3057\u3001\u30d8\u30de\u30c8\u30af\u30ea\u30c3\u30c8\u5024\u306e\u5909\u52d5\u3092\u6291\u5236\u3059\u308b\u305f\u3081\u306b\u3001\u3088\u308a\u5c11\u91cf\u3067\u983b\u56de\u306a\u6ce8\u5c04\uff08\u4f8b\u3048\u3070\u3001\u90312\u56de50\uff5e80 mg\u3001\u591a\u304f\u306e\u5834\u5408\u76ae\u4e0b\u6295\u4e0e\uff09\u3092\u597d\u3093\u3067\u3044\u307e\u3059\u3002.7,8<\/sup><\/p>\n

\u9577\u6642\u9593\u4f5c\u7528\u578b\u306e\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u30a6\u30f3\u30c7\u30ab\u30ce\u30a8\u30fc\u30c8\u306f\u3001\u521d\u671f\u6295\u4e0e\u671f\u9593\u3092\u7d4c\u3066\u304b\u308910\uff5e14\u9031\u9593\u3054\u3068\u306b\u6df1\u90e8\u7b4b\u8089\u5185\u6ce8\u5c04\u306b\u3088\u308a\u6295\u4e0e\u3055\u308c\u3001\u8840\u4e2d\u6fc3\u5ea6\u3092\u5b89\u5b9a\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u7c73\u56fd\u4ee5\u5916\u3067\u306f\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u3002\u4e00\u65b9\u3001\u7c73\u56fd\u306e\u88fd\u5264\u306b\u3064\u3044\u3066\u306f\u3001\u904e\u53bb\u306b\u306f\u307e\u308c\u3067\u306f\u3042\u308b\u304c\u80ba\u6cb9\u5fae\u5c0f\u585e\u6813\u75c7\u306e\u30ea\u30b9\u30af\u304c\u3042\u308b\u305f\u3081\u3001\u8a3a\u7642\u6240\u3067\u306e\u7d4c\u904e\u89b3\u5bdf\u304c\u5fc5\u8981\u3068\u3055\u308c\u308b\u3002.51<\/sup><\/p>\n

3\uff5e6\u304b\u6708\u3054\u3068\u306b\u57cb\u3081\u8fbc\u3080\u76ae\u4e0b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u30da\u30ec\u30c3\u30c8\u306f\u3001\u6295\u4e0e\u983b\u5ea6\u3092\u5c11\u306a\u304f\u3057\u305f\u3044\u7537\u6027\u306b\u5b89\u5b9a\u3057\u305f\u8840\u4e2d\u6fc3\u5ea6\u3092\u3082\u305f\u3089\u3057\u307e\u3059\u3002.8<\/sup><\/p>\n

\u7d4c\u53e3\u30c6\u30b9\u30c6\u30ed\u30ce\u30f3\u30c7\u30ab\u30ce\u30a8\u30fc\u30c8\uff08\u73fe\u5728\u306e\u7c73\u56fd\u88fd\u5264\u3067\u306f\u30ea\u30f3\u30d1\u7d4c\u8def\u3092\u4ecb\u3057\u3066\u5438\u53ce\u3055\u308c\u308b\uff09\u304a\u3088\u3073\u9f3b\u8154\u5185\u30c6\u30b9\u30c6\u30ed\u30ce\u30f3\u30b2\u30eb\u3082\u9078\u629e\u80a2\u3068\u3057\u3066\u6319\u3052\u3089\u308c\u3001\u305d\u308c\u305e\u308c\u306b\u7279\u5b9a\u306e\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u4e0a\u306e\u7559\u610f\u70b9\u304c\u3042\u308b\u3002.<\/p>\n

10.3 SHBG\u5024\u304c\u9ad8\u3044\u5834\u5408\u3068\u4f4e\u3044\u5834\u5408\u306b\u304a\u3051\u308b\u6295\u4e0e\u91cf<\/h4>\n

SHBG\u5024\u304c\u9ad8\u3044\u7537\u6027\uff08\u591a\u304f\u306e\u5834\u5408\u3001\u9ad8\u9f62\u3001\u75e9\u305b\u578b\u3001\u7121\u75c7\u5019\u6027\u7532\u72b6\u817a\u6a5f\u80fd\u4ea2\u9032\u75c7\u3001\u307e\u305f\u306f\u6297\u3051\u3044\u308c\u3093\u85ac\u3092\u670d\u7528\u3057\u3066\u3044\u308b\uff09\u3067\u306f\u3001\u5341\u5206\u306a\u751f\u7269\u5b66\u7684\u5229\u7528\u80fd\u30ec\u30d9\u30eb\u3092\u9054\u6210\u3059\u308b\u305f\u3081\u306b\u9ad8\u7528\u91cf\u304c\u6c42\u3081\u3089\u308c\u308b\u5834\u5408\u304c\u3042\u308a\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u306f\u6b63\u5e38\u5024\u306e\u4e0a\u9650\u4ed8\u8fd1\u306b\u306a\u308b\u5fc5\u8981\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002 SHBG\u304c\u4f4e\u3044\u7537\u6027\uff08\u5178\u578b\u7684\u306b\u306f\u80a5\u6e80\u307e\u305f\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u5448\u3059\u308b\uff09\u3067\u306f\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u307f\u306e\u5024\u306b\u57fa\u3065\u3044\u3066\u7528\u91cf\u3092\u8abf\u6574\u3059\u308b\u3068\u3001\u6a19\u6e96\u7528\u91cf\u3067\u3082\u904a\u96e2\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u304c\u904e\u5270\u3068\u306a\u308a\u3001\u306b\u304d\u3073\u3001\u795e\u7d4c\u904e\u654f\u3001\u304a\u3088\u3073\u8d64\u8840\u7403\u5897\u52a0\u306e\u52a0\u901f\u3092\u62db\u304f\u6050\u308c\u304c\u3042\u308b\u3002\u3044\u305a\u308c\u306e\u96c6\u56e3\u306b\u304a\u3044\u3066\u3082\u3001\u7b97\u51fa\u3055\u308c\u305f\u751f\u7269\u5b66\u7684\u5229\u7528\u80fd\u306e\u3042\u308b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3092\u57fa\u6e96\u3068\u3057\u3066\u7528\u91cf\u3092\u8abf\u6574\u3059\u3079\u304d\u3067\u3042\u308b\u3002.<\/p>\n

11. \u30d2\u30c8\u7d68\u6bdb\u6027\u30b4\u30ca\u30c9\u30c8\u30ed\u30d4\u30f3\uff1a\u4f5c\u7528\u6a5f\u5e8f\u3068\u81e8\u5e8a\u7684\u5fdc\u7528<\/h3>\n

