\u98ce\u9669\u6bd4 \u2014 \u4efb\u4f55\u5fc3\u810f\u4e8b\u4ef6<\/strong><\/td>\n| 1.0 (\u53c2\u8003)<\/td>\n | 2.47\uff0895% \u7f6e\u4fe1\u533a\u95f4\uff1a1.48-4.20\uff09<\/td>\n | \u663e\u8457<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \u5965\u5c3c\u4ec0 D \u7b49. <\/em>JAMA. 1998;280(23):2001-7 (PMID: 9863851)\u3002\u6570\u636e\u6765\u81ea\u5177\u6709\u5b8c\u65745\u5e74\u8840\u7ba1\u9020\u5f71\u968f\u8bbf\u7684\u53d7\u9650\u5b50\u961f\u5217\u3002\u6240\u6709\u6570\u636e\u5747\u5df2\u4e0e\u5df2\u53d1\u8868\u7684\u539f\u59cb\u6765\u6e90\u8fdb\u884c\u6838\u5bf9\u3002.<\/em><\/p>\n\u4e94\u5e74\u6570\u636e\u663e\u793a\uff0c\u4e0e\u5b9e\u9a8c\u7ec4\u76f8\u6bd4\uff0c\u5bf9\u7167\u7ec4\u53d1\u751f\u91cd\u5927\u5fc3\u810f\u4e8b\u4ef6\u7684\u98ce\u9669\u6bd4\u4e3a2.47\uff0895% \u7f6e\u4fe1\u533a\u95f4\uff1a1.48-4.20\uff09\uff0c\u8fd9\u8bc1\u5b9e\u4e86\u5728\u8be5\u9ad8\u5371\u4eba\u7fa4\u4e2d\uff0c\u6807\u51c6\u6cbb\u7597\u4e2d\u7684\u2018\u9002\u5ea6\u2019\u63aa\u65bd\u4e0d\u8db3\u4ee5\u963b\u6b62\u75be\u75c5\u8fdb\u5c55\u3002(2) \u5b9e\u9a8c\u7ec4\u5fc3\u7ede\u75db\u53d1\u751f\u9891\u7387\u4e0b\u964d\u4e8672%\uff0c\u800c\u5bf9\u7167\u7ec4\u4ec5\u4e0b\u964d\u4e8636%\u3002(2) \u8fd9\u4e9b\u6570\u636e\u652f\u6301\u4e86\u4ee5\u4e0b\u5047\u8bbe\uff1a<10%\u7684\u8102\u80aa\u6444\u5165\u9608\u503c\u8d77\u5230\u4e86\u751f\u7269\u5b66\u5e95\u9650\u7684\u4f5c\u7528\uff0c\u5f53\u6444\u5165\u91cf\u4f4e\u4e8e\u8be5\u9608\u503c\u65f6\uff0c\u52a8\u8109\u7ec4\u7ec7\u4f1a\u8fdb\u5165\u4e00\u79cd\u4fee\u590d\u72b6\u6001\uff0c\u800c\u8fd9\u79cd\u72b6\u6001\u5728\u66f4\u9ad8\u8102\u80aa\u6444\u5165\u91cf\u4e0b\u65e0\u6cd5\u5b9e\u73b0\u3002.<\/p>\n 2.2 \u57c3\u745f\u65af\u5ef7\u514b\u5229\u592b\u5170\u8bca\u6240\u961f\u5217<\/h4>\n\u57c3\u585e\u5c14\u65af\u6c40\uff08Esselstyn\uff09\u4e8e2014\u5e74\u9488\u5bf9198\u4f8b\u91cd\u5ea6\u51a0\u5fc3\u75c5\uff08CAD\uff09\u60a3\u8005\u5f00\u5c55\u7684\u89c2\u5bdf\u6027\u7814\u7a76\uff08\u300a\u5bb6\u5ead\u533b\u5b66\u6742\u5fd7\u300b\uff0cPMID\uff1a25198208\uff09\u4e3a\u665a\u671f\u75be\u75c5\u4eba\u7fa4\u4e2d\u7684\u201c\u65e0\u6cb9\u5168\u690d\u7269\u6027\u996e\u98df\uff08WFPB\uff09\u201d\u65b9\u6848\u63d0\u4f9b\u4e86\u6700\u5927\u89c4\u6a21\u7684\u6570\u636e\u96c6\u3002(5) \u8be5\u961f\u5217\u5305\u62ec\u5df2\u5bf9\u5e38\u89c4\u6cbb\u7597\uff08\u5305\u62ec\u591a\u6b21\u8840\u7ba1\u91cd\u5efa\u672f\uff09\u65e0\u6548\u7684\u60a3\u8005\u3002\u5728\u5e73\u5747\u9075\u5faa\u8be5\u65b9\u68483.7\u5e74\u7684177\u540d\u60a3\u8005\u4e2d\uff0c\u4ec5\u53d1\u751f1\u4f8b\u5fc3\u8840\u7ba1\u4e8b\u4ef6\uff08\u4e8b\u4ef6\u53d1\u751f\u73870.6%\uff09\u3002 \u572821\u540d\u672a\u9075\u5b88\u65b9\u6848\u7684\u60a3\u8005\u4e2d\uff0c\u53d1\u751f\u4e8613\u8d77\u4e8b\u4ef6\uff08\u4e8b\u4ef6\u7387\u4e3a62%\uff09\u3002(5) \u968f\u8bbf\u8840\u7ba1\u9020\u5f71\u663e\u793a\uff0c22%\u7684\u9075\u4ece\u65b9\u6848\u53c2\u4e0e\u8005\u51fa\u73b0\u4e86\u52a8\u8109\u7ca5\u6837\u786c\u5316\u9006\u8f6c\u3002(5) Gould\u7b49\u4eba\uff08\u300a\u7f8e\u56fd\u533b\u5b66\u4f1a\u6742\u5fd7\u300b1995\u5e74\uff0cPMID: 7674504\uff09\u63d0\u4f9b\u4e86\u6b63\u7535\u5b50\u53d1\u5c04\u65ad\u5c42\u626b\u63cf\uff08PET\uff09\u6210\u50cf\u8bc1\u636e\uff0c\u8bc1\u5b9e\u91c7\u7528\u7b49\u6548\u996e\u98df\u65b9\u6848\u53ef\u6539\u5584\u5fc3\u808c\u704c\u6ce8\u3002(29)<\/p>\n \u57c3\u745f\u5c14\u65af\u5ef7\u961f\u5217\u7814\u7a76\u7684\u4e00\u4e2a\u91cd\u8981\u65b9\u6cd5\u5b66\u5c40\u9650\u6027\u5728\u4e8e\uff0c\u5927\u591a\u6570\u60a3\u8005\u540c\u65f6\u670d\u7528\u4e86\u964d\u80c6\u56fa\u9187\u836f\u7269\uff0c\u8fd9\u4f7f\u5f97\u65e0\u6cd5\u5c06\u996e\u98df\u5bf9\u89c2\u5bdf\u5230\u7684\u8840\u8102\u964d\u4f4e\u548c\u4e8b\u4ef6\u53d1\u751f\u7387\u6570\u636e\u7684\u8d21\u732e\u4e0e\u836f\u7269\u7684\u8d21\u732e\u533a\u5206\u5f00\u6765\u3002\u7136\u800c\uff0c\u4f9d\u4ece\u7ec4\u4e0e\u4e0d\u4f9d\u4ece\u7ec4\u4e4b\u95f4\u4e8b\u4ef6\u53d1\u751f\u7387\u5dee\u8ddd\u7684\u5de8\u5927\u7a0b\u5ea6\u2014\u2014\u4e24\u7ec4\u90fd\u83b7\u5f97\u4e86\u7c7b\u4f3c\u7684\u836f\u7269\u652f\u6301\u2014\u2014\u8868\u660e\uff0c\u9664\u4e86\u5355\u72ec\u4f7f\u7528\u836f\u7269\u6240\u4ea7\u751f\u7684\u5f71\u54cd\u5916\uff0c\u996e\u98df\u5177\u6709\u663e\u8457\u7684\u72ec\u7acb\u5f71\u54cd\u3002(5)<\/p>\n 3. \u5b9a\u6027\u8102\u80aa\u8303\u5f0f\uff1a\u8102\u80aa\u66ff\u4ee3\u4e0e\u5730\u4e2d\u6d77\u6a21\u5f0f<\/h3>\n\u53e6\u4e00\u79cd\u4e0e\u4e4b\u5f62\u6210\u9c9c\u660e\u5bf9\u6bd4\u7684\u8303\u5f0f\u2014\u2014\u8be5\u8303\u5f0f\u5f97\u5230\u4e86\u7f8e\u56fd\u5fc3\u810f\u534f\u4f1a\uff08AHA\uff09\u7684\u652f\u6301\uff0c\u5e76\u4f53\u73b0\u5728\u5730\u4e2d\u6d77\u996e\u98df\u6a21\u5f0f\u4e2d\u2014\u2014\u8ba4\u4e3a\u8102\u80aa\u7684\u603b\u91cf\u4e0d\u5982\u8102\u80aa\u7684\u8d28\u91cf\u5177\u6709\u51b3\u5b9a\u6027\u4f5c\u7528\u3002 \u8fd9\u79cd\u2018\u66ff\u4ee3\u903b\u8f91\u2019\u4fa7\u91cd\u4e8e\u7528\u591a\u4e0d\u9971\u548c\u8102\u80aa\u9178\uff08PUFA\uff09\u548c\u5355\u4e0d\u9971\u548c\u8102\u80aa\u9178\uff08MUFA\uff09\u66ff\u4ee3\u9971\u548c\u8102\u80aa\u9178\uff08SFA\uff09\u548c\u53cd\u5f0f\u8102\u80aa\u9178\uff08TFA\uff09\uff0c\u901a\u5e38\u4f7f\u603b\u8102\u80aa\u6444\u5165\u91cf\u5360\u603b\u70ed\u91cf\u768430-45%\u3002(24,31)<\/p>\n 3.1 \u5317\u5361\u7d2f\u5229\u963f\u9879\u76ee\u2014\u2014\u8102\u80aa\u66ff\u4ee3\u7684\u4eba\u7fa4\u6c34\u5e73\u8bc1\u636e<\/h4>\n\u5317\u5361\u7d2f\u5229\u963f\u9879\u76ee\u4e3a\u66ff\u4ee3\u6a21\u578b\u63d0\u4f9b\u4e86\u6700\u5177\u8bf4\u670d\u529b\u7684\u4eba\u53e3\u5c42\u9762\u5b9e\u8bc1\u4e4b\u4e00\u3002\u901a\u8fc7\u7cfb\u7edf\u6027\u5730\u5f15\u5bfc\u82ac\u5170\u6c11\u4f17\u4ece\u6444\u5165\u9971\u548c\u4e73\u8102\u8f6c\u5411\u98df\u7528\u83dc\u7c7d\u6cb9\uff08\u6cb9\u83dc\u7c7d\u6cb9\uff09\u5e76\u589e\u52a0\u852c\u83dc\u6444\u5165\u91cf\uff0c \u8fd9\u9879\u6301\u7eed\u6570\u5341\u5e74\u7684\u516c\u5171\u536b\u751f\u5e72\u9884\u63aa\u65bd\u572840\u5e74\u95f4\u4f7f35\u81f364\u5c81\u7537\u6027\u51a0\u5fc3\u75c5\u6b7b\u4ea1\u7387\u964d\u4f4e\u4e86\u7ea684%\uff0c\u8fd9\u4e00\u7ed3\u679c\u7531Jousilahti\u7b49\u4eba\u53d1\u8868\u5728\u300a\u5168\u7403\u5fc3\u810f\u300b\uff08Global Heart\uff0cPMID: 27242088\uff09\u4e0a\u3002(11) \u636eVartiainen\u7b49\u4eba\uff08PMID: 27242084\uff09\u7684\u8bb0\u5f55\uff0c\u9762\u5305\u4e0a\u6d82\u62b9\u9ec4\u6cb9\u7684\u4eba\u53e3\u6bd4\u4f8b\u4ece1972\u5e74\u768490%\u4ee5\u4e0a\u4e0b\u964d\u81f32012\u5e74\u76845%\u4ee5\u4e0b\u3002(12)<\/p>\n \u88682. \u5317\u5361\u7d2f\u5229\u963f\u9879\u76ee\u2014\u2014\u8102\u80aa\u66ff\u4ee3\u7684\u4eba\u7fa4\u6c34\u5e73\u5f71\u54cd\uff081972-2012\u5e74\uff09<\/em><\/strong><\/p>\n\n\n\n\u53c2\u6570<\/strong><\/td>\n1972\u5e74\u57fa\u51c6\u7ebf<\/strong><\/td>\n2012\u5e74\u7ed3\u679c<\/strong><\/td>\n\u5f71\u54cd<\/strong><\/td>\n<\/tr>\n\n\u9762\u5305\u4e0a\u7684\u9ec4\u6cb9\u7528\u6cd5<\/strong><\/td>\n| >90% \u7684\u4eba\u53e3<\/td>\n | <5% \u7684\u4eba\u53e3<\/td>\n | \u5927\u5e45\u51cf\u5c11\u9971\u548c\u8102\u80aa\u9178<\/td>\n<\/tr>\n | \n\u4e3b\u8981\u8102\u80aa\u6765\u6e90<\/strong><\/td>\n| \u9971\u548c\uff08\u4e73\u5236\u54c1\/\u9ec4\u6cb9\uff09<\/td>\n | \u4e0d\u9971\u548c\uff08\u83dc\u7c7d\/\u690d\u7269\uff09\u6cb9<\/td>\n | \u5c55\u793a\u66ff\u6362\u903b\u8f91<\/td>\n<\/tr>\n | \n\u8840\u6e05\u80c6\u56fa\u9187<\/strong><\/td>\n| \u660e\u663e\u5347\u9ad8<\/td>\n | \u663e\u8457\u51cf\u5c11<\/td>\n | \u5fc3\u8840\u7ba1\u75be\u75c5\u6b7b\u4ea1\u7387\u7684\u6700\u5927\u9a71\u52a8\u56e0\u7d20<\/td>\n<\/tr>\n | \n\u51a0\u5fc3\u75c5\u6b7b\u4ea1\u7387\uff0835-64\u5c81\u7537\u6027\uff09<\/strong><\/td>\n| \u5168\u7403\u6700\u9ad8<\/td>\n | ~84% \u8fd8\u539f<\/td>\n | \u4eba\u7fa4\u6c34\u5e73\u7684\u9006\u8f6c<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \u8d44\u6599\u6765\u6e90\uff1aJousilahti P \u7b49. <\/em>Glob Heart. 