Author Archives: Peter Megdal PhD

Atherosclerosis is a chronic, progressive vascular condition traditionally managed by interventions aimed at slowing its advancement.1 The measurable reversal of this condition—defined as structural regression—is the highest therapeutic outcome in cardiovascular disease management.2 Regression is evidenced angiographically by an increase in Minimal Lumen Diameter (MLD) or a decrease in Percent Diameter Stenosis ( %DS ).
We all aspire to be winners, but what does it truly mean to be a winner? It’s often defined as someone who places first in a race or excels in a competition. However, winning can encompass much more than that.

After a week of racing at the Masters National Championships in Milwaukee, Wisconsin, I believe I emerged as a winner with finishes of 2nd, 14th, and 5th place in various events organized by USA Cycling.
For years, we've heard the chorus: "Eat more plants for a healthier heart!" And largely, that advice holds true. Numerous studies have championed the benefits of plant-forward eating patterns in reducing the risk of cardiovascular disease. But a recent study from the robust NutriNet-Santé cohort in France has introduced a crucial nuance, revealing that the type of plant-based diet matters — a lot. Simply going "plant-based" might not be enough if your plate is piled high with highly processed foods.
Neu5Gc, Plant-Based Protection, and Atherosclerotic Heart Disease
Q1. What is Neu5Gc, and why is it linked to heart disease?

Neu5Gc (N-glycolylneuraminic acid) is a type of sialic acid found on the cells of most mammals—meaning it is present in red meat (beef, pork, lamb). Humans, however, cannot make Neu5Gc because of a mutation in the CMAH gene that occurred after our lineage split from great apes.
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