\u30d2\u30c8\u7d68\u6bdb\u6027\u30b4\u30ca\u30c9\u30c8\u30ed\u30d4\u30f3\uff08hCG\uff09\u306f\u9ec4\u4f53\u5f62\u6210\u30db\u30eb\u30e2\u30f3\uff08LH\uff09\u306e\u30a2\u30ca\u30ed\u30b0\u3068\u3057\u3066\u4f5c\u7528\u3057\u3001\u30e9\u30a4\u30c7\u30a3\u30c3\u30d2\u7d30\u80de\u4e0a\u306eLH\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3057\u3066\u3001\u7cbe\u5de3\u5185\u3067\u306e\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u7523\u751f\u3092\u76f4\u63a5\u523a\u6fc0\u3057\u307e\u3059\u3002 \u5916\u56e0\u6027\u306e\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306f\u4e0b\u5782\u4f53\u304b\u3089\u306eLH\u304a\u3088\u3073FSH\u306e\u5206\u6ccc\u3092\u6291\u5236\u3057\u3001\u5185\u56e0\u6027\u306e\u30e9\u30a4\u30c7\u30a3\u30c3\u30d2\u7d30\u80de\u3078\u306e\u523a\u6fc0\u3092\u906e\u65ad\u3059\u308b\u305f\u3081\uff08\u305d\u306e\u7d50\u679c\u3001\u7cbe\u5de3\u5185\u3067\u306e\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u6fc3\u5ea6\u304c\u4f4e\u4e0b\u3057\u3001\u7cbe\u5b50\u5f62\u6210\u304c\u6291\u5236\u3055\u308c\u308b\uff09\u3001hCG\u306f\u81e8\u5e8a\u7684\u306b2\u3064\u306e\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3002\u3059\u306a\u308f\u3061\u3001\u7279\u5b9a\u306e\u7537\u6027\u306b\u5bfe\u3059\u308b\u5358\u5264\u7642\u6cd5\u3068\u3057\u3066\u3001\u304a\u3088\u3073\u4e0d\u598a\u6cbb\u7642\u306b\u304a\u3044\u3066\u751f\u6b96\u80fd\u529b\u306e\u6e29\u5b58\u304c\u91cd\u8981\u306a\u5834\u5408\u306b\u304a\u3051\u308b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u88dc\u5145\u7642\u6cd5\u306e\u88dc\u52a9\u7642\u6cd5\u3068\u3057\u3066\u3067\u3042\u308b\u3002.<\/p>\n

11.1 \u7cbe\u5de3\u5185\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u554f\u984c<\/h4>\n

\u7cbe\u5b50\u5f62\u6210\u306b\u306f\u3001\u8840\u4e2d\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u6fc3\u5ea6\u306e\u7d0450\uff5e100\u500d\u306b\u76f8\u5f53\u3059\u308b\u7cbe\u5de3\u5185\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u6fc3\u5ea6\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002\u5916\u56e0\u6027\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306f\u3001LH\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u3001\u7cbe\u5de3\u5185\u3067\u306e\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u7523\u751f\u3092\u4fc3\u3059\u523a\u6fc0\u3092\u53d6\u308a\u9664\u3044\u3066\u3057\u307e\u3046\u3002 Coviello\u3089\u306f\u3001\u5916\u56e0\u6027\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3068\u4f75\u7528\u3057\u3066\u4f4e\u7528\u91cf\u306ehCG\uff081\u65e5\u304a\u304d\u306b250 IU\u3092\u76ae\u4e0b\u6295\u4e0e\uff09\u3092\u6295\u4e0e\u3059\u308b\u3068\u3001\u7cbe\u5de3\u5185\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u6fc3\u5ea6\u304c\u6b63\u5e38\u7bc4\u56f2\u5185\u306b\u7dad\u6301\u3055\u308c\u308b\u306e\u306b\u5bfe\u3057\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5358\u72ec\u6295\u4e0e\u3067\u306f90\uff05\u4ee5\u4e0a\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3057\u305f\u3002.41<\/sup><\/p>\n

\u305d\u306e\u5f8c\u3001Hsieh\u3089\u306f\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u88dc\u5145\u7642\u6cd5\u3068\u4f4e\u7528\u91cf\u306ehCG\uff08\u901a\u5e38\u3001\u90313\u56de500 IU\uff09\u306e\u4f75\u7528\u7642\u6cd5\u3092\u53d7\u3051\u305f\u7537\u6027\u3067\u306f\u3001\u6cbb\u7642\u671f\u9593\u3092\u901a\u3058\u3066\u7cbe\u6db2\u30d1\u30e9\u30e1\u30fc\u30bf\u304c\u7dad\u6301\u3055\u308c\u305f\u306e\u306b\u5bfe\u3057\u3001hCG\u3092\u4f75\u7528\u3057\u306a\u304b\u3063\u305f\u7537\u6027\u3067\u306f\u3001\u4e88\u60f3\u901a\u308a\u4e4f\u7cbe\u5b50\u75c7\u307e\u305f\u306f\u7121\u7cbe\u5b50\u75c7\u3092\u767a\u75c7\u3057\u305f\u3053\u3068\u3092\u793a\u3057\u305f\u3002.42<\/sup> Ramasamy\u3089\u306f\u3001\u751f\u6b96\u6a5f\u80fd\u6e29\u5b58\u3092\u76ee\u7684\u3068\u3057\u305f\u4f75\u7528\u7642\u6cd5\u306e\u5b9f\u8df5\u7684\u306a\u5b9f\u65bd\u65b9\u6cd5\u306b\u3064\u3044\u3066\u307e\u3068\u3081\u305f\u3002.43<\/sup><\/p>\n

11.2 hCG\u5358\u5264\u7642\u6cd5<\/h4>\n

\u4e8c\u6b21\u6027\u307e\u305f\u306f\u6df7\u5408\u6027\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u3092\u5448\u3057\u3001\u751f\u6b96\u80fd\u529b\u306e\u7dad\u6301\u3092\u5e0c\u671b\u3059\u308b\u82e5\u5e74\u7537\u6027\u306b\u304a\u3044\u3066\u306f\u3001hCG\u5358\u5264\u7642\u6cd5\u304c\u59a5\u5f53\u306a\u7b2c\u4e00\u9078\u629e\u3068\u306a\u308b\u3002 \u4e00\u822c\u7684\u306a\u6295\u4e0e\u91cf\u306f\u3001\u90312\uff5e3\u56de\u30011,000\uff5e1,500 IU\u3092\u76ae\u4e0b\u6295\u4e0e\u3059\u308b\u3053\u3068\u304b\u3089\u958b\u59cb\u3057\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3001\u904a\u96e2\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3001\u304a\u3088\u3073\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb\u306e\u53cd\u5fdc\u306b\u5fdc\u3058\u3066\u7528\u91cf\u3092\u8abf\u6574\u3059\u308b\u3002 \u591a\u304f\u306e\u7537\u6027\u306f\u3001\u5358\u5264\u7642\u6cd5\u306b\u3088\u308a\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u304c\u6b63\u5e38\u7bc4\u56f2\u306e\u4e2d\u592e\u5024\u306b\u9054\u3059\u308b\u3002\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb\u306f\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u88dc\u5145\u7642\u6cd5\u306e\u5834\u5408\u3088\u308a\u3082\u4e0a\u6607\u3057\u3084\u3059\u3044\uff08\u7cbe\u5de3\u3067\u306e\u30a2\u30ed\u30de\u30bf\u30fc\u30bc\u4f5c\u7528\u304c\u4fdd\u305f\u308c\u3066\u3044\u308b\u305f\u3081\uff09\u305f\u3081\u3001\u30a2\u30ed\u30de\u30bf\u30fc\u30bc\u963b\u5bb3\u5264\u306e\u9078\u629e\u7684\u306a\u4f7f\u7528\u304c\u6642\u6298\u5fc5\u8981\u3068\u306a\u308b\u304c\u3001\u3053\u308c\u306f\u53cd\u5c04\u7684\u306b\u884c\u3046\u3079\u304d\u3067\u306f\u306a\u3044\u3002.41,43,44<\/sup><\/p>\n