2016;11(2):207-12 (PMID: 27242088); Vartiainen E et al. Glob Heart. 2016;11(2):179-84 (PMID: 27242084); Puska P et al. Glob Heart. 2016;11(2):173-8 (PMID: 27242083).<\/em><\/p>\n3.2 PREDIMED \u8bd5\u9a8c\u2014\u2014\u5730\u4e2d\u6d77\u996e\u98df\u4e3b\u8981\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u8bc1\u636e\u7684\u6279\u5224\u6027\u8bc4\u4ef7<\/h4>\nPREDIMED\u8bd5\u9a8c\u662f\u652f\u6301\u5730\u4e2d\u6d77\u996e\u98df\u6a21\u5f0f\u7528\u4e8e\u5fc3\u8840\u7ba1\u75be\u75c5\u4e00\u7ea7\u9884\u9632\u7684\u6700\u5e38\u88ab\u5f15\u7528\u7684\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff08RCT\uff09\u3002 \u8be5\u8bd5\u9a8c\u4ee57,447\u540d\u9ad8\u5371\u53d7\u8bd5\u8005\u4e3a\u5bf9\u8c61\uff0c\u5c06\u2018\u4f4e\u8102\u2019\u5bf9\u7167\u996e\u98df\u4e0e\u4e24\u4e2a\u5730\u4e2d\u6d77\u996e\u98df\u7ec4\uff08\u8865\u5145\u7279\u7ea7\u521d\u69a8\u6a44\u6984\u6cb9\u7ec4\u548c\u8865\u5145\u575a\u679c\u7ec4\uff09\u8fdb\u884c\u6bd4\u8f83\uff0c\u7ed3\u679c\u663e\u793a\u5730\u4e2d\u6d77\u996e\u98df\u7ec4\u7684\u4e3b\u8981\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u53d1\u751f\u7387\u964d\u4f4e\u4e86\u7ea630%\u3002(6) \u7136\u800c\uff0c\u6b63\u5982\u672c\u7efc\u8ff0\u7b2c 5 \u8282\u6240\u8be6\u8ff0\u7684\uff0cPREDIMED \u5b58\u5728\u591a\u9879\u4e25\u91cd\u7684\u65b9\u6cd5\u5b66\u5c40\u9650\u6027\uff0c\u8fd9\u4e9b\u5c40\u9650\u6027\u5927\u5927\u964d\u4f4e\u4e86\u5176\u7ed3\u8bba\u7684\u786e\u5b9a\u6027\u3002\u5173\u4e8e\u8fd9\u4e9b\u95ee\u9898\u7684\u7cfb\u7edf\u6027\u5206\u6790\uff0c\u8bf7\u53c2\u9605\u8868 4\u3002.<\/p>\n \u672c\u7efc\u8ff0\u6838\u5fc3\u8ba8\u8bba\u7684\u4e00\u4e2a\u6839\u672c\u5c40\u9650\u5728\u4e8e\uff0cPREDIMED\u7814\u7a76\u7684\u5bf9\u7167\u7ec4\u4ece\u672a\u771f\u6b63\u8fbe\u5230\u4f4e\u8102\u996e\u98df\u72b6\u6001\uff1a \u7814\u7a76\u7ed3\u675f\u65f6\uff0c\u5bf9\u7167\u7ec4\u7684\u5e73\u5747\u8102\u80aa\u6444\u5165\u91cf\u8fbe\u523037%\u5361\u8def\u91cc\u2014\u2014\u8fd9\u8fdc\u9ad8\u4e8e\u4efb\u4f55\u516c\u8ba4\u7684\u4f4e\u8102\u996e\u98df\u5b9a\u4e49\uff0c\u4e5f\u5b8c\u5168\u65e0\u6cd5\u4e0e\u6591\u5757\u9006\u8f6c\u7814\u7a76\u4e2d\u91c7\u7528\u7684<10%\u8102\u80aa\u9608\u503c\u76f8\u63d0\u5e76\u8bba\u3002(6,7) \u56e0\u6b64\uff0cPREDIMED\u7814\u7a76\u4ec5\u8bc1\u660e\u4e86\u5728\u4e24\u79cd\u9ad8\u8102\u80aa\u996e\u98df\u6a21\u5f0f\u4e2d\uff0c\u5730\u4e2d\u6d77\u996e\u98df\u66f4\u4f18\uff1b\u4f46\u5e76\u672a\u8bc1\u660e\u5730\u4e2d\u6d77\u996e\u98df\u76f8\u5bf9\u4e8e\u771f\u6b63\u4f4e\u8102\u996e\u98df\u6216\u5168\u690d\u7269\u6027\u996e\u98df\uff08WFPB\uff09\u5bf9\u7167\u7ec4\u7684\u4f18\u8d8a\u6027\u3002.<\/p>\n 3.3 \u91cc\u6602\u5fc3\u810f\u996e\u98df\u7814\u7a76\u2014\u2014\u4e8c\u7ea7\u9884\u9632\u8bc1\u636e<\/h4>\n\u91cc\u6602\u996e\u98df\u5fc3\u810f\u7814\u7a76\u4e3a\u5730\u4e2d\u6d77\u996e\u98df\u6a21\u5f0f\u5728\u4e8c\u7ea7\u9884\u9632\u65b9\u9762\u7684\u529f\u6548\u63d0\u4f9b\u4e86\u65b9\u6cd5\u5b66\u4e0a\u66f4\u53ef\u9760\u7684\u8bc1\u636e\u3002(8,9) \u8fd9\u9879\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u8868\u660e\uff0c\u572827\u4e2a\u6708\u5185\uff0c\u91c7\u7528\u5bcc\u542bALA\u7684\u5730\u4e2d\u6d77\u996e\u98df\u6a21\u5f0f\u4e0e\u91c7\u7528\u6807\u51c6\u996e\u98df\u6a21\u5f0f\u76f8\u6bd4\uff0c\u5fc3\u6e90\u6027\u6b7b\u4ea1\u548c\u975e\u81f4\u6b7b\u6027\u5fc3\u808c\u6897\u6b7b\u53d1\u751f\u7387\u663e\u8457\u964d\u4f4e\uff08\u8c03\u6574\u540e\u76f8\u5bf9\u98ce\u9669\u4e3a0.27\uff0c 95% \u7f6e\u4fe1\u533a\u95f4 0.12-0.59\uff0cp = 0.001\uff09\uff0c\u8be5\u7814\u7a76\u5c06\u5bcc\u542b\u03b1-\u4e9a\u9ebb\u9178\uff08ALA\uff09\u7684\u5730\u4e2d\u6d77\u996e\u98df\u6a21\u5f0f\u4e0e\u6807\u51c6\u5fc3\u808c\u6897\u6b7b\u540e\u996e\u98df\u8fdb\u884c\u6bd4\u8f83\uff0c\u5e76\u56e0\u89c2\u5bdf\u5230\u7684\u83b7\u76ca\u5e45\u5ea6\u663e\u8457\u800c\u63d0\u524d\u7ec8\u6b62\u3002(9) \u4e0ePREDIMED\u8bd5\u9a8c\u4e0d\u540c\uff0c\u91cc\u6602\u8bd5\u9a8c\u4e0d\u5b58\u5728\u7b2c5\u8282\u4e2d\u8ba8\u8bba\u7684\u968f\u673a\u5316\u53ca\u5bf9\u7167\u7ec4\u6c61\u67d3\u95ee\u9898\uff0c\u56e0\u6b64\u5176\u7814\u7a76\u7ed3\u679c\u5728\u65b9\u6cd5\u5b66\u4e0a\u66f4\u5177\u53ef\u4fe1\u5ea6\u3002.<\/p>\n \u7136\u800c\uff0c\u91cc\u6602\u7814\u7a76\u5e76\u672a\u89e3\u51b3\u6838\u5fc3\u4e89\u8bae\uff1a\u5b83\u5c06\u5730\u4e2d\u6d77\u996e\u98df\u4e0e\u6807\u51c6\u7684\u897f\u65b9\u5fc3\u808c\u6897\u6b7b\u540e\u996e\u98df\u8fdb\u884c\u4e86\u5bf9\u6bd4\uff0c\u800c\u4e0d\u662f\u4e0e\u5168\u98df\u690d\u7269\u6027\u996e\u98df\uff08WFPB\uff09\u6216\u6781\u4f4e\u8102\u65b9\u6848\u8fdb\u884c\u5bf9\u6bd4\u3002\u5176\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u5728\u4e8c\u7ea7\u9884\u9632\u65b9\u9762\uff0c\u5730\u4e2d\u6d77\u996e\u98df\u6a21\u5f0f\u660e\u663e\u4f18\u4e8e\u6807\u51c6\u7684\u897f\u65b9\u996e\u98df\u2014\u2014\u8fd9\u4e00\u7ed3\u8bba\u5f97\u5230\u4e86\u8bc1\u636e\u7684\u5145\u5206\u652f\u6301\u3002\u8be5\u7814\u7a76\u7ed3\u679c\u5e76\u672a\u8bf4\u660e\u5730\u4e2d\u6d77\u996e\u98df\u6a21\u5f0f\u5728\u6591\u5757\u9006\u8f6c\u65b9\u9762\u662f\u5426\u7b49\u540c\u4e8e\u6216\u4f18\u4e8e\u5168\u98df\u690d\u7269\u6027\u996e\u98df\uff08WFPB\uff09\u65b9\u6848\u3002.<\/p>\n ![\"\"](\"https:\/\/www.curingheartdisease.com\/wp-content\/uploads\/2026\/04\/low-fat-Deep-Dive-Infographic-2.png\") <\/p>\n
4. \u4eba\u53e3\u7814\u7a76\u4e0e\u957f\u5bff\u6096\u8bba<\/h3>\n\u4e24\u4e2a\u4eba\u7fa4\u957f\u5bff\u4e14\u622a\u7136\u4e0d\u540c\u2014\u2014\u4f20\u7edf\u7684\u51b2\u7ef3\u4eba\u4ee5\u53ca\u5730\u4e2d\u6d77\u4f0a\u5361\u5229\u4e9a\u5c9b\u548c\u6492\u4e01\u5c9b\u7684\u201c\u84dd\u8272\u5730\u5e26\u201d\u5c45\u6c11\u2014\u2014\u4e3a\u996e\u98df\u7ed3\u6784\u548c\u5fc3\u8840\u7ba1\u957f\u5bff\u63d0\u4f9b\u4e86\u5bcc\u6709\u542f\u793a\u7684\u81ea\u7136\u5b9e\u9a8c\u3002.<\/p>\n \u8868 3. \u957f\u5bff\u4eba\u7fa4\u4e2d\u5b8f\u91cf\u8425\u517b\u7d20\u5206\u5e03\u7684\u6bd4\u8f83<\/em><\/strong><\/p>\n\n\n\n\u8425\u517b\u7269\u8d28<\/strong><\/td>\n\u4f20\u7edf\u51b2\u7ef3\uff081970\u5e74\u4ee5\u524d\uff09<\/strong><\/td>\n\u5730\u4e2d\u6d77\u84dd\u8272\u5730\u5e26\uff08\u4f0a\u5361\u5229\u4e9a \/ \u6492\u4e01\u5c9b\uff09<\/strong><\/td>\n\u73b0\u4ee3\u897f\u65b9\u996e\u98df<\/strong><\/td>\n<\/tr>\n\n\u603b\u8102\u80aa\uff08% \u5343\u5361\uff09<\/strong><\/td>\n| 6%<\/td>\n | 30-45%<\/td>\n | 35-40%<\/td>\n<\/tr>\n | \n\u9971\u548c\u8102\u80aa\uff08% \u5343\u5361\uff09<\/strong><\/td>\n| 2%<\/td>\n | 8-10%<\/td>\n | 12-15%<\/td>\n<\/tr>\n | \n\u78b3\u6c34\u5316\u5408\u7269\uff08% \u5343\u5361\uff09<\/strong><\/td>\n| 85%<\/td>\n | 40-45%<\/td>\n | 45-50%<\/td>\n<\/tr>\n | \n\u4e3b\u8981\u8102\u80aa\u6765\u6e90<\/strong><\/td>\n| \u5927\u8c46 \/ \u6d77\u85fb<\/td>\n | \u6a44\u6984\u6cb9 \/ \u575a\u679c<\/td>\n | \u9ec4\u6cb9 \/ \u732a\u6cb9 \/ \u7cbe\u70bc\u6cb9<\/td>\n<\/tr>\n | \n\u51a0\u5fc3\u75c5\u6b7b\u4ea1\u7387\uff08\u76f8\u5bf9\uff09<\/strong><\/td>\n| \u7ea6\u4e3a\u7f8e\u56fd\u8d39\u7387\u7684 1\/8<\/td>\n | \u6781\u4f4e<\/td>\n | \u9ad8<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \u6765\u6e90\uff1aWillcox DC \u7b49. <\/em>J Am Coll Nutr. 2009;28(Suppl):500S-516S (PMID: 20234038); Trichopoulou A \u7b49\u3002. <\/em>N Engl J Med. 2003;348(26):2599-608 (PMID: 12826634); Poulain M et al. Exp Gerontol. <\/em>2004;39(9):1423-9 (PMID: 15489066).