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Coronaire atherosclerose kan onder bepaalde omstandigheden afnemen. Seri\u00eble intravasculaire echografie (IVUS) en coronaire computertomografie-angiografie (CCTA) tonen aan dat intensieve verlaging van low-density lipoprote\u00efne-cholesterol (LDL-C) via high-intensity statines, PCSK9-remmers en, in geselecteerde situaties, icosapent-ethyl, het plaquevolume kan doen krimpen. Paradoxaal genoeg blijft het arteri\u00eble lumen vaak ongewijzigd of kan het zelfs vernauwen als gevolg van een omgekeerde of constrictieve remodellering. 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