\u3053\u306e\u3088\u3046\u306a\u72b6\u6cc1\u306b\u304a\u3051\u308bhCG\u306e\u4f7f\u7528\u306f\u3001\u307b\u3068\u3093\u3069\u306e\u6cd5\u57df\u306b\u304a\u3044\u3066\u4e00\u822c\u7684\u306b\u9069\u5fdc\u5916\u3067\u3042\u308a\u3001\u500b\u3005\u306e\u60a3\u8005\u306e\u72b6\u6cc1\u306b\u5fdc\u3058\u3066\u5224\u65ad\u3059\u3079\u304d\u3067\u3042\u308b\u3002\u4e0d\u598a\u6cbb\u7642\u3092\u660e\u78ba\u306a\u76ee\u6a19\u3068\u3059\u308b\u5834\u5408\u306f\u3001\u7406\u60f3\u7684\u306b\u306f\u751f\u6b96\u6ccc\u5c3f\u5668\u79d1\u306e\u5c02\u9580\u5bb6\u306e\u95a2\u4e0e\u306e\u3082\u3068\u3067\u5b9f\u65bd\u3059\u3079\u304d\u3067\u3042\u308b\u3002hCG\u30d7\u30ed\u30c8\u30b3\u30eb\u3092\u652f\u6301\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u3001\u5927\u898f\u6a21\u306a\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3068\u3044\u3046\u3088\u308a\u306f\u3001\u4e3b\u306b\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u3059\u308b\u7814\u7a76\u3084\u5c0f\u898f\u6a21\u306a\u89b3\u5bdf\u7814\u7a76\u3001\u3042\u308b\u3044\u306f\u524d\u5411\u304d\u8a66\u9a13\u306b\u57fa\u3065\u3044\u3066\u3044\u308b\u3002.<\/p>\n

11.3 \u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u88dc\u5145\u7642\u6cd5\u3078\u306ehCG\u306e\u4f75\u7528<\/h4>\n

\u751f\u6b96\u80fd\u529b\u306e\u7dad\u6301\u3092\u5e0c\u671b\u3059\u308b\u3001\u3042\u308b\u3044\u306f\u4e0d\u5feb\u306a\u7cbe\u5de3\u840e\u7e2e\u3092\u7d4c\u9a13\u3057\u3066\u3044\u308b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u88dc\u5145\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u308b\u7537\u6027\u306b\u5bfe\u3057\u3066\u306f\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u7642\u6cd5\u306b\u4f4e\u7528\u91cf\u306ehCG\uff08\u901a\u5e38\u3001\u90312\uff5e3\u56de\u3001500 IU\uff09\u3092\u8ffd\u52a0\u3059\u308b\u3002\u3053\u306e\u7528\u91cf\u306b\u3088\u308a\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3084\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb\u306e\u904e\u5270\u306a\u4e0a\u6607\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u306a\u304f\u3001\u7cbe\u5de3\u5185\u306e\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u6fc3\u5ea6\u3068\u7cbe\u5b50\u5f62\u6210\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002.41,42,43<\/sup> \u5358\u5264\u7642\u6cd5\u3068\u540c\u69d8\u3001\u3053\u306e\u4f75\u7528\u7642\u6cd5\u3082\u4e00\u822c\u7684\u306b\u9069\u5fdc\u5916\u3067\u3042\u308a\u3001\u305d\u306e\u6709\u52b9\u6027\u3092\u88cf\u4ed8\u3051\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u4e3b\u306b\u89b3\u5bdf\u7814\u7a76\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308b\u3002.<\/p>\n

11.4 \u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u4e2d\u6b62\u5f8c\u306e\u30d7\u30ed\u30c8\u30b3\u30eb\u306e\u518d\u958b<\/h4>\n

\u5916\u56e0\u6027\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\uff08\u51e6\u65b9\u3055\u308c\u305f\u3082\u306e\u3067\u3042\u308c\u3001\u30a2\u30ca\u30dc\u30ea\u30c3\u30af\u30fb\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u5264\u306e\u4f7f\u7528\u306e\u4e00\u74b0\u3067\u3042\u308c\uff09\u3092\u4f7f\u7528\u3057\u3066\u3044\u305f\u7537\u6027\u306e\u3046\u3061\u3001\u5185\u56e0\u6027\u306e\u6a5f\u80fd\u3068\u751f\u6b96\u80fd\u529b\u306e\u56de\u5fa9\u3092\u5e0c\u671b\u3059\u308b\u4eba\u306f\u3001\u6a5f\u80fd\u56de\u5fa9\u30d7\u30ed\u30c8\u30b3\u30eb\u306e\u5bfe\u8c61\u3068\u306a\u308a\u307e\u3059\u3002 \u3053\u306e\u30d7\u30ed\u30c8\u30b3\u30eb\u306b\u306f\u901a\u5e38\u3001\u30e9\u30a4\u30c7\u30a3\u30d2\u7d30\u80de\u306e\u56de\u5fa9\u3092\u4fc3\u9032\u3059\u308bhCG\u3001\u4e0b\u5782\u4f53\u304b\u3089\u306e\u6027\u817a\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\u5206\u6ccc\u306e\u6291\u5236\u3092\u89e3\u9664\u3059\u308b\u9078\u629e\u7684\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\uff08\u30af\u30ed\u30df\u30d5\u30a7\u30f3\u307e\u305f\u306f\u30bf\u30e2\u30ad\u30b7\u30d5\u30a7\u30f3\uff09\u3001\u305d\u3057\u3066\u7cbe\u5b50\u5f62\u6210\u304c\u56de\u5fa9\u3057\u306a\u3044\u5834\u5408\u306b\u306f\u3001\u5834\u5408\u306b\u3088\u3063\u3066\u306f\u7d44\u63db\u3048FSH\u304c\u542b\u307e\u308c\u307e\u3059\u3002 Wenker\u3089\u306f\u3001\u5916\u56e0\u6027\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u66dd\u9732\u5f8c\u306b\u751f\u6b96\u80fd\u529b\u306e\u56de\u5fa9\u3092\u8a66\u307f\u308b\u7537\u6027\u306b\u304a\u3044\u3066\u3001\u3053\u306e\u3088\u3046\u306a\u4f75\u7528\u7642\u6cd5\u306b\u3088\u308a\u6709\u671b\u306a\u56de\u5fa9\u7387\u304c\u5f97\u3089\u308c\u305f\u3068\u5831\u544a\u3057\u3066\u3044\u308b\u3002.44,45<\/sup><\/p>\n