<\/em><\/p>\n4.1 \u51b2\u7ef3\u6a21\u5f0f\u2014\u2014\u4f5c\u4e3a\u5fc3\u8840\u7ba1\u957f\u5bff\u67b6\u6784\u7684\u6781\u4f4e\u8102\u996e\u98df<\/h4>\n1970\u5e74\u4e4b\u524d\u7684\u4f20\u7edf\u51b2\u7ef3\u996e\u98df\u2014\u2014Willcox\u7b49\u4eba\uff08\u300a\u7f8e\u56fd\u8425\u517b\u5b66\u9662\u6742\u5fd7\u300b2009\u5e74\uff0cPMID: 20234038\uff09\u5c06\u5176\u63cf\u8ff0\u4e3a\u8102\u80aa6%\u3001\u78b3\u6c34\u5316\u5408\u726985%\u3001 9%\u86cb\u767d\u8d28\uff0c\u4ee5\u8425\u517b\u4e30\u5bcc\u7684\u7ea2\u85af\u4f5c\u4e3a\u4e3b\u8981\u70ed\u91cf\u6765\u6e90\u2014\u2014\u5176\u51a0\u5fc3\u75c5\u6b7b\u4ea1\u7387\u7ea6\u4e3a\u540c\u65f6\u671f\u7f8e\u56fd\u6c34\u5e73\u7684\u516b\u5206\u4e4b\u4e00\uff0c\u4e14\u9884\u671f\u5bff\u547d\u4f4d\u5c45\u4e16\u754c\u4e4b\u9996\u3002(13,14) \u5f53\u51b2\u7ef3\u4eba\u8f6c\u5411\u897f\u5316\u996e\u98df\u2014\u2014\u603b\u8102\u80aa\u6444\u5165\u91cf\u5347\u81f3\u7ea627%\u2014\u2014\u5fc3\u8840\u7ba1\u75be\u75c5\u6b7b\u4ea1\u7387\u663e\u8457\u4e0a\u5347\uff0c\u5176\u957f\u5bff\u6392\u540d\u4e5f\u968f\u4e4b\u4e0b\u964d\u3002(14) \u8fd9\u4e00\u957f\u671f\u8f6c\u53d8\u63d0\u4f9b\u4e86\u4e00\u4e2a\u81ea\u7136\u5b9e\u9a8c\uff1a\u603b\u8102\u80aa\u6444\u5165\u91cf\u589e\u52a0\u3001\u9971\u548c\u8102\u80aa\u9178\u6444\u5165\u91cf\u589e\u52a0\u4ee5\u53ca\u5168\u690d\u7269\u98df\u7269\u5bc6\u5ea6\u4e0b\u964d\uff0c\u4e0e\u5fc3\u8840\u7ba1\u98ce\u9669\u4e0a\u5347\u540c\u65f6\u53d1\u751f\uff0c\u8fd9\u652f\u6301\u4e86\u5b9a\u91cf\u8102\u80aa\u9650\u5236\u5047\u8bf4\u3002.<\/p>\n 4.2 \u5730\u4e2d\u6d77\u84dd\u8272\u5730\u5e26\u6096\u8bba\u53ca\u5176\u542f\u793a<\/h4>\n\u4f0a\u5361\u91cc\u4e9a\u5c9b\u548c\u6492\u4e01\u5c9b\u7684\u201c\u84dd\u8272\u533a\u57df\u201d\u5c45\u6c11\uff0c\u5176\u996e\u98df\u4e2d\u7684\u603b\u8102\u80aa\u6444\u5165\u91cf\u901a\u5e38\u8d85\u8fc735%\uff0c\u5374\u62e5\u6709\u4e16\u754c\u9886\u5148\u7684\u957f\u5bff\u6c34\u5e73\u548c\u8f83\u4f4e\u7684\u5fc3\u8840\u7ba1\u75be\u75c5\u53d1\u75c5\u7387\u3002(15,17) \u8fd9\u5f62\u6210\u4e86\u4e00\u4e2a\u660e\u663e\u7684\u6096\u8bba\uff1a\u5982\u679c\u8d85\u4f4e\u8102\u80aa\u6444\u5165\u662f\u51b2\u7ef3\u957f\u5bff\u7684\u5173\u952e\u56e0\u7d20\uff0c\u90a3\u4e48\u8102\u80aa\u6444\u5165\u91cf\u8fdc\u9ad8\u4e8e\u51b2\u7ef3\u7684\u5730\u4e2d\u6d77\u5730\u533a\u4eba\u7fa4\uff0c\u4e3a\u4f55\u4e5f\u80fd\u8fbe\u5230\u76f8\u4f3c\u7684\u957f\u5bff\u6c34\u5e73\uff1f<\/p>\n \u8fd9\u4e00\u6096\u8bba\u7684\u89e3\u51b3\u5728\u4e8e\u533a\u5206\u603b\u8102\u80aa\u6570\u91cf\u4e0e\u8102\u80aa\u8d28\u91cf\uff0c\u5e76\u7ed3\u5408\u4ee5\u4e0b\u89c2\u5bdf\u7ed3\u679c\uff1a\u8fd9\u4e24\u4e2a\u4eba\u7fa4\u5171\u4eab\u4ee5\u4e0b\u7ed3\u6784\u5171\u8bc6\uff1a\u9ad8\u5168\u690d\u7269\u6027\u98df\u7269\u5bc6\u5ea6\u3001\u6700\u4f4e\u9650\u5ea6\u7684\u52a0\u5de5\u98df\u54c1\u6444\u5165\u3001\u6700\u4f4e\u9650\u5ea6\u7684\u7cbe\u5236\u7cd6\u6d88\u8d39\u4ee5\u53ca\u6700\u4f4e\u9650\u5ea6\u7684\u52a8\u7269\u86cb\u767d\u3002(15,16,17) \u7279\u522b\u9488\u5bf9\u5fc3\u8840\u7ba1\u75be\u75c5\u6bd4\u8f83\u7684\u5173\u952e\u533a\u522b\u5728\u4e8e\uff0c\u76f4\u63a5\u6d41\u884c\u75c5\u5b66\u6570\u636e\u8868\u660e\uff0c\u4f20\u7edf\u51b2\u7ef3\u5730\u533a\u7684\u51a0\u5fc3\u75c5\u6b7b\u4ea1\u7387\u751a\u81f3\u4f4e\u4e8e\u5730\u4e2d\u6d77\u84dd\u8272\u5730\u5e26\u2014\u2014\u8fd9\u8868\u660e\uff0c\u867d\u7136\u8fd9\u4e24\u79cd\u996e\u98df\u67b6\u6784\u76f8\u5bf9\u4e8e\u897f\u65b9\u996e\u98df\u90fd\u80fd\u9884\u9632\u5fc3\u8840\u7ba1\u75be\u75c5\uff0c\u4f46\u6781\u4f4e\u8102\u80aa\u7684\u5168\u98df\u690d\u7269\u6027\u996e\u98df\u6a21\u5f0f\u53ef\u80fd\u4f1a\u5e26\u6765\u6570\u91cf\u4e0a\u66f4\u4f18\u8d8a\u7684\u51a0\u72b6\u52a8\u8109\u4fdd\u62a4\u7a0b\u5ea6\u3002(13,14)<\/p>\n 5. PREDIMED \u8bd5\u9a8c\u7684\u4e34\u754c\u8bc4\u4f30 \u2014 \u7cfb\u7edf\u65b9\u6cd5\u5b66\u5206\u6790<\/h3>\n\u9274\u4e8ePREDIMED\u4f5c\u4e3a\u5fc3\u8840\u7ba1\u9884\u9632\u4e2d\u5730\u4e2d\u6d77\u996e\u98df\u6a21\u5f0f\u7684\u4e3b\u8981\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff08RCT\uff09\u8bc1\u636e\u57fa\u7840\u7684\u5960\u57fa\u6027\u4f5c\u7528\uff0c\u5bf9\u5176\u65b9\u6cd5\u5b66\u5b8c\u6574\u6027\u8fdb\u884c\u4e25\u683c\u8bc4\u4f30\u81f3\u5173\u91cd\u8981\u3002\u4ee5\u4e0b\u5206\u6790\u501f\u9274\u4e86\u64a4\u7a3f\u58f0\u660e\u53ca\u91cd\u65b0\u53d1\u8868\u7684\u8bba\u6587\uff08Estruch\u7b49\u4eba\uff0c\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b2018\u5e74\uff0cPMID: 29897866\uff09\u4ee5\u53ca\u963f\u52a0\u74e6\u5c14\uff08Agarwal\uff09\u548c\u7ea6\u5c3c\u8fea\u65af\uff08Ioannidis\uff09\u540c\u884c\u8bc4\u8bae\u7684\u65b9\u6cd5\u5b66\u6279\u5224\uff08\u300a\u82f1\u56fd\u533b\u5b66\u6742\u5fd7\u300b2019\u5e74\uff0cPMID: 30733217\uff09\u3002\uff086,7\uff09<\/p>\n \u8868 4. PREDIMED \u8bd5\u9a8c \u2014 \u7cfb\u7edf\u6027\u65b9\u6cd5\u5b66\u95ee\u9898<\/em><\/strong><\/p>\n\n\n\n\u65b9\u6cd5\u8bba\u95ee\u9898<\/strong><\/td>\n\u63cf\u8ff0<\/strong><\/td>\n\u5faa\u8bc1\u8bc4\u4f30<\/strong><\/td>\n<\/tr>\n\n\u968f\u673a\u5316\u5931\u8d25<\/strong><\/td>\n| \u5171\u670921%\u540d\u53d7\u8bd5\u8005\uff08n=1,588\uff09\u672a\u88ab\u6b63\u786e\u5730\u8fdb\u884c\u4e2a\u4f53\u968f\u673a\u5206\u7ec4\uff1a\u5305\u62ec\u6309\u5bb6\u5ead\u5206\u914d\u3001\u8bca\u6240\u5c42\u9762\u7684\u5206\u7ec4\uff0c\u4ee5\u53ca\u591a\u4e2a\u7814\u7a76\u70b9\u5b58\u5728\u7684\u672a\u8bb0\u5f55\u7684\u504f\u79bb\u60c5\u51b5<\/td>\n | NEJM 2018\u5e74\u786e\u8ba4\u64a4\u7a3f\u5e76\u91cd\u65b0\u53d1\u8868\u3002\u65b9\u5411\u6027\u7ed3\u679c\u672a\u53d8\uff0c\u4f46\u8bc1\u636e\u7684\u786e\u5207\u6027\u5927\u5e45\u964d\u7ea7<\/td>\n<\/tr>\n | \n\u8bd5\u9a8c\u63d0\u524d\u7ec8\u6b62<\/strong><\/td>\n| \u5728\u4e2d\u671f\u663e\u793a\u51fa\u83b7\u76ca\u4fe1\u53f7\u540e\uff0c\u539f\u8ba1\u52126\u5e74\u4f46\u5728\u7b2c4.8\u5e74\u65f6\u7ec8\u6b62\uff1b\u5728\u996e\u98df\u5e72\u9884\u8bd5\u9a8c\u4e2d\uff0c\u63d0\u524d\u7ec8\u6b62\u4f1a\u7cfb\u7edf\u6027\u5730\u5938\u5927\u6548\u5e94\u91cf<\/td>\n | \u963f\u52a0\u74e6\u5c14\u548c\u7ea6\u5b89\u5c3c\u8fea\u65af\uff08BMJ 2019\uff0cPMID 30733217\uff09\uff1a\u9274\u4e8e\u4fee\u6b63\u540e\u7684\u7ed3\u679c\uff0c\u63d0\u524d\u7ec8\u6b62\u2018\u662f\u4e0d\u5408\u9002\u7684\u2019<\/td>\n<\/tr>\n | \n\u5bf9\u7167\u7ec4\u5e76\u975e\u771f\u6b63\u7684\u4f4e\u8102<\/strong><\/td>\n| \u5bf9\u7167\u7ec4\u5728\u7814\u7a76\u7ed3\u675f\u65f6\u603b\u8102\u80aa\u6444\u5165\u91cf\u8fbe\u523037%\uff1b\u524d3\u5e74\uff0c\u2018\u4f4e\u8102\u2019\u6307\u5bfc\u4ec5\u4ee5\u5ba3\u4f20\u518c\u5f62\u5f0f\u63d0\u4f9b\u3002\u771f\u6b63\u7684\u4f4e\u8102\u5b9a\u4e49\u4e3a\u70ed\u91cf\u6444\u5165\uff1c10%<\/td>\n | \u4f0a\u5965\u5b89\u5c3c\u8fea\u65af\uff1a\u2018PREDIMED\u7814\u7a76\u5bf9\u6bd4\u4e8641%\u4e0e37%\u9ad8\u8102\u996e\u98df\u6a21\u5f0f\u2014\u2014\u8fd9\u662f\u4e24\u79cd\u9ad8\u8102\u996e\u98df\u6a21\u5f0f\u7684\u6bd4\u8f83\uff0c\u800c\u975e\u5730\u4e2d\u6d77\u996e\u98df\u4e0e\u771f\u6b63\u4f4e\u8102\u996e\u98df\u7684\u5bf9\u6bd4\u3002\u2019<\/td>\n<\/tr>\n | \n\u5e72\u9884\u5f3a\u5ea6\u4e0d\u5e73\u8861<\/strong><\/td>\n| \u5730\u4e2d\u6d77\u996e\u98df\u7ec4\u81ea\u7814\u7a76\u5f00\u59cb\u5373\u83b7\u5f97\u514d\u8d39\u98df\u7269\uff08\u6bcf\u54681\u5347\u521d\u69a8\u6a44\u6984\u6cb9\u6216\u6bcf\u592930\u514b\u575a\u679c\uff09\u53ca\u5bc6\u96c6\u7684\u5b63\u5ea6\u54a8\u8be2\uff1b\u5bf9\u7167\u7ec4\u5728\u524d3\u5e74\u4ec5\u6536\u5230\u5ba3\u4f20\u518c<\/td>\n | \u5dee\u5f02\u5316\u6ce8\u610f\u548c\u98df\u7269\u63d0\u4f9b\u6df7\u6dc6\u4e86\u996e\u98df\u5f52\u56e0\uff1b\u5176\u76ca\u5904\u53ef\u80fd\u90e8\u5206\u53cd\u6620\u4e86\u975e\u996e\u98df\u6548\u5e94<\/td>\n<\/tr>\n | \n\u5352\u4e2d\u4e3a\u4e3b\u7684\u590d\u5408\u7ec8\u70b9<\/strong><\/td>\n| \u4e3b\u8981\u590d\u5408\u7ec8\u70b9\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff0c\u4e3b\u8981\u662f\u7531\u5352\u4e2d\u51cf\u5c11\u9a71\u52a8\u7684\uff1b\u5fc3\u808c\u6897\u6b7b\uff08MI\uff09\u548c\u5fc3\u8840\u7ba1\u6b7b\u4ea1\uff08CVD\uff09\u7387\u5728\u5404\u7ec4\u4e4b\u95f4\u65e0\u663e\u8457\u5dee\u5f02\u3002<\/td>\n | NICE\u7cfb\u7edf\u8bc4\u4ef7\uff1aPREDIMED\u5728\u4e2a\u4f53\u5fc3\u8840\u7ba1\u75be\u75c5\u7ed3\u679c\u4e0a\u9762\u4e34\u2018\u4e25\u91cd\u2019\u504f\u501a\u98ce\u9669\uff1b\u6b7b\u4ea1\u7387\u7ec8\u70b9\u7684\u6570\u636e\u4e3a\u2018\u4f4e\u6216\u6781\u4f4e\u8d28\u91cf\u2019<\/td>\n<\/tr>\n | \n\u4e8c\u6b21\u51fa\u7248\u589e\u751f<\/strong><\/td>\n| \u4f7f\u7528PREDIMED\u6570\u636e\u5e93\u53d1\u8868\u4e86267\u9879\u4ee5\u4e0a\u7684\u4e8c\u6b21\u5206\u6790\uff1b\u62a5\u544a\u4e86\u591a\u9879\u96be\u4ee5\u7f6e\u4fe1\u7684\u89c2\u5bdf\u6027\u58f0\u660e\uff08\u4f8b\u5982\uff0c\u5403\u575a\u679c\u7684\u9891\u7387\u53ef\u4ee5\u9884\u6d4b\u5168\u56e0\u6b7b\u4ea1\u7387\uff09<\/td>\n | \u2018PREDIMED\u5404\u7bc7\u51fa\u7248\u7269\u6240\u62a5\u544a\u7684\u6570\u636e\u4e4b\u95f4\u5b58\u5728\u591a\u5904\u77db\u76fe\uff0c\u8fd9\u8868\u660e\u8be5\u8bd5\u9a8c\u7684\u8d28\u91cf\u5b58\u5728\u66f4\u666e\u904d\u7684\u95ee\u9898\u2019\uff08Agarwal & Ioannidis, BMJ 2019\uff09<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \u6765\u6e90\uff1aEstruch R \u7b49. <\/em>N Engl J Med. 2018;378(25):e34 (PMID: 29897866); Agarwal A, Ioannidis JPA. BMJ. 2019;364:l341 (PMID: 30733217).<\/em><\/p>\n\u5982\u679c\u5355\u72ec\u6765\u770b\uff0c\u8fd9\u4e9b\u95ee\u9898\u4e2d\u7684\u6bcf\u4e00\u4e2a\u5728\u4e00\u9879\u5927\u578b\u7684\u771f\u5b9e\u4e16\u754c\u996e\u98df\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff08RCT\uff09\u7684\u80cc\u666f\u4e0b\u90fd\u53ef\u80fd\u662f\u53ef\u63a7\u7684\u3002\u4f46\u7efc\u5408\u8d77\u6765\u770b\uff0c\u5b83\u4eec\u5927\u5927\u524a\u5f31\u4e86\u53ef\u4ee5\u8d4b\u4e88PREDIMED\u8bd5\u9a8c\u7684\u8bc1\u636e\u5206\u91cf\uff0c\u4f7f\u5176\u65e0\u6cd5\u6210\u4e3a\u5730\u4e2d\u6d77\u996e\u98df\u4f18\u4e8e\u771f\u6b63\u4f4e\u8102\u5bf9\u7167\u996e\u98df\u7684\u786e\u51ff\u8bc1\u636e\u3002\u963f\u52a0\u74e6\u5c14\uff08Agarwal\uff09\u548c\u4f0a\u5965\u5c3c\u8fea\u65af\uff08Ioannidis\uff09\u5f97\u51fa\u7ed3\u8bba\u8ba4\u4e3a\uff0c\u2018PREDIMED\u5404\u7bc7\u51fa\u7248\u7269\u6240\u62a5\u544a\u7684\u6570\u636e\u4e4b\u95f4\u5b58\u5728\u591a\u5904\u77db\u76fe\uff0c\u8fd9\u8868\u660e\u8be5\u8bd5\u9a8c\u7684\u8d28\u91cf\u5b58\u5728\u66f4\u666e\u904d\u7684\u95ee\u9898\u2019\uff0c\u5e76\u4e14\u2018\u91cd\u65b0\u53d1\u8868\u53ef\u80fd\u65e0\u6cd5\u89e3\u51b3\u4f9d\u7136\u5b58\u5728\u7684\u8bf8\u591a\u95ee\u9898\u2019\u3002\uff087\uff09<\/p>\n \u91cd\u8981\u7684\u662f\uff0c\u8fd9\u4e9b\u62c5\u5fe7\u5e76\u975e\u5728\u64a4\u7a3f\u540e\u624d\u4e8b\u540e\u63d0\u51fa\uff1aNICE \u5bf9 PREDIMED \u7684\u7cfb\u7edf\u8bc4\u4ef7\u2014\u2014\u5728 2018 \u5e74\u64a4\u7a3f\u4e4b\u524d\u72ec\u7acb\u8fdb\u884c\u2014\u2014\u5c31\u5df2\u7ecf\u5c06\u8be5\u8bd5\u9a8c\u5bf9\u4e2a\u4f53\u5fc3\u8840\u7ba1\u75be\u75c5\uff08CVD\uff09\u7ed3\u5c40\u7684\u504f\u501a\u98ce\u9669\u8bc4\u5b9a\u4e3a\u2018\u4e25\u91cd\u2019\uff0c\u6b7b\u4ea1\u7387\u7ec8\u70b9\u7684\u6570\u636e\u88ab\u5206\u7c7b\u4e3a\u2018\u4f4e\u8d28\u91cf\u6216\u6781\u4f4e\u8d28\u91cf\u2019\uff087\uff09\u3002\u8fd9\u4e00\u64a4\u7a3f\u524d\u7684\u8bc4\u4f30\u5177\u6709\u9ad8\u5ea6\u91cd\u8981\u6027\uff0c\u5e76\u5f3a\u6709\u529b\u5730\u53cd\u9a73\u4e86\u8fd9\u6837\u4e00\u79cd\u89e3\u91ca\uff1a\u5373 PREDIMED \u63d0\u4f9b\u4e86\u51b3\u5b9a\u6027\u8bc1\u636e\uff0c\u8bc1\u660e\u5730\u4e2d\u6d77\u996e\u98df\u5728\u786c\u6027\u5fc3\u8840\u7ba1\u7ec8\u70b9\u65b9\u9762\u4f18\u4e8e\u771f\u6b63\u7684\u4f4e\u8102\u996e\u98df\u65b9\u6cd5\u3002.<\/p>\n \u91cc\u6602\u996e\u98df\u5fc3\u810f\u7814\u7a76\uff08Lyon Diet Heart Study\uff09\u907f\u514d\u4e86PREDIMED\u7814\u7a76\u4e2d\u5b58\u5728\u7684\u968f\u673a\u5206\u7ec4\u548c\u5bf9\u7167\u7ec4\u95ee\u9898\uff0c\u5e76\u5728\u4e8c\u7ea7\u9884\u9632\u4eba\u7fa4\u4e2d\u663e\u793a\u51fa\u5fc3\u810f\u6b7b\u4ea1\u548c\u975e\u81f4\u547d\u6027\u5fc3\u808c\u6897\u6b7b\u53d1\u751f\u7387\u964d\u4f4e\u4e8673%\uff0c\u8be5\u7814\u7a76\u81f3\u4eca\u4ecd\u662f\u540c\u884c\u8bc4\u5ba1\u6587\u732e\u4e2d\u5173\u4e8e\u996e\u98df\u4e8c\u7ea7\u9884\u9632\u7684\u5355\u9879\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff08RCT\uff09\u4e2d\u6700\u6709\u529b\u7684\u7ed3\u679c\u3002(8,9)<\/p>\n 6. \u4e34\u5e8a\u673a\u5236\uff1aApoB \u8102\u86cb\u767d\u3001\u5185\u76ae\u4e00\u6c27\u5316\u6c2e\u4e0e\u6591\u5757\u751f\u7269\u5b66<\/h3>\n6.1 \u52a8\u8109\u7ca5\u6837\u786c\u5316\u5f62\u6210\u4e0e\u542bApoB\u7684\u8102\u86cb\u767d<\/h4>\n\u73b0\u4ee3\u9884\u9632\u5fc3\u810f\u75c5\u5b66\u5c06\u8f7d\u8102\u86cb\u767dB\uff08ApoB\uff09\u8bc6\u522b\u4e3a\u52a8\u8109\u7ca5\u6837\u786c\u5316\u98ce\u9669\u7684\u4e3b\u8981\u81f4\u75c5\u6807\u5fd7\u7269\u3002\u6bcf\u4e2aVLDL\u3001IDL\u548cLDL\u9897\u7c92\u6070\u597d\u5305\u542b\u4e00\u4e2aApoB-100\u5206\u5b50\uff0c\u8fd9\u610f\u5473\u7740\u8840\u6d46ApoB\u6d53\u5ea6\u76f4\u63a5\u91cf\u5316\u4e86\u5faa\u73af\u4e2d\u6f5c\u5728\u81f4\u75c5\u9897\u7c92\u7684\u603b\u6570\u3002(21)\u7531\u4e8e\u52a8\u8109\u6591\u5757\u7684\u5f62\u6210\u53d6\u51b3\u4e8e\u9897\u7c92\u4e0e\u5185\u76ae\u76f8\u4e92\u4f5c\u7528\u7684\u6982\u7387\uff0c\u56e0\u6b64\u4e0e\u4f20\u7edf\u7684LDL-C\u6d53\u5ea6\u76f8\u6bd4\uff0cApoB\u662f\u5fc3\u808c\u6897\u6b7b\u66f4\u5177\u56e0\u679c\u7279\u5f02\u6027\u7684\u9884\u6d4b\u6307\u6807\u3002Marston\u7b49\u4eba\u5bf9\u82f1\u56fd\u751f\u7269\u6837\u672c\u5e93\uff08UK Biobank\uff09\u7684\u5206\u6790\u8bc1\u5b9e\u4e86\u8fd9\u4e00\u70b9\uff08JAMA Cardiol 2022, PMID: 34773460\uff09\uff0c\u8be5\u5206\u6790\u8868\u660e\uff0c\u5728\u5bf9389,529\u540d\u53d7\u8bd5\u8005\u7ec4\u6210\u7684\u961f\u5217\u8fdb\u884c\u5168\u9762\u6821\u6b63\u540e\uff0cApoB\u662f\u552f\u4e00\u4e0e\u5fc3\u808c\u6897\u6b7b\u72ec\u7acb\u76f8\u5173\u7684\u8102\u8d28\u53c2\u6570\u3002(22)<\/p>\n \u996e\u98df\u4e2d\u7684\u9971\u548c\u8102\u80aa\u9178\u901a\u8fc7\u7ec6\u80de\u5185\u80c6\u56fa\u9187\u91cd\u65b0\u5206\u914d\u7684\u673a\u5236\u964d\u4f4e\u809d\u810fLDL\u53d7\u4f53\u8868\u8fbe\uff0c\u4ece\u800c\u524a\u5f31\u53d7\u4f53\u4ecb\u5bfc\u7684\u8840\u6db2\u4e2dApoB\u9897\u7c92\u6e05\u9664\u3002(23) \u8fd9\u4e00\u673a\u5236\u7531Woollett\u3001Spady\u548cDietschy\uff08J Lipid Res 1992, PMID: 1552235\uff09\u786e\u7acb\uff0c\u5e76\u5f97\u5230\u4e86Mensink\u7b49\u4eba\uff08Am J Clin Nutr 2003, PMID: 12716665\uff09\u5305\u542b60\u9879\u8bd5\u9a8c\u7684\u835f\u8403\u5206\u6790\u7684\u8bc1\u5b9e\u3002(23,24) \u6781\u4f4e\u8102\u5168\u98df\u7269\u690d\u7269\u6027\u996e\u98df\uff08WFPB\uff09\u6a21\u5f0f\u901a\u8fc7\u4e24\u6761\u540c\u65f6\u8d77\u4f5c\u7528\u7684\u9014\u5f84\u5b9e\u73b0LDL-C\u548cApoB\u7684\u964d\u4f4e\uff1a\u663e\u8457\u51cf\u5c11\u603b\u9971\u548c\u8102\u80aa\u9178\uff08SFA\uff09\u7684\u8f93\u5165\uff0c\u4ee5\u53ca\u63d0\u9ad8ApoB\u7684\u5206\u79bb\u4ee3\u8c22\u7387\u2014\u2014\u5f53\u81b3\u98df\u603b\u8102\u8d28\u8f93\u5165\u6781\u5c11\u65f6\uff0c\u809d\u810f\u6e05\u9664\u81f4\u52a8\u8109\u7ca5\u6837\u786c\u5316\u9897\u7c92\u7684\u901f\u5ea6\u4f1a\u5927\u5e45\u52a0\u5feb\u3002(1,2)<\/p>\n 