Author Archives: Peter Megdal PhD

The Interplay of Apolipoprotein B and Systemic Inflammation in Atherosclerotic Cardiovascular Disease: Causality, Mechanisms, and Clinical Paradigms. Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of morbidity and mortality worldwide. For decades, the field debated the fundamental pathophysiological nature of atherogenesis.

The identification of individuals at extreme risk for atherosclerotic cardiovascular disease (ASCVD) and sudden cardiac death (SCD) has transitioned from a reliance on population-based probability models to a more granular, individualistic assessment of genetic architecture. Central to this transition is the "gene dosing" model of inheritance, which provides a quantitative framework for understanding how the accumulation of pathogenic alleles within a family unit correlates with the temporal onset of clinical disease.