11.5 \u5b9f\u52d9\u4e0a\u306e\u8003\u616e\u4e8b\u9805<\/h4>\n

hCG\u306f\u76ae\u4e0b\u6ce8\u5c04\u306b\u3088\u3063\u3066\u6295\u4e0e\u3055\u308c\u307e\u3059\u3002\u526f\u4f5c\u7528\u306f\u901a\u5e38\u8efd\u5ea6\u3067\u3042\u308a\u3001\u6ce8\u5c04\u90e8\u4f4d\u306e\u5c40\u6240\u53cd\u5fdc\u3001\u8efd\u5ea6\u306e\u5973\u6027\u5316\u4e73\u623f\uff08\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb\u304c\u4e0a\u6607\u3057\u305f\u5834\u5408\uff09\u3001\u304a\u3088\u3073\u306b\u304d\u3073\u306a\u3069\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u8cbb\u7528\u306f\u3053\u308c\u307e\u3067\u5909\u52d5\u3057\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u54c1\u8cea\u7ba1\u7406\u304c\u6b63\u5f53\u306a\u81e8\u5e8a\u4e0a\u306e\u61f8\u5ff5\u4e8b\u9805\u3068\u306a\u308b\u4e00\u90e8\u306e\u5730\u57df\u3067\u306f\u3001\u8abf\u5264\u88fd\u5264\u304c\u5165\u624b\u53ef\u80fd\u3067\u3059\u3002.<\/p>\n

12. \u6cbb\u7642\u306e\u7d4c\u904e\u89b3\u5bdf<\/h3>\n

\u6cbb\u7642\u306e\u958b\u59cb\u304a\u3088\u3073\u6295\u4e0e\u91cf\u306e\u8abf\u6574\u306b\u306f\u3001\u4f53\u7cfb\u7684\u306a\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u304c\u5fc5\u8981\u3067\u3059\u3002\u4ee5\u4e0b\u306e\u67a0\u7d44\u307f\u306f\u3001\u5185\u5206\u6ccc\u5b66\u4f1a\u304a\u3088\u3073AUA\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u6cbf\u3063\u305f\u3082\u306e\u3067\u3042\u308a\u3001\u524d\u8ff0\u306e\u5fc3\u8840\u7ba1\u7cfb\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u3066\u4fee\u6b63\u3055\u308c\u3066\u3044\u307e\u3059\u3002.7,8<\/sup><\/p>\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3002. <\/strong>\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\uff08LC-MS\/MS \u307e\u305f\u306f\u691c\u8a3c\u6e08\u307f\u306e\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u30a2\u30c3\u30bb\u30a4\uff09\u3001SHBG\u3001\u7b97\u51fa\u3055\u308c\u305f\u904a\u96e2\u307e\u305f\u306f\u751f\u7269\u5b66\u7684\u5229\u7528\u80fd\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\uff08Vermeulen\u6cd5\uff09\u3001\u7b97\u51fa\u3092\u884c\u3046\u5834\u5408\u306f\u30a2\u30eb\u30d6\u30df\u30f3\u3001LH \u304a\u3088\u3073 FSH\uff08\u539f\u767a\u6027\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u3068\u7d9a\u767a\u6027\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u3092\u533a\u5225\u3059\u308b\u305f\u3081\uff09\u3001\u30d7\u30ed\u30e9\u30af\u30c1\u30f3\uff08\u7279\u5b9a\u306e\u75c7\u4f8b\uff09\u3001 TSH\u3001\u5168\u8840\u7403\u8a08\u7b97\uff08\u30d8\u30de\u30c8\u30af\u30ea\u30c3\u30c8\u5024\u306b\u7559\u610f\uff09\u3001\u5305\u62ec\u7684\u4ee3\u8b1d\u30d1\u30cd\u30eb\u3001ApoB\u304c\u6e2c\u5b9a\u53ef\u80fd\u306a\u5834\u5408\u306f\u305d\u308c\u3092\u542b\u3080\u7a7a\u8179\u6642\u8102\u8cea\u30d1\u30cd\u30eb\u300140\u6b73\u4ee5\u4e0a\u306e\u7537\u6027\u306b\u304a\u3051\u308bPSA\u3001\u304a\u3088\u3073AUA\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u57fa\u3065\u304f\u76f4\u8178\u6307\u8a3a\u3002.<\/p>\n

3\u30f6\u6708\u3002. <\/strong>\u75c7\u72b6\u306e\u518d\u8a55\u4fa1\uff08\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3068\u3057\u3066\u6027\u6b32\u3092\u7528\u3044\u308b\uff09\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u518d\u6e2c\u5b9a\uff08\u88fd\u5264\u306b\u5fdc\u3058\u3066\u9069\u5207\u306a\u30bf\u30a4\u30df\u30f3\u30b0\u3067\uff1a\u7b4b\u8089\u5185\u6295\u4e0e\u306e\u30a8\u30b9\u30c6\u30eb\u88fd\u5264\u306f\u30c8\u30e9\u30d5\u5024\u3001\u30b2\u30eb\u88fd\u5264\u306f\u5857\u5e03\u5f8c2\uff5e8\u6642\u9593\uff09\u3001\u5168\u8840\u7403\u8a08\u7b97\uff08CBC\uff09\u3001\u304a\u3088\u3073\u5fc5\u8981\u306b\u5fdc\u3058\u3066PSA\u306e\u6e2c\u5b9a\u3092\u884c\u3046\u3002\u30d8\u30de\u30c8\u30af\u30ea\u30c3\u30c8\u5024\u304c54\uff05\u3092\u8d85\u3048\u308b\u5834\u5408\u306f\u3001\u6295\u4e0e\u91cf\u306e\u6e1b\u91cf\u307e\u305f\u306f\u88fd\u5264\u306e\u5909\u66f4\u3092\u884c\u3046\u3002.<\/p>\n