6.2 HDL\u529f\u80fd\u4e0e\u80c6\u56fa\u9187\u9006\u5411\u8f6c\u8fd0<\/h4>\nHernaez \u7b49\u4eba\u7684 PREDIMED \u5b50\u7814\u7a76\uff08\u300aCirculation\u300b2017 \u5e74\uff0cPMID\uff1a28193797\uff09\u63d0\u4f9b\u4e86\u7ecf\u540c\u884c\u8bc4\u5ba1\u7684\u8bc1\u636e\uff0c\u8868\u660e\u5bcc\u542b\u7279\u7ea7\u521d\u69a8\u6a44\u6984\u6cb9\uff08EVOO\uff09\u7684\u5730\u4e2d\u6d77\u996e\u98df\u80fd\u663e\u8457\u6539\u5584\u9ad8\u5bc6\u5ea6\u8102\u86cb\u767d\uff08HDL\uff09\u7684\u80c6\u56fa\u9187\u5916\u6d41\u529f\u80fd\uff0c\u4e14\u8be5\u4f5c\u7528\u4e0e HDL-C \u6d53\u5ea6\u65e0\u5173\u3002(25) \u8fd9\u4f53\u73b0\u4e86\u5730\u4e2d\u6d77\u996e\u98df\u6a21\u5f0f\u7684\u4e00\u4e2a\u771f\u6b63\u673a\u5236\u4f18\u52bf\uff1aHDL\u9897\u7c92\u7684\u5b9a\u6027\u529f\u80fd\u5f97\u5230\u4e86\u589e\u5f3a\u3002 \u8d85\u4f4e\u8102\u6a21\u578b\u7684\u652f\u6301\u8005\u627f\u8ba4\u8fd9\u4e00\u53d1\u73b0\uff0c\u4f46\u8ba4\u4e3a\u5728\u8102\u80aa\u542b\u91cf\u4f4e\u4e8e10%\u7684\u5168\u690d\u7269\u6027\u996e\u98df\uff08WFPB\uff09\u4e2d\uff0c\u6444\u5165\u7684\u80c6\u56fa\u9187\u7edd\u5bf9\u8d1f\u62c5\u5df2\u5927\u5e45\u964d\u4f4e\uff0c\u56e0\u6b64\u5373\u4f7f\u6ca1\u6709\u5bf9\u5355\u4e2aHDL\u9897\u7c92\u529f\u80fd\u7684\u7b49\u6548\u589e\u5f3a\uff0c\u51c0\u6591\u5757\u80c6\u56fa\u9187\u901a\u91cf\u2014\u2014\u4ee5\u53ca\u7531\u6b64\u5e26\u6765\u7684\u6591\u5757\u6d88\u9000\u901f\u7387\u2014\u2014\u4e5f\u66f4\u4f18\u3002\uff081,2,35\uff09 \u76ee\u524d\u5c1a\u65e0\u4efb\u4f55\u5934\u5bf9\u5934\u8bd5\u9a8c\u901a\u8fc7\u6d4b\u91cf\u4e24\u79cd\u996e\u98df\u6761\u4ef6\u4e0b\u52a8\u8109\u6591\u5757\u80c6\u56fa\u9187\u7684\u51c0\u5e73\u8861\u6765\u89e3\u51b3\u8fd9\u4e00\u5177\u4f53\u7684\u673a\u5236\u4e89\u8bae\u3002.<\/p>\n 6.3 \u7cbe\u70bc\u6cb9\u3001\u9910\u540e\u5185\u76ae\u635f\u4f24\u4e0e\u4e00\u6c27\u5316\u6c2e\u751f\u7269\u5229\u7528\u5ea6<\/h4>\n\u80b1\u52a8\u8109\u7684\u8840\u6d41\u4ecb\u5bfc\u7684\u8212\u5f20\uff08FMD\uff09\u662f\u7ecf\u9a8c\u8bc1\u7684\u8bc4\u4f30\u5185\u76ae\u4e00\u6c27\u5316\u6c2e\u751f\u6210\u80fd\u529b\u7684\u4e34\u5e8a\u6307\u6807\uff0c\u4e5f\u662f\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u7684\u524d\u77bb\u6027\u9884\u6d4b\u6307\u6807\u3002Vogel\u3001Corretti \u548c Plotnick\uff08\u300a\u7f8e\u56fd\u5fc3\u810f\u75c5\u5b66\u4f1a\u6742\u5fd7\u300b2000 \u5e74\uff0cPMID: 11079642\uff09\u7684\u7814\u7a76\u8868\u660e\uff0c\u4e00\u987f\u542b\u6709\u6a44\u6984\u6cb9\u7684\u9ad8\u8102\u80aa\u9910\u53ef\u4f7f\u80b1\u52a8\u8109FMD\u964d\u4f4e\u7ea631%\uff0c\u5176\u53d7\u635f\u7a0b\u5ea6\u4e0e\u9ad8\u9971\u548c\u8102\u80aa\u5feb\u9910\u6240\u81f4\u7684\u6548\u679c\u76f8\u5f53\u3002(18) Fewkes\u7b49\u4eba\uff08\u300a\u7f8e\u56fd\u4e34\u5e8a\u8425\u517b\u5b66\u6742\u5fd7\u300b2022\u5e74\uff0cPMID: 35665799\uff09\u5bf9131\u9879\u996e\u98df\u8bd5\u9a8c\u8fdb\u884c\u7684\u7cfb\u7edf\u7efc\u8ff0\u548c\u835f\u8403\u5206\u6790\u8bc1\u5b9e\uff0c\u65e0\u8bba\u8102\u80aa\u7c7b\u578b\u5982\u4f55\uff0c\u9ad8\u8102\u81b3\u98df\u90fd\u4f1a\u4e00\u81f4\u4e14\u53ef\u91cd\u590d\u5730\u635f\u5bb3\u9910\u540e\u5185\u76ae\u529f\u80fd\u3002(20)<\/p>\n \u76f8\u6bd4\u4e4b\u4e0b\uff0cCortes \u7b49\u4eba\uff08J Am Coll Cardiol 2006, PMID: 17045905\uff09\u8bc1\u5b9e\uff0c\u542b\u6709\u4e0e\u6a44\u6984\u6cb9\u9910\u7b49\u70ed\u91cf\u8102\u80aa\u7684\u6838\u6843\uff0c\u80fd\u591f\u4fdd\u6301\u6216\u6539\u5584\u9910\u540e FMD\uff0c\u8fd9\u5f52\u56e0\u4e8e\u5168\u98df\u7269\u57fa\u8d28\u4e2d\u5b58\u5728\u4f46\u7cbe\u5236\u6cb9\u4e2d\u7f3a\u5c11\u7684\u7cbe\u6c28\u9178\u6210\u5206\uff08\u4e00\u6c27\u5316\u6c2e\u7684\u76f4\u63a5\u524d\u4f53\uff09\u548c omega-3 \u8102\u80aa\u9178\u3002(19) Ros \u7b49\u4eba\uff08Circulation 2004, PMID: 15037535\uff09\u8bc1\u5b9e\uff0c\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u53d7\u8bd5\u8005\u7ecf\u5e38\u98df\u7528\u6838\u6843\u53ef\u4f7f FMD \u5f97\u5230\u6301\u7eed\u6539\u5584\u3002(33)<\/p>\n \u8868 5. \u5404\u79cd\u8102\u80aa\u6765\u6e90\u5bf9\u9910\u540e\u5185\u76ae\u53cd\u5e94\u7684\u5f71\u54cd\uff08\u8840\u6d41\u4ecb\u5bfc\u7684\u6269\u5f20\uff09<\/em><\/strong><\/p>\n\n\n\n\u8102\u80aa\u6765\u6e90 \/ \u9910<\/strong><\/td>\nFMD \u5f71\u54cd\uff08\u9910\u540e 3-4 \u5c0f\u65f6\uff09<\/strong><\/td>\n\u673a\u5236\u89e3\u91ca<\/strong><\/td>\n<\/tr>\n\n\u7cbe\u70bc\u6a44\u6984\u6cb9<\/strong><\/td>\n| ~31% \u80b1\u52a8\u8109\u6269\u5f20\u7a0b\u5ea6\u964d\u4f4e<\/td>\n | \u9910\u540e\u8102\u8840\uff1b\u6c27\u5316\u5e94\u6fc0\uff1b\u4e00\u6c27\u5316\u6c2e\u6291\u5236<\/td>\n<\/tr>\n | \n\u83dc\u7c7d\u6cb9<\/strong><\/td>\n| \u8f7b\u5fae\u635f\u4f24<\/td>\n | \u8f83\u9ad8 ALA\uff08\u6b27\u7c73\u8304-3\uff09\u542b\u91cf\u5177\u6709\u90e8\u5206\u4fdd\u62a4\u4f5c\u7528<\/td>\n<\/tr>\n | \n\u4e09\u6587\u9c7c\/\u9c7c\u6cb9<\/strong><\/td>\n| \u65e0\u6216\u6781\u8f7b\u5fae\u529f\u80fd\u635f\u5bb3<\/td>\n | \u4fdd\u62a4\u6027 EPA\/DHA + \u4e00\u6c27\u5316\u6c2e\u534f\u540c\u4f5c\u7528<\/td>\n<\/tr>\n | \n\u6838\u6843\uff08\u5929\u7136\u5168\u98df\u54c1\uff09<\/strong><\/td>\n| \u4fdd\u5b58\u6216\u6539\u5584FMD<\/td>\n | \u7cbe\u6c28\u9178\uff08\u4e00\u6c27\u5316\u6c2e\u524d\u4f53\uff09+ Omega-3\uff1b\u7cbe\u6c28\u9178\u4e0d\u5b58\u5728\u4e8e\u7cbe\u70bc\u6cb9\u4e2d<\/td>\n<\/tr>\n | \n\u6a44\u6984\u6cb9 + \u6c99\u62c9 \/ \u918b<\/strong><\/td>\n| \u663e\u7740\u7f13\u51b2\u7684\u635f\u4f24<\/td>\n | \u852c\u83dc\u4e2d\u7684\u591a\u915a\u548c\u6297\u6c27\u5316\u5242\u53ef\u4e2d\u548c\u9910\u540e\u8102\u8d28\u5e94\u6fc0<\/td>\n<\/tr>\n | \n\u9ad8\u9971\u548c\u8102\u80aa\u9178\u9910\uff08\u9ec4\u6cb9\/\u8428\u62c9\u7c73\u9999\u80a0\uff09<\/strong><\/td>\n| \u4e25\u91cd\u53d7\u635f<\/td>\n | \u76f4\u63a5\u4fc3\u708e\u6027\u5185\u76ae\u635f\u4f24\uff1b\u4e25\u91cd\u7684\u4e00\u6c27\u5316\u6c2e\uff08NO\uff09\u6291\u5236<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \u8d44\u6599\u6765\u6e90\uff1aVogel RA \u7b49. <\/em>J Am Coll Cardiol. 2000;36(5):1455-60 (PMID: 11079642); Cortes B et al. J Am Coll Cardiol. 2006;48(8):1666-71 (PMID: 17045905); Ros E et al. Circulation. 2004;109(13):1609-14 (PMID: 15037535); Fewkes JJ et al. Am J Clin Nutr. 2022;116(3):699-729 (PMID: 35665799).<\/em><\/p>\n\u8fd9\u4e9b FMD \u53d1\u73b0\u5177\u6709\u76f4\u63a5\u7684\u4e34\u5e8a\u610f\u4e49\uff1a\u57c3\u745f\u65af\u8482\u6587\u65b9\u6848\u6392\u9664\u4e86\u6240\u6709\u7cbe\u70bc\u6cb9\uff08\u5305\u62ec\u7279\u7ea7\u521d\u69a8\u6a44\u6984\u6cb9\uff09\uff0c\u4ece\u800c\u6d88\u9664\u4e86\u9910\u540e\u5bf9\u6240\u6709\u8fdb\u9910\u65f6\u6bb5\u5185\u76ae\u7ec6\u80de\u7684\u5e94\u6fc0\u6e90\uff0c\u4f7f\u5185\u76ae\u7ec6\u80de\u5728\u5168\u5929\u90fd\u80fd\u4fdd\u6301\u6301\u7eed\u8f83\u9ad8\u7684\u4e00\u6c27\u5316\u6c2e\u751f\u7269\u5229\u7528\u5ea6\u3002\u5728\u5730\u4e2d\u6d77\u996e\u98df\u4e2d\uff0c\u5185\u76ae\u529f\u80fd\u5728\u542b\u6cb9\u9910\u540e\u7684\u7a97\u53e3\u671f\u4f1a\u53d7\u635f\uff0c\u5373\u4f7f\u7a7a\u8179\u5185\u76ae\u6d4b\u91cf\u503c\u4ecd\u7136\u4fdd\u6301\u826f\u597d (5,18,35)\u3002\u6c83\u683c\u5c14\u7684\u89e3\u91ca\u662f\uff0c\u5730\u4e2d\u6d77\u996e\u98df\u7684\u597d\u5904\u4e0d\u5728\u4e8e\u6a44\u6984\u6cb9\u672c\u8eab\uff0c\u800c\u5728\u4e8e\u4e0e\u5176\u4e00\u8d77\u98df\u7528\u7684\u5bcc\u542b\u6297\u6c27\u5316\u5242\u7684\u852c\u83dc\u548c\u918b\uff0c\u5b83\u4eec\u90e8\u5206\u7f13\u51b2\u4e86\u9910\u540e\u7684\u5185\u76ae\u5e94\u6fc0 (18)\u3002<\/p>\n 