6\u304b\u6708\u306812\u304b\u6708\u3002. <\/strong>\u540c\u3058\u691c\u67fb\u30d1\u30cd\u30eb\u306b\u52a0\u3048\u3001\u4ee3\u8b1d\u6027\u75be\u60a3\u3092\u6709\u3059\u308b\u7537\u6027\u3092\u5bfe\u8c61\u3068\u3057\u305f\u4f53\u7d44\u6210\u304a\u3088\u3073\u30a6\u30a8\u30b9\u30c8\u5468\u56f2\u5f84\u306e\u518d\u8a55\u4fa1\u3001\u8102\u8cea\u53cd\u5fdc\u3001\u306a\u3089\u3073\u306b\u8840\u7cd6\u5024\u6307\u6a19\u306e\u518d\u8a55\u4fa1\u3002.<\/p>\n

\u305d\u306e\u5f8c\u306f\u6bce\u5e74\u3002. <\/strong>\u75c7\u72b6\u306e\u78ba\u8a8d\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u304a\u3088\u3073\u904a\u96e2\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u6e2c\u5b9a\u3001\u30d8\u30de\u30c8\u30af\u30ea\u30c3\u30c8\u5024\u306e\u6e2c\u5b9a\u300140\u6b73\u4ee5\u4e0a\u306e\u7537\u6027\u306b\u304a\u3051\u308bPSA\u691c\u67fb\u3001\u306a\u3089\u3073\u306b\u5305\u62ec\u7684\u306a\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u518d\u8a55\u4fa1\u300212\u30f6\u6708\u4ee5\u5185\u306bPSA\u5024\u304c1.4 ng\/mL\u4ee5\u4e0a\u4e0a\u6607\u3057\u305f\u5834\u5408\u3001\u307e\u305f\u306fPSA\u5024\u304c4.0 ng\/mL\u4ee5\u4e0a\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u305f\u5834\u5408\u306f\u3001\u6ccc\u5c3f\u5668\u79d1\u3067\u306e\u691c\u67fb\u304c\u5fc5\u8981\u3068\u306a\u308b\u3002.7,8,53<\/sup><\/p>\n

13. \u5b89\u5168\u6027\uff1a\u6ce8\u610f\u3059\u3079\u304d\u70b9\u3068\u89e3\u6c7a\u6e08\u307f\u306e\u4e8b\u9805<\/h3>\n

13.1 \u524d\u7acb\u817a<\/h4>\n

\u6700\u65b0\u306e\u30c7\u30fc\u30bf\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306e\u524d\u7acb\u817a\u306b\u7570\u5e38\u306e\u306a\u3044\u7537\u6027\u306b\u304a\u3044\u3066\u3001\u751f\u7406\u7684\u306a\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u88dc\u5145\u7642\u6cd5\u304c\u524d\u7acb\u817a\u304c\u3093\u3092\u5f15\u304d\u8d77\u3053\u3059\u3068\u3044\u3046\u5f93\u6765\u306e\u8003\u3048\u65b9\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u30e2\u30eb\u30b2\u30f3\u30bf\u30fc\u30e9\u30fc\u3089\u304c\u63d0\u5531\u3057\u305f\u300c\u98fd\u548c\u30e2\u30c7\u30eb\u300d\u3067\u306f\u3001\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u304c\u751f\u7406\u7684\u7bc4\u56f2\u5185\u3067\u98fd\u548c\u72b6\u614b\u306b\u3042\u308b\u3068\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u306e\u30e2\u30c7\u30eb\u306f\u3001\u5f93\u6765\u306e\u63a8\u5968\u4e8b\u9805\u306b\u6697\u9ed9\u7684\u306b\u542b\u307e\u308c\u3066\u3044\u305f\u300c\u7dda\u5f62\u523a\u6fc0\u30e2\u30c7\u30eb\u300d\u3088\u308a\u3082\u3001\u5165\u624b\u53ef\u80fd\u306a\u30c7\u30fc\u30bf\u3068\u3088\u308a\u3088\u304f\u4e00\u81f4\u3057\u3066\u3044\u307e\u3059\u3002.52,53<\/sup> \u3053\u308c\u306f\u3001\u672a\u6cbb\u7642\u306e\u524d\u7acb\u817a\u304c\u3093\u306b\u304a\u3044\u3066\u30db\u30eb\u30e2\u30f3\u88dc\u5145\u7642\u6cd5\u304c\u5b89\u5168\u3067\u3042\u308b\u3053\u3068\u3092\u610f\u5473\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3064\u307e\u308a\u3001\u5408\u4f75\u75c7\u306e\u306a\u3044\u826f\u6027\u524d\u7acb\u817a\u80a5\u5927\u75c7\u3067\u3042\u308a\u3001PSA\u5024\u304c\u5b89\u5b9a\u3057\u3066\u3044\u308b\u5834\u5408\u3067\u3082\u3001\u75c7\u5019\u6027\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308c\u3070\u3001\u30db\u30eb\u30e2\u30f3\u88dc\u5145\u7642\u6cd5\u306e\u7981\u5fcc\u3068\u306f\u306a\u3089\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002.<\/p>\n

13.2 \u8d64\u8840\u7403\u5897\u52a0\u75c7<\/h4>\n

\u7b2c6.5\u7bc0\u3067\u8ad6\u3058\u3089\u308c\u3066\u3044\u308b\u3002\u8d64\u8840\u7403\u5897\u52a0\u306f\u3001TRT\u306b\u304a\u3044\u3066\u6700\u3082\u3088\u304f\u307f\u3089\u308c\u308b\u7528\u91cf\u5236\u9650\u8981\u56e0\u3068\u306a\u308b\u691c\u67fb\u5024\u306e\u7570\u5e38\u3067\u3042\u308b\u3002\u9069\u5207\u306a\u7528\u91cf\u3092\u6295\u4e0e\u3057\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u8d64\u8840\u7403\u5897\u52a0\u304c\u6301\u7d9a\u3059\u308b\u7537\u6027\u306b\u3064\u3044\u3066\u306f\u3001\u9589\u585e\u6027\u7761\u7720\u6642\u7121\u547c\u5438\u306e\u4f75\u5b58\u306e\u6709\u7121\u3092\u78ba\u8a8d\u3059\u3079\u304d\u3067\u3042\u308b\u3002.<\/p>\n

13.3 \u751f\u6b96\u80fd\u529b<\/h4>\n

\u5916\u56e0\u6027\u306e\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306f\u3001\u78ba\u5b9f\u306b\u7cbe\u5b50\u5f62\u6210\u3092\u6291\u5236\u3059\u308b\u3002\u751f\u6b96\u5e74\u9f62\u306e\u7537\u6027\u306b\u306f\u4e8b\u524d\u306b\u8aac\u660e\u3092\u884c\u3046\u5fc5\u8981\u304c\u3042\u308a\u3001\u751f\u6b96\u80fd\u529b\u306e\u7dad\u6301\u3092\u5e0c\u671b\u3059\u308b\u60a3\u8005\u306b\u306f\u3001hCG\u3092\u57fa\u76e4\u3068\u3057\u305f\u4f75\u7528\u7642\u6cd5\u3092\u63d0\u6848\u3059\u3079\u304d\u3067\u3042\u308b\u3002.41,42,43,45<\/sup><\/p>\n