7. \u5faa\u8bc1\u7efc\u5408\uff1a\u5168\u98df\u7269\u690d\u7269\u6027\uff08WFPB\uff09\u65b9\u6848\u4f5c\u4e3a\u552f\u4e00\u88ab\u8bc1\u5b9e\u7684\u6591\u5757\u9006\u8f6c\u7b56\u7565<\/h3>\n7.1 \u8840\u7ba1\u9020\u5f71\u56de\u5f52\u8bc1\u636e\u5e93\u7684\u72ec\u7279\u6027<\/h4>\n\u622a\u81f3\u672c\u7efc\u8ff0\u53d1\u5e03\u4e4b\u65f6\uff0c\u6781\u4f4e\u8102\u7eaf\u690d\u7269\u6027\u996e\u98df\uff08WFPB\uff09\u662f\u552f\u4e00\u5728\u7ecf\u540c\u884c\u8bc4\u5ba1\u7684\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff08RCT\uff09\u6570\u636e\u4e2d\uff0c\u901a\u8fc7\u8840\u7ba1\u9020\u5f71\u8bc1\u5b9e\u53ef\u9006\u8f6c\u52a8\u8109\u6591\u5757\uff0c\u4e14\u968f\u8bbf\u65f6\u95f4\u957f\u8fbe\u6570\u5e74\u7684\u996e\u98df\u65b9\u6848\u3002 \u5965\u5c3c\u4ec0\u751f\u6d3b\u65b9\u5f0f\u5fc3\u810f\u8bd5\u9a8c\uff08Ornish Lifestyle Heart Trial\uff09\u8bb0\u5f55\u663e\u793a\uff0c\u5728\u4e94\u5e74\u5185\uff0c\u5b9e\u9a8c\u7ec4\u51a0\u72b6\u52a8\u8109\u72ed\u7a84\u7684\u5e73\u5747\u76f8\u5bf9\u9006\u8f6c\u7387\u4e3a7.9%\uff0c\u800c\u5bf9\u7167\u7ec4\u4e3a27.7%\uff08p < 0.001\uff09\uff0c \u4e14\u5bf9\u7167\u7ec4\u7684\u5fc3\u810f\u4e8b\u4ef6\u53d1\u751f\u7387\u9ad8\u51fa2.47\u500d\u3002(2) \u76ee\u524d\u5c1a\u65e0\u9488\u5bf9\u5730\u4e2d\u6d77\u996e\u98df\u6a21\u5f0f\u5728\u53d7\u63a7\u524d\u77bb\u6027\u8bd5\u9a8c\u4e2d\u83b7\u5f97\u7684\u53ef\u6bd4\u6027\u8840\u7ba1\u9020\u5f71\u51a0\u72b6\u52a8\u8109\u6591\u5757\u9006\u8f6c\u6570\u636e\u3002.<\/p>\n CORDIOPREV\u8bd5\u9a8c\uff08Delgado-Lista \u7b49\uff0c\u300a\u67f3\u53f6\u5200\u300b2022\u5e74\uff0cPMID\uff1a 35525255\uff09\u7814\u7a76\u8bc1\u5b9e\uff0c\u4e0e\u4f4e\u8102\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u91c7\u7528\u5730\u4e2d\u6d77\u996e\u98df\u57285-7\u5e74\u5185\u663e\u8457\u51cf\u7f13\u4e86\u9888\u52a8\u8109\u5185\u819c\u4e2d\u5c42\u539a\u5ea6\uff08IMT-CC\uff09\u7684\u8fdb\u5c55\uff0c\u5e76\u4f7f\u5176\u51fa\u73b0\u8f7b\u5ea6\u9006\u8f6c\uff0c\u540c\u65f6\u9888\u52a8\u8109\u6591\u5757\u9ad8\u5ea6\u4e5f\u6709\u6240\u964d\u4f4e\u3002(26,27) \u8fd9\u4e9b\u90fd\u662f\u5177\u6709\u91cd\u8981\u610f\u4e49\u7684\u66ff\u4ee3\u6027\u7814\u7a76\u7ed3\u679c\u3002 \u7136\u800c\uff0cCORDIOPREV\u8bd5\u9a8c\u4e2d\u91c7\u7528\u7684\u4f4e\u8102\u5bf9\u7167\u7ec4\u6bcf\u65e5\u8102\u80aa\u6444\u5165\u91cf\u7ea6\u4e3a28-30% \u2014\u2014\u672a\u8fbe\u5230<10%\u7684\u7eaf\u690d\u7269\u6027\u5168\u98df\uff08WFPB\uff09\u9608\u503c\u2014\u2014\u4e14\u8be5\u8bd5\u9a8c\u91c7\u7528\u9888\u52a8\u8109IMT\u800c\u975e\u51a0\u72b6\u52a8\u8109\u9020\u5f71\u4f5c\u4e3a\u4e3b\u8981\u66ff\u4ee3\u7ec8\u70b9\uff0c\u56e0\u6b64\u4ece\u7814\u7a76\u65b9\u6cd5\u5b66\u4e0a\u8bb2\uff0c\u65e0\u6cd5\u4e0e\u5965\u5c3c\u4ec0\uff08Ornish\uff09\u7684\u9020\u5f71\u9006\u8f6c\u6570\u636e\u8fdb\u884c\u76f4\u63a5\u6bd4\u8f83\u3002(26)<\/p>\n \u524d\u7f8e\u56fd\u5fc3\u810f\u75c5\u5b66\u4f1a\u524d\u4e3b\u5e2d\u7684\u4e34\u5e8a\u7acb\u573a\u4e0e\u6b64\u76f4\u63a5\u76f8\u5173\uff1a\u5a01\u5ec9\u59c6\u65af\u5728\u540c\u884c\u8bc4\u8bae\u7684\u8bc4\u8bba\u4e2d\u6307\u51fa\uff0c\u5728\u7ecf\u8840\u7ba1\u9020\u5f71\u786e\u8bca\u7684\u51a0\u5fc3\u75c5\u60a3\u8005\u4e2d\uff0c\u2018\u5df2\u88ab\u8bc1\u660e\u5177\u6709\u53ef\u63a5\u53d7\u7684\u98ce\u9669\/\u6548\u76ca\u6bd4\u7684\u6591\u5757\u9006\u8f6c\u65b9\u6cd5\u4ec5\u6709\u56db\u79cd\u2019\u2014\u2014\u5965\u5c3c\u65af\u996e\u98df\u3001\u57c3\u745fstyn\u996e\u98df\u3001\u5927\u5242\u91cf\u963f\u6258\u4f10\u4ed6\u6c40\u548c\u5927\u5242\u91cf\u745e\u8212\u4f10\u4ed6\u6c40\u3002\u5730\u4e2d\u6d77\u996e\u98df\u6a21\u5f0f\u4e0d\u5728\u5176\u4e2d\u3002(35)<\/p>\n 7.2 \u5730\u4e2d\u6d77\u996e\u98df\u8bc1\u636e\u7b49\u7ea7\u7684\u91cd\u65b0\u8bc4\u4f30<\/h4>\n\u5730\u4e2d\u6d77\u996e\u98df\u6a21\u5f0f\u5728\u5fc3\u8840\u7ba1\u75be\u75c5\u4e00\u7ea7\u9884\u9632\u65b9\u9762\u62e5\u6709\u624e\u5b9e\u7684\u8bc1\u636e\u57fa\u7840\uff0c\u8fd9\u5f97\u5230\u4e86\u4ee5\u4e0b\u7814\u7a76\u7684\u652f\u6301\uff1a\u91cc\u6602\u996e\u98df\u5fc3\u810f\u7814\u7a76\uff08Lyon Diet Heart Study\uff09\u5728\u4e8c\u7ea7\u9884\u9632\u4e2d\u663e\u793a\u51fa73%\u4e8b\u4ef6\u53d1\u751f\u7387\u7684\u964d\u4f4e\uff08PMID\uff1a9989963\uff09\uff0c \u5317\u5361\u7d2f\u5229\u963f\u9879\u76ee40\u5e74\u5185\u51a0\u5fc3\u75c5\u6b7b\u4ea1\u7387\u964d\u4f4e84%\uff08PMID: 27242088\uff09\uff0c\u4ee5\u53caTrichopoulou\u7b49\u4eba\u63d0\u4f9b\u7684\u524d\u77bb\u6027\u961f\u5217\u6570\u636e\uff08\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b2003\u5e74\uff0cPMID: 12826634\uff09\u7684\u524d\u77bb\u6027\u961f\u5217\u6570\u636e\uff0c\u4ee5\u53caDinu\u7b49\u4eba\u6db5\u76d657\u9879\u835f\u8403\u5206\u6790\u7684\u4f1e\u5f0f\u835f\u8403\u5206\u6790\uff08\u300a\u6b27\u6d32\u4e34\u5e8a\u8425\u517b\u5b66\u6742\u5fd7\u300b2018\u5e74\uff0cPMID: 28488692\uff09\u3002(9,11,15,31) \u8fd9\u4e00\u7cfb\u5217\u8bc1\u636e\u5341\u5206\u5145\u5206\uff0c\u652f\u6301\u5176\u786e\u5b9e\u5177\u6709\u5fc3\u8840\u7ba1\u75be\u75c5\u9884\u9632\u4f5c\u7528\u3002.<\/p>\n \u7136\u800c\uff0cPREDIMED\u2014\u2014\u4f5c\u4e3a\u5730\u4e2d\u6d77\u996e\u98df\u6a21\u5f0f\u5728\u4e00\u7ea7\u9884\u9632\u9886\u57df\u7684\u57fa\u7840\u6027\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff08RCT\uff09\u2014\u2014\u7531\u4e8e\u5b58\u5728\u4ee5\u4e0b\u95ee\u9898\uff0c\u65e0\u6cd5\u88ab\u89c6\u4e3a\u5728\u65b9\u6cd5\u5b66\u4e0a\u5177\u6709\u51b3\u5b9a\u6027\u610f\u4e49\u7684\u8bd5\u9a8c\uff1a21%\u540d\u53d7\u8bd5\u8005\u7684\u968f\u673a\u5206\u7ec4\u5931\u8d25\u3001\u56e0\u63d0\u524d\u7ec8\u6b62\u8bd5\u9a8c\u800c\u5bfc\u81f4\u6548\u5e94\u91cf\u88ab\u5938\u5927\u3001\u5bf9\u7167\u7ec4\u4ece\u672a\u8fbe\u5230\u4f4e\u8102\u996e\u98df\u6807\u51c6\u3001 \u5e72\u9884\u5f3a\u5ea6\u4e0d\u5747\u8861\uff0c\u4ee5\u53caNICE\u5728\u64a4\u56de\u524d\u8bc4\u4f30\u4e2d\u6307\u51fa\u7684\u2018\u5b58\u5728\u4e25\u91cd\u504f\u501a\u98ce\u9669\u2019\u3002(6,7) \u4ec5\u51edPREDIMED\u6570\u636e\u5c31\u5f97\u51fa\u5730\u4e2d\u6d77\u996e\u98df\u4f18\u4e8e\u771f\u6b63\u4f4e\u8102\u996e\u98df\u7684\u7ed3\u8bba\uff0c\u5728\u8ba4\u8bc6\u8bba\u4e0a\u7f3a\u4e4f\u4f9d\u636e\u3002.<\/p>\n 7.3 \u8d85\u4f4e\u8102\u8bc1\u636e\u57fa\u7840\u7684\u5173\u952e\u5c40\u9650\u6027<\/h4>\n\u77e5\u8bc6\u8bda\u5b9e\u8981\u6c42\u5bf9\u5168\u98df\u690d\u7269\u6027\u996e\u98df\uff08WFPB\uff09\u7684\u8bc1\u636e\u8fdb\u884c\u540c\u6837\u4e25\u5bc6\u7684\u5ba1\u67e5\u3002\u201c\u751f\u6d3b\u65b9\u5f0f\u5fc3\u810f\u8bd5\u9a8c\u201d\u4ec5\u968f\u673a\u7eb3\u5165\u4e86 48 \u540d\u60a3\u8005\uff0c\u5176\u4e2d 35 \u4eba\u5b8c\u6210\u4e86\u4e94\u5e74\u7684\u8840\u7ba1\u9020\u5f71\u968f\u8bbf\u2014\u2014\u6837\u672c\u91cf\u8f83\u5c0f\u4e14\u666e\u9002\u6027\u6709\u9650 (1,2)\u3002\u8be5\u8ba1\u5212\u5c06\u996e\u98df\u4e0e\u8fd0\u52a8\u3001\u538b\u529b\u7ba1\u7406\u548c\u793e\u4f1a\u652f\u6301\u76f8\u7ed3\u5408\uff0c\u4ec5\u4ece\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff08RCT\uff09\u6570\u636e\u4e2d\u5728\u65b9\u6cd5\u5b66\u4e0a\u65e0\u6cd5\u5c06\u996e\u98df\u7684\u4f5c\u7528\u5355\u72ec\u9694\u79bb\u51fa\u6765 (2)\u3002\u57c3\u585e\u5c14\u65af\u5ef7 2014 \u5e74\u7684\u961f\u5217\u7814\u7a76\u662f\u89c2\u5bdf\u6027\u7684\uff0c\u800c\u975e\u968f\u673a\u7684\uff0c\u4e14\u5927\u591a\u6570\u60a3\u8005\u540c\u65f6\u63a5\u53d7\u4e86\u964d\u80c6\u56fa\u9187\u836f\u7269\u6cbb\u7597\uff0c\u8fd9\u9650\u5236\u4e86\u5c06\u56e0\u679c\u5173\u7cfb\u5355\u7eaf\u5f52\u56e0\u4e8e\u996e\u98df (5)\u3002<\/p>\n \u8fd9\u4e9b\u5c40\u9650\u6027\u5e76\u672a\u5426\u5b9a\u7814\u7a76\u7ed3\u679c\u7684\u4e34\u5e8a\u610f\u4e49\uff0c\u4f46\u9002\u5f53\u5730\u9650\u5236\u4e86\u56e0\u679c\u5173\u7cfb\u7684\u786e\u5b9a\u6027\u3002 \u8be5\u9886\u57df\u4e9f\u9700\u4e00\u9879\u5927\u89c4\u6a21\u3001\u5177\u6709\u5145\u5206\u7edf\u8ba1\u6548\u80fd\uff08\u6bcf\u7ec4n \u2265 400\uff09\u3001\u591a\u7ec4\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff08RCT\uff09\uff0c\u76f4\u63a5\u6bd4\u8f83<10%\u4f4e\u8102\u5168\u690d\u7269\u6027\u996e\u98df\u65b9\u6848\u3001\u5730\u4e2d\u6d77\u996e\u98df\u4e0e\u4f18\u5316\u836f\u7269\u6cbb\u7597\u7684\u6548\u679c\uff0c\u5e76\u4ee5\u51a0\u72b6\u52a8\u8109CTA\u6591\u5757\u5b9a\u91cf\u4f5c\u4e3a\u4e3b\u8981\u5f71\u50cf\u5b66\u7ec8\u70b9\u3002 DISCO-CT\u968f\u673a\u8bd5\u9a8c\uff08Henzel \u7b49\uff0cJACC Cardiovasc Imaging 2021\uff0cPMID: 33341413\uff09\u4e3a\u7ed3\u5408\u51a0\u72b6\u52a8\u8109CTA\u5f71\u50cf\u5b66\u7ed3\u5c40\u6307\u6807\u7684\u5f3a\u5316\u751f\u6d3b\u65b9\u5f0f\u5e72\u9884\u63d0\u4f9b\u4e86\u73b0\u4ee3\u5316\u7684\u65b9\u6cd5\u5b66\u6a21\u677f\u3002(34)<\/p>\n 8. \u5171\u8bc6\u77e9\u9635\u4e0e\u5faa\u8bc1\u5206\u6b67\u70b9<\/h3>\n\u8868 6\uff1a\u5fc3\u8840\u7ba1\u8425\u517b\u5b66\u5171\u8bc6\u4e0e\u57fa\u4e8e\u8bc1\u636e\u7684\u5206\u6b67\u77e9\u9635<\/em><\/strong><\/p>\n\n\n\n\u996e\u98df\u56e0\u7d20<\/strong><\/td>\n\u5171\u8bc6\u9886\u57df<\/strong><\/td>\n\u5faa\u8bc1\u533b\u5b66\u5206\u6b67\u9886\u57df<\/strong><\/td>\n<\/tr>\n\n\u81b3\u98df\u7ea4\u7ef4<\/strong><\/td>\n| \u901a\u8fc7\u80c6\u6c41\u9178\u87af\u5408\u4f5c\u7528\u5bf9\u6e05\u9664\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u80c6\u56fa\u9187\uff08LDL-C\uff09\u548c\u8f7d\u8102\u86cb\u767dB\uff08ApoB\uff09\u81f3\u5173\u91cd\u8981\uff0c\u8fd9\u4e00\u70b9\u5df2\u5f97\u5230\u666e\u904d\u8ba4\u53ef\uff1b\u4e24\u6d3e\u89c2\u70b9\u5747\u8d5e\u6210\u9ad8\u7ea4\u7ef4\u6444\u5165\u3002<\/td>\n | \u65e0\u51b2\u7a81\uff1b\u4e24\u79cd\u8303\u5f0f\u666e\u904d\u8d5e\u540c\u66f4\u9ad8\u6444\u5165\u91cf<\/td>\n<\/tr>\n | \n\u86cb\u767d\u8d28\u6765\u6e90<\/strong><\/td>\n| \u4e24\u8005\u90fd\u5f3a\u8c03\u8c46\u7c7b\u3001\u5927\u8c46\u548c\u690d\u7269\u86cb\u767d\uff1b\u4e00\u81f4\u8ba4\u4e3a\u52a0\u5de5\u8089\u7c7b\u5177\u6709\u81f4\u52a8\u8109\u7ca5\u6837\u786c\u5316\u4f5c\u7528<\/td>\n | \u9006\u8f6c\u996e\u98df\u9635\u8425\u5b8c\u5168\u6392\u9664\u4e86\u9c7c\u7c7b\uff1b\u800c\u5730\u4e2d\u6d77\u996e\u98df\u9635\u8425\u5219\u56e0\u5bcc\u542b\u6b27\u7c73\u4f3d-3\u800c\u63a8\u5d07\u591a\u8102\u9c7c\u7c7b\u3002<\/td>\n<\/tr>\n | \n\u7cbe\u5236\u78b3\u6c34\u5316\u5408\u7269<\/strong><\/td>\n| \u4e24\u8005\u5747\u5c06\u7cbe\u5236\u8c37\u7269\u548c\u6dfb\u52a0\u7cd6\u8bc6\u522b\u4e3a\u72ec\u7acb\u7684\u7684\u5fc3\u8840\u7ba1\u98ce\u9669\u9a71\u52a8\u56e0\u7d20<\/td>\n | \u6ca1\u6709\u51b2\u7a81\uff1b\u4e24\u8005\u90fd\u9650\u5236\u7cbe\u5236\u6dc0\u7c89\u548c\u6dfb\u52a0\u7cd6<\/td>\n<\/tr>\n | \n\u9971\u548c\u8102\u80aa<\/strong><\/td>\n| \u53cc\u65b9\u5747\u8ba4\u4e3a\uff0cSFA \u901a\u8fc7\u4e0b\u8c03\u809d\u810f\u4e2d\u7684 LDL \u53d7\u4f53\u6c34\u5e73\u6765\u5347\u9ad8 LDL-C\uff0c\u4e14\u5176\u70ed\u91cf\u6444\u5165\u5e94\u4f4e\u4e8e 7-10%\u3002<\/td>\n | \u65b9\u5411\u4e00\u81f4\uff1b\u53cd\u5411\u6d3e\u7684\u76ee\u6807\u662f<2%\u7684SFA\uff08\u4f5c\u4e3a\u603b\u8102\u80aa\u7684\u4e00\u90e8\u5206\uff09\uff0c\u76ee\u6807\u503c\u4e3a<10%\uff1b\u5730\u4e2d\u6d77\u996e\u98df\u6d3e\u7684\u76ee\u6807\u662f<7-8%<\/td>\n<\/tr>\n | \n\u603b\u8102\u80aa %<\/strong><\/td>\n| \u666e\u904d\u8ba4\u4e3a\uff0c\u897f\u65b9\u56fd\u5bb635-40%\u603b\u8102\u80aa\u7684\u5e73\u5747\u6c34\u5e73\u5177\u6709\u81f4\u52a8\u8109\u7ca5\u6837\u786c\u5316\u4f5c\u7528\uff0c\u5e94\u4e88\u4ee5\u964d\u4f4e<\/td>\n | \u9006\u8f6c\u5b66\u6d3e\uff1a<10%\u65b9\u53ef\u5b9e\u73b0\u6591\u5757\u9006\u8f6c\uff1b\u5730\u4e2d\u6d77\u5b66\u6d3e\uff1a30-45%\u9002\u7528\u4e8e\u4e00\u7ea7\u9884\u9632<\/td>\n<\/tr>\n | \n\u7cbe\u70bc\u6cb9<\/strong><\/td>\n| \u53cc\u65b9\u90fd\u4e00\u81f4\u8ba4\u4e3a\uff0c\u4f5c\u4e3a\u8102\u80aa\u6765\u6e90\uff0c\u521d\u69a8\u7279\u7ea7\u521d\u69a8\u6a44\u6984\u6cb9\uff08EVOO\uff09\u8fdc\u4f18\u4e8e\u9ec4\u6cb9\u548c\u53cd\u5f0f\u8102\u80aa\uff1b\u53cc\u65b9\u90fd\u4e0d\u8d5e\u6210\u90e8\u5206\u6c22\u5316\u6cb9\u3002<\/td>\n | \u9006\u8f6c\u9635\u8425\uff1a\u96f6\u6dfb\u52a0\u7cbe\u70bc\u6cb9\uff08\u6240\u6709\u7cbe\u70bc\u6cb9\u90fd\u4f1a\u5728\u9910\u540e\u7a97\u53e3\u671f\u5185\u635f\u5bb3\u5185\u76ae\u4f9d\u8d56\u6027\u8840\u8102\u4ecb\u5bfc\u7684\u8840\u7ba1\u8212\u5f20\u529f\u80fd\uff09\uff1b\u5730\u4e2d\u6d77\u9635\u8425\uff1a\u5927\u529b\u63d0\u5021\u4f7f\u7528\u7279\u7ea7\u521d\u69a8\u6a44\u6984\u6cb9\uff08EVOO\uff09<\/td>\n<\/tr>\n | \n\u575a\u679c\u548c\u79cd\u5b50<\/strong><\/td>\n| \u603b\u4f53\u4eba\u7fa4\u961f\u5217\u6570\u636e\u4e00\u81f4\u8868\u660e\uff0c\u98df\u7528\u6574\u575a\u679c\u4e0e\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u7684\u51cf\u5c11\u76f8\u5173\uff1b\u53cc\u65b9\u9635\u8425\u90fd\u627f\u8ba4\u8fd9\u4e00\u70b9<\/td>\n | \u57c3\u585e\u5c14\u65af\u6c40\u5b66\u6d3e\u5728\u665a\u671f\u51a0\u5fc3\u75c5\u60a3\u8005\u4e2d\u9650\u5236\u575a\u679c\u6444\u5165\uff0c\u4ee5\u5c06\u603b\u8102\u80aa\u6444\u5165\u91cf\u63a7\u5236\u572810%\u4ee5\u4e0b\uff1b\u5965\u5c3c\u4ec0\u5b66\u6d3e\u548c\u5730\u4e2d\u6d77\u996e\u98df\u5b66\u6d3e\u5219\u5141\u8bb8\u9002\u91cf\u6444\u5165\u575a\u679c<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \u7efc\u5408\u81ea\uff1aOrnish D \u7b49. <\/em>\u300a\u7f8e\u56fd\u533b\u5b66\u4f1a\u6742\u5fd7\u300b\u30021998;280(23):2001-7\uff1b\u57c3\u745f\u5c14\u65af\u5ef7\u00b7CB\u00b7\u5c0f \u7b49\u3002. <\/em>J Fam Pract. 2014;63(7):356-364b; Estruch R et al. N Engl J Med. 2018;378(25):e34; Mensink RP et al. Am J Clin Nutr. 2003;77(5):1146-55.<\/em><\/p>\n9. \u5faa\u8bc1\u7ed3\u8bba\u4e0e\u4e34\u5e8a\u5efa\u8bae<\/h3>\n9.1 \u4e00\u7ea7\u9884\u9632\u2014\u2014\u5730\u4e2d\u6d77\u6a21\u5f0f\u4f5c\u4e3a\u4e00\u79cd\u5145\u5206\u7684\u996e\u98df\u7ed3\u6784<\/h4>\n\u5bf9\u4e8e\u5c1a\u672a\u786e\u8bca\u51a0\u72b6\u52a8\u8109\u75be\u75c5\u7684\u4e2a\u4f53\u800c\u8a00\uff0c\u6839\u636e\u73b0\u6709\u7ecf\u540c\u884c\u8bc4\u5ba1\u7684\u6587\u732e\uff0c\u4e00\u79cd\u5bcc\u542b\u6574\u9897\u6c34\u679c\u3001\u852c\u83dc\u3001\u8c46\u7c7b\u548c\u5168\u8c37\u7269\u7684\u5730\u4e2d\u6d77\u5f0f\u996e\u98df\u6a21\u5f0f\u2014\u2014\u5176\u8102\u80aa\u4e3b\u8981\u6765\u6e90\u4e8e\u6574\u9897\u575a\u679c\u3001\u79cd\u5b50\u548c\u7279\u7ea7\u521d\u69a8\u6a44\u6984\u6cb9\u2014\u2014\u662f\u9884\u9632\u539f\u53d1\u6027\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u8bc1\u636e\u6700\u5145\u5206\u7684\u996e\u98df\u5e72\u9884\u63aa\u65bd\u3002 \u603b\u8102\u80aa\u6444\u5165\u5e94\u5360\u603b\u70ed\u91cf\u768425-35%\uff0c\u5176\u4e2d\u9971\u548c\u8102\u80aa\u4e25\u683c\u9650\u5236\u5728<7%\uff0c\u5e76\u5c3d\u91cf\u51cf\u5c11\u7cbe\u5236\u78b3\u6c34\u5316\u5408\u7269\u7684\u6444\u5165\u3002(15,24,31) \u8be5\u5efa\u8bae\u5f97\u5230\u4e86\u5927\u91cf\u76f8\u4e92\u5370\u8bc1\u7684\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff08RCT\uff09\u6570\u636e\uff08\u91cc\u6602\u996e\u98df\u5fc3\u810f\u7814\u7a76\uff09\u3001\u524d\u77bb\u6027\u961f\u5217\u7814\u7a76\uff08Trichopoulou\u7b49\uff09\u3001 \u4eba\u7fa4\u5e72\u9884\u6570\u636e\uff08\u5317\u5361\u7d2f\u5229\u963f\u9879\u76ee\uff09\u4ee5\u53ca\u835f\u8403\u5206\u6790\u8bc1\u636e\uff08Dinu\u7b49\uff09\u6240\u652f\u6301\u7684\uff0c\u4f46\u9700\u627f\u8ba4PREDIMED\u7814\u7a76\u2014\u2014\u5c3d\u7ba1\u5728\u65b9\u5411\u4e0a\u652f\u6301\u8be5\u5efa\u8bae\u2014\u2014\u5728\u65b9\u6cd5\u5b66\u4e0a\u4e0d\u5e94\u88ab\u89c6\u4e3a\u5177\u6709\u51b3\u5b9a\u6027\u3002\uff089,11,15,31\uff09<\/p>\n 