13.4 \u5fc3\u8840\u7ba1\u7cfb<\/h4>\n

\u7b2c6\u7bc0\u3067\u8a73\u3057\u304f\u8ad6\u3058\u3089\u308c\u3066\u3044\u308b\u901a\u308a\u3001TRAVERSE\u8a66\u9a13\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u60a3\u8005\u3092\u542b\u3080\u75c7\u5019\u6027\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u306e\u7537\u6027\u306b\u304a\u3044\u3066\u3001\u751f\u7406\u5b66\u7684\u30db\u30eb\u30e2\u30f3\u88dc\u5145\u7642\u6cd5\u304c\u3001\u672c\u7814\u7a76\u3067\u5bfe\u8c61\u3068\u3057\u305f\u8ffd\u8de1\u671f\u9593\u306b\u304a\u3044\u3066\u3001\u4e3b\u8981\u306a\u5fc3\u8840\u7ba1\u6709\u5bb3\u4e8b\u8c61\u306e\u5897\u52a0\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u306f\u793a\u3055\u308c\u3066\u3044\u306a\u3044\u3068\u3044\u3046\u3001\u30ec\u30d9\u30eb1\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u63d0\u4f9b\u3057\u3066\u3044\u308b\u3002.36<\/sup> 2025\u5e74\u306eFDA\u306b\u3088\u308b\u6dfb\u4ed8\u6587\u66f8\u6539\u8a02\u306b\u306f\u3001\u3053\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u53cd\u6620\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8d64\u8840\u7403\u5897\u52a0\u75c7\u3001\u5fc3\u623f\u7d30\u52d5\u3001\u8840\u5727\u3001\u304a\u3088\u3073\u9759\u8108\u8840\u6813\u585e\u6813\u75c7\u306f\u3001\u5f15\u304d\u7d9a\u304d\u76e3\u8996\u5bfe\u8c61\u3068\u306a\u308b\u30b7\u30b0\u30ca\u30eb\u3067\u3059\u3002.<\/p>\n

13.5 \u305d\u306e\u4ed6\u306e\u8003\u616e\u4e8b\u9805<\/h4>\n

\u306b\u304d\u3073\u3001\u8efd\u5ea6\u306e\u5973\u6027\u5316\u4e73\u623f\uff08\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb\u5024\u304c\u4e0a\u6607\u3057\u305f\u5834\u5408\uff09\u3001\u304a\u3088\u3073\u6d6e\u816b\u306f\u6295\u4e0e\u91cf\u306b\u4f9d\u5b58\u3057\u3066\u304a\u308a\u3001\u901a\u5e38\u306f\u7ba1\u7406\u53ef\u80fd\u3067\u3059\u3002\u9ad8\u7528\u91cf\u3067\u306f\u7761\u7720\u6642\u7121\u547c\u5438\u304c\u60aa\u5316\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u6c17\u5206\u306e\u5909\u5316\uff08\u901a\u5e38\u306f\u6539\u5584\u304c\u898b\u3089\u308c\u307e\u3059\u304c\u3001\u751f\u7406\u7684\u7bc4\u56f2\u3092\u8d85\u3048\u308b\u7528\u91cf\u3067\u306f\u6642\u6298 irritability \u304c\u898b\u3089\u308c\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\uff09\u306b\u3064\u3044\u3066\u306f\u3001\u691c\u67fb\u5024\u3068\u3068\u3082\u306b\u7d4c\u904e\u89b3\u5bdf\u3092\u884c\u3046\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002.<\/p>\n

14. \u7d50\u8ad6<\/h3>\n

\u7537\u6027\u306b\u304a\u3051\u308b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u6b20\u4e4f\u75c7\u306e\u8a3a\u65ad\u306f\u3001\u57fa\u672c\u7684\u306b\u3001\u691c\u67fb\u5831\u544a\u66f8\u306e\u6570\u5024\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u3067\u306f\u306a\u304f\u3001\u7d44\u7e54\u30ec\u30d9\u30eb\u3067\u306e\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u66dd\u9732\u3092\u7279\u5b9a\u3059\u308b\u3053\u3068\u306b\u3042\u308b\u3002 \u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u30c4\u30fc\u30eb\u3067\u3042\u308a\u3001SHBG\u306e\u751f\u7269\u5b66\u7684\u6a5f\u80fd\u304c\u6b63\u5e38\u306a\u82e5\u3044\u7537\u6027\u306b\u306f\u6709\u7528\u3067\u3059\u304c\u3001\u9ad8\u9f62\u306e\u7537\u6027\u3084\u4ee3\u8b1d\u6027\u75be\u60a3\u3092\u6709\u3059\u308b\u60a3\u8005\u3067\u306f\u3001\u3057\u3070\u3057\u3070\u8aa4\u89e3\u3092\u62db\u304f\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u9ad8\u54c1\u8cea\u306a\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u6e2c\u5b9a\u5024\u3068SHBG\u6e2c\u5b9a\u5024\u304b\u3089\u4fe1\u983c\u6027\u9ad8\u304f\u7b97\u51fa\u3055\u308c\u308b\u300c\u751f\u7269\u5b66\u7684\u5229\u7528\u80fd\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u300d\u3053\u305d\u304c\u3001\u91cd\u8981\u306a\u6307\u6a19\u306a\u306e\u3067\u3059\u3002.<\/p>\n

SHBG\u81ea\u4f53\u306f\u3001\u901a\u5e38\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u4ee5\u4e0a\u306b\u81e8\u5e8a\u7684\u306a\u6ce8\u76ee\u306b\u5024\u3059\u308b\u3002SHBG\u306f\u3001\u52a0\u9f62\u3001\u7532\u72b6\u817a\u6a5f\u80fd\u4ea2\u9032\u75c7\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u66dd\u9732\u3001\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u3001\u304a\u3088\u3073\u809d\u6a5f\u80fd\u969c\u5bb3\u306b\u4f34\u3044\u4e0a\u6607\u3059\u308b\u3002\u4e00\u65b9\u3001\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u8840\u75c7\u3001\u80a5\u6e80\u3001\u304a\u3088\u3073\u540c\u5316\u30b9\u30c6\u30ed\u30a4\u30c9\u306e\u4f7f\u7528\u306b\u4f34\u3044\u4f4e\u4e0b\u3059\u308b\u3002 \u81e8\u5e8a\u7684\u306b\u9ad8\u5024\u3068\u306a\u3063\u305fSHBG\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u305f\u3081\u306e\u4e3b\u306a\u975e\u85ac\u7269\u7642\u6cd5\u3068\u3057\u3066\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u306e\u6539\u5584\u3001\u7532\u72b6\u817a\u6a5f\u80fd\u7570\u5e38\u306e\u662f\u6b63\u3001\u9069\u5fdc\u304c\u3042\u308b\u5834\u5408\u306f\u7d4c\u53e3\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u304b\u3089\u7d4c\u76ae\u5438\u53ce\u578b\u3078\u306e\u5207\u308a\u66ff\u3048\u3001\u5341\u5206\u306a\u30ab\u30ed\u30ea\u30fc\u304a\u3088\u3073\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6442\u53d6\u306e\u78ba\u4fdd\u3001\u305d\u3057\u3066\u57fa\u790e\u306b\u3042\u308b\u809d\u75be\u60a3\u306e\u6cbb\u7642\u304c\u6319\u3052\u3089\u308c\u308b\u3002.<\/p>\n

\u81e8\u5e8a\u7684\u306b\u306f\u3001\u5c11\u306a\u304f\u3068\u30822\u56de\u306e\u671d\u306e\u6e2c\u5b9a\u306b\u304a\u3044\u3066\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u304c\u4e00\u8cab\u3057\u3066\u4f4e\u3044\u3053\u3068\u304c\u751f\u5316\u5b66\u7684\u306b\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u5834\u5408\u3001\u6027\u6b32\u306e\u4f4e\u4e0b\u306f\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u6b20\u4e4f\u75c7\u306e\u8a3a\u65ad\u306b\u304a\u3044\u3066\u6700\u3082\u6709\u7528\u306a\u5358\u4e00\u306e\u75c7\u72b6\u3067\u3042\u308b\u3002 \u751f\u4f53\u5229\u7528\u53ef\u80fd\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u4f4e\u5024\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u72b6\u6cc1\u4e0b\u3067\u3001\u6027\u6b32\u306e\u4f4e\u4e0b\u3068\u671d\u306e\u52c3\u8d77\u306e\u6d88\u5931\u3092\u5448\u3059\u308b\u7537\u6027\u306f\u3001\u30db\u30eb\u30e2\u30f3\u88dc\u5145\u7642\u6cd5\u306e\u6069\u6075\u3092\u53d7\u3051\u308b\u53ef\u80fd\u6027\u304c\u6700\u3082\u9ad8\u3044\u60a3\u8005\u3067\u3042\u308b\u3002\u4e00\u65b9\u3001\u52c3\u8d77\u4e0d\u5168\u306e\u307f\u3092\u5448\u3057\u3001\u751f\u4f53\u5229\u7528\u53ef\u80fd\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u304c\u6b63\u5e38\u306a\u7537\u6027\u306f\u3001\u6069\u6075\u3092\u53d7\u3051\u308b\u53ef\u80fd\u6027\u304c\u6700\u3082\u4f4e\u304f\u3001\u4ee3\u308f\u308a\u306b\u5fc3\u8840\u7ba1\u7cfb\u306e\u8a55\u4fa1\u3092\u5fc5\u8981\u3068\u3059\u308b\u53ef\u80fd\u6027\u304c\u6700\u3082\u9ad8\u3044\u3002.<\/p>\n

\u3053\u306e10\u5e74\u9593\u3067\u3001\u5fc3\u8840\u7ba1\u7cfb\u306e\u5074\u9762\u304c\u6ce8\u76ee\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u5185\u56e0\u6027\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u4f4e\u5024\u306f\u3001\u5fc3\u8840\u7ba1\u6b7b\u304a\u3088\u3073\u5168\u6b7b\u4ea1\u7387\u306e\u5897\u52a0\u3068\u76f8\u95a2\u3057\u3066\u3044\u307e\u3059\u3002 \u8d64\u8840\u7403\u5897\u52a0\u75c7\u3084\u8840\u5727\u3092\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3057\u306a\u304c\u3089\u751f\u7406\u7684\u7bc4\u56f2\u307e\u3067\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u6fc3\u5ea6\u3092\u56de\u5fa9\u3055\u305b\u3066\u3082\u3001\u73fe\u6642\u70b9\u3067\u6700\u5927\u898f\u6a21\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\uff08TRAVERSE\uff09\u3067\u306f\u3001\u4e3b\u8981\u306a\u5fc3\u8840\u7ba1\u6709\u5bb3\u4e8b\u8c61\u306e\u5897\u52a0\u306f\u8a8d\u3081\u3089\u308c\u3066\u304a\u3089\u305a\u3001\u7279\u5b9a\u306e\u96c6\u56e3\u306b\u304a\u3044\u3066\u306f\u3001\u89b3\u5bdf\u7814\u7a76\u30c7\u30fc\u30bf\u306b\u304a\u3044\u3066\u30ea\u30b9\u30af\u4f4e\u6e1b\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002 2025\u5e74\u306eFDA\u306b\u3088\u308b\u6dfb\u4ed8\u6587\u66f8\u6539\u8a02\u306f\u3001\u3053\u3046\u3057\u305f\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u9032\u5c55\u3092\u53cd\u6620\u3057\u305f\u3082\u306e\u3067\u3042\u308b\u3002\u88dc\u5145\u7642\u6cd5\u306f\u3001ApoB\u4f4e\u4e0b\u7642\u6cd5\u3084\u751f\u6d3b\u7fd2\u6163\u4ecb\u5165\u306e\u4ee3\u66ff\u3068\u306a\u308b\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u771f\u306e\u6b20\u4e4f\u72b6\u614b\u306b\u3042\u308b\u7537\u6027\u306b\u304a\u3044\u3066\u3001\u5fc3\u8840\u7ba1\u304a\u3088\u3073\u4ee3\u8b1d\u30ea\u30b9\u30af\u306e\u7279\u5b9a\u306e\u8981\u56e0\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306e\u88dc\u52a9\u7642\u6cd5\u3067\u3042\u308b\u3002.<\/p>\n

\u6cbb\u7642\u7684\u306a\u6a5f\u80fd\u56de\u5fa9\u306f\u3001\u60a3\u8005\u306e\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u3084\u85ac\u7269\u52d5\u614b\u4e0a\u306e\u30cb\u30fc\u30ba\u306b\u5408\u308f\u305b\u3066\u9078\u629e\u3055\u308c\u305f\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u88fd\u5264\u306b\u3088\u3063\u3066\u9054\u6210\u3055\u308c\u308b\u3002 \u751f\u6b96\u5e74\u9f62\u306e\u7537\u6027\u3001\u7cbe\u5de3\u840e\u7e2e\u3092\u61f8\u5ff5\u3059\u308b\u7537\u6027\u3001\u3042\u308b\u3044\u306f\u4e8c\u6b21\u6027\u6027\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u3067\u3042\u308a\u3001\u751f\u6b96\u80fd\u529b\u3092\u7dad\u6301\u3057\u305f\u3044\u3068\u671b\u3080\u7537\u6027\u306b\u304a\u3044\u3066\u306f\u3001hCG\uff08\u5358\u72ec\u307e\u305f\u306f\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3068\u306e\u4f75\u7528\uff09\u304c\u3088\u308a\u9069\u5207\u306a\u6cbb\u7642\u6226\u7565\u3068\u306a\u308a\u307e\u3059\u3002\u81e8\u5e8a\u533b\u306e\u5f79\u5272\u306f\u3001\u60a3\u8005\u306e\u751f\u7406\u6a5f\u80fd\u306b\u5408\u308f\u305b\u3066\u6cbb\u7642\u6cd5\u3092\u8abf\u6574\u3057\u3001\u7dbf\u5bc6\u306b\u7d4c\u904e\u3092\u89b3\u5bdf\u3059\u308b\u3053\u3068\u3067\u3059\u3002.<\/p>\n