9.2 \u4e8c\u7ea7\u9884\u9632\u4e0e\u6591\u5757\u9006\u8f6c\u2014\u2014\u552f\u4e00\u88ab\u8bc1\u660e\u7684\u67b6\u6784\uff1a\u5168\u98df\u7d20\u98df\uff08WFPB\uff09\u65b9\u6848<\/h4>\n\u5bf9\u4e8e\u786e\u8bca\u60a3\u6709\u51a0\u72b6\u52a8\u8109\u75be\u75c5\u4e14\u5e0c\u671b\u5b9e\u73b0\u751f\u7269\u6027\u6591\u5757\u9006\u8f6c\u7684\u60a3\u8005\uff0c\u5f53\u524d\u7ecf\u540c\u884c\u8bc4\u5ba1\u7684\u8bc1\u636e\u8868\u660e\uff0c\u4e0d\u542b\u989d\u5916\u6dfb\u52a0\u6cb9\u8102\u7684\u8d85\u4f4e\u8102\uff08<10% \u70ed\u91cf\uff09\u5168\u690d\u7269\u6027\u996e\u98df\uff08WFPB\uff09\u662f\u552f\u4e00\u4e00\u79cd\u5728\u591a\u5e74\u968f\u8bbf\u4e2d\u7ecf\u8840\u7ba1\u9020\u5f71\u8bc1\u5b9e\u6709\u6548\u7684\u996e\u98df\u5e72\u9884\u63aa\u65bd\u3002(1,2,5) \u8fd9\u4e00\u5efa\u8bae\u4e0e\u7f8e\u56fd\u5fc3\u810f\u75c5\u5b66\u4f1a\u524d\u4e3b\u5e2d\u9610\u8ff0\u7684\u4e34\u5e8a\u7acb\u573a\u4e00\u81f4\uff0c\u4ed6\u6307\u51fa\uff0c\u5965\u5c3c\u4ec0\uff08Ornish\uff09\u548c\u57c3\u585e\u5c14\u65af\u6c40\uff08Esselstyn\uff09\u65b9\u6848\u662f\u4ec5\u6709\u7684\u56db\u79cd\u65b9\u6cd5\u4e2d\u7684\u4e24\u79cd\u2014\u2014\u53e6\u5916\u4e24\u79cd\u662f\u9ad8\u5242\u91cf\u963f\u6258\u4f10\u4ed6\u6c40\u548c\u7f57\u82cf\u4f10\u4ed6\u6c40\u2014\u2014\u5176\u98ce\u9669\/\u83b7\u76ca\u6bd4\u5728\u7ecf\u8840\u7ba1\u9020\u5f71\u8bc1\u5b9e\u53ef\u4f7f\u6591\u5757\u9006\u8f6c\u7684\u60c5\u51b5\u4e0b\u5904\u4e8e\u53ef\u63a5\u53d7\u8303\u56f4\u5185\u3002(35)<\/p>\n \u4e0e\u8bb0\u5f55\u5728\u6848\u7684\u75c5\u53d8\u9006\u8f6c\u76f8\u5173\u7684\u751f\u5316\u76ee\u6807\u9608\u503c\uff08\u8840\u6e05\u603b\u80c6\u56fa\u9187\u4f4e\u4e8e 150 mg\/dL\uff0c\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u80c6\u56fa\u9187 [LDL-C] \u4f4e\u4e8e 70-85 mg\/dL\uff09\u5982\u679c\u4ec5\u901a\u8fc7\u5730\u4e2d\u6d77\u996e\u98df\u6a21\u5f0f\u6765\u7ef4\u6301\uff0c\u5728\u6ca1\u6709\u663e\u8457\u836f\u7269\u8f85\u52a9\u7684\u60c5\u51b5\u4e0b\u5f88\u96be\u6301\u7eed\u8fbe\u5230\u3002(1,2,3,4) \u8d85\u4f4e\u8102\u5168\u690d\u7269\u996e\u98df\uff08WFPB\uff09\u65b9\u6848\u901a\u8fc7\u540c\u6b65\u673a\u5236\u5b9e\u73b0\u4e86\u8fd9\u4e9b\u76ee\u6807\uff1a\u663e\u8457\u51cf\u5c11\u81b3\u98df\u8102\u8d28\u6444\u5165\uff1b\u63d0\u9ad8\u8f7d\u8102\u86cb\u767d B\uff08ApoB\uff09\u7684\u5206\u89e3\u4ee3\u8c22\u7387\uff1b\u901a\u8fc7\u9ad8\u690d\u7269\u7ea4\u7ef4\u6444\u5165\u4fc3\u8fdb\u80c6\u6c41\u4e2d\u80c6\u56fa\u9187\u7684\u6392\u6cc4\uff1b\u4ee5\u53ca\u901a\u8fc7\u6d88\u9664\u7cbe\u70bc\u6cb9\u5f15\u8d77\u7684\u9910\u540e\u8102\u8d28\u5e94\u6fc0\uff0c\u6062\u590d\u5185\u76ae\u4e00\u6c27\u5316\u6c2e\u7684\u751f\u7269\u5229\u7528\u5ea6\u3002(1,2,5,18,21)<\/p>\n \u91cd\u8981\u7684\u662f\uff0c\u8fd9\u4e24\u79cd\u996e\u98df\u7ed3\u6784\u5728\u60a3\u8005\u7684\u6574\u4e2a\u75c5\u7a0b\u4e2d\u5e76\u4e0d\u9700\u8981\u88ab\u8ba4\u4e3a\u662f\u4e92\u76f8\u6392\u65a5\u7684\u3002\u5730\u4e2d\u6d77\u6a21\u5f0f\u53ef\u4ee5\u9002\u5f53\u5730\u4f5c\u4e3a\u65e9\u4e2d\u5e74\u7684\u521d\u7ea7\u9884\u9632\u7b56\u7565\uff1b\u5728\u8bca\u65ad\u51fa\u51a0\u5fc3\u75c5\u65f6\u8fc7\u6e21\u5230\u66f4\u4e25\u683c\u7684\u690d\u7269\u6027\u5168\u98df\u7269\uff08WFPB\uff09\u65e0\u6cb9\u65b9\u6848\uff0c\u5219\u4ee3\u8868\u4e86\u4e00\u79cd\u4e34\u5e8a\u4e0a\u5408\u7406\u7684\u9ad8\u6548\u6cbb\u7597\u65b9\u6848\uff0c\u7c7b\u4f3c\u4e8e\u9488\u5bf9\u65e2\u5b9a\u75be\u75c5\u8d1f\u62c5\u800c\u8fdb\u884c\u7684\u836f\u7269\u5242\u91cf\u5347\u7ea7\u3002.<\/p>\n 9.3 \u672a\u6765\u7814\u7a76\u5efa\u8bae<\/h4>\n\u73b0\u6709\u8bc1\u636e\u57fa\u7840\u5b58\u5728\u4e00\u4e2a\u5173\u952e\u7f3a\u53e3\uff1a\u5c1a\u65e0\u4efb\u4f55\u5177\u6709\u8db3\u591f\u6837\u672c\u91cf\u7684\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff08RCT\uff09\uff0c\u66fe\u4ee5\u786c\u6027\u5f71\u50cf\u5b66\u7ec8\u70b9\uff08\u51a0\u72b6\u52a8\u8109CTA\u6591\u5757\u5b9a\u91cf\u6216\u8840\u7ba1\u5185\u8d85\u58f0\uff09\u4e3a\u6807\u51c6\uff0c\u76f4\u63a5\u6bd4\u8f83\u8fc7\u201c<10%\u201d\u4f4e\u8102\u5168\u690d\u7269\u6027\u996e\u98df\u65b9\u6848\u3001\u5730\u4e2d\u6d77\u996e\u98df\u4e0e\u4f18\u5316\u836f\u7269\u6cbb\u7597\u7684\u6548\u679c\u3002 \u4e00\u9879\u4e3a\u671f\u81f3\u5c11\u4e09\u5e74\u3001\u4ee5\u51a0\u72b6\u52a8\u8109\u6591\u5757\u4f53\u79ef\u4e3a\u4e3b\u8981\u7ec8\u70b9\u7684\u6b64\u7c7b\u8bd5\u9a8c\uff0c\u5c06\u89e3\u51b3\u672c\u7efc\u8ff0\u7684\u6838\u5fc3\u4e34\u5e8a\u95ee\u9898\uff0c\u5e76\u63d0\u4f9b\u8fd9\u4e24\u79cd\u996e\u98df\u6a21\u5f0f\u76ee\u524d\u5747\u7f3a\u4e4f\u7684\u786e\u51ff\u6570\u636e\u3002.<\/p>\n \u53c2\u8003\u6587\u732e<\/h3>\n\n- \u5965\u5c3c\u65af D, \u5e03\u6717 SE, \u8c22\u5c14\u7ef4\u8328 LW, \u7b49\u3002\u751f\u6d3b\u65b9\u5f0f\u6539\u53d8\u80fd\u5426\u9006\u8f6c\u51a0\u5fc3\u75c5\uff1f\u751f\u6d3b\u65b9\u5f0f\u5fc3\u810f\u8bd5\u9a8c\u3002. \u67f3\u53f6\u5200<\/em>. 1990;336(8708):129-133. doi:10.1016\/0140-6736(90)91656-u<\/li>\n
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- \u57c3\u585e\u5c14\u65af\u5ef7 CB \u5c0f\uff0c\u57c3\u5229\u65af SG\uff0c\u95e8\u591a\u666e SV\uff0c\u514b\u7f57 TD\u3002\u963b\u6b62\u548c\u9006\u8f6c\u51a0\u72b6\u52a8\u8109\u75be\u75c5\u7684\u7b56\u7565\uff1a\u5bf9\u4e00\u4f4d\u5185\u79d1\u533b\u751f\u8bca\u7597\u5b9e\u8df5\u7684 5 \u5e74\u7eb5\u5411\u7814\u7a76\u3002. \u5168\u79d1\u533b\u5b66\u6742\u5fd7<\/em>. 1995;41(6):560-568.<\/li>\n
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\u957f\u671f\u4ee5\u6765\uff0c\u5927\u591a\u6570\u533b\u751f\u548c\u60a3\u8005\u90fd\u8ba4\u4e3a\u5fc3\u810f\u75c5\u662f\u4e00\u6761\u5355\u884c\u9053\u3002\u4e00\u65e6\u4f60\u7684\u52a8\u8109\u5f00\u59cb\u79ef\u805a\u6591\u5757\uff0c\u6cbb\u7597\u7684\u76ee\u6807\u5c31\u53ea\u662f\u51cf\u7f13\u75c5\u60c5\u6076\u5316\u3002\u6211\u4eec\u628a\u5b83\u5f53\u4f5c\u8001\u65e7\u6c7d\u8f66\u4e0a\u7684\u751f\u9508\u95ee\u9898\u6765\u5904\u7406\u2014\u2014\u4f60\u65e0\u6cd5\u771f\u6b63\u9664\u6389\u94c1\u9508\uff1b\u4f60\u53ea\u80fd\u8bd5\u7740\u5728\u4e0a\u9762\u5237\u6f06\u6216\u963b\u6b62\u5b83\u8513\u5ef6\u5f97\u592a\u5feb\u3002\u8fd9\u611f\u89c9\u5c31\u50cf\u662f\u8870\u8001\u7684\u4e00\u79cd\u4e0d\u53ef\u963b\u6321\u7684\u529b\u91cf\u3002\u4f46\u5982\u679c\u5fc3\u810f\u75c5\u5e76\u975e\u65e0\u671f\u5f92\u5211\u5462\uff1f\u60f3\u8c61\u4e00\u4e0b\u4f60\u7684\u52a8\u8109\u5c31\u50cf\u4e00\u6839\u82b1\u56ed\u6c34\u7ba1\u3002 .<\/p>","protected":false},"author":16,"featured_media":10559,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[216,222,223,224],"tags":[],"class_list":["post-10550","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-diet-and-nutrition","category-plant-based-diets","category-plaque-arteries-and-disease","category-regression-and-reversal"],"acf":[],"yoast_head":"\n The Only Diet Proven to Shrink Arterial Plaque (It\u2019s Not Mediterranean!) - The Premiere Heart Health Education Platform<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.curingheartdisease.com\/zh\/\u552f\u4e00\u88ab\u8bc1\u660e\u80fd\u7f29\u5c0f\u52a8\u8109\u6591\u5757\u7684\u996e\u98df\uff0c\u4e0d\u662f\u5730\u4e2d\u6d77\u996e\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Only Diet Proven to Shrink Arterial Plaque (It\u2019s Not Mediterranean!) - The Premiere Heart Health Education Platform\" \/>\n<meta property=\"og:description\" content=\"For a long time, most doctors and patients believed that heart disease was a one-way street. 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