\u8b1d\u8f9e<\/h3>\n

\u8457\u8005\u306f\u3001\u672c\u539f\u7a3f\u306e\u8d77\u8349\u3001\u69cb\u6210\u3001\u304a\u3088\u3073\u7de8\u96c6\u4e0a\u306e\u4fee\u6b63\u306b\u304a\u3044\u3066\u3001AI\u8a00\u8a9e\u30e2\u30c7\u30eb\uff08Claude\u3001Anthropic\uff09\u3092\u4f7f\u7528\u3057\u305f\u3053\u3068\u3092\u660e\u8a18\u3059\u308b\u3002\u3059\u3079\u3066\u306e\u79d1\u5b66\u7684\u30b3\u30f3\u30c6\u30f3\u30c4\u3001\u81e8\u5e8a\u7684\u89e3\u91c8\u3001\u6587\u732e\u5f15\u7528\u3001\u304a\u3088\u3073\u57fa\u790e\u3068\u306a\u308b\u7814\u7a76\u306e\u7d71\u5408\u306f\u3001\u8457\u8005\u306e\u8457\u4f5c\u304a\u3088\u3073\u5224\u65ad\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308b\u3002 \u5f15\u7528\u3055\u308c\u305f\u3059\u3079\u3066\u306e\u51fa\u5178\u306f\u3001\u8457\u8005\u306b\u3088\u3063\u3066\u72ec\u81ea\u306b\u7279\u5b9a\u304a\u3088\u3073\u691c\u8a3c\u3055\u308c\u305f\u3082\u306e\u3067\u3042\u308b\u3002AI\u306f\u57f7\u7b46\u304a\u3088\u3073\u7de8\u96c6\u306e\u30c4\u30fc\u30eb\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u305f\u3082\u306e\u3067\u3042\u308a\u3001\u672c\u7dcf\u8aac\u306e\u77e5\u7684\u307e\u305f\u306f\u79d1\u5b66\u7684\u306a\u5185\u5bb9\u306b\u306f\u5bc4\u4e0e\u3057\u3066\u3044\u306a\u3044\u3002\u672c\u958b\u793a\u306f\u3001AI\u3092\u6d3b\u7528\u3057\u305f\u539f\u7a3f\u4f5c\u6210\u306b\u95a2\u3059\u308b\u65b0\u305f\u306a\u7de8\u96c6\u57fa\u6e96\u306b\u5f93\u3063\u3066\u884c\u308f\u308c\u3066\u3044\u308b\u3002.<\/p>\n

\u53c2\u8003\u6587\u732e<\/h3>\n
    \n
  1. Hammond GL. \u751f\u6b96\u306b\u304a\u3051\u308b\u6027\u30db\u30eb\u30e2\u30f3\u7d50\u5408\u30b0\u30ed\u30d6\u30ea\u30f3\u306e\u591a\u69d8\u306a\u5f79\u5272\u3002Biol Reprod. 2011;85(3):431-441. doi:10.1095\/biolreprod.111.092593<\/li>\n
  2. Goldman AL\u3001Bhasin S\u3001Wu FCW\u3001Krishna M\u3001Matsumoto AM\u3001Jasuja R. \u8840\u4e2d\u306b\u304a\u3051\u308b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u7d50\u5408\u306b\u95a2\u3059\u308b\u518d\u8a55\u4fa1\uff1a\u751f\u7406\u5b66\u7684\u304a\u3088\u3073\u81e8\u5e8a\u7684\u610f\u7fa9\u3002Endocr Rev. 2017;38(4):302-324. doi:10.1210\/er.2017-00025<\/li>\n
  3. Vermeulen A\u3001Verdonck L\u3001Kaufman JM. \u8840\u6e05\u4e2d\u904a\u96e2\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u63a8\u5b9a\u306b\u95a2\u3059\u308b\u7c21\u6613\u6cd5\u306e\u6279\u5224\u7684\u8a55\u4fa1\u3002J Clin Endocrinol Metab. 1999;84(10):3666-3672. doi:10.1210\/jcem.84.10.6079<\/li>\n
  4. Mendel CM. \u904a\u96e2\u30db\u30eb\u30e2\u30f3\u4eee\u8aac\uff1a\u751f\u7406\u5b66\u306b\u57fa\u3065\u3044\u305f\u6570\u5b66\u7684\u30e2\u30c7\u30eb. Endocr Rev. 1989;10(3):232-274. doi:10.1210\/edrv-10-3-232<\/li>\n
  5. Selva DM\u3001Hogeveen KN\u3001Innis SM\u3001Hammond GL. \u5358\u7cd6\u985e\u306b\u3088\u308b\u8102\u8cea\u751f\u5408\u6210\u306f\u3001\u30d2\u30c8\u809d\u81d3\u306e\u6027\u30db\u30eb\u30e2\u30f3\u7d50\u5408\u30b0\u30ed\u30d6\u30ea\u30f3\u907a\u4f1d\u5b50\u3092\u8abf\u7bc0\u3059\u308b\u3002J Clin Invest. 2007;117(12):3979-3987. doi:10.1172\/JCI32249<\/li>\n
  6. Pugeat M\u3001Nader N\u3001Hogeveen K\u3001Raverot G\u3001D\u00e9chaud H\u3001Grenot C. \u809d\u81d3\u306b\u304a\u3051\u308b\u6027\u30db\u30eb\u30e2\u30f3\u7d50\u5408\u30b0\u30ed\u30d6\u30ea\u30f3\u907a\u4f1d\u5b50\u306e\u767a\u73fe\uff1a\u85ac\u5264\u3068\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u3002Mol Cell Endocrinol. 2010;316(1):53-59. doi:10.1016\/j.mce.2009.09.020<\/li>\n
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  8. Mulhall JP\u3001Trost LW\u3001Brannigan RE\u3001\u4ed6. \u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u6b20\u4e4f\u75c7\u306e\u8a55\u4fa1\u3068\u7ba1\u7406\uff1aAUA\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3. J Urol. 2018;200(2):423-432. doi:10.1016\/j.juro.2018.03.115<\/